Three-Point Correlations in f(R) Models of Gravity

Modifications of general relativity provide an alternative explanation to dark energy for the observed acceleration of the universe. We calculate quasilinear effects in the growth of structure in f(R) models of gravity using perturbation theory. We find significant deviations in the bispectrum that depend on cosmic time, length scale and triangle shape. However the deviations in the reduced bispectrum Q for f(R) models are at the percent level, much smaller than the deviations in the bispectrum itself. This implies that three-point correlations can be predicted to a good approximation simply by using the modified linear growth factor in the standard gravity formalism. Our results suggest that gravitational clustering in the weakly nonlinear regime is not fundamentally altered, at least for a class of gravity theories that are well described in the Newtonian regime by the parameters G_eff and Phi/Psi. This approximate universality was also seen in the N-body simulation measurements of the power spectrum by Stabenau and Jain (2006), and in other recent studies based on simulations. Thus predictions for such modified gravity models in the regime relevant to large-scale structure observations may be less daunting than expected on first principles. We discuss the caveats that apply to such predictions.Comment: 10 pages, 7 figures, Submitted to PR

In search for geroprotectors: in silico screening and in vitro validation of signalome-level mimetics of young healthy state

ABSTRACT Populations in developed nations throughout the world are rapidly aging, and the search for geroprotectors, or anti-aging interventions, has never been more important. Yet while hundreds of geroprotectors have extended lifespan in animal models, none have yet been approved for widespread use in humans. GeroScope is a computational tool that can aid prediction of novel geroprotectors from existing human gene expression data. GeroScope maps expression differences between samples from young and old subjects to aging-related signaling pathways, then profiles pathway activation strength (PAS) for each condition. Known substances are then screened and ranked for those most likely to target differential pathways and mimic the young signalome. Here we used GeroScope and shortlisted ten substances, all of which have lifespan-extending effects in animal models, and tested 6 of them for geroprotective effects in senescent human fibroblast cultures. PD-98059, a highly selective MEK1 inhibitor, showed both life-prolonging and rejuvenating effects. Natural compounds like N-acetyl-L-cysteine, Myricetin and Epigallocatechin gallate also improved several senescence-associated properties and were further investigated with pathway analysis. This work not only highlights several potential geroprotectors for further study, but also serves as a proof-of-concept for GeroScope, Oncofinder and other PAS-based methods in streamlining drug prediction, repurposing and personalized medicine

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements