Implementación de una Biblioteca Infantil en el Centro Preescolar de Aplicación “Arlen Siu” de la UNAN Managua

El mundo entero y en especial nuestro país enfrentamos cambios, en la cual debemos de dar prioridad de importancia a la educación y de manera primordial a la educación infantil. Los nuevos profesionales de la educación, gestores de la información, bibliotecarios, analistas documentales, técnicos de archivos, etc., debemos tener habilidades de gestión que nos permitan flexibilizar al máximo la prestación de servicios a la comunidad y aún más teniendo en cuenta el entorno comunitario regido por la administración pública de nuestro país Nicaragua. Los nuevos profesionales y gestores de la información de la UNAN Managua, debemos coincidir en señalar que el cambio será una constante en la gestión de todo tipo de organizaciones, incluyendo las culturales, educativas y científicas. De allí que surge la idea de implementar el buen funcionamiento de una biblioteca, donde profesionales de la educación puedan generar aprendizaje de lectura a los niños y niñas del Centro de Aplicación Arlen Siu, todo con el objetivo de ayudar a la sociedad en la transformación educativa de los niños, con servicios altamente influidos por las tecnologías que serán nuestro fundamental apoyo y lograr un cambio de época. La implementación de esta biblioteca tendrá la capacidad de aportar valor a lo que persigue la UNAN Managua como institución que la acoge, estará integrada en la Facultad de Educación e Idiomas, quien será su ente gobernador para su administración, por ser parte de apoyo fundamental para el Centro de Aplicación Arlen Siu, debido a que contribuye a sus finalidades, mismas que serán enfocadas en incrementar la interdisciplinariedad y motivación de los infantes por la lectura y hábitos educativos integrales

Use of formative research in developing a knowledge translation approach to rotavirus vaccine introduction in developing countries

BACKGROUND: Rotavirus gastroenteritis is the leading cause of diarrheal disease mortality among children under five, resulting in 450,000 to 700,000 deaths each year, and another 2 million hospitalizations, mostly in the developing world. Nearly every child in the world is infected with rotavirus at least once before they are five years old. Vaccines to prevent rotavirus or minimize its severity are now becoming available, and have already been introduced into the public vaccine programs of several Latin American countries. The World Health Organization (WHO) has made rotavirus vaccine introduction in developing countries a high priority. The WHOs Guidelines for Vaccine Introduction indicates that a key determinant to achieving vaccine introduction is the public health priority of the disease, suggesting that where the disease is not a priority uptake of the vaccine is unlikely. WHO recommends conducting a qualitative analysis of opinions held by the public health community to determine the perceptions of the disease and the priority given to the vaccine. METHODS: This paper presents the formative research results of a qualitative survey of public health providers in five low- and middle-income countries to determine if and to what degree rotavirus is perceived to be a problem and the priority of a vaccine. Open-ended surveys were carried out through focus group discussions and one-on-one interviews. RESULTS: Researchers discovered that in all five countries knowledge of rotavirus was extremely low, and as a result was not considered a high priority. However, diarrhea among young children was considered a high priority among public health providers in the three poorest countries with relatively high levels of child mortality: India, Indonesia, and Nicaragua. CONCLUSION: In the poorest countries, advocacy and communication efforts to raise awareness about rotavirus sufficient for prioritization and accelerated vaccine introduction might benefit from a knowledge translation approach that delivers information and evidence about rotavirus through the broader context of diarrheal disease control, an existing priority, and including information about other new interventions, specifically low-osmolarity oral rehydration solution and zinc treatment

La ocupación solutrense del Abrigo de la Boja (Mula, Murcia, España)

El relleno pleistoceno del Abrigo de la Boja (ADB) empieza con un nivel adscrito al Magdaleniense superior, seguido de un potente paquete con ocupación difusa bajo el cual se desarrolla una secuencia depositada durante el último máximo glacial caracterizada por una serie de estructuras de combustión, de tipo hogar plano/amorfo (open hearth), existiendo también hogares de cubeta. Destaca un hogar enlosado, completo y muy bien conservado, excavado en 2012 y adscrito provisionalmente al Solutreogravetiense. Los niveles solutrenses subyacentes son ricos en elementos de adorno, entre los cuales conchas perforadas de Littorina obtusata y Smaragdia viridis; su industria lítica incluye raspadores, algunas puntas, y escasos buriles. La datación 14C de muestras de carbón de Juniperus sp. sitúa este paquete entre 16990 ± 70 BP (VERA-5364a), a techo, y 20980 ± 120 BP (VERA-5366), a muro. The Pleistocene fill of the La Boja rock shelter (ADB) starts with an Upper Magdalenian level, followed by a thick package with poorly defined occupations under which there is a Last Glacial Maximum sequence with combustion features, mostly of the open hearth type. A particularly well preserved and seemingly complete stone-paved hearth of probable Solutreogravettian age was excavated in 2012. The abundant ornaments in the Solutrean levels include pierced Littorina obtusata and Smaragdia viridis shells and the stone tool assem- blages feature endscrapers, some points and rare burins. The 14C dating of Juniperus sp. charcoal samples places this sequence between 16990 ± 70 BP (VERA-5364a), at the top, and 20980 ± 120 BP (VERA-5366), at the bottom

