Hard X-ray spectral variability of the brightest Seyfert AGN in the Swift/BAT sample

Aims: We used data from the 58 month long, continuous Swift/Burst Alert Telescope (BAT) observations of the five brightest Seyfert galaxies at hard X-rays, to study their flux and spectral variability in the 20-100 keV energy band. The column density in these objects is less than 10^24 cm-2, which implies that the Swift/BAT data allow us to study the "true" variability of the central source. Results: All objects show significant variations, with an amplitude which is similar to the AGN variability amplitude at energies below 10 keV. We found evidence for an anti-correlation between variability amplitude and black hole mass. The light curves in both bands are well correlated, with no significant delays on time scales as short as 2 days. NGC 4151 and NGC 2110 do not show spectral variability, but we found a significant anti-correlation between hardness ratios and source flux in NGC 4388 (and NGC 4945, IC 4329, to a lesser extent). This "softer when brighter" behaviour is similar to what has been observed at energies below 10 keV, and cannot be explained if the continuum varies only in flux; the intrinsic shape should also steepen with increasing flux. Conclusions: The presence of significant flux variations indicate that the central source in these objects is intrinsically variable on time scales as short as 1-2 days. The intrinsic slope of the continuum varies with the flux (at least in NGC 4388). The positive "spectral slope-flux" correlation can be explained if the temperature of the hot corona decreases with increasing flux. The lack of spectral variations in two objects, could be due to the fact that they may operate in a different "state", as their accretion rate is less than 1% of the Eddington limit (significantly smaller than the rate of the other three objects in the sample).Comment: Accepted (29/10/11) for publication in A&A (12 pages, containing 14 figures and 2 tables). (Abstract shortened --see link for the complete one

The First INTEGRAL AGN Catalog

We present the first INTEGRAL AGN catalog, based on observations performed from launch of the mission in October 2002 until January 2004. The catalog includes 42 AGN, of which 10 are Seyfert 1, 17 are Seyfert 2, and 9 are intermediate Seyfert 1.5. The fraction of blazars is rather small with 5 detected objects, and only one galaxy cluster and no star-burst galaxies have been detected so far. A complete subset consists of 32 AGN with a significance limit of 7 sigma in the INTEGRAL/ISGRI 20-40 keV data. Although the sample is not flux limited, the distribution of sources shows a ratio of obscured to unobscured AGN of 1.5 - 2.0, consistent with luminosity dependent unified models for AGN. Only four Compton-thick AGN are found in the sample. Based on the INTEGRAL data presented here, the Seyfert 2 spectra are slightly harder (Gamma = 1.95 +- 0.01) than Seyfert 1.5 (Gamma = 2.10 +- 0.02) and Seyfert 1 (Gamma = 2.11 +- 0.05).Comment: 17 pages, 12 figures, accepted for publication in Ap

INTEGRAL and XMM-Newton Spectral Studies of NGC 4388

We present first INTEGRAL and XMM-Newton observations of a Seyfert galaxy, the type 2 AGN NGC 4388. Several INTEGRAL observations performed in 2003 allow us to study the spectrum in the 20 - 300 keV range. In addition two XMM-Newton observations give detailed insight into the 0.2 - 10 keV emission. The measurements presented here and comparison with previous observations by BeppoSAX, SIGMA and CGRO/OSSE show that the overall spectrum from soft X-rays up to the gamma-rays can be described by a highly absorbed (N_H = 2.7e23 1/cm^2) and variable non-thermal component in addition to constant non-absorbed thermal emission (T = 0.8 keV) of low abundance (7% solar), plus a constant Fe K-alpha and K-beta line. The hard X-ray component is well described by a simple power law with a mean photon index of 1.7. During the INTEGRAL observations the 20 - 100 keV flux increased by a factor of 1.4. The analysis of XMM-Newton data implies that the emission below 3 keV is decoupled from the AGN and probably due to extended emission as seen in Chandra observations. The constant iron line emission is apparently also decoupled from the direct emission of the central engine and likely to be generated in the obscuring material, e.g. in the molecular torus.Comment: 11 pages, 5 figures, accepted for publication in Ap

Study of stability of relativistic ideal Bose-Einstein condensates

A relativistic complex scalar boson field at finite temperature $T$ is examined below its critical Bose-Einstein condensation temperature. It is shown that at the same $T$ the state with antibosons has higher entropy, lower Helmholtz free energy and higher pressure than the state without antibosons, but the same Gibbs free energy as it should. This implies that the configuration without antibosons is metastable. Results are generalized for arbitrary $d$ spatial dimensions.Comment: Accepted for publication in Phys.Lett.

Detection of blueshifted emission and absorption and a relativistic Iron line in the X-ray spectrum of ESO 323-G077

We report on the X-ray observation of the Seyfert 1 ESO323-G077 performed with XMM-Newton. The spectra show a complex spectrum with conspicuous absorption and emission features. The continuum emission can be modelled with a power law with an index of 1.99+/-0.02 in the whole XMM-Newton energy band, marginally consistent with typical values of Type-I objects. An absorption component with an uncommonly high equivalent Hydrogen column, n_H=5.82(+0.12/-0.11)x10^22 cm-2, is affecting the soft part of the spectrum. Additionally, two warm absorption components are also present. The lower ionised one has an ionisation parameter of Log(U)=2.14(+0.06/-0.07) and an outflowing velocity of v=3200(+600/-200) km/s. Two absorption lines located at ~6.7 and ~7.0 keV can be modelled with the highly ionised absorber. The ionisation parameter and outflowing velocity of the gas measured are Log(U)=3.26(+0.19/-0.15) and v=1700(+600/-400) km/s, respectively. Four emission lines were also detected in the soft energy band. The most likely explanation for these emission lines is that they are associated with an outflowing gas with a velocity of ~2000 km/s. The data suggest that the same gas which is causing the absorption could also being responsible of these emission features. Finally, the spectrum shows the presence of a relativistic iron emission line likely originated in the accretion disc of a Kerr BH with an inclination of ~25 deg. We propose a model to explain the observed X-ray properties which invokes the presence of a two-phase outflow with cone-like structure and a velocity of the order of 2,000-4,000 km/s. The inner layer of the cone would be less ionised, or even neutral, than the outer layer. The inclination angle would be lower than the opening angle of the outflowing cone.Comment: 11 pages, accepted in MNRA

A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.

Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies ~7.3 million variants in 84,457 breast cancer patients in relation to breast cancer survival and confirms the results on 12,381 independent patients. Aggregating the prognostic effects of genetic variants across multiple genes, we identify four gene modules associated with survival in estrogen receptor (ER)-negative and one in ER-positive disease. The modules show biological enrichment for cancer-related processes such as G-alpha signaling, circadian clock, angiogenesis, and Rho-GTPases in apoptosis

Extragalactic H_2O masers and X-ray absorbing column densities

Having conducted a search for the 22 GHz water vapor line towards galaxies with nuclear activity, large nuclear column densities or high infrared luminosities, we present H_2O spectra for NGC2273, UGC5101 and NGC3393 with isotropic luminosities of 7, 1500, and 400 L_sun. The H_2O maser in UGC5101 is by far the most luminous yet found in an ultraluminous infrared galaxy. NGC3393 reveals the classic spectrum of a `disk maser', represented by three distinct groups of Doppler components. As in all other known cases except NGC4258, the rotation velocity of the putative masing disk is well below 1000 km/s. Based on the literature and archive data, X-ray absorbing column densities are compiled for the 64 galaxies with reported maser sources beyond the Magellanic Clouds. For NGC2782 and NGC5728, we present Chandra archive data that indicate the presence of an active galactic nucleus in both galaxies. The correlation between absorbing column and H_2O emission is analyzed. There is a striking difference between kilo- and megamasers with megamasers being associated with higher column densities. All kilomasers (L_H_2O < 10 L_sun) except NGC2273 and NGC5194 are Compton-thin, i.e. their absorbing columns are < 10^24 cm^-2. Among the H_2O megamasers, 50% arise from Compton-thick and 85% from heavily obscured (> 10^23 cm^-2) active galactic nuclei. These values are not larger but consistent with those from samples of Seyfert 2 galaxies not selected on the basis of maser emission. The similarity in column densities can be explained by small deviations in position between maser spots and nuclear X-ray source and a high degree of clumpiness in the circumnuclear interstellar medium.Comment: 16 pages, 7 figures, 5 tables. Accepted for publication in A&

X-ray Absorption and Reflection in Active Galactic Nuclei

X-ray spectroscopy offers an opportunity to study the complex mixture of emitting and absorbing components in the circumnuclear regions of active galactic nuclei, and to learn about the accretion process that fuels AGN and the feedback of material to their host galaxies. We describe the spectral signatures that may be studied and review the X-ray spectra and spectral variability of active galaxies, concentrating on progress from recent Chandra, XMM-Newton and Suzaku data for local type 1 AGN. We describe the evidence for absorption covering a wide range of column densities, ionization and dynamics, and discuss the growing evidence for partial-covering absorption from data at energies > 10 keV. Such absorption can also explain the observed X-ray spectral curvature and variability in AGN at lower energies and is likely an important factor in shaping the observed properties of this class of source. Consideration of self-consistent models for local AGN indicates that X-ray spectra likely comprise a combination of absorption and reflection effects from material originating within a few light days of the black hole as well as on larger scales. It is likely that AGN X-ray spectra may be strongly affected by the presence of disk-wind outflows that are expected in systems with high accretion rates, and we describe models that attempt to predict the effects of radiative transfer through such winds, and discuss the prospects for new data to test and address these ideas.Comment: Accepted for publication in the Astronomy and Astrophysics Review. 58 pages, 9 figures. V2 has fixed an error in footnote

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.

Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality. Studies of rare human disorders of puberty and animal models point to a complex hypothalamic-pituitary-hormonal regulation, but the mechanisms that determine pubertal timing and underlie its links to disease risk remain unclear. Here, using genome-wide and custom-genotyping arrays in up to 182,416 women of European descent from 57 studies, we found robust evidence (P < 5 × 10(-8)) for 123 signals at 106 genomic loci associated with age at menarche. Many loci were associated with other pubertal traits in both sexes, and there was substantial overlap with genes implicated in body mass index and various diseases, including rare disorders of puberty. Menarche signals were enriched in imprinted regions, with three loci (DLK1-WDR25, MKRN3-MAGEL2 and KCNK9) demonstrating parent-of-origin-specific associations concordant with known parental expression patterns. Pathway analyses implicated nuclear hormone receptors, particularly retinoic acid and γ-aminobutyric acid-B2 receptor signalling, among novel mechanisms that regulate pubertal timing in humans. Our findings suggest a genetic architecture involving at least hundreds of common variants in the coordinated timing of the pubertal transition