Venous malformations in children - a literature review

Introduction: Venous malformations are congenital, the most occurring subtype of vascular malformations. They are characterized by slow flow, tortuosity and lack of macular layer within the vessel. Venous malformations can be highly problematic to diagnose and treat, thus differentiation the venous malformations with other diseases in pediatric population is important.   Aim of the study: The aim of the study is to summarize the available knowledge about venous malformation in pediatric population. The options in diagnosis, treatment and potential new methods were summarized and described. Materials and methods The literature available in the PubMed database was reviewed using the following keywords: “Vascular malformations”, “Venous Malformations”, “Venous malformations treatment, “Children”. Conclusions: Venous malformations are an important problem in pediatric population, as a seldom affliction they can be easily misdiagnosed as other diseases and treated inadequately. Widening of awareness of venous malformations and possible methods of diagnosing and treating them is very important to raise quality of health care in children

IQOS - new heat-not-burn tobacco products and its impact on health

Introduction: Iqos and other heat-not-burn products according to tobacco companies are a safer alternative to cigarettes. The aim of this article is to objectively review the potential impact of iQOS® on human health by searching for and integrating published research findings. This article provides a comprehensive review and analysis of the scientific research conducted on the effects of Iqos use on human health, distinguishing between specific medical fields. Materials and methods: This study is based on medical articles collected from the PubMed database spanning the years 2016-2023. The research was conducted through the analysis of keywords such as "Iqos", "Heat not burn", and "Iqos health impact".  Results: Tobacco heaters are seen as potentially less harmful. However, emerging research on their harmfulness clearly shows that despite reduced concentrations of compounds hazardous to health, the aerosol produced by heaters still contains the same harmful substances. Further studies show that the toxic impact of the aerosol is at a similar level to that of smoke from traditional cigarettes

New technologies in the surgical treatment of wounds

Introduction: Many wounds are treated surgically. For many years the method itself consisted mainly in cleaning the wounds and bringing its edges closer together, either by  strips for closing the wounds or by suturing the wound with classic sutures or staples. Recently, new methods have emerged to support wound healing, which are discussed in this article. Materials and methods: The basis of the work were medical articles collected in the PubMed database. The research was conducted by analyzing key words such as: "surgical treatment of wounds", "new technologies in wounds", "wound healing and new technologies", "dressings in wound treatment", "new methods of accelerating wound healing". Results: In the process of surgical wound treatment the basis is still the closure and connection of the edges of the wounds, which prevents infections, accelerates healing and improves the cosmetic effect. However this is not the final stage of wound healing. Equally important is the subsequent appropriate selection of the dressing - appropriate in terms of its composition of active substances and absorption properties. The choice of the right dressing has a large impact on the final effect and the avoidance of infections or the subsequent appearance of the scar. Now we also have many new technologies to help heal wounds. They help not only to reduce the risk of infection, but also accelerate the healing process and shorten the treatment time

The stilbene and dibenzo[b,f]oxepine derivatives as anticancer compounds

In the present study, the synthesis and cytotoxic effect of six stilbenes and three oxepine derivatives against twocancerous–HeLa and U87, and two normal–EUFA30 and HEK293 cell lines has been reported. The results ofcytotoxic assay andflow cytometry analysis revealed that compounds 9-nitrobenzo[b]naphtho[1,2-f]oxepine(4), (E)-3,3′,4,4′,5,5′-hexamethoxystilbene (6) and 4-hydroxy-2′,4′-dinitrostilbene (8) were the most active andtheir interaction with tubulin (crystal structure from PDB) has been analyzed by computer molecular modeling.Molecular docking of these compounds on colchicine binding site of the tubulin indicates the interaction of (4),(6) and (8) with tubulin. The compound (4) could interact stronger with tubulin, relative to colchicine, however,with no selectivity of action against cancer and normal cells. Conversely, compounds (6) and (8) interact moreweakly with tubulin, relative to colchicine but they act more selectively towards cancerous versus normal celllines. Obtained results proved that the compounds that are the most active against cancerous cells operatethrough tubulin binding

Azimuthal anisotropy of charged jet production in root s(NN)=2.76 TeV Pb-Pb collisions

We present measurements of the azimuthal dependence of charged jet production in central and semi-central root s(NN) = 2.76 TeV Pb-Pb collisions with respect to the second harmonic event plane, quantified as nu(ch)(2) (jet). Jet finding is performed employing the anti-k(T) algorithm with a resolution parameter R = 0.2 using charged tracks from the ALICE tracking system. The contribution of the azimuthal anisotropy of the underlying event is taken into account event-by-event. The remaining (statistical) region-to-region fluctuations are removed on an ensemble basis by unfolding the jet spectra for different event plane orientations independently. Significant non-zero nu(ch)(2) (jet) is observed in semi-central collisions (30-50% centrality) for 20 <p(T)(ch) (jet) <90 GeV/c. The azimuthal dependence of the charged jet production is similar to the dependence observed for jets comprising both charged and neutral fragments, and compatible with measurements of the nu(2) of single charged particles at high p(T). Good agreement between the data and predictions from JEWEL, an event generator simulating parton shower evolution in the presence of a dense QCD medium, is found in semi-central collisions. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Peer reviewe

Forward-central two-particle correlations in p-Pb collisions at root s(NN)=5.02 TeV

Two-particle angular correlations between trigger particles in the forward pseudorapidity range (2.5 2GeV/c. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B. V.Peer reviewe

Event-shape engineering for inclusive spectra and elliptic flow in Pb-Pb collisions at root(NN)-N-S=2.76 TeV

Peer reviewe

Pseudorapidity and transverse-momentum distributions of charged particles in proton-proton collisions at root s=13 TeV

The pseudorapidity (eta) and transverse-momentum (p(T)) distributions of charged particles produced in proton-proton collisions are measured at the centre-of-mass energy root s = 13 TeV. The pseudorapidity distribution in vertical bar eta vertical bar <1.8 is reported for inelastic events and for events with at least one charged particle in vertical bar eta vertical bar <1. The pseudorapidity density of charged particles produced in the pseudorapidity region vertical bar eta vertical bar <0.5 is 5.31 +/- 0.18 and 6.46 +/- 0.19 for the two event classes, respectively. The transverse-momentum distribution of charged particles is measured in the range 0.15 <p(T) <20 GeV/c and vertical bar eta vertical bar <0.8 for events with at least one charged particle in vertical bar eta vertical bar <1. The evolution of the transverse momentum spectra of charged particles is also investigated as a function of event multiplicity. The results are compared with calculations from PYTHIA and EPOS Monte Carlo generators. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Peer reviewe