1,642 research outputs found
Response of microchannel plates to single particles and to electromagnetic showers
We report on the response of microchannel plates (MCPs) to single
relativistic particles and to electromagnetic showers. Particle detection by
means of secondary emission of electrons at the MCP surface has long been
proposed and is used extensively in ion time-of-flight mass spectrometers. What
has not been investigated in depth is their use to detect the ionizing
component of showers. The time resolution of MCPs exceeds anything that has
been previously used in calorimeters and, if exploited effectively, could aid
in the event reconstruction at high luminosity colliders. Several prototypes of
photodetectors with the amplification stage based on MCPs were exposed to
cosmic rays and to 491 MeV electrons at the INFN-LNF Beam-Test Facility. The
time resolution and the efficiency of the MCPs are measured as a function of
the particle multiplicity, and the results used to model the response to
high-energy showers.Comment: Paper submitted to NIM
Response of microchannel plates in ionization mode to single particles and electromagnetic showers
Hundreds of concurrent collisions per bunch crossing are expected at future
hadron colliders. Precision timing calorimetry has been advocated as a way to
mitigate the pileup effects and, thanks to their excellent time resolution,
microchannel plates (MCPs) are good candidate detectors for this goal. We
report on the response of MCPs, used as secondary emission detectors, to single
relativistic particles and to electromagnetic showers. Several prototypes, with
different geometries and characteristics, were exposed to particle beams at the
INFN-LNF Beam Test Facility and at CERN. Their time resolution and efficiency
are measured for single particles and as a function of the multiplicity of
particles. Efficiencies between 50% and 90% to single relativistic particles
are reached, and up to 100% in presence of a large number of particles. Time
resolutions between 20ps and 30ps are obtained.Comment: 20 pages, 9 figures. Paper submitted to NIM
Performance of a Tungsten-Cerium Fluoride Sampling Calorimeter in High-Energy Electron Beam Tests
A prototype for a sampling calorimeter made out of cerium fluoride crystals
interleaved with tungsten plates, and read out by wavelength-shifting fibres,
has been exposed to beams of electrons with energies between 20 and 150 GeV,
produced by the CERN Super Proton Synchrotron accelerator complex. The
performance of the prototype is presented and compared to that of a Geant4
simulation of the apparatus. Particular emphasis is given to the response
uniformity across the channel front face, and to the prototype's energy
resolution.Comment: 6 pages, 6 figures, Submitted to NIM
Three-Dimensional Geometric Analysis of Felid Limb Bone Allometry
Studies of bone allometry typically use simple measurements taken in a small number of locations per bone; often the midshaft diameter or joint surface area is compared to body mass or bone length. However, bones must fulfil multiple roles simultaneously with minimum cost to the animal while meeting the structural requirements imposed by behaviour and locomotion, and not exceeding its capacity for adaptation and repair. We use entire bone volumes from the forelimbs and hindlimbs of Felidae (cats) to investigate regional complexities in bone allometry.Computed tomographic (CT) images (16435 slices in 116 stacks) were made of 9 limb bones from each of 13 individuals of 9 feline species ranging in size from domestic cat (Felis catus) to tiger (Panthera tigris). Eleven geometric parameters were calculated for every CT slice and scaling exponents calculated at 5% increments along the entire length of each bone. Three-dimensional moments of inertia were calculated for each bone volume, and spherical radii were measured in the glenoid cavity, humeral head and femoral head. Allometry of the midshaft, moments of inertia and joint radii were determined. Allometry was highly variable and related to local bone function, with joint surfaces and muscle attachment sites generally showing stronger positive allometry than the midshaft.Examining whole bones revealed that bone allometry is strongly affected by regional variations in bone function, presumably through mechanical effects on bone modelling. Bone's phenotypic plasticity may be an advantage during rapid evolutionary divergence by allowing exploitation of the full size range that a morphotype can occupy. Felids show bone allometry rather than postural change across their size range, unlike similar-sized animals
Mortality and pulmonary complications in patients undergoing surgery with perioperative sars-cov-2 infection: An international cohort study
Background The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (740%) had emergency surgery and 280 (248%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (261%) patients. 30-day mortality was 238% (268 of 1128). Pulmonary complications occurred in 577 (512%) of 1128 patients; 30-day mortality in these patients was 380% (219 of 577), accounting for 817% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 175 [95% CI 128-240], p<00001), age 70 years or older versus younger than 70 years (230 [165-322], p<00001), American Society of Anesthesiologists grades 3-5 versus grades 1-2 (235 [157-353], p<00001), malignant versus benign or obstetric diagnosis (155 [101-239], p=0046), emergency versus elective surgery (167 [106-263], p=0026), and major versus minor surgery (152 [101-231], p=0047). Interpretation Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research
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