129 research outputs found
Cathepsin K induces platelet dysfunction and affects cell signaling in breast cancer - molecularly distinct behavior of cathepsin K in breast cancer
- Author
- Andrade Sheila Siqueira
- Campos Antonio Hugo J. F. M.
- Castro Eloisa Dognani
- da Silva Ismael D. C. G.
- de Paula Claudia A. A.
- Facina Gil
- Girao Manoel J. B. C.
- Gouvea Iuri Estrada
- Juliano Maria
- Okamoto Debora
- Oliva Maria Luiza V.
- Oliveira Lilian
- Ottaiano Tatiana
- Paredes-Gamero Edgar Julian
- Peres Giovani Bravin
- Pinto Nazario Afonso Celso
- Silva Mariana Cristina C.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Background: Breast cancer comprises clinically and molecularly distinct tumor subgroups that differ in cell histology and biology and show divergent clinical phenotypes that impede phase III trials, such as those utilizing cathepsin K inhibitors. Here we correlate the epithelial-mesenchymal-like transition breast cancer cells and cathepsin K secretion with activation and aggregation of platelets. Cathepsin K is up-regulated in cancer cells that proteolyze extracellular matrix and contributes to invasiveness. Although proteolytically activated receptors (PARs) are activated by proteases, the direct interaction of cysteine cathepsins with PARs is poorly understood. In human platelets, PAR-1 and -4 are highly expressed, but PAR-3 shows low expression and unclear functions. Methods: Platelet aggregation was monitored by measuring changes in turbidity. Platelets were immunoblotted with anti-phospho and total p38, Src-Tyr-416, FAK-Tyr-397, and TGF beta monoclonal antibody. Activation was measured in a flow cytometer and calcium mobilization in a confocal microscope. Mammary epithelial cells were prepared from the primary breast cancer samples of 15 women with Luminal-B subtype to produce primary cells. Results: We demonstrate that platelets are aggregated by cathepsin K in a dose-dependent manner, but not by other cysteine cathepsins. PARs-3 and -4 were confirmed as the cathepsin K target by immunodetection and specific antagonists using a fibroblast cell line derived from PARs deficient mice. Moreover, through co-culture experiments, we show that platelets activated by cathepsin K mediated the up-regulation of SHH, PTHrP, OPN, and TGF beta in epithelial-mesenchymal-like cells from patients with Luminal B breast cancer. Conclusions: Cathepsin K induces platelet dysfunction and affects signaling in breast cancer cells.Associacao Beneficente de Coleta de Sangue (Colsan)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)Univ Fed Sao Paulo, Dept Gynecol, BR-04024002 Sao Paulo, SP, BrazilCOLSAN, Charitable Assoc Blood Collect, BR-04080006 Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Dept Biophys, BR-04024002 Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Dept Biochem, BR-04024002 Sao Paulo, SP, BrazilAntonio Prudente Fdn, AC Camargo Canc Ctr, AC Camargo Hosp Biobank, Dept Pathol, BR-01509010 Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Cellular Gynecol Lab, Dept Gynecol, Rua Napoleao Barros 608, BR-04024002 Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Gynecol, BR-04024002 Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Dept Biophys, BR-04024002 Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Dept Biochem, BR-04024002 Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Cellular Gynecol Lab, Dept Gynecol, Rua Napoleao Barros 608, BR-04024002 Sao Paulo, BrazilFAPESP: 2012/19780-3FAPESP: 2012/19851-8FAPESP: 2009/53766-5Web of Scienc
Cathepsin K induces platelet dysfunction and affects cell signaling in breast cancer - molecularly distinct behavior of cathepsin K in breast cancer
- Author
- A Mazharian
- AB Jensen
- Afonso Celso Pinto Nazário
- Antonio Hugo J. F. M. Campos
- B Chen
- C Gall Le
- C Medina
- Cláudia A. A. de Paula
- D Bromme
- D Bromme
- D Musil
- Debora Okamoto
- E Candia De
- E Nery Del
- Edgar Julian Paredes-Gamero
- Eloísa Dognani Castro
- F Lecaille
- F Schaffner
- G Caliendo
- Gil Facina
- Giovani Bravin Peres
- H Ishihara
- H Kennecke
- HS Kuznetsov
- I Podgorski
- Ismael D. C. G. da Silva
- Iuri Estrada Gouvea
- J Reiser
- J Trejo
- JH Lindeman
- JN McLaughlin
- JS Isenberg
- K Brix
- K Brix
- KV Honn
- L Burnier
- LD Cupit
- LE Sanman
- Lilian Oliveira
- LJ Gay
- M Canault
- M Fonovic
- M Holinstat
- M Jonathan
- M Labelle
- M Nakanishi-Matsui
- Manoel J. B. C. Girão
- Maria Juliano
- Maria Luiza V. Oliva
- Mariana Cristina C. Silva
- MJ Ludeman
- ML Kahn
- MT Harper
- P Clezardin
- PC Almeida
- PF Angelo
- R Bar-Shavit
- R Ramachandran
- S Das
- S Valastyan
- Sheila Siqueira Andrade
- SS Andrade
- T Goerge
- Tatiana Ottaiano
- TJ Scase
- V Almendro
- V Evangelista
- VA Schmidt
- VB Reddy
- VB Reddy
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).
