Are group- and cluster-scale dark matter halos over-concentrated?

We investigate the relationship between the halo mass, M_200, and concentration, c, for a sample of 26 group- and cluster-scale strong gravitational lenses. In contrast with previous results, we find that these systems are only ~ 0.1 dex more over-concentrated than similar-mass halos from dark matter simulations; the concentration of a halo with M_200 = 10^14 M_sun is log c = 0.78\pm0.05, while simulations of halos with this mass at similar redshifts (z ~ 0.4) predict log c ~ 0.56 - 0.71. We also find that we are unable to make informative inference on the slope of the M_200-c relation in spite of our large sample size; we note that the steep slopes found in previous studies tend to follow the slope in the covariance between M_200 and c, indicating that these results may be measuring the scatter in the data rather than the intrinsic signal. Furthermore, we conclude that our inability to constrain the M_200-c slope is due to a limited range of halo masses, as determined by explicitly modelling our halo mass distribution, and we suggest that other studies may be producing biased results by using an incorrect distribution for their halo masses.Comment: 8 pages; accepted to MNRA

Calibration and sensitivity of the Virgo detector during its second science run

The Virgo detector is a kilometer-length interferometer for gravitational wave detection located near Pisa (Italy). During its second science run (VSR2) in 2009, six months of data were accumulated with a sensitivity close to its design. In this paper, the methods used to determine the parameters for sensitivity estimation and gravitational wave reconstruction are described. The main quantities to be calibrated are the frequency response of the mirror actuation and the sensing of the output power. Focus is also put on their absolute timing. The monitoring of the calibration data as well as the parameter estimation with independent techniques are discussed to provide an estimation of the calibration uncertainties. Finally, the estimation of the Virgo sensitivity in the frequency-domain is described and typical sensitivities measured during VSR2 are shown.Comment: 30 pages, 23 figures, 1 table. Published in Classical and Quantum Gravity (CQG), Corrigendum include

Directional limits on persistent gravitational waves using LIGO S5 science data

The gravitational-wave (GW) sky may include nearby pointlike sources as well as astrophysical and cosmological stochastic backgrounds. Since the relative strength and angular distribution of the many possible sources of GWs are not well constrained, searches for GW signals must be performed in a model-independent way. To that end we perform two directional searches for persistent GWs using data from the LIGO S5 science run: one optimized for pointlike sources and one for arbitrary extended sources. The latter result is the first of its kind. Finding no evidence to support the detection of GWs, we present 90% confidence level (CL) upper-limit maps of GW strain power with typical values between 2-20x10^-50 strain^2 Hz^-1 and 5-35x10^-49 strain^2 Hz^-1 sr^-1 for pointlike and extended sources respectively. The limits on pointlike sources constitute a factor of 30 improvement over the previous best limits. We also set 90% CL limits on the narrow-band root-mean-square GW strain from interesting targets including Sco X-1, SN1987A and the Galactic Center as low as ~7x10^-25 in the most sensitive frequency range near 160 Hz. These limits are the most constraining to date and constitute a factor of 5 improvement over the previous best limits.Comment: 10 pages, 4 figure

A rapid review of communication strategies for physical activity guidelines and physical activity promotion: A review of worldwide strategies

BACKGROUND: To support the strategy development for communication of the updated physical activity (PA) guidelines, the UK Chief Medical Officers’ Expert Panel for Communication was created. METHODS: To help inform this process a rapid review was performed to identify and describe how other nations are communicating their PA guidelines and PA generally. Elements of the Health enhancing physical activity (HEPA) policy audit tool (PAT) created by the World Health Organization (WHO) were used to investigate all 195 countries. RESULTS: Seventy-seven countries had their own guidelines, 53 used the WHO guidelines, and for 65 countries no guidelines could be found. For the communication, 27 countries used infographics, 56 had government policies/documents, and 11 used a mass media campaign. Only 6 of these had been evaluated. Although many countries used infographics, there were no associated evaluations. As such any future communication strategies should incorporate an evaluation. Mass media campaigns had the strongest evidence base, proving to be an effective strategy, particularly when incorporating aspects of social marketing. CONCLUSION: This review provides an insight into strategies countries worldwide have taken to communicate PA guidelines and PA promotion. These should be carefully considered when deciding how best to communicate and promote PA guidelines