Prognostic significance of FLT3-ITD length in AML patients treated with intensive regimens

FLT3-ITD mutations are detected in approximately 25% of newly diagnosed adult acute myeloid leukemia (AML) patients and confer an adverse prognosis. The FLT3-ITD allelic ratio has clear prognostic value. Nevertheless, there are numerous manuscripts with contradictory results regarding the prognostic relevance of the length and insertion site (IS) of the FLT3-ITD fragment. We aimed to assess the prognostic impact of these variables on the complete remission (CR) rates, overall survival (OS) and relapse-free survival (RFS) of AML patients with FLT3-ITDmutations. We studied the FLT3-ITD length of 362 adult AML patients included in the PETHEMA AML registry. We tried to validate the thresholds of ITD length previously published (i.e., 39 bp and 70 bp) in intensively treated AML patients (n = 161). We also analyzed the mutational profile of 118 FLT3-ITD AML patients with an NGS panel of 39 genes and correlated mutational status with the length and IS of ITD. The AUC of the ROC curve of the ITD length for OS prediction was 0.504, and no differences were found when applying any of the thresholds for OS, RFS or CR rate. Only four out of 106 patients had ITD IS in the TKD1 domain. Our results, alongside previous publications, confirm that FLT3-ITD length lacks prognostic value and clinical applicability. © 2021, The Author(s)

Search for new particles in events with energetic jets and large missing transverse momentum in proton-proton collisions at root s=13 TeV

A search is presented for new particles produced at the LHC in proton-proton collisions at root s = 13 TeV, using events with energetic jets and large missing transverse momentum. The analysis is based on a data sample corresponding to an integrated luminosity of 101 fb(-1), collected in 2017-2018 with the CMS detector. Machine learning techniques are used to define separate categories for events with narrow jets from initial-state radiation and events with large-radius jets consistent with a hadronic decay of a W or Z boson. A statistical combination is made with an earlier search based on a data sample of 36 fb(-1), collected in 2016. No significant excess of events is observed with respect to the standard model background expectation determined from control samples in data. The results are interpreted in terms of limits on the branching fraction of an invisible decay of the Higgs boson, as well as constraints on simplified models of dark matter, on first-generation scalar leptoquarks decaying to quarks and neutrinos, and on models with large extra dimensions. Several of the new limits, specifically for spin-1 dark matter mediators, pseudoscalar mediators, colored mediators, and leptoquarks, are the most restrictive to date.Peer reviewe

Combined searches for the production of supersymmetric top quark partners in proton-proton collisions at root s=13 TeV

A combination of searches for top squark pair production using proton-proton collision data at a center-of-mass energy of 13 TeV at the CERN LHC, corresponding to an integrated luminosity of 137 fb(-1) collected by the CMS experiment, is presented. Signatures with at least 2 jets and large missing transverse momentum are categorized into events with 0, 1, or 2 leptons. New results for regions of parameter space where the kinematical properties of top squark pair production and top quark pair production are very similar are presented. Depending on themodel, the combined result excludes a top squarkmass up to 1325 GeV for amassless neutralino, and a neutralinomass up to 700 GeV for a top squarkmass of 1150 GeV. Top squarks with masses from 145 to 295 GeV, for neutralino masses from 0 to 100 GeV, with a mass difference between the top squark and the neutralino in a window of 30 GeV around the mass of the top quark, are excluded for the first time with CMS data. The results of theses searches are also interpreted in an alternative signal model of dark matter production via a spin-0 mediator in association with a top quark pair. Upper limits are set on the cross section for mediator particle masses of up to 420 GeV

Probing effective field theory operators in the associated production of top quarks with a Z boson in multilepton final states at root s=13 TeV

Peer reviewe

Measurements of Higgs boson production cross sections and couplings in the diphoton decay channel at root s=13 TeV

Measurements of Higgs boson production cross sections and couplings in events where the Higgs boson decays into a pair of photons are reported. Events are selected from a sample of proton-proton collisions at root s = 13TeV collected by the CMS detector at the LHC from 2016 to 2018, corresponding to an integrated luminosity of 137 fb(-1). Analysis categories enriched in Higgs boson events produced via gluon fusion, vector boson fusion, vector boson associated production, and production associated with top quarks are constructed. The total Higgs boson signal strength, relative to the standard model (SM) prediction, is measured to be 1.12 +/- 0.09. Other properties of the Higgs boson are measured, including SM signal strength modifiers, production cross sections, and its couplings to other particles. These include the most precise measurements of gluon fusion and vector boson fusion Higgs boson production in several different kinematic regions, the first measurement of Higgs boson production in association with a top quark pair in five regions of the Higgs boson transverse momentum, and an upper limit on the rate of Higgs boson production in association with a single top quark. All results are found to be in agreement with the SM expectations.Peer reviewe