Fixing feedback revision rules in online markets

Feedback withdrawal mechanisms in online markets aim to facilitate the resolution of conflicts during transactions. Yet, frequently used online feedback withdrawal rules are flawed and may backfire by inviting strategic transaction and feedback behavior. Our laboratory experiment shows how a small change in the design of feedback withdrawal rules, allowing unilateral rather than mutual withdrawal, can both reduce incentives for strategic gaming and improve coordination of expectations. This leads to less trading risk, more cooperation, and higher market efficiency.Series: Department of Strategy and Innovation Working Paper Serie

Fast Converging Path Integrals for Time-Dependent Potentials I: Recursive Calculation of Short-Time Expansion of the Propagator

In this and subsequent paper arXiv:1011.5185 we develop a recursive approach for calculating the short-time expansion of the propagator for a general quantum system in a time-dependent potential to orders that have not yet been accessible before. To this end the propagator is expressed in terms of a discretized effective potential, for which we derive and analytically solve a set of efficient recursion relations. Such a discretized effective potential can be used to substantially speed up numerical Monte Carlo simulations for path integrals, or to set up various analytic approximation techniques to study properties of quantum systems in time-dependent potentials. The analytically derived results are numerically verified by treating several simple models.Comment: 29 pages, 5 figure

Sequential (gemcitabine/vinorelbine) and concurrent (gemcitabine) radiochemotherapy with FDG-PET-based target volume definition in locally advanced non-small cell lung cancer: first results of a phase I/II study

BACKGROUND: The aim of the study was to determine the maximal tolerated dose (MTD) of gemcitabine every two weeks concurrent to radiotherapy, administered during an aggressive program of sequential and simultaneous radiochemotherapy for locally advanced, unresectable non-small cell lung cancer (NSCLC) and to evaluate the efficacy of this regime in a phase II study. METHODS: 33 patients with histologically confirmed NSCLC were enrolled in a combined radiochemotherapy protocol. 29 patients were assessable for evaluation of toxicity and tumor response. Treatment included two cycles of induction chemotherapy with gemcitabine (1200 mg/m(2)) and vinorelbine (30 mg/m(2)) at day 1, 8 and 22, 29 followed by concurrent radiotherapy (2.0 Gy/d; total dose 66.0 Gy) and chemotherapy with gemcitabine every two weeks at day 43, 57 and 71. Radiotherapy planning included [(18)F] fluorodeoxyglucose positron emission tomography (FDG PET) based target volume definition. 10 patients were included in the phase I study with an initial gemcitabine dose of 300 mg/m(2). The dose of gemcitabine was increased in steps of 100 mg/m(2 )until the MTD was realized. RESULTS: MTD was defined for the patient group receiving gemcitabine 500 mg/m(2 )due to grade 2 (next to grade 3) esophagitis in all patients resulting in a mean body weight loss of 5 kg (SD = 1.4 kg), representing 8% of the initial weight. These patients showed persisting dysphagia 3 to 4 weeks after completing radiotherapy. In accordance with expected complications as esophagitis, dysphagia and odynophagia, we defined the MTD at this dose level, although no dose limiting toxicity (DLT) grade 3 was reached. In the phase I/II median follow-up was 15.7 months (4.1 to 42.6 months). The overall response rate after completion of therapy was 64%. The median overall survival was 19.9 (95% CI: [10.1; 29.7]) months for all eligible patients. The median disease-free survival for all patients was 8.7 (95% CI: [2.7; 14.6]) months. CONCLUSION: After induction chemotherapy, the maximum tolerated dose and frequency of gemcitabine was defined at 500 mg/m(2 )every two weeks in three cycles during a maximum of 7 weeks of thoracic radiotherapy for the phase II study. This regimen represents an effective and tolerable therapy in the treatment of NSCLC