The similarity of the stellar mass fractions of galaxy groups and clusters

We employ a large sample of 20171 optically-selected groups and clusters at 0.15 < z < 0.4 in the SDSS to investigate how the stacked stellar mass fraction varies across a wide range of total mass, $M_{500}$. Our study improves upon previous observational studies in a number of important ways, including having a much larger sample size, an explicit inclusion of the intracluster light (ICL) component, and a thorough examination of the accuracy of our total mass estimates via comparisons to simulations and weak lensing observations. We find that the stellar mass fraction depends only weakly on total mass and that the contribution of ICL to the total stellar mass fraction is significant (typically 20-40 per cent). Both of these findings are in excellent accordance with the predictions of cosmological simulations. Under the assumption of a Chabrier (Salpeter) IMF, the derived star formation efficiency ($f_{star}$/$f_{b}$, where $f_b=\Omega_b/\Omega_m$) is relatively low at 8 per cent (14 per cent) and is consistent with the global star formation efficiency of semi-analytic models that reproduce the galaxy stellar mass function. When our measured stellar mass fractions are combined with the observed relation between hot gas mass fraction and total mass from X-ray observations, our results imply that galaxy groups have significantly lower baryon fractions than massive clusters. Ejection of gas due to energetic AGN feedback (most likely at high redshift) provides a plausible mechanism for explaining the trends we observe.Comment: accepted to MNRAS; minor revision

Macrophages promote angiogenesis in human breast tumour spheroids in vivo

An in vivo model has been established to study the role of macrophages in the initiation of angiogenesis by human breast tumour spheroids in vivo. The extent of the angiogenic response induced by T47D spheroids implanted into the dorsal skinfold chamber in nude mice was measured in vivo and compared to that induced by spheroids infiltrated with human macrophages prior to implantation. Our results indicate that the presence of macrophages in spheroids resulted in at least a three-fold upregulation in the release of vascular endothelial growth factor (VEGF) in vitro when compared with spheroids composed only of tumour cells. The angiogenic response measured around the spheroids, 3 days after in vivo implantation, was significantly greater in the spheroids infiltrated with macrophages. The number of vessels increased (macrophages vs no macrophages 34±1.9 vs 26±2.5, P<0.01), were shorter in length (macrophages vs no macrophages 116±4.92 vs 136±6.52, P<0.008) with an increased number of junctions (macrophages vs no macrophages 14±0.93 vs 11±1.25, P<0.025) all parameters indicative of new vessel formation. This is the first study to demonstrate a role for macrophages in the initiation of tumour angiogenesis in vivo

The radial distribution of galaxies in groups and clusters

We present a new catalogue of 55,121 groups and clusters centred on Luminous Red Galaxies from SDSS DR7 in the redshift range 0.15<z<0.4. We provide halo mass estimates for each of these groups derived from a calibration between the optical richness of bright galaxies (M_r<-20.5) within 1 Mpc, and X-ray-derived mass for a small subset of 129 groups and clusters with X-ray measurements. We derive the mean (stacked) surface number density profiles of galaxies as a function of total halo mass in different mass bins. We find that derived profiles can be well-described by a projected NFW profile with a concentration parameter (~2.6) that is approximately a factor of two lower than that of the dark matter (as predicted by N-body cosmological simulations) and nearly independent of halo mass. Interestingly, in spite of the difference in shape between the galaxy and dark matter radial distributions, both exhibit a high degree of self-similarity. A self-consistent comparison to several recent semi-analytic models of galaxy formation indicates that: (1) beyond ~0.3 r_500 current models are able to reproduce both the shape and normalisation of the satellite profiles; and (2) within ~0.3 r_500 the predicted profiles are sensitive to the details of the satellite-BCG merger timescale calculation. The former is a direct result of the models being tuned to match the global galaxy luminosity function combined with the assumption that the satellite galaxies do not suffer significant tidal stripping, even though their surrounding dark matter haloes can be removed through this process. Combining our results with measurements of the intracluster light should provide a way to inform theoretical models on the efficacy of the tidal stripping and merging processes.Comment: Resubmitted to MNRAS with minor revision

