81 research outputs found
Neuroinflammation:Synapses pruned in lupus
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 22/06/2017
- Field of study
Get PDFPrecise measurement of the W-boson mass with the CDF II detector
- Author
- Aaltonen T.
- Abbaneo D
- Adzic P
- Aguilar-Benitez M
- Ahmad M
- Ahmed I
- Albajar C
- Allfrey P
- Almeida N
- Alvarez Gonzalez B.
- Amerio S.
- Amidei D.
- Anastassov A.
- Andreev V
- Andreev Y
- Annovi A.
- Antos J.
- Apollinari G.
- Appel J. A.
- Arce P
- Arisawa T.
- Artikov A.
- Asaadi J.
- Asghar MI
- Ashmanskas W.
- Auerbach B.
- Auffray E
- Aurisano A.
- Auzinger G
- Azarkin M
- Azfar F.
- Azhgirey I
- Badgett W.
- Bae T.
- Baillon P
- Ball AH
- Barbaro-Galtieri A.
- Barnes V. E.
- Barnett B. A.
- Barney D
- Barria P.
- Bartos P.
- Battilana C
- Bauce M.
- Bedeschi F.
- Bedoya CF
- Beecher D.
- Behari S.
- Bell AJ
- Bellettini G.
- Bellinger J.
- Belotelov I
- Benedetti D
- Benjamin D.
- Beretvas A.
- Bernet C
- Bhatti A.
- Bialas W
- Bilinskas MJ
- Binkley M.
- Bisello D.
- Bitioukov S
- Bizjak I.
- Bland K. R.
- Bloch P
- Blumenfeld B.
- Bocci A
- Bocci A.
- Bodek A.
- Bolognesi S
- Bondar N
- Boos E
- Bortoletto D.
- Boudreau J.
- Boveia A.
- Breuker H
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- Brona G
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- Budagov J.
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- Burelo ED
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- Caballero IG
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- Zalewski R
- Zanetti A.
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- Zhokin A
- Zhou C.
- Zucchelli S..
- Zucchelli S..ng S
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
Get PDFWe have measured the W-boson mass MW using data corresponding to 2.2/fb of
integrated luminosity collected in proton-antiproton collisions at 1.96 TeV
with the CDF II detector at the Fermilab Tevatron collider. Samples consisting
of 470126 W->enu candidates and 624708 W->munu candidates yield the measurement
MW = 80387 +- 12 (stat) +- 15 (syst) = 80387 +- 19 MeV. This is the most
precise measurement of the W-boson mass to date and significantly exceeds the
precision of all previous measurements combined
X-ray emission from the Sombrero galaxy: discrete sources
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Acosta D
- Acosta JG
- Acosta MV
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Aguilo E
- Ahmad M
- Ahmad WH
- Ahmed I
- Ahuja S
- Akchurin N
- Akgun B
- Akgun U
- Akin IV
- Alagoz E
- Albajar C
- Albayrak EA
- Albergo S
- Albrow M
- Alexander J
- Aliev T
- Allfrey P
- Almeida N
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- Anagnostou G
- Anastassov A
- Anderson J
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- Andreev V
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- Andreev Y
- Andrews W
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- Antunes JR
- Antunovic Z
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- Apollinari G
- Appelt E
- Aranyi A
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- Arcidiacono R
- Arenton MW
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- Asaadi J
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2010
- Field of study
Get PDFWe present a study of discrete X-ray sources in and around the
bulge-dominated, massive Sa galaxy, Sombrero (M104), based on new and archival
Chandra observations with a total exposure of ~200 ks. With a detection limit
of L_X = 1E37 erg/s and a field of view covering a galactocentric radius of ~30
kpc (11.5 arcminute), 383 sources are detected. Cross-correlation with Spitler
et al.'s catalogue of Sombrero globular clusters (GCs) identified from HST/ACS
observations reveals 41 X-rays sources in GCs, presumably low-mass X-ray
binaries (LMXBs). We quantify the differential luminosity functions (LFs) for
both the detected GC and field LMXBs, whose power-low indices (~1.1 for the
GC-LF and ~1.6 for field-LF) are consistent with previous studies for
elliptical galaxies. With precise sky positions of the GCs without a detected
X-ray source, we further quantify, through a fluctuation analysis, the GC LF at
fainter luminosities down to 1E35 erg/s. The derived index rules out a
faint-end slope flatter than 1.1 at a 2 sigma significance, contrary to recent
findings in several elliptical galaxies and the bulge of M31. On the other
hand, the 2-6 keV unresolved emission places a tight constraint on the field
LF, implying a flattened index of ~1.0 below 1E37 erg/s. We also detect 101
sources in the halo of Sombrero. The presence of these sources cannot be
interpreted as galactic LMXBs whose spatial distribution empirically follows
the starlight. Their number is also higher than the expected number of cosmic
AGNs (52+/-11 [1 sigma]) whose surface density is constrained by deep X-ray
surveys. We suggest that either the cosmic X-ray background is unusually high
in the direction of Sombrero, or a distinct population of X-ray sources is
present in the halo of Sombrero.Comment: 11 figures, 5 tables, ApJ in pres
Measurement of the Z/gamma* + b-jet cross section in pp collisions at 7 TeV
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2012
- Field of study
Get PDFThe production of b jets in association with a Z/gamma* boson is studied
using proton-proton collisions delivered by the LHC at a centre-of-mass energy
of 7 TeV and recorded by the CMS detector. The inclusive cross section for
Z/gamma* + b-jet production is measured in a sample corresponding to an
integrated luminosity of 2.2 inverse femtobarns. The Z/gamma* + b-jet cross
section with Z/gamma* to ll (where ll = ee or mu mu) for events with the
invariant mass 60 < M(ll) < 120 GeV, at least one b jet at the hadron level
with pT > 25 GeV and abs(eta) < 2.1, and a separation between the leptons and
the jets of Delta R > 0.5 is found to be 5.84 +/- 0.08 (stat.) +/- 0.72 (syst.)
