Autonomous RPCs for a Cosmic Ray ground array

We report on the behaviour of Resistive Plate Chambers (RPC) developed for muon detection in ultra-high energy cosmic ray (UHECR) experiments. The RPCs were developed for the MARTA project and were tested on field conditions. These RPCs cover an area of $1.5 \times 1.2\,{m^2}$ and are instrumented with 64 pickup electrodes providing a segmentation better than $20\,$cm. By shielding the detector units with enough slant mass to absorb the electromagnetic component in the air showers, a clean measurement of the muon content is allowed, a concept to be implemented in a next generation of UHECR experiments. The operation of a ground array detector poses challenging demands, as the RPC must operate remotely under extreme environmental conditions, with limited budgets for power and minimal maintenance. The RPC, DAQ, High Voltage and monitoring systems are enclosed in an aluminium-sealed case, providing a compact and robust unit suited for outdoor environments, which can be easily deployed and connected. The RPCs developed at LIP-Coimbra are able to operate using a very low gas flux, which allows running them for few years with a small gas reservoir. Several prototypes have already been built and tested both in the laboratory and outdoors. We report on the most recent tests done in the field that show that the developed RPCs have operated in a stable way for more than 2 years in field conditions.Comment: To appear in the proceedings of the 35th International Cosmic Ray Conference (ICRC2017), Busan, South Korea. Presented by R. Concei\c{c}\~{a}o. 8 page

Observatories of the Solar Corona and Active Regions (OSCAR)

Coronal Mass Ejections (CMEs) and Corotating Interaction Regions (CIRs) are major sources of magnetic storms on Earth and are therefore considered to be the most dangerous space weather events. The Observatories of Solar Corona and Active Regions (OSCAR) mission is designed to identify the 3D structure of coronal loops and to study the trigger mechanisms of CMEs in solar Active Regions (ARs) as well as their evolution and propagation processes in the inner heliosphere. It also aims to provide monitoring and forecasting of geo- effective CMEs and CIRs. OSCAR would contribute to significant advancements in the field of solar physics, improvements of the current CME prediction models, and provide data for reliable space weather forecasting. These objectives are achieved by utilising two spacecraft with identical instrumentation, located at a heliocentric orbital distance of 1 AU from the Sun. The spacecraft will be separated by an angle of 68° to provide optimum stereoscopic view of the solar corona. We study the feasibility of such a mission and propose a preliminary design for OSCAR

Autonomous RPCs for a Cosmic Ray ground array

We report on the behaviour of Resistive Plate Chambers (RPC) developed for muon detection in ultra-high energy cosmic ray (UHECR) experiments. The RPCs were developed for the MARTA project and were tested on field conditions. These RPCs cover an area of $1.5 \times 1.2\,{m^2}$ and are instrumented with 64 pickup electrodes providing a segmentation better than $20\,$cm. By shielding the detector units with enough slant mass to absorb the electromagnetic component in the air showers, a clean measurement of the muon content is allowed, a concept to be implemented in a next generation of UHECR experiments. The operation of a ground array detector poses challenging demands, as the RPC must operate remotely under extreme environmental conditions, with limited budgets for power and minimal maintenance. The RPC, DAQ, High Voltage and monitoring systems are enclosed in an aluminium-sealed case, providing a compact and robust unit suited for outdoor environments, which can be easily deployed and connected. The RPCs developed at LIP-Coimbra are able to operate using a very low gas flux, which allows running them for few years with a small gas reservoir. Several prototypes have already been built and tested both in the laboratory and outdoors. We report on the most recent tests done in the field that show that the developed RPCs have operated in a stable way for more than 2 years in field conditions.Peer Reviewe

CTCs expression profiling for advanced breast cancer monitoring

The study of circulating tumor cells (CTCs) has a huge clinical interest in advance and metastatic breast cancer patients. However, many approaches are biased by the use of epithelial markers, which underestimate non-epithelial CTCs phenotypes. CTCs enumeration provides valuable prognostic information; however, molecular characterization could be the best option to monitor patients throughout the disease since it may provide more relevant clinical information to the physicians. In this work, we aimed at enumerating and performing a molecular characterization of CTCs from a cohort of 20 patients with metastatic breast cancer (MBC), monitoring the disease at different time points of the therapy, and at progression when it occurred. To this end, we used a CTC negative enrichment protocol that allowed us to recover a higher variety of CTCs phenotypes. With this strategy, we were able to obtain gene expression data from CTCs from all the patients. In addition, we found that high expression levels of PALB2 and MYC were associated with a worse outcome. Interestingly, we identified that CTCs with an EpCAM(high)VIM(low)ALDH1A1(high) signature showed both shorter overall survival (OS) and progression-free survival (PFS), suggesting that CTCs with epithelial-stem features had the most aggressive phenotype

Modeling the shock-cloud interaction in SN 1006: unveiling the origin of nonthermal X-ray and gamma-ray emission

Context. The supernova remnant SN 1006 is a source of high-energy particles and its southwestern limb is interacting with a dense ambient cloud, thus being a promising region for γ−ray hadronic emission. Aims. We aim at describing the physics and the nonthermal emission associated with the shock-cloud interaction to derive the physical parameters of the cloud (poorly constrained by the data analysis), to ascertain the origin of the observed spatial variations in the spectral properties of the X-ray synchrotron emission, and to predict spectral and morphological features of the resulting γ−ray emission. Methods. We performed 3-D magnetohydrodynamic simulations modeling the evolution of SN 1006 and its interaction with the ambient cloud, and explored different model setups. By applying the REMLIGHT code on the model results, we synthesized the synchrotron X-ray emission, and compared it with actual observations, to constrain the parameters of the model. We also synthesized the leptonic and hadronic γ−ray emission from the models, deriving constraints on the energy content of the hadrons accelerated at the southwestern limb. Results. We found that the impact of the SN 1006 shock front with a uniform cloud with density 0.5 cm^(−3) can explain the observed morphology, the azimuthal variations of the cutoff frequency of the X-ray synchrotron emission, and the shock proper motion in the interaction region. Our results show that the current upper limit for the total hadronic energy in the southwestern limb is 2.5 × 10^(49) erg

Erratum: A space weather mission concept: Observatories of the solar corona and active regions (oscar) (Journal of Space Weather and Space Climate (2015) 5 (A4) DOI: 10.1051/swsc/2015003)

In this erratum we acknowledge EASCO as one of the inspirational mission concepts that helped the development of our original mission concept OSCAR

Goodbye Hartmann trial: a prospective, international, multicenter, observational study on the current use of a surgical procedure developed a century ago

Background: Literature suggests colonic resection and primary anastomosis (RPA) instead of Hartmann's procedure (HP) for the treatment of left-sided colonic emergencies. We aim to evaluate the surgical options globally used to treat patients with acute left-sided colonic emergencies and the factors that leading to the choice of treatment, comparing HP and RPA. Methods: This is a prospective, international, multicenter, observational study registered on ClinicalTrials.gov. A total 1215 patients with left-sided colonic emergencies who required surgery were included from 204 centers during the period of March 1, 2020, to May 31, 2020. with a 1-year follow-up. Results: 564 patients (43.1%) were females. The mean age was 65.9 ± 15.6 years. HP was performed in 697 (57.3%) patients and RPA in 384 (31.6%) cases. Complicated acute diverticulitis was the most common cause of left-sided colonic emergencies (40.2%), followed by colorectal malignancy (36.6%). Severe complications (Clavien-Dindo ≥ 3b) were higher in the HP group (P < 0.001). 30-day mortality was higher in HP patients (13.7%), especially in case of bowel perforation and diffused peritonitis. 1-year follow-up showed no differences on ostomy reversal rate between HP and RPA. (P = 0.127). A backward likelihood logistic regression model showed that RPA was preferred in younger patients, having low ASA score (≤ 3), in case of large bowel obstruction, absence of colonic ischemia, longer time from admission to surgery, operating early at the day working hours, by a surgeon who performed more than 50 colorectal resections. Conclusions: After 100 years since the first Hartmann's procedure, HP remains the most common treatment for left-sided colorectal emergencies. Treatment's choice depends on patient characteristics, the time of surgery and the experience of the surgeon. RPA should be considered as the gold standard for surgery, with HP being an exception

Evolving trends in the management of acute appendicitis during COVID-19 waves. The ACIE appy II study