Seasonal pattern of peptic ulcer hospitalizations: analysis of the hospital discharge data of the Emilia-Romagna region of Italy

BACKGROUND: Previous studies have reported seasonal variation in peptic ulcer disease (PUD), but few large-scale, population-based studies have been conducted. METHODS: To verify whether a seasonal variation in cases of PUD (either complicated or not complicated) requiring acute hospitalization exists, we assessed the database of hospital admissions of the region Emilia Romagna (RER), Italy, obtained from the Center for Health Statistics, between January 1998 and December 2005. Admissions were categorized by sex, age ( or = 75 yrs), site of PUD lesion (stomach or duodenum), main complication (hemorrhage or perforation), and final outcome (intended as fatal outcome: in-hospital death; nonfatal outcome: patient discharged alive). Temporal patterns in PUD admissions were assessed in two ways, considering a) total counts per single month and season, and b) prevalence proportion, such as the monthly prevalence of PUD admissions divided by the monthly prevalence of total hospital admissions, to assess if the temporal patterns in the raw data might be the consequence of seasonal and annual variations in hospital admissions per se in the region. For statistical analysis, the chi2 test for goodness of fit and inferential chronobiologic method (Cosinor and partial Fourier series) were used. RESULTS: Of the total sample of PUD patients (26,848 [16,795 males, age 65 +/- 16 yrs; 10,053 females, age 72 +/- 15 yrs, p or = 75 yrs of age. There were more cases of duodenal (DU). (89.8%) than gastric ulcer (GU) (3.6%), and there were 1,290 (4.8%) fatal events. Data by season showed a statistically difference with the lowest proportion of PUD hospital admissions in summer (23.3%) (p < 0.001), for total cases and rather all subgroups. Chronobiological analysis identified three major peaks of PUD hospitalizations (September-October, January-February, and April-May) for the whole sample (p = 0.035), and several subgroups, with nadir in July. Finally, analysis of the monthly prevalence proportions yielded a significant (p = 0.025) biphasic pattern with a main peak in August-September-October, and a secondary one in January-February. CONCLUSIONS: A seasonal variation in PUD hospitalization, characterized by three peaks of higher incidence (Autumn, Winter, and Spring) is observed. When data corrected by monthly admission proportions are analyzed, late summer-autumn and winter are confirmed as higher risk periods. The underlying pathophysiologic mechanisms are unknown, and need further studies. In subjects at higher risk, certain periods of the year could deserve an appropriate pharmacological protection to reduce the risk of PUD hospitalization

Cancer Induces Cardiomyocyte Remodeling and Hypoinnervation in the Left Ventricle of the Mouse Heart

Cancer is often associated with cachexia, cardiovascular symptoms and autonomic dysregulation. We tested whether extracardiac cancer directly affects the innervation of left ventricular myocardium. Mice injected with Lewis lung carcinoma cells (tumor group, TG) or PBS (control group, CG) were analyzed after 21 days. Cardiac function (echocardiography), serum levels of TNF-α and Il-6 (ELISA), structural alterations of cardiomyocytes and their innervation (design-based stereology) and levels of innervation-related mRNA (quantitative RT-PCR) were analysed. The groups did not differ in various functional parameters. Serum levels of TNF-α and Il-6 were elevated in TG. The total length of axons in the left ventricle was reduced. The number of dense core vesicles per axon profile was reduced. Decreased myofibrillar volume, increased sarcoplasmic volume and increased volume of lipid droplets were indicative of metabolic alterations of TG cardiomyocytes. In the heart, the mRNA level of nerve growth factor was reduced whereas that of β1-adrenergic receptor was unchanged in TG. In the stellate ganglion of TG, mRNA levels of nerve growth factor and neuropeptide Y were decreased and that of tyrosine hydroxylase was increased. In summary, cancer induces a systemic pro-inflammatory state, a significant reduction in myocardial innervation and a catabolic phenotype of cardiomyocytes in the mouse. Reduced expression of nerve growth factor may account for the reduced myocardial innervation

Measurements of Superattenuator seismic isolation by Virgo interferometer

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