Planetary heat flow from shallow subsurface measurements: Mars

Planetary heat flow probes measure heat flow (depth-resolved temperature and thermal conductivity) to provide insight into the internal state of a planet. The probes have been utilized extensively on Earth, twice on the Moon, and once on the Surface of comet 67P-CG. Mars is an important target for heat flow measurement as heat flow is a critical parameter in Martian thermal history models. Earlier studies indicate that Martian planetary heat flow can be accessed at 5 m below the surface in dry regolith monitored over at least one Martian year. A one Martian year monitoring period is necessary because, in the shallow subsurface, heat flow from the interior is superposed with time varying heat flow contributions, primarily due to insolation. Given that a heat flow probe may not achieve its target depth or monitoring period, this study investigates how the depth (2–5 m), duration (0–1 Martian year) and quality of measurements influence the accuracy of planetary heat flow. An inverse model is used to show that, in the preceding scenarios, the accuracy of planetary heat flow directly estimated from depth-dependent thermal conductivity with 10–20% precision errors, temperatures with 50–100 mK precision errors and modelling uncertainties up to 500 mK, can, on average, be improved by a factor of 27 with optimization to 13%. Accuracies increase with sensor penetration depth and regolith monitoring period. Heat flow optimized from instantaneous measurements or those with the shortest regolith monitoring periods have increased accuracy where the frequency and amplitude of the temperature variation are lowest. The inverse model is based on the Function Specification Inversion method. This study demonstrates that a solution subspace can be identified within a space of uncertainties modelled for the temperature measurements and planetary heat flow: the subspace is defined by a constant log-ratio of their respective standard deviations. Optimized heat flow estimates display reduced correlation with increasing temperature precision and systematic conductivity errors, with the constraint of other known model parameters. Consequently, the model permits upper bounds to be placed on the conductivity estimate without conductivity optimization, as heat flows are optimized to a limiting value with increasing systematic conductivity errors for any given parameter set. Overall, the results demonstrate a 52% chance of achieving a direct heat flow estimate accurate to within 40%, with the same being 82% after optimization

Автоматизированная система управления бизнес-процессами на базе малого предприятия

Проектирование системы автоматизированного управления бизнес-процессами на базе малого предприятия по производству пластика для 3D-печати. Объектом исследования является бизнес-процессы, протекающие на предприятии по производству пластика для 3D-печати Целью работы является разработка системы управления бизнес-процессами.Designing an automated business process management system based on a small plastic manufacturing enterprise for 3D printin

An estimate of the number of tropical tree species

The high species richness of tropical forests has long been recognized, yet there remains substantial uncertainty regarding the actual number of tropical tree species. Using a pantropical tree inventory database from closed canopy forests, consisting of 657,630 trees belonging to 11,371 species, we use a fitted value of Fisher’s alpha and an approximate pantropical stem total to estimate the minimum number of tropical forest tree species to fall between ∼40,000 and ∼53,000, i.e. at the high end of previous estimates. Contrary to common assumption, the Indo-Pacific region was found to be as species-rich as the Neotropics, with both regions having a minimum of ∼19,000–25,000 tree species. Continental Africa is relatively depauperate with a minimum of ∼4,500–6,000 tree species. Very few species are shared among the African, American, and the Indo-Pacific regions. We provide a methodological framework for estimating species richness in trees that may help refine species richness estimates of tree-dependent taxa

Identification of regulatory variants associated with genetic susceptibility to meningococcal disease.

Non-coding genetic variants play an important role in driving susceptibility to complex diseases but their characterization remains challenging. Here, we employed a novel approach to interrogate the genetic risk of such polymorphisms in a more systematic way by targeting specific regulatory regions relevant for the phenotype studied. We applied this method to meningococcal disease susceptibility, using the DNA binding pattern of RELA - a NF-kB subunit, master regulator of the response to infection - under bacterial stimuli in nasopharyngeal epithelial cells. We designed a custom panel to cover these RELA binding sites and used it for targeted sequencing in cases and controls. Variant calling and association analysis were performed followed by validation of candidate polymorphisms by genotyping in three independent cohorts. We identified two new polymorphisms, rs4823231 and rs11913168, showing signs of association with meningococcal disease susceptibility. In addition, using our genomic data as well as publicly available resources, we found evidences for these SNPs to have potential regulatory effects on ATXN10 and LIF genes respectively. The variants and related candidate genes are relevant for infectious diseases and may have important contribution for meningococcal disease pathology. Finally, we described a novel genetic association approach that could be applied to other phenotypes

Estimation de l'humidité des sols par des mesures SAR polarimétriques

Ce travail est consacré à l'estimation de l'humidité des sols par des mesures SAR polarimétriques. Une conséquence de la nature vectorielle du champ électromagnétique est la polarisation des ondes. Les mesures SAR polarimétriques quantifient le changement de polarisation entre le champ incident, qui illumine la scène, et le champ rétrodiffusé. Il existe de nombreux modèles de rétrodiffusion surfaciques qui expriment les caractéristiques polarimétriques en fonction de l'humidité et de la rugosité des sols. Des effets de dépolaristion, non prédits par des modèles classiques, ont été observé. Cela nous a amené au de veloppement d'un nouveau modèle de rétrodiffusion baptisé F-Bragg. Ce modèle, développé au moyen d'une technique de perturbation, permet non seulement de rendre compte des effets observés mais s'applique également à une large classe de rugosité, notamment aux sols fractals. Nous proposons ensuite un algorithme d'inversion rapide qui permet de retrouver les propriétés du sol à partir de données SAR complètement ou partiellement polarimétrique.RENNES1-BU Sciences Philo (352382102) / SudocSudocFranceF