Background: In 2020, ACIE Appy study showed that COVID-19 pandemic heavily affected the management of patients with acute appendicitis (AA) worldwide, with an increased rate of non-operative management (NOM) strategies and a trend toward open surgery due to concern of virus transmission by laparoscopy and controversial recommendations on this issue. The aim of this study was to survey again the same group of surgeons to assess if any difference in management attitudes of AA had occurred in the later stages of the outbreak. Methods: From August 15 to September 30, 2021, an online questionnaire was sent to all 709 participants of the ACIE Appy study. The questionnaire included questions on personal protective equipment (PPE), local policies and screening for SARS-CoV-2 infection, NOM, surgical approach and disease presentations in 2021. The results were compared with the results from the previous study. Results: A total of 476 answers were collected (response rate 67.1%). Screening policies were significatively improved with most patients screened regardless of symptoms (89.5% vs. 37.4%) with PCR and antigenic test as the preferred test (74.1% vs. 26.3%). More patients tested positive before surgery and commercial systems were the preferred ones to filter smoke plumes during laparoscopy. Laparoscopic appendicectomy was the first option in the treatment of AA, with a declined use of NOM. Conclusion: Management of AA has improved in the last waves of pandemic. Increased evidence regarding SARS-COV-2 infection along with a timely healthcare systems response has been translated into tailored attitudes and a better care for patients with AA worldwide

Outcomes of elective liver surgery worldwide: a global, prospective, multicenter, cross-sectional study

Background: The outcomes of liver surgery worldwide remain unknown. The true population-based outcomes are likely different to those vastly reported that reflect the activity of highly specialized academic centers. The aim of this study was to measure the true worldwide practice of liver surgery and associated outcomes by recruiting from centers across the globe. The geographic distribution of liver surgery activity and complexity was also evaluated to further understand variations in outcomes. Methods: LiverGroup.org was an international, prospective, multicenter, cross-sectional study following the Global Surgery Collaborative Snapshot Research approach with a 3-month prospective, consecutive patient enrollment within January–December 2019. Each patient was followed up for 90 days postoperatively. All patients undergoing liver surgery at their respective centers were eligible for study inclusion. Basic demographics, patient and operation characteristics were collected. Morbidity was recorded according to the Clavien–Dindo Classification of Surgical Complications. Country-based and hospital-based data were collected, including the Human Development Index (HDI). (NCT03768141). Results: A total of 2159 patients were included from six continents. Surgery was performed for cancer in 1785 (83%) patients. Of all patients, 912 (42%) experienced a postoperative complication of any severity, while the major complication rate was 16% (341/2159). The overall 90-day mortality rate after liver surgery was 3.8% (82/2,159). The overall failure to rescue rate was 11% (82/ 722) ranging from 5 to 35% among the higher and lower HDI groups, respectively. Conclusions: This is the first to our knowledge global surgery study specifically designed and conducted for specialized liver surgery. The authors identified failure to rescue as a significant potentially modifiable factor for mortality after liver surgery, mostly related to lower Human Development Index countries. Members of the LiverGroup.org network could now work together to develop quality improvement collaboratives

Azimuthal anisotropy of charged jet production in root s(NN)=2.76 TeV Pb-Pb collisions

We present measurements of the azimuthal dependence of charged jet production in central and semi-central root s(NN) = 2.76 TeV Pb-Pb collisions with respect to the second harmonic event plane, quantified as nu(ch)(2) (jet). Jet finding is performed employing the anti-k(T) algorithm with a resolution parameter R = 0.2 using charged tracks from the ALICE tracking system. The contribution of the azimuthal anisotropy of the underlying event is taken into account event-by-event. The remaining (statistical) region-to-region fluctuations are removed on an ensemble basis by unfolding the jet spectra for different event plane orientations independently. Significant non-zero nu(ch)(2) (jet) is observed in semi-central collisions (30-50% centrality) for 20 <p(T)(ch) (jet) <90 GeV/c. The azimuthal dependence of the charged jet production is similar to the dependence observed for jets comprising both charged and neutral fragments, and compatible with measurements of the nu(2) of single charged particles at high p(T). Good agreement between the data and predictions from JEWEL, an event generator simulating parton shower evolution in the presence of a dense QCD medium, is found in semi-central collisions. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Peer reviewe