Desencuentro de los periodistas con YouTube

The disagreement of journalists with YouTube. YouTube, owned by Google, is the second search engine in the world. The increase in online video consumption has provoked a reaction in the journalistic industry to attend the need to connect with an audience that constantly demands audiovisual content. This exploratory research shows that although video has become a priority for media and social platforms such as Facebook, in Spain there are few journalists who take the initiative to take an active role in the main video sharing platform. From the analysis of active channels developed by reporters, we conclude that the role of the journalist promoting his/her professional profile on YouTube is scarce, and that most of his/her accounts ignore, alter or redesign his usual work activity

Desencuentro de los periodistas con YouTube

The disagreement of journalists with YouTube. YouTube, owned by Google, is the second search engine in the world. The increase in online video consumption has provoked a reaction in the journalistic industry to attend the need to connect with an audience that constantly demands audiovisual content. This exploratory research shows that although video has become a priority for media and social platforms such as Facebook, in Spain there are few journalists who take the initiative to take an active role in the main video sharing platform. From the analysis of active channels developed by reporters, we conclude that the role of the journalist promoting his/her professional profile on YouTube is scarce, and that most of his/her accounts ignore, alter or redesign his usual work activity

[Panel] Redes sociales y participación de la audiencia: prácticas mediáticas en España

La televisión sigue siendo el medio tradicional de mayor penetración, y dos terceras partes de los jóvenes españoles entre 18 y 29 años aseguran ver las noticias emitidas por esa vía diariamente (Matsa, Silver, Shearer, y Walker, 2018). No obstante, Youtube es la segunda red social para el consumo de noticias, sólo por detrás de Faceboook(Reuters Institute, 2018), y en 2018 la plataforma ha incrementado su compromiso con el periodismo de calidad promocionando fuentes informativas con autoridad y recomendando el consumo de dichos vídeos para combatir la desinformación (Lapowsky, 2018). Los medios, conscientes de esta realidad, han reaccionado aumentando su oferta de contenidos audiovisuales (Kalogeropoulos, 2018), a pesar de que ello suponga descentralizar su producción y distribuir sus contenidos en plataformas de terceros (Peer & Ksiazek, 2011). Este contexto se ha rodeado de múltiples incertidumbres: ¿por qué la actividad periodística en Youtube es tan reducida?, ¿qué aporta esta herramienta a los periodistas?, ¿qué saben de su audiencia y cómo se relacionan?, ¿influye el usuario en la planificación y producción del contenido?. En un estudio preliminar se ha elaborado un directorio analizando la presencia de periodistas españoles en Youtube y creando categorías en función de la participación detectada. Los datos muestran que la presencia de profesionales en la Red es muy limitada: de más de siete mil periodistas inscritos en España, son 207 quienes tienen un perfil público en la plataforma, y de ellos tan solo 36 obtienen resultados satisfactorios...Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Red nacional de monitoreo de pastizales naturales de Argentina: productividad forrajera de la vegetación extrapampeana