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- Aaroe H.
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- Abdel-Qader M.
- Abdelrahman H.
- Abdul A.
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- Abe M. (Masatake)
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- Winnik S.
- Wirdby A.
- Wisaratapong T.
- Wiswedel H.
- Woehrer C.
- Wojewoda P.
- Wojnowski L.
- Wolf T.
- Wollaert B.
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- Wong S. W.
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- Wongtheptien W.
- Woo J. J.
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- Wozakowska-Kaplon B.
- Wozniak-Skowerska I
- Wright D.
- Wrobel M.
- Wu R. N.
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- Wurziger J.
- Wutthimanop A.
- Xhaet O.
- Xie Q.
- Xiong L. G.
- Xu R. Y.
- Xue L.
- Yagensky A.
- Yakupov E.
- Yamada T.
- Yamagishi T.
- Yamaguchi H.
- Yamamoto K.
- Yamamoto K. (Kenichi)
- Yamamoto K. (Kentaro)
- Yamamoto K. (Kunihiko)
- Yamamoto T.
- Yamasawa M.
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- Yan X. W.
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- Yasui K.
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- Yeter E.
- Yildirim E.
- Yildirim R.
- Yilmaz F.
- Yilmaz M. B.
- Yilmaz O.
- Yim K. H.
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- Yokoyama Y.
- Yong R.
- Yoo K. M.
- Yoon E. J.
- Yoon J. H.
- Yorgun H.
- Yoshida H.
- Yoshida K.
- Yoshida T. (Tetsuro)
- Yoshida T. (Tomoki)
- Yoshimura A.
- Yoshizawa N.
- Yousef G.
- Yu H. Y.
- Yu J. H.
- Yu T.
- Yuksekdag V
- Yun S. Y.
- Yunis M. E.
- Zaatout E.
- Zaidi S. M. A.
- Zaitsu R.
- Zak J.
- Zakutynska-Kowalczyk K.
- Zaluska R.
- Zaman K.
- Zanolin D.
- Zapata G.
- Zateyshchikov D.
- Zateyshchikova A.
- Zauzig H-D
- Zauzig H.
- Zecca C.
- Zemlianskaia O.
- Zhai H.
- Zhan Q.
- Zhang G. S.
- Zhang H. Q.
- Zhang Q.
- Zhang R.
- Zhang Y.
- Zhao R. P.
- Zhao Y. S.
- Zheng W. Y.
- Zhirov I
- Zhou B.
- Zhou Z. H.
- Zhu X. Y.
- Zhuravleva E.
- Zhurba S.
- Zidek M.
- Zidkova E.
- Ziefle S.
- Zika J.
- Zillo M.
- Zimmett L.
- Zimny H-H
- Zincke S.
- Zinka E.
- Zotova I
- Zrazhevskiy K.
- Zubeeva G.
- Zuber M.
- Zurbrigk F. J.
- Zutz S.
- Zyczynska-Szmon M.
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2018
- Field of study
Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)
Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.
- Author
- A. Abd El-Aziz
- A. Abdul
- A. Agakhanyan
- A. Aggarwala
- A. Agrawal
- A. Al Mulla
- A. Al Naeemi
- A. Alfieri
- A. Ali
- A. Altun
- A. Alvarez D'Amelio
- A. Andersson
- A. Argena
- A. Austria
- A. Aydinlar
- A. Babyesiza
- A. Barai
- A. Barreau
- A. Barszcz
- A. Bartes
- A. Bazzoni Ruiz
- A. Beattie
- A. Bianchi
- A. Biernacka
- A. Black
- A. Blenkhorn
- A. Branjovich Tijuan
- A. Bremmelgaard
- A. Brown
- A. Browne
- A. Capucci
- A. Caspar
- A. Catanchin
- A. Chmielowski
- A. Choi
- A. Cieszynska
- A. Conde Y Bolado
- A. Connelly
- A. Cortada Cabrera
- A. Davids
- A. De Blasio
- A. De Wolf
- A. Dickerson
- A. Domenech Borras
- A. Dumikyan
- A. Edin
- A. Egilsson
- A. El-Etreby
- A. Elbahry
- A. Elorriaga Madariaga
- A. Espallargas
- A. Ewert
- A. Fearon
- A. Fedorowsky
- A. Ferreira-Jardim
- A. Ferrer
- A. Filippi
- A. Fleck
- A. Flynn
- A. Forero
- A. Frankiewicz
- A. Fujisawa
- A. Gallagher
- A. Ganatra
- A. Gegenhuber
- A. Gieroba
- A. Gilliland
- A. Giombolini
- A. Gonzales Segovia
- A. Grande Ruiz
- A. Grau
- A. Grytzmann
- A. Gubanov
- A. Guerrero Molina
