Intervenções sobre a linguagem: a produção de um esquecimento na colônia-brasilis

Starting from the lacanian notion that the unconscious is structured as a language, the intention of this article is to reflect from the formal prohibition of the Língua Geral Brasílica that occurred in the 18th century and its replacement by the Portuguese language as a result of a directive from the empire colonial. It is a psychoanalytic essay on this event, with contributions from linguistics, anthropology, sociology, decolonial studies, Tupi grammar and parallel texts on the subject. Not restricted to a historical debate, it is signaled how a forbidden language continues, unconsciously, being spoken, extracting from this an articulation between psychoanalysis, the unconscious and the radicality of the symbolic.Partiendo de la noción lacaniana de que el inconsciente se estructura como un lenguaje, la intención de este artículo es reflexionar sobre la prohibición formal de la Língua Geral Brasílica ocurrida en el siglo XVIII y su sustitución por la lengua portuguesa a raíz de una directriz del imperio colonial. Se trata de un ensayo psicoanalítico sobre este acontecimiento, con aportes de la lingüística, la antropología, la sociología, los estudios decoloniales, la gramática tupí y textos paralelos sobre el tema. No restringida a un debate histórico, muestra cómo se sigue hablando, inconscientemente, un lenguaje prohibido, extrayendo de allí una articulación entre el psicoanálisis, el inconsciente y la radicalidad de lo simbólico.En partant de la notion lacanienne selon laquelle l'inconscient est structuré comme un langage, l'intention de cet article est de réfléchir sur l'interdiction formelle de la Língua Geral Brasílica survenue au XVIIIe siècle et son remplacement par la langue portugaise à la suite d'une directive de l'empire colonial. Il s'agit d'un essai psychanalytique sur cet événement, avec des contributions de la linguistique, de l'anthropologie, de la sociologie, des études décoloniales, de la grammaire tupi et de textes parallèles sur le sujet. Ne se limitant pas à un débat historique, il montre comment un langage interdit continue, inconsciemment, à être parlé, en extrayant une articulation entre la psychanalyse, l'inconscient et la radicalité du symbolique.Partindo da noção lacaniana de que o inconsciente é estruturado como linguagem, a intenção deste artigo é a de refletir sobre a proibição formal da Língua Geral Brasílica ocorrida no século XVIII e a da sua substituição pela língua portuguesa por efeito de uma diretiva do império colonial. Trata-se de um ensaio psicanalítico sobre esse evento, contando para isso com aportes também da linguística, da antropologia, da sociologia, dos estudos decoloniais, da gramática do tupi e de textos paralelos sobre o tema. Não se restringindo a um debate histórico, sinaliza-se como uma língua proibida continua, inconscientemente, sendo falada, extraindo-se daí uma articulação entre a psicanálise, o inconsciente e a radicalidade do simbólico

One-pot total chemical synthesis of human α-synuclein

Post-translational modifications (PTMs) regulate key aspects of the physiological and pathogenic properties of Parkinson's disease-associated presynaptic protein α-synuclein. We herein describe a one-pot total chemical synthesis that should enable site-specific introduction of single or multiple PTMs or small molecule probes essentially at any site within the protein

Clinical Study A Reappraisal of Chemotherapy-Induced Liver Injury in Colorectal Liver Metastases before the Era of Antiangiogenics

Background and Aims. Chemotherapy of colorectal liver metastases can induce hepatotoxicity in noncancerous liver. We describe these lesions and assess risk factors and impacts on postresection morbidity and mortality in naive patients to chemotherapy before the era of bevacizumab. Methods. Noncancerous liver tissue lesions were analysed according to tumour, chemotherapy, surgery, and patient characteristics. Results. Fifty patients aged 62 ± 9.3 years were included between 2003 and 2007. Thirty-three (66%) received chemotherapy, with Folfox (58%), Folfiri (21%), LV5FU2 (12%), or Xelox (9%) regimens. Hepatotoxicity consisted of 18 (36%) cases of severe sinusoidal dilatation (SD), 13 (26%) portal fibrosis, 7 (14%) perisinusoidal fibrosis (PSF), 6 (12%) nodular regenerative hyperplasia (NRH), 2 (4%) steatosis >30%, zero steatohepatitis, and 16 (32%) surgical hepatitis. PSF was more frequent after chemotherapy (21% versus 0%, = 0.04), especially LV5FU2 ( = 0.02). SD was associated with oxaliplatin (54.5% versus 23.5%, = 0.05) and low body mass index ( = 0.003). NRH was associated with oxaliplatin ( = 0.03) and extensive resection ( = 0.04). No impact on mortality and morbidity was observed, apart postoperative elevation of bilirubin levels in case of PSF ( = 0.03), longer hospitalization in case of surgical hepatitis ( = 0.03), and greater blood loss in case of portal fibrosis ( = 0.03). Conclusions. Chemotherapy of colorectal liver metastases induces sinusoidal dilatation related to oxaliplatin and perisinusoidal fibrosis related to 5FU, without any impact on postoperative mortality

High-precision molecular dynamics simulation of UO2-PuO2: superionic transition in uranium dioxide

Our series of articles is devoted to high-precision molecular dynamics simulation of mixed actinide-oxide (MOX) fuel in the rigid ions approximation using high-performance graphics processors (GPU). In this article we assess the 10 most relevant interatomic sets of pair potential (SPP) by reproduction of the Bredig superionic phase transition (anion sublattice premelting) in uranium dioxide. The measurements carried out in a wide temperature range from 300K up to melting point with 1K accuracy allowed reliable detection of this phase transition with each SPP. The {\lambda}-peaks obtained are smoother and wider than it was assumed previously. In addition, for the first time a pressure dependence of the {\lambda}-peak characteristics was measured, in a range from -5 GPa to 5 GPa its amplitudes had parabolic plot and temperatures had linear (that is similar to the Clausius-Clapeyron equation for melting temperature).Comment: 7 pages, 6 figures, 1 tabl

2020 WSES guidelines for the detection and management of bile duct injury during cholecystectomy.

Bile duct injury (BDI) is a dangerous complication of cholecystectomy, with significant postoperative sequelae for the patient in terms of morbidity, mortality, and long-term quality of life. BDIs have an estimated incidence of 0.4-1.5%, but considering the number of cholecystectomies performed worldwide, mostly by laparoscopy, surgeons must be prepared to manage this surgical challenge. Most BDIs are recognized either during the procedure or in the immediate postoperative period. However, some BDIs may be discovered later during the postoperative period, and this may translate to delayed or inappropriate treatments. Providing a specific diagnosis and a precise description of the BDI will expedite the decision-making process and increase the chance of treatment success. Subsequently, the choice and timing of the appropriate reconstructive strategy have a critical role in long-term prognosis. Currently, a wide spectrum of multidisciplinary interventions with different degrees of invasiveness is indicated for BDI management. These World Society of Emergency Surgery (WSES) guidelines have been produced following an exhaustive review of the current literature and an international expert panel discussion with the aim of providing evidence-based recommendations to facilitate and standardize the detection and management of BDIs during cholecystectomy. In particular, the 2020 WSES guidelines cover the following key aspects: (1) strategies to minimize the risk of BDI during cholecystectomy; (2) BDI rates in general surgery units and review of surgical practice; (3) how to classify, stage, and report BDI once detected; (4) how to manage an intraoperatively detected BDI; (5) indications for antibiotic treatment; (6) indications for clinical, biochemical, and imaging investigations for suspected BDI; and (7) how to manage a postoperatively detected BDI

Search for standard model production of four top quarks in the lepton + jets channel in pp collisions at √s = 8 TeV

Open Access, Copyright CERN, for the benefit of the CMS Collaboration. Article funded by SCOAP3.Abstract: A search is presented for standard model (SM) production of four top quarks (Formula presented.) in pp collisions in the lepton + jets channel. The data correspond to an integrated luminosity of 19.6 fb−1 recorded at a centre-of-mass energy of 8 TeV with the CMS detector at the CERN LHC. The expected cross section for SM (Formula presented.) production is (Formula presented.). A combination of kinematic reconstruction and multivariate techniques is used to distinguish between the small signal and large background. The data are consistent with expectations of the SM, and an upper limit of 32 fb is set at a 95% confidence level on the cross section for producing four top quarks in the SM, where a limit of 32 ± 17 fb is expected

Search for new physics in events with two soft oppositely charged leptons and missing transverse momentum in proton-proton collisions at root s=13 TeV

A search is presented for new physics in events with two low-momentum, oppositely charged leptons (electrons or muons) and missing transverse momentum in proton-proton collisions at a centre-of-mass energy of 13TeV. The data collected using the CMS detector at the LHC correspond to an integrated luminosity of 35.9 fb(-1). The observed event yields are consistent with the expectations from the standard model. The results are interpreted in terms of pair production of charginos and neutralinos ((chi) over tilde (+/-)(1) and (chi) over tilde (0)(2)) with nearly degenerate masses, as expected in natural supersymmetry models with light higgsinos, as well as in terms of the pair production of top squarks ((t) over tilde), when the lightest neutralino and the top squark have similar masses. At 95% confidence level, wino-like (chi) over tilde (+/-)(1)/(chi) over tilde (0)(2) masses are excluded up to 230GeVfor a mass difference of 20GeV relative to the lightest neutralino. In the higgsino-like model, masses are excluded up to 168GeV for the same mass difference. For (t) over tilde pair production, top squark masses up to 450GeVare excluded for a mass difference of 40GeV relative to the lightest neutralino. (C) 2018 The Author(s). Published by Elsevier B.V.Peer reviewe