Las regiones extrapampeanas sostienen una porción relevante de la producción ganadera de Argentina (bovinos, caprinos, ovinos y camélidos), sustentada principalmente por el aporte forrajero de la vegetación nativa. En este contexto, es fundamental generar herramientas que permitan un manejo forrajero sustentable de estos ambientes. Para ello, el INTA implementó en 2006 una red nacional de sitios de monitoreo forrajero de la vegetación nativa. En este trabajo se analizó la productividad forrajera de 179 sitios extrapampeanos involucrados en la red (productividad anual promedio de entre 3 a 6 años). Se detectaron asimetrías regionales en cuanto a la disponibilidad de sitios monitoreados y a la longitud de las series de datos de productividad forrajera. Las regiones mejor representadas fueron el distrito ñandubay del Espinal, las estepas patagónicas, el extremo occidental de la provincia fitogeográfica chaqueña y la Puna catamarqueña. Contrariamente, el distrito oriental de la provincia fitogeográfica chaqueña, la porción central del Monte y la provincia Paranaense fueron detectadas como regiones de vacancia. En 101 de los 179 sitios de la red, la productividad forrajera herbácea (PFH) fue inferior a 1.000 kg ha-1 año-1. Lo mismo ocurrió con la productividad forrajera leñosa (PFL) en los 85 sitios evaluados. Los mayores valores de PFH se reportaron en mallines de Patagonia, vegas de la Puna, el distrito de ñandubay en el Espinal y en comunidades vegetales ribereñas de Entre Ríos. Mientras que la PFH de humedales aumentó significativamente con el incremento de la temperatura media anual (TMA), la PFH de sitios no correspondientes a humedales aumentó con la precipitación media anual (PMA). Finalmente, se observó qué sitios históricamente sobrepastoreados presentaron valores de PFH muy inferiores a sitios sometidos a pastoreo más conservativo. Los resultados de este trabajo aportan información relevante para la planificación forrajera de la ganadería a escala regional, y también pueden ser utilizados como insumo para la calibración de modelos de estimación de la productividad forrajera basados en el uso de sensores remotos.In Argentina, a significant portion of livestock production (cows, goats, sheeps and camelids) is sustained by the extra-pampean region, mainly supported by the forage contribution of native plant communities. In this context, it is essential to generate tools that allow a sustainable forage management of these environments. During 2006, INTA implemented a national network for monitoring forage productivity of native plant communities. We analyzed the forage productivity of 179 extra-pampean sites involved in the network. We detected regional asymmetries in relation to the number of monitored sites and the length of forage productivity datasets. The best-represented regions were the “ñandubay” district of the Espinal phytogeographical province, the Patagonian steppes, the western end of the Chaco province, and the Puna in Catamarca. Herbaceous forage productivity (HFP) was less than 1,000 kg ha-1 year-1 in 101 of the 179 sites, and the same was true for woody forage productivity (WFP) in the analyzed 85 sites. The highest HFP values were reported in wetlands of Patagonia (“mallines”) and Puna (“vegas”), the “ñandubay” district of the Espinal and riparian communities of Entre Ríos. While the HFP in the wetlands increased significantly with the increase of mean annual temperature (MAT), the HFP of non-wetland sites increased with mean annual rainfall (MAP). Finally, we observed that overgrazed sites had HFP values lower than those sites subject to conservative grazing. These results could be relevant for planning livestock production at regional scale, as well as an input for forage productivity models based on remote sensing.EEA La RiojaFil: Blanco, Lisandro Javier. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria La Rioja; ArgentinaFil: Durante, Martin. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Concepción del Uruguay; ArgentinaFil: Ferrante, Daniela. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Santa Cruz; ArgentinaFil: Quiroga, Raul Emiliano. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Catamarca; ArgentinaFil: Demaria, Manuel Rodolfo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria San Luis; ArgentinaFil: Di Bella, Carlos Marcelo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Clima y Agua; Argentin

Human breast cancer-derived soluble factors facilitate CCL19-induced chemotaxis of human dendritic cells

Breast cancer remains as a challenging disease with high mortality in women. Increasing evidence points the importance of understanding a crosstalk between breast cancers and immune cells, but little is known about the effect of breast cancer-derived factors on the migratory properties of dendritic cells (DCs) and their consequent capability in inducing T cell immune responses. Utilizing a unique 3D microfluidic device, we here showed that breast cancers (MCF-7, MDA-MB-231, MDA-MB-436 and SK-BR-3)-derived soluble factors increase the migration of DCs toward CCL19. The enhanced migration of DCs was mainly mediated via the highly activated JNK/c-Jun signaling pathway, increasing their directional persistence, while the velocity of DCs was not influenced, particularly when they were co-cultured with triple negative breast cancer cells (TNBCs or MDA-MB-231 and MDA-MB-436). The DCs up-regulated inflammatory cytokines IL-1?? and IL-6 and induced T cells more proliferative and resistant against activation-induced cell death (AICD), which secret high levels of inflammatory cytokines IL-1??, IL-6 and IFN-??. This study demonstrated new possible evasion strategy of TNBCs utilizing their soluble factors that exploit the directionality of DCs toward chemokine responses, leading to the building of inflammatory milieu which may support their own growth.ope

Herramientas audiovisuales online y protocolos en la formación, adaptación y gestión de lentes de contacto. Un modelo innovador en la Clínica Universitaria de Optometría de la UCM

Con fines docentes y asistenciales, incluye Videos sobre manejo y limpieza de distintos tipos de lentes de contacto. Para la correcta formación de los estudiantes incluye varios manuales sobre el estudio ocular previo a la adaptación. Con fines asistenciales incorpora Material para acompañar la adaptación y entrega de las lentes de contacto. Para mejorar la gestión, incluye un Video-tutorial y los protocolos creados para los pedidos y gestión de las lentes de contacto

Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction

Plasmacytoid dendritic cells (pDCs) produce copious type I interferon (IFN) upon sensing nucleic acids through Toll-like receptor (TLR) 7 and TLR9. Uncontrolled pDC activation and IFN production are implicated in lymphopenia and autoimmune diseases; therefore, a mechanism controlling pDC IFN production is essential. Human pDCs specifically express an orphan receptor, immunoglobulin-like transcript 7 (ILT7). Here, we discovered an ILT7 ligand expressed by human cell lines and identified it as bone marrow stromal cell antigen 2 (BST2; CD317). BST2 directly binds to purified ILT7 protein, initiates signaling via the ILT7–FcϵRIγ complex, and strongly inhibits production of IFN and proinflammatory cytokines by pDCs. Readily induced by IFN and other proinflammatory cytokines, BST2 may modulate the human pDC’s IFN responses through ILT7 in a negative feedback fashion

Exploring the link between MORF4L1 and risk of breast cancer.

INTRODUCTION: Proteins encoded by Fanconi anemia (FA) and/or breast cancer (BrCa) susceptibility genes cooperate in a common DNA damage repair signaling pathway. To gain deeper insight into this pathway and its influence on cancer risk, we searched for novel components through protein physical interaction screens. METHODS: Protein physical interactions were screened using the yeast two-hybrid system. Co-affinity purifications and endogenous co-immunoprecipitation assays were performed to corroborate interactions. Biochemical and functional assays in human, mouse and Caenorhabditis elegans models were carried out to characterize pathway components. Thirteen FANCD2-monoubiquitinylation-positive FA cell lines excluded for genetic defects in the downstream pathway components and 300 familial BrCa patients negative for BRCA1/2 mutations were analyzed for genetic mutations. Common genetic variants were genotyped in 9,573 BRCA1/2 mutation carriers for associations with BrCa risk. RESULTS: A previously identified co-purifying protein with PALB2 was identified, MRG15 (MORF4L1 gene). Results in human, mouse and C. elegans models delineate molecular and functional relationships with BRCA2, PALB2, RAD51 and RPA1 that suggest a role for MRG15 in the repair of DNA double-strand breaks. Mrg15-deficient murine embryonic fibroblasts showed moderate sensitivity to γ-irradiation relative to controls and reduced formation of Rad51 nuclear foci. Examination of mutants of MRG15 and BRCA2 C. elegans orthologs revealed phenocopy by accumulation of RPA-1 (human RPA1) nuclear foci and aberrant chromosomal compactions in meiotic cells. However, no alterations or mutations were identified for MRG15/MORF4L1 in unclassified FA patients and BrCa familial cases. Finally, no significant associations between common MORF4L1 variants and BrCa risk for BRCA1 or BRCA2 mutation carriers were identified: rs7164529, Ptrend = 0.45 and 0.05, P2df = 0.51 and 0.14, respectively; and rs10519219, Ptrend = 0.92 and 0.72, P2df = 0.76 and 0.07, respectively. CONCLUSIONS: While the present study expands on the role of MRG15 in the control of genomic stability, weak associations cannot be ruled out for potential low-penetrance variants at MORF4L1 and BrCa risk among BRCA2 mutation carriers.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are