+(0.25)/-(0.55) (theory) pb. The kinematic properties of the events are also
studied and found to be in agreement with the predictions made by the MadGraph
event generator with the parton shower and the hadronisation performed by
PYTHIA.Comment: Submitted to the Journal of High Energy Physic
Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain
- Author
- A Klos
- AH Stephan
- AH Stephan
- AJ Tenner
- Andrea J. Tenner
- AP Sjoberg
- AR Bialas
- B Stevens
- C Nilsberth
- CN Parkhurst
- D Ricklin
- DA Fraser
- DH Cribbs
- DP Schafer
- F Bossi
- F Petry
- G Hajishengallis
- GR Howell
- Grant R. MacGregor
- H Lui
- I Rozovsky
- IH Cheng
- J Huang
- J Zhou
- JA Harris
- JJ Alexander
- K Yasojima
- KBM Reid
- LG Bodea
- Lila Modarresi
- LM Chow
- LT Roumenina
- M Botto
- M Ide
- M Ikarashi
- M Li
- Maria I. Fonseca
- ME Benoit
- ME Benoit
- ME Benoit
- Melody J. Fang
- MI Fonseca
- MI Fonseca
- MI Fonseca
- Michael X. Hernandez
- MJ Vasek
- MK Khoury
- NC Shaner
- OL Brekke
- P Young
- Pooja Selvan
- Q Shi
- R Bulla
- R Fan
- R Feil
- R Veerhuis
- S Hong
- S Jung
- S Yona
- SD Webster
- Shu-Hui Chu
- SS Bohlson
- T Abe
- T Armbrust
- T Wyss-Coray
- TD Schmittgen
- VH Perry
- Y Chu
- Y Miura-Shimura
- Y Shen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2017
- Field of study
Get PDFBACKGROUND: The complement cascade not only provides protection from infection but can also mediate destructive inflammation. Complement is also involved in elimination of neuronal synapses which is essential for proper development, but can be detrimental during aging and disease. C1q, required for several of these complement-mediated activities, is present in the neuropil, microglia, and a subset of interneurons in the brain. METHODS: To identify the source(s) of C1q in the brain, the C1qa gene was selectively inactivated in the microglia or Thy-1(+) neurons in both wild type mice and a mouse model of Alzheimerâs disease (AD), and C1q synthesis assessed by immunohistochemistry, QPCR, and western blot analysis. RESULTS: While C1q expression in the brain was unaffected after inactivation of C1qa in Thy-1(+) neurons, the brains of C1qa (FL/FL) :Cx3cr1 (CreERT2) mice in which C1qa was ablated in microglia were devoid of C1q with the exception of limited C1q in subsets of interneurons. Surprisingly, this loss of C1q occurred even in the absence of tamoxifen by 1Â month of age, demonstrating that Cre activity is tamoxifen-independent in microglia in Cx3cr1 (CreERT2/WganJ) mice. C1q expression in C1qa (FL/FL) : Cx3cr1 (CreERT2/WganJ) mice continued to decline and remained almost completely absent through aging and in AD model mice. No difference in C1q was detected in the liver or kidney from C1qa (FL/FL) : Cx3cr1 (CreERT2/WganJ) mice relative to controls, and C1qa (FL/FL) : Cx3cr1 (CreERT2/WganJ) mice had minimal, if any, reduction in plasma C1q. CONCLUSIONS: Thus, microglia, but not neurons or peripheral sources, are the dominant source of C1q in the brain. While demonstrating that the Cx3cr1 (CreERT2/WganJ) deleter cannot be used for adult-induced deletion of genes in microglia, the model described here enables further investigation of physiological roles of C1q in the brain and identification of therapeutic targets for the selective control of complement-mediated activities contributing to neurodegenerative disorders. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12974-017-0814-9) contains supplementary material, which is available to authorized users
Association of brain immune genes with social behavior of inbred mouse strains
- Author
- A Corvin
- A Franceschini
- A Holmes
- AK McAllister
- AR Bialas
- AS Brown
- B Ansoleaga
- B Olivier
- B Stevens
- C Onore
- CC Park
- CL Raison
- CS Carter
- D Ehninger
- D Jin
- D Wahlsten
- D Wahlsten
- E Haroon
- E Pineda
- EY Hsiao
- G Bernard
- GK Kusek
- H Daoud
- Heikki Rauvala
- JJ Crowley
- JJ Nadler
- L Tian
- Li Ma
- Li Tian
- LM Fraser
- M Tetreault
- MD Bauman
- MJ Kas
- MN Cook
- N Kulesskaya
- Natalia Kulesskaya
- NC Derecki
- ND Powell
- Network Pathway Analysis Subgroup of the Psychiatric Genomics C, International Inflammatory Bowel Disease Genetics C, International Inflammatory Bowel Disease Genetics Consortium I
- NN Karpova
- NV Malkova
- P Rezacova
- P Squarzoni
- RA Corriveau
- RE Brown
- S Horvath
- Sami Piirainen
- Schizophrenia Working Group of the Psychiatric Genomics C
- SE Smith
- SG Tangye
- SJ Clapcote
- SK Chen
- SS Moy
- SS Moy
- SV Bhave
- TL Bale
- TP Maddatu
- V Voikar
- VH Perry
- W Huang da
- Y Zhan
- Z Li
- Publication venue
- 'Springer Science and Business Media LLC'
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- Field of study
Get PDFSearch for dijet resonances in 7 TeV pp collisions at CMS
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- Yilmaz Y
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- Zielinski M
- Zito G
- Zoeller MH
- Zorbilmez C
- Zotto P
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2010
- Field of study
Get PDFThis is the Pre-print version of the Article. The official published version of the paper can be accessed from the link below - Copyright @ 2010 APSA search for narrow resonances in the dijet mass spectrum is performed using data corresponding to an integrated luminosity of 2.9ââpb-1 collected by the CMS experiment at the Large Hadron Collider. Upper limits at the 95% confidence level are presented on the product of the resonance cross section, branching fraction into dijets, and acceptance, separately for decays into quark-quark, quark-gluon, or gluon-gluon pairs. The data exclude new particles predicted in the following models at the 95% confidence level: string resonances, with mass less than 2.50 TeV, excited quarks, with mass less than 1.58 TeV, and axigluons, colorons, and E6 diquarks, in specific mass intervals. This extends previously published limits on these models.This work is supported by FMSR (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ, and FAPESP (Brazil); MES (Bulgaria); CERN; CAS, MoST, and NSFC (China); COLCIENCIAS (Colombia); MSES (Croatia); RPF (Cyprus); Academy of Sciences and NICPB (Estonia); Academy of Finland, ME, and HIP (Finland); CEA and CNRS/IN2P3 (France); BMBF, DFG, and HGF (Germany); GSRT (Greece); OTKA and NKTH (Hungary); DAE and DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); NRF and WCU (Korea); LAS (Lithuania); CINVESTAV, CONACYT, SEP, and UASLP-FAI (Mexico); PAEC (Pakistan); SCSR (Poland); FCT (Portugal); JINR (Armenia, Belarus, Georgia, Ukraine, Uzbekistan); MST and MAE (Russia); MSTD (Serbia); MICINN and CPAN (Spain); Swiss Funding Agencies (Switzerland); NSC (Taipei); TUBITAK and TAEK (Turkey); STFC (United Kingdom); DOE and NSF (USA)
Transverse-momentum and pseudorapidity distributions of charged hadrons in pp collisions at âs=7 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Ahmad M
- Ahmad WH
- Ahmed I
- Ahuja S
- Akchurin N
- Akgun B
- Akgun U
- Akin IV
- Alagoz E
- Albajar C
- Albayrak EA
- Albergo S
- Albrow M
- Alexander J
- Aliev T
- Allfrey P
- Almeida N
- Altsybeev I
- Alver B
- Alverson G
- Alves GA
- Amapane N
- Ambroglini F
- Amsler C
- Anagnostou G
- Anastassov A
- Anderson J
- Anderson M
- Andrea J
- Andreev V
- Andreev V
- Andreev Y
- Andrews W
- Anghel IM
- Antonelli L
- Antunovic Z
- Apanasevich L
- Apollinari G
- Appelt E
- Aranyi A
- Arce P
- Arcidiacono R
- Arenton MW
- Arfaei H
- Argiro S
- Arisaka K
- Arneodo M
- Asaadi J
- Asghar MI
- Askew A
- Ata M
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- Zalewski P
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- Zatzerklyaniy A
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- Zeinali M
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- Zennamo J
- Zeuner WD
- Zeyrek M
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- Zhang Z
- Zheng Y
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- Zhu B
- Zhu RY
- Zhukov V
- Zhukova V
- Ziebarth EB
- Ziegler J
- Zielinski M
- Zinonos Z
- Zito G
- Zoeller MH
- Zorbilmez C
- Zumerle G
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2010
- Field of study
Get PDFThis is the pre-print version of the Published Article which can be accessed from the link below.Charged-hadron transverse-momentum and pseudorapidity distributions in proton-proton collisions at âs=7ââTeV are measured with the inner tracking system of the CMS detector at the LHC. The charged-hadron yield is obtained by counting the number of reconstructed hits, hit pairs, and fully reconstructed charged-particle tracks. The combination of the three methods gives a charged-particle multiplicity per unit of pseudorapidity dNch/dΡ||Ρ|<0.5=5.78Âą0.01(stat)Âą0.23(syst) for non-single-diffractive events, higher than predicted by commonly used models. The relative increase in charged-particle multiplicity from âs=0.9 to 7 TeV is [66.1Âą1.0(stat)Âą4.2(syst)]%. The mean transverse momentum is measured to be 0.545Âą0.005(stat)Âą0.015(syst)ââGeV/c. The results are compared with similar measurements at lower energies
Dijet azimuthal decorrelations in pp collisions at âs = 7TeV
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- Yilmaz Y
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- Zhang Z
- Zheng Y
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- Zhu B
- Zhu RY
- Zhukov V
- Zhukova V
- Ziebarth EB
- Ziegler J
- Zielinski M
- Zito G
- Zoeller MH
- Zorbilmez C
- Zotto P
- Zou W
- Zumerle G
- Zuranski A
- Publication venue
- American Physical Society
- Publication date
- 01/01/2011
- Field of study
Get PDFThis is the pre-print version of the Published Article which can be accessed from the link below.Measurements of dijet azimuthal decorrelations in pp collisions at âs=7ââTeV using the CMS detector at the CERN LHC are presented. The analysis is based on an inclusive dijet event sample corresponding to an integrated luminosity of 2.9ââpb-1. The results are compared to predictions from perturbative QCD calculations and various Monte Carlo event generators. The dijet azimuthal distributions are found to be sensitive to initial-state gluon radiation
Search for supersymmetry in pp collisions at 7 TeV in events with jets and missing transverse energy
- Author
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- Abbiendi G
- Abbrescia M
- Abdullin S
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- Publication venue
- Elsevier
- Publication date
- 01/01/2011
- Field of study
Get PDFThis is the Pre-print version of the Article. The official published version of the paper can be accessed from the link below - Copyright @ 2011 ElsevierA search for supersymmetry with R-parity conservation in proton-proton collisions at a centre-of-mass energy of 7 TeV is presented. The data correspond to an integrated luminosity of 35 inverse picobarns collected by the CMS experiment at the LHC. The search is performed in events with jets and significant missing transverse energy, characteristic of the decays of heavy, pair-produced squarks and gluinos. The primary background, from standard model multijet production, is reduced by several orders of magnitude to a negligible level by the application of a set of robust kinematic requirements. With this selection, the data are consistent with the standard model backgrounds, namely t t-bar, W + jet and Z + jet production, which are estimated from data control samples. Limits are set on the parameters of the constrained minimal supersymmetric extension of the standard model. These limits extend those set previously by experiments at the Tevatron and LEP colliders.This work is supported by FMSR (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ, and FAPESP (Brazil); MES (Bulgaria); CERN; CAS, MoST, and NSFC (China); COLCIENCIAS (Colombia); MSES (Croatia); RPF (Cyprus); Academy of Sciences and NICPB (Estonia); Academy of Finland, ME, and HIP (Finland); CEA and CNRS/IN2P3 (France); BMBF, DFG, and HGF (Germany); GSRT (Greece); OTKA and NKTH (Hungary); DAE and DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); NRF and WCU (Korea); LAS (Lithuania); CINVESTAV, CONACYT,
SEP, and UASLP-FAI (Mexico); PAEC (Pakistan); SCSR (Poland); FCT (Portugal); JINR (Armenia, Belarus, Georgia, Ukraine, Uzbekistan); MST and MAE (Russia); MSTD (Serbia); MICINN and CPAN (Spain); Swiss Funding Agencies (Switzerland); NSC (Taipei); TUBITAK and TAEK (Turkey); STFC (United Kingdom); DOE and NSF (USA)
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