Hybrids and inbred lines of silkworm (Lepidoptera: Bombyx mori L.): preliminary productive results

TIn Argentina sericulture is a new activity and is carried out by small producers as a complementary activity. The use of hybrid vigor in the silk production is used in several developed countries and the productivity and the quality depend on the hybrid involved. The objective of this work is to evaluate, in a preliminary way, some productive features of hybrids derived from inbred lines from the Faculty of Agronomy of the University of Buenos Aires. Were used four inbred and six crosses between them were bred in controlled conditions of temperature and humidity. Were fed four times a day with fresh mulberry leaves. In a 20 individuals sample four quantitative variables were measured: larval weight in the 5th stage, whole cocoon weight, cocoon without pupa weight and cocoon length. Significant differences between the means of the 10 genotypes for all the variables analyzed were detected. The crosses have shown different results depending on the crossing and the studied character. The overall result is that the hybrids productivity in these preliminary trials shows the superiority of some crosses over others and over the inbred lines.Fil: Basso, C.P. Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Métodos Cuantitativos y Sistemas de Información. Cátedra de Producciones Animales Alternativas. Buenos Aires, ArgentinaFil: Dobler, S. Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Métodos Cuantitativos y Sistemas de Información. Cátedra de Producciones Animales Alternativas. Buenos Aires, ArgentinaFil: Lopez Zieher, X. Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Métodos Cuantitativos y Sistemas de Información. Cátedra de Producciones Animales Alternativas. Buenos Aires, ArgentinaFil: Bartoloni, N. Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Métodos Cuantitativos y Sistemas de Información. Cátedra de Producciones Animales Alternativas. Buenos Aires, ArgentinaEn Argentina la sericicultura es una actividad novedosa y es llevada a cabo por pequeños productores como actividad complementaria. La utilización del vigor híbrido en la producción de seda se emplea en la mayoría de los países desarrollados y la productividad y calidad dependen del híbrido involucrado. El objetivo del trabajo es evaluar, en forma preliminar, algunas características productivas de híbridos obtenidos a partir de líneas endocriadas en la Facultad de Agronomía de la Universidad de Buenos Aires. Se utilizaron 4 líneas endocriadas y 6 cruzamientos entre ellas, criadas en condiciones de temperatura y humedad controladas. La alimentación se realizó 4 veces al día con hojas frescas de moreras. En una muestra de 20 individuos, se midieron 4 variables cuantitativas: peso larval en el 5º estadio, peso del capullo entero, peso del capullo sin pupa y largo de capullos. Se detectaron diferencias significativas entre las medias de los 10 genotipos para todas las variables analizadas. Los cruzamientos realizados han exhibido diferentes resultados según el cruzamiento y el carácter estudiado. El resultado general es que la productividad de los híbridos en estas pruebas preliminares muestra la superioridad de determinados cruzamientos sobre otros y sobre las líneas endocriadas

Evaluation of the reliability of the measurement of key magnetocaloric properties: a round robin study of La(Fe,Si,Mn)Hδ conducted by the SSEEC consortium of European laboratories

Managing refrigeration of our homes, our food and our work environments in energy efficient ways is of increasing importance. Refrigeration using solid state magnetic cooling is one of a number of technologies that may make a significant contribution to addressing this problem. In order to develop materials that may enable commercial development of this increasingly relevant field it is important to review the reliability of methods used to extract key physical properties, so that as the field matures the community can develop recognised standards of measurement. Here we measure key physical properties in one composition taken from a series of La(Fe,Si,Mn)Hδ 1:13‐type samples grown by a source laboratory and measured independently in a consortium of European laboratories using both commercial and bespoke facilities

Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options.

TCF3-HLF-positive acute lymphoblastic leukemia (ALL) is currently incurable. Using an integrated approach, we uncovered distinct mutation, gene expression and drug response profiles in TCF3-HLF-positive and treatment-responsive TCF3-PBX1-positive ALL. We identified recurrent intragenic deletions of PAX5 or VPREB1 in constellation with the fusion of TCF3 and HLF. Moreover somatic mutations in the non-translocated allele of TCF3 and a reduction of PAX5 gene dosage in TCF3-HLF ALL suggest cooperation within a restricted genetic context. The enrichment for stem cell and myeloid features in the TCF3-HLF signature may reflect reprogramming by TCF3-HLF of a lymphoid-committed cell of origin toward a hybrid, drug-resistant hematopoietic state. Drug response profiling of matched patient-derived xenografts revealed a distinct profile for TCF3-HLF ALL with resistance to conventional chemotherapeutics but sensitivity to glucocorticoids, anthracyclines and agents in clinical development. Striking on-target sensitivity was achieved with the BCL2-specific inhibitor venetoclax (ABT-199). This integrated approach thus provides alternative treatment options for this deadly disease

Search for flavour-changing neutral currents in processes with one top quark and a photon using 81 fb⁻¹ of pp collisions at \sqrts = 13 TeV with the ATLAS experiment

A search for flavour-changing neutral current (FCNC) events via the coupling of a top quark, a photon, and an up or charm quark is presented using 81 fb−1 of proton–proton collision data taken at a centre-of-mass energy of 13 TeV with the ATLAS detector at the LHC. Events with a photon, an electron or muon, a b-tagged jet, and missing transverse momentum are selected. A neural network based on kinematic variables differentiates between events from signal and background processes. The data are consistent with the background-only hypothesis, and limits are set on the strength of the tqγ coupling in an effective field theory. These are also interpreted as 95% CL upper limits on the cross section for FCNC tγ production via a left-handed (right-handed) tuγ coupling of 36 fb (78 fb) and on the branching ratio for t→γu of 2.8×10−5 (6.1×10−5). In addition, they are interpreted as 95% CL upper limits on the cross section for FCNC tγ production via a left-handed (right-handed) tcγ coupling of 40 fb (33 fb) and on the branching ratio for t→γc of 22×10−5 (18×10−5). © 2019 The Author(s

Study of Z → llγ decays at √s = 8 TeV with the ATLAS detector

This paper presents a study of Z → llγ decays with the ATLAS detector at the Large Hadron Collider. The analysis uses a proton–proton data sample corresponding to an integrated luminosity of 20.2 fb−1 collected at a centre-ofmass energy √s = 8 TeV. Integrated fiducial cross-sections together with normalised differential fiducial cross-sections, sensitive to the kinematics of final-state QED radiation, are obtained. The results are found to be in agreement with stateof-the-art predictions for final-state QED radiation. First measurements of Z → llγ γ decays are also reported

Constraints on spin-0 dark matter mediators and invisible Higgs decays using ATLAS 13 TeV pp collision data with two top quarks and missing transverse momentum in the final state

This paper presents a statistical combination of searches targeting final states with two top quarks and invisible particles, characterised by the presence of zero, one or two leptons, at least one jet originating from a b-quark and missing transverse momentum. The analyses are searches for phenomena beyond the Standard Model consistent with the direct production of dark matter in pp collisions at the LHC, using 139 fb−1 of data collected with the ATLAS detector at a centre-of-mass energy of 13 TeV. The results are interpreted in terms of simplified dark matter models with a spin-0 scalar or pseudoscalar mediator particle. In addition, the results are interpreted in terms of upper limits on the Higgs boson invisible branching ratio, where the Higgs boson is produced according to the Standard Model in association with a pair of top quarks. For scalar (pseudoscalar) dark matter models, with all couplings set to unity, the statistical combination extends the mass range excluded by the best of the individual channels by 50 (25) GeV, excluding mediator masses up to 370 GeV. In addition, the statistical combination improves the expected coupling exclusion reach by 14% (24%), assuming a scalar (pseudoscalar) mediator mass of 10 GeV. An upper limit on the Higgs boson invisible branching ratio of 0.38 (0.30+0.13−0.09) is observed (expected) at 95% confidence level

Search for heavy Majorana or Dirac neutrinos and right-handed W gauge bosons in final states with charged leptons and jets in pp collisions at √s = 13 TeV with the ATLAS detector

A search for heavy right-handed Majorana or Dirac neutrinos NR and heavy right-handed gauge bosons WR is performed in events with energetic electrons or muons, with the same or opposite electric charge, and energetic jets. The search is carried out separately for topologies of clearly separated final-state products (“resolved” channel) and topologies with boosted final states with hadronic and/or leptonic products partially overlapping and reconstructed as a large-radius jet (“boosted” channel). The events are selected from pp collision data at the LHC with an integrated luminosity of 139 fb−1 collected by the ATLAS detector at √s = 13 TeV. No significant deviations from the Standard Model predictions are observed. The results are interpreted within the theoretical framework of a left-right symmetric model, and lower limits are set on masses in the heavy righthanded WR boson and NR plane. The excluded region extends to about m(WR) = 6.4 TeV for both Majorana and Dirac NR neutrinos at m(NR) < 1 TeV. NR with masses of less than 3.5 (3.6) TeV are excluded in the electron (muon) channel at m(WR) = 4.8 TeV for the Majorana neutrinos, and limits of m(NR) up to 3.6 TeV for m(WR) = 5.2 (5.0) TeV in the electron (muon) channel are set for the Dirac neutrinos. These constitute the most stringent exclusion limits to date for the model considered