- A. Guinand
- A. Haideri
- A. Hajimirsadeghi
- A. Hallaråker
- A. Halpin
- A. Hay
- A. Heer
- A. Heyse
- A. Horak
- A. Hot-Bjelac
- A. Howitt
- A. Iglesias Garcia
- A. Ishihara
- A. Ivanov
- A. Iñiguez Romo
- A. Jackun-Podlesna
- A. Jaremczuk-Kaczmarczyk
- A. Jarzebowski
- A. Jefferies
- A. Jekthammer
- A. Jerzewski
- A. John Camm
- A. John Camm
- A. John Camm
- A. Jones
- A. Kaczmarzyk-Radka
- A. Karczmarczyk
- A. Katta
- A. Kemmel
- A. Khan
- A. Khokhlov
- A. Koch
- A. Kolesnikova
- A. Kolodzinska
- A. Komlo
- A. Konopka
- A. Kopf
- A. Krueger
- A. Krzesiak-Lodyga
- A. Lavoie
- A. Lawande
- A. Lee
- A. Lettenström
- A. Leyva Rendón
- A. Lindberg
- A. Lindh
- A. Lindourkova
- A. Lischka-Lindner
- A. Lo Buglio
- A. Lopes
- A. Lopez
- A. Lucassen
- A. Ludkova
- A. Lysek-Jozefowicz
- A. Mannermyr
- A. Manzanal Rey
- A. Mariani
- A. Markiewicz
- A. Marquand
- A. Martin Vila
- A. Martinelli
- A. Maselli
- A. Matoltsy
- A. Mauric
- A. Meirino
- A. Menezes Lorga Filho
- A. Merliss
- A. Metzgier-Gumiela
- A. Mielot
- A. Mirtl
- A. Miyashita
- A. Mizuno
- A. Mowafy
- A. Murray
- A. Naguib
- A. Nagy
- A. Nakagomi
- A. Nakata
- A. Navarro
- A. Negrete Palma
- A. Negri
- A. Niemirycz-Makurat
- A. Nowak
- A. Nygaard
- A. Ohanissian
- A. Ohlsson
- A. Olofsson
- A. Ortiz
- A. Osberg
- A. Ota
- A. Oto
- A. Ovsannikova
- A. Page
- A. Papp
- A. Parkhomenko
- A. Pawelska-Buczen
- A. Pedersen
- A. Phrommintikul
- A. Pinter
- A. Pizzini
- A. Plauskat
- A. Podczeck-Schweighofer
- A. Postolache
- A. Pronk
- A. Pustelnik
- A. Quick
- A. Quietzsch
- A. Quisi
- A. Raczynska
- A. Raisaro
- A. Ramdass
- A. Reda
- A. Rodrigues
- A. Ross
- A. Sabir
- A. Sage
- A. Said
- A. Salinas
- A. Sapatyi
- A. Sasaki
- A. Scaccianoce
- A. Seoane Blanco
- A. Sidor
- A. Singal
- A. Skein
- A. Soliman
- A. Soma
- A. Sossich
- A. Spyropoulos
- A. Srinivas
- A. Sriwichian
- A. Stallinga-de Vos
- A. Steffens
- A. Suissa
- A. Sulc
- A. Svilaas
- A. Sword
- A. Szczepanska
- A. Szilagyi
- A. Szulowska
- A. Taguchi
- A. Talkenberger
- A. Tangsirira
- A. Tetlak
- A. Thatcher
- A. Therkelsen
- A. Thomson
- A. Tomasello
- A. Ushakov
- A. Vandorpe
- A. Vertes
- A. Vishnevsky
- A. Vonbank
- A. Wakeman
- A. Waldman
- A. Warke
- A. Wassef
- A. Wierzbicka
- A. Williams
- A. Wilson
- A. Wirdby
- A. Wutthimanop
- A. Yagensky
- A. Yoshimura
- A. Zateyshchikova
- A. Østrem
- A.-B. Ekstrand
- A.-K. Ascoop
- A.-M. Barbuto
- A.-M. Ohlin
- A.A. Damonte
- A.A. Fernandez
- A.B. Lensebraaten
- A.C. Billiaux
- A.C. Ingaramo
- A.C. Rothwell
- A.C. Tovar Castaneda
- A.C.P. Barretto
- A.D. Hrabar
- A.G. Ravi Shankar
- A.J. Kleiban
- A.J. McLeod
- A.L. Baek
- A.L. Cappi
- A.L. Tufare
- A.M. Jackson
- A.P. Drummond Wainstein
- A.P. Macagnan
- A.R. Kelsall
- A.R. Park
- A.S. Pandey
- Ajay K. Kakkar
- Ajay K. Kakkar
- Alex Parkhomenko
- Alex Spyropoulos
- Alexander G.G. Turpie
- Ali Oto
- Antonio Carlos Pereira Barretto
- B. Allasia
- B. Alzand
- B. Ayres
- B. Chatlaong
- B. Clarke
- B. Conway
- B. Coutu
- B. Crousillat
- B. Curyllo
- B. Deshpande
- B. Dolecka
- B. Doucet
- B. Dubois
- B. Dudzik-Richter
- B. Eriksson
- B. Fox
- B. Gaszner
- B. Ghezai
- B. Gosciniecka
- B. Hawkins
- B. Herrero Maeso
- B. Hoffmann
- B. Ikitimur
- B. Jacobson
- B. Jacobson
- B. Jansson
- B. Jimeno Besa
- B. Kurylo
- B. Kurylo
- B. Li
- B. Liu
- B. Lokesh
- B. Martinsson
- B. Mautner
- B. Merkely
- B. Mooso
- B. Naratreekoon
- B. Okopien
- B. Opielowska-Nowak
- B. Ostrowska-Pomian
- B. Racz
- B. Raghuraman
- B. Ramjattan
- B. Rzyczkowska
- B. Sarai
- B. Schaefer
- B. Schneeweiß
- B. Schweitzer
- B. Sievers
- B. Silaruks
- B. Singh
- B. Sinha
- B. Stephanie
- B. Strohmer
- B. Subbaraman
- B. Unterkircher
- B. Uppelschoten
- B. Vandrus
- B. Vanhauwaert
- B. Vishwanathan
- B. Vogel
- B. Voigts
- B. Ward
- B. Wollaert
- B. Wozakowska-Kaplon
- B. Zhou
- B.-T. Kellner
- B.A.J. Stockins Fernandez
- B.C. Jung
- B.E. Groenemeijer
- B.R. Park
- B.Y. Sayin
- Barry Jacobson
- Bernard J. Gersh
- C. A'Court
- C. Arabetti
- C. Astudillo
- C. Axthelm
- C. Batta
- C. Beltra
- C. Bergeron
- C. Bergeron
- C. Bester
- C. Boshoff
- C. Bothin
- C. Bouvy
- C. Bradshaw
- C. Brike
- C. Brotons Cuixart
- C. Bugueño Gutiérrez
- C. Buiks
- C. Bulla
- C. Buzzetti
- C. Cannon
- C. Cantú Brito
- C. Chami
- C. Chigbo
- C. Ciabatta
- C. Conejeros
- C. Correa
- C. Corros Vicente
- C. Costantini Ortiz
- C. D'Arienzo
- C. Dias
- C. Dooldeniya
- C. Díaz de la Vega
- C. Ellervik
- C. Femiano
- C. Fonseca
- C. Fritz
- C. Funosas
- C. Giles
- C. Gines Garcia
- C. Gomez
- C. Grässjö
- C. Guldener
- C. Gómez Pajuelo
- C. Hagn
- C. Hawkins
- C. Hernández Herrera
- C. Herrick
- C. Hines
- C. Houzvic
- C. Hutton
- C. Jacobs
- C. Jean
- C. Juergens
- C. Kongsin
- C. Lara
- C. Latella
- C. Lewis
- C. Liley
- C. Lodigiani
- C. Martinelli
- C. Mazzone
- C. McCarthy
- C. McIntosh
- C. Moncada
- C. Moro Serrano
- C. Mulholland
- C. Munhoz da Fontoura Tavares
- C. Mussap
- C. Nanzer Vital
- C. Nilsson
- C. Ogurusu
- C. Ormundo
- C. Orosco
- C. Ortiz Cortes
- C. Paul
- C. Pisani
- C. Queirantes
- C. Ramesh
- C. Ravenhorst
- C. Reichelt
- C. Reimer
- C. Rey
- C. Richard
- C. Ricotti
- C. Rivera Ramos
- C. Robertson
- C. Roca Saumell
- C. Rodrigo
- C. Santolaya
- C. Scarone
- C. Scheurwegs
- C. Schubert
- C. Schwencke
- C. Seamark
- C. Simon Valero
- C. Singh
- C. Singleton
- C. Smessaert
- C. Stoll
- C. Stöcklöcker
- C. Sugimoto
- C. Takanaka
- C. Thorsen
- C. Tondo
- C. Torres
- C. Treasure
- C. Vantomme
- C. Verdi
- C. Vicente
- C. Villan
- C. Wöhrer
- C. Yeo
- C. Zecca
- C.-J. Kim
- C.-J. Lindholm
- C.A. Almeida Fernández
- C.A. Neden
- C.C. Broilo França
- C.G. Foo
- C.H. Del Carlo
- C.H. Gimenez
- C.J. Sánchez Díaz
- C.K. Ching
- C.L. Bai
- C.L. Gonzalez Garcia
- C.M. Diaz Lopez
- C.P. Jones
- C.R. Costantini Frack
- C.R. Frack Costantini
- C.S. Lee
- Carlos Jerjes Sánchez Díaz
- Carmela Alonso
- Concepcion Alonso
- D. Adak
- D. Alpay
- D. Alvarez
- D. Amstutz
- D. Andrzejewski
- D. Aras
- D. Armaganijan
- D. Atar
- D. Belenky
- D. Bertolim Precoma
- D. Blaszczyk
- D. Buckert
- D. Cassidy
- D. Castro Fernandez
- D. Chemello
- D. Cholsaringkarl
- D. Colquhoun
- D. Conde
- D. Coulshed
- D. Cresp
- D. Crimmins
- D. Davies
- D. De Cleen
- D. Denie
- D. Diercks
- D. Eccleston
- D. Edwards
- D. Faes
- D. Farquhar
- D. Fielder
- D. Fitzmaurice
- D. Fitzpatrick
- D. Flores Martínez
- D. Fournier
- D. Galley
- D. Geatch
- D. Genc
- D. Glatzel
- D. Goodwin
- D. Gray
- D. Greyling
- D. Guanaes
- D. Guedj-Meynier
- D. Gulyas
- D. Ikeda
- D. Jackson
- D. Jain
- D. Kernick
- D. Kettles
- D. Kociolek
- D. Komar
- D. Konyushenko
- D. Kroll
- D. Kruczyk
- D. Kusiak
- D. Kustrzycka-Kratochwil
- D. Lesniewska-Krynska
- D. Leung
- D. Lopes
- D. López Villezca
- D. Martinez Vasquez
- D. Merritt
- D. Michalik
- D. Montes
- D. Moreira
- D. Naik
- D. Nicolaus
- D. Nishijima
- D. O'Donnell
- D. Obadia
- D. Otero Tomera
- D. Platonov
- D. Plevak
- D. Poli
- D. Redpath
- D. Reimer
- D. Roy
- D. Rozewska-Furmanek
- D. Russell
- D. Sanchez
- D. Santos
- D. Seamark
- D. Shah
- D. Shah
- D. Shepherd
- D. Theodoro
- D. Tragen
- D. Uzun Alkan
- D. Van Lier
- D. Vandenbroeck
- D. Wright
- D. Zanolin
- D. Zateyshchikov
- D.-G. Shin
- D.-K. Kim
- D.B. Kim
- D.C. Esteves
- D.C. Sobral Filho
- D.D. Chen
- D.F. Cumberlidge
- D.H. Kim
- D.J. Choi
- D.R. Ryu
- D.W. Wang
- D.Y. Hu
- Dan Atar
- David A. Fitzmaurice
- David Fitzmaurice
- Dayi Hu
- E. Ahbeck
- E. Alborough
- E. Aleksandrova
- E. Banfi
- E. Barraquer Feu
- E. Bearez
- E. Bekieszczuk
- E. Belisario Falchetto
- E. Berge
- E. Blumberg
- E. Broton
- E. Buckley
- E. Burke
- E. Calvo Martinez
- E. Cardona Muñoz
- E. Chuquiure Valenzuela
- E. Corrihons
- E. Daros
- E. Davies
- E. Deweerd
- E. Domanska
- E. Ducasse
- E. Eißfeller
- E. Ellie
- E. Eriksen
- E. Escrivá Montserrat
- E. Fernandes
- E. Fernandez Escobar
- E. Fernandez Mas
- E. Feys
- E. Fisher
- E. Fulop
- E. Gasior
- E. Gjertsen
- E. Gorbunova
- E. Hartranft
- E. Hettwer Magedanz
- E. Hevia Rodriguez
- E. Jaskulska-Niedziela
- E. Kamenska
- E. Kiralyhazine Gyorke
- E. Kis
- E. Kochanska
- E. Korczowska
- E. Kowal
- E. Krcova
- E. Kremis
- E. Kropacheva
- E. Lanna Figueiredo
- E. Lewicka
- E. Lichota
- E. Lileeva
- E. Loyd
- E. Lustosa
- E. López Rosas
- E. Malone
- E. Mazur
- E. Mesolella
- E. Miedlar
- E. Molina
- E. Mollica Poeta
- E. Márquez Contreras
- E. Nagata
- E. Noori
- E. Novikova
- E. Okuyan
- E. Otaki
- E. Ozcelik
- E. Palmegiani
- E. Panchenko
- E. Pawlik-Rak
- E. Pena Garcia
- E. Polkanova
- E. Prochazkova
- E. Raymenants
- E. Rodriguez
- E. Saga
- E. Salomone
- E. Schaflinger
- E. Serralvo
- E. Shutemova
- E. Staniszewska
- E. Strieder
- E. Stuart
- E. Szuchnik
- E. Tiraferri
- E. Vanhalst
- E. Villeda Espinosa
- E. Watson
- E. Wilford
- E. Yakupov
- E. Yeter
- E. Yildirim
- E. Zaatout
- E. Zhuravleva
- E. Zidkova
- E. Zinka
- E.A. Choi
- E.B. Karaayvaz
- E.D. Alaguibe
- E.G. Lino
- E.H. Choi
- E.H. Lee
- E.J. Gonzalez Felix
- E.J. Yoon
- E.M. Esheiba
- E.M. Jang
- E.M. Koomen
- E.M. Pogliani
- E.P. Gurfinkel
- E.R. Fernandes Manenti
- E.S. Heo
- Elizaveta Panchenko
- F. Ahmed
- F. Al-Khalili
- F. Alban
- F. Aras
- F. Ayala-Paredes
- F. Banaeian
- F. Berli
- F. Bernsten
- F. Bitakova
- F. Bosman
- F. Busch
- F. Calcagnoli
- F. Casassus
- F. Chemin
- F. Chieza
- F. Choudhary
- F. Colombo Berra
- F. Cools
- F. Cosmi
- F. da Silva Paulitsch
- F. Diez
- F. Dormal
- F. Epelde Gonzalo
- F. Fernandez Voena
- F. Ferroni
- F. Flores Silva
- F. Forcignanò
- F. Freihoff
- F. Freire
- F. Geerlings
- F. Germini
- F. Gits
- F. Guerra
- F. Hakimi
- F. Hoshino
- F. Igansi
- F. Iseki
- F. Jannuzzi
- F. Juhasz
- F. Kahl
- F. Lanas
- F. Lillo
- F. Macellari
- F. Melone
- F. Mendez Zurita
- F. Minetti
- F. Okuda
- F. Paganelli
- F. Perez
- F. Petrie
- F. Ridocci Soriano
- F. Robin
- F. Rolandi
- F. Roquette
- F. Scouller
- F. Sellem
- F. Shaik
- F. Sztanyik
- F. Toyota
- F. Tradati
- F. Van Durme
- F. van Zyl
- F. Villaça Guimarães Filho
- F. Yilmaz
- F.A. Alves da Costa
- F.E. Camazzola
- F.J. Bermudez Jimenez
- F.J. Zurbrigk
- F.R. Jaufeerally
- F.Z. Wang
- Frank Cools
- Frank Misselwitz
- Freek W.A. Verheugt
- G. Agnelli
- G. Ambrosio
- G. Angel
- G. Arriagada
- G. Avanzino
- G. Baglioni
- G. Bantwal
- G. Barón Esquivias
- G. Berko
- G. Biazus
- G. Boggian
- G. Bonkowski
- G. Brauer
- G. Burns
- G. Campagna
- G. Cancho Corchado
- G. Charme Vilches
- G. Ciliberti
- G. Cimmino
- G. Conway
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- Y. Wakasa
- Y. Ye
- Y. Yokoyama
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- Y.-I. Kim
- Y.H. Li
- Y.H. Sun
- Y.H. Yin
- Y.J. Yang
- Y.J. Yang
- Y.K. On
- Y.M. Chen
- Y.M. Lee
- Y.M. Sohn
- Y.R. Jeon
- Y.S. Oh
- Y.S. Son
- Y.S. Zhao
- Y.Y. Liu
- Ying Wang
- Yoichi Nakamura
- Yong Wang
- Yoshihisa Fujiura
- Yoshitake Fujiura
- Yuhei Shiga
- Yuichiro Nakamura
- Yukihiro Koretsune
- Yukio Shiga
- Z. Babjakova
- Z. Boda
- Z. Djaidani
- Z. Lajkowski
- Z. Laszlo
- Z. May
- Z. Monhart
- Z. Ongen
- Z. Radics
- Z.C. Lu
- Z.H. Zhou
- Z.M. Yang
- Publication venue
- Indian Heart J
- Publication date
- 01/01/2018
- Field of study
BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity
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- A. Abraheem
- A. Agasou
- A. Ahmed
- A. Ali
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- Wadha Al-Muftah
- WES/WGS Working Group Within the HGI
- Wiktoria Izdebska
- Wilna Oosthuyzen
- X. Qiu
- Xia Shen
- Y. Baird
- Y. Choudhury
- Y. Hussain
- Y. Jackson
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- Yang Wu
- Yaser Al-Sarraj
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- Z. Farzad
- Z. Fernandez
- Z. Garland
- Z. Maqsood
- Z. Omar
- Z. Prime
- Z. Scott
- Zhijian Yang
- Publication venue
- Publication date
- 01/01/2022
- Field of study
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the presence of variants in each gene. An ensemble of LASSO logistic regression models was used to identify the most informative Boolean features with respect to the genetic bases of severity. The Boolean features selected by these logistic models were combined into an Integrated PolyGenic Score that offers a synthetic and interpretable index for describing the contribution of host genetics in COVID-19 severity, as demonstrated through testing in several independent cohorts. Selected features belong to ultra-rare, rare, low-frequency, and common variants, including those in linkage disequilibrium with known GWAS loci. Noteworthily, around one quarter of the selected genes are sex-specific. Pathway analysis of the selected genes associated with COVID-19 severity reflected the multi-organ nature of the disease. The proposed model might provide useful information for developing diagnostics and therapeutics, while also being able to guide bedside disease management. © 2021, The Author(s)
Five insights from the Global Burden of Disease Study 2019
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- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
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- Abrams EM
- Abreu LG
- Abrigo MRM
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- Abu-Raddad LJ
- Abualhasan A
- Abushouk AI
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- Weiss DJ
- Weiss J
- Welay FT
- Weldesamuel GT
- Werdecker A
- West JJ
- Westerman R
- Whisnant JL
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- Wickramasinghe ND
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- Wilner LB
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- Wojtyniak B
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- Yearwood JA
- Yeheyis TY
- Yeshitila YG
- Yilgwan CS
- Yilma MT
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- Yoon S-J
- York HW
- Younis MZ
- Younker TP
- Yousefi B
- Yousefi Z
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- Yousefinezhadi T
- Yousuf AY
- Yu C
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- Yuce D
- Yusefzadeh H
- Zadey S
- Zahabi SS
- Zaidi SS
- Zaki L
- Zaki MES
- Zakzuk J
- Zamani M
- Zamanian M
- Zandian H
- Zangeneh A
- Zarafshan H
- Zastrozhin MS
- Zewdie KA
- Zhang J
- Zhang Y
- Zhang Z-J
- Zhao JT
- Zhao X-JG
- Zhao Y
- Zheleva B
- Zheng P
- Zhou M
- Zhu C
- Ziapour A
- Zimsen SRM
- Zlavog BS
- Zodpey S
- Publication venue
- Publication date
- 01/01/2020
- Field of study
The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system responses. GBD 2019 covered 204 countries and territories, as well as first administrative level disaggregations for 22 countries, from 1990 to 2019. Because GBD is highly standardised and comprehensive, spanning both fatal and non-fatal outcomes, and uses a mutually exclusive and collectively exhaustive list of hierarchical disease and injury causes, the study provides a powerful basis for detailed and broad insights on global health trends and emerging challenges. GBD 2019 incorporates data from 281 586 sources and provides more than 3.5 billion estimates of health outcome and health system measures of interest for global, national, and subnational policy dialogue. All GBD estimates are publicly available and adhere to the Guidelines on Accurate and Transparent Health Estimate Reporting. From this vast amount of information, five key insights that are important for health, social, and economic development strategies have been distilled. These insights are subject to the many limitations outlined in each of the component GBD capstone papers.Peer reviewe
Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdollahi M
- Abdollahpour I
- Abdulkader RS
- Abdullah KH
- Abedi A
- Abedi P
- Abegaz KH
- Abolhassani H
- Abosetugn AE
- Aboyans V
- Abrams EM
- Abreu LG
- Abrigo MRM
- Abu Haimed AK
- Abu-Gharbieh E
- Abu-Raddad LJ
- Abualhasan A
- Abushouk AI
- Acebedo A
- Ackerman IN
- Adabi M
- Adair T
- Adamu AA
- Adebayo OM
- Adedeji IA
- Adekanmbi V
- Adelson JD
- Adeoye AM
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- Advani SM
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- Afshari M
- Afshin A
- Agardh EE
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- Ahmadi A
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- Ahmadpour E
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- Akalu TY
- Akinyemi RO
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- Dessie GA
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- Dharmaratne SD
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- El Sayed I
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- Neupane S
- Ngari KN
- Nguefack-Tsague G
- Ngunjiri JW
- Nguyen CT
- Nguyen DN
- Nguyen HLT
- Nguyen J
- Nguyen M
- Nguyen M
- Nguyen TH
- Nichols E
- Nigatu D
- Nigatu YT
- Nikbakhsh R
- Nikpoor AR
- Nixon MR
- Nnaji CA
- Nomura S
- Norheim OF
- Norrving B
- Noubiap JJ
- Nowak C
- Nsoesie EO
- Nunez-Samudio V
- Oancea B
- Odell CM
- Ogbo FA
- Oghenetega OB
- Oh I-H
- Oiu AO
- Okunga EW
- Oladnabi M
- Olagunju AT
- Olusanya BO
- Olusanya JO
- Oluwasanu MM
- Omer MO
- Ong KL
- Ong S
- Onwujekwe OE
- Oren E
- Orji AU
- Orpana HM
- Ortega-Altamirano DV
- Ortiz A
- Osarenotor O
- Osei FB
- Ostojic SM
- Ostroff SM
- Otstavnov N
- Otstavnov SS
- Overland S
- Owolabi MO
- Padubidri JR
- Pakhale S
- Pakhare AP
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- Palladino R
- Pana A
- Panda-Jonas S
- Pandey A
- Pangaribuan HU
- Park E-K
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- Parmar PGK
- Parry CDH
- Pasovic M
- Pasupula DK
- Patel JR
- Patel SK
- Paternina-Caicedo AJ
- Pathak A
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- Patten SB
- Patton GC
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- Pease SA
- Peden AE
- Pennini A
- Pepito VCF
- Peprah EK
- Pereira A
- Pereira DM
- Pereira J
- Perico N
- Pescarini JM
- Pesudovs K
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- Piccinelli C
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- Pigott DM
- Pilgrim T
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- Pinheiro M
- Piradov MA
- Pirsaheb M
- Pishgar F
- Plana-Ripoll O
- Plass D
- Pletcher M
- Pokhrel KN
- Polibin RV
- Polinder S
- Polkinghorne KR
- Pond CD
- Postma MJ
- Pottoo FH
- Pourjafar H
- Pourmalek F
- Pourshams A
- Poznanska A
- Prada SI
- Prakash S
- Prakash V
- Prasad N
- Preotescu L
- Pribadi DRA
- Pupillo E
- Quazi Syed Z
- Quintanilla BPA
- Rabiee M
- Rabiee N
- Radfar A
- Rafiee A
- Rafiei A
- Raggi A
- Rahim F
- Rahimi-Movaghar A
- Rahman MA
- Rahman MHU
- Rajabpour-Sanati A
- Rajati F
- Rakovac I
- Ram P
- Ramezanzadeh K
- Rana SM
- Ranabhat CL
- Ranta A
- Rao PC
- Rao SJ
- Rasella D
- Rashedi V
- Rastogi P
- Rath GK
- Rathi P
- Rawaf DL
- Rawaf S
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- Rawassizadeh R
- Rawat R
- Razo C
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- Reiner RCJ
- Reinig N
- Reitsma MB
- Remuzzi G
- Renjith V
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- Resnikoff S
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- Rezaei N
- Rezai MS
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- Rhinehart P-A
- Riahi SM
- Ribeiro ALP
- Ribeiro D
- Ribeiro DC
- Rickard J
- Rincon JCC
- Rivera JA
- Robalik T
- Roberts NLS
- Roberts S
- Robinson SR
- Rodriguez-Ramirez S
- Roever L
- Rolfe S
- Romoli M
- Ronfani L
- Room R
- Roshandel G
- Rostamian M
- Roth GA
- Rothenbacher D
- Rubagotti E
- Rumisha SF
- Rwegerera GM
- Saadatagah S
- Sabour S
- Sachdev PS
- Saddik B
- Sadeghi E
- Sadeghi M
- Saeedi R
- Saeidi S
- Safari Y
- Safi S
- Safiri S
- Sagar R
- Sahebkar A
- Sahraian MA
- Sajadi SM
- Salahshoor MR
- Salam N
- Salama JS
- Salamati P
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- Salimzadeh H
- Salman OM
- Salomon JA
- Salz I
- Samad Z
- Sambala EZ
- Samy AM
- Sanabria J
- Sanchez-Pimienta TG
- Santomauro DF
- Santos IS
- Santos JV
- Santric-Milicevic MM
- Saraswathy SYI
- Sarmiento-Suarez R
- Sarrafzadegan N
- Sartorius B
- Sarveazad A
- Sathian B
- Sathish T
- Sattin D
- Savic M
- Sawyer SM
- Saxena D
- Saxena S
- Saylan M
- Sbarra AN
- Schaeffer LE
- Schiavolin S
- Schlaich MP
- Schmidt MI
- Schutte AE
- Schwebel DC
- Schwendicke F
- Section MPA
- Seedat S
- Sekerija M
- Senbeta AM
- Senthilkumaran S
- Sepanlou SG
- Serdar B
- Serre ML
- Servan-Mori E
- Sha F
- Shabani M
- Shackelford KA
- Shadid J
- Shafaat O
- Shahabi S
- Shahbaz M
- Shaheen AA
- Shaikh MA
- Shaji KS
- Shalash AS
- Shams-Beyranvand M
- Shamsi M
- Shamsizadeh M
- Shannawaz M
- Sharafi K
- Sharafi Z
- Sharan S
- Sharara F
- Sharifi H
- Sharma R
- Shaw DH
- Sheena BS
- Sheikh A
- Sheikhtaheri A
- Shetty BSK
- Shetty RS
- Shibuya K
- Shield KD
- Shiferaw WS
- Shigematsu M
- Shin JI
- Shin M-J
- Shiri R
- Shirkoohi R
- Shivakumar KM
- Shrime MG
- Shuval K
- Siabani S
- Sierpinski R
- Sigfusdottir ID
- Sigurvinsdottir R
- Silva DAS
- Silva JP
- Simonetti B
- Simpson KE
- Singh A
- Singh JA
- Singh P
- Sinha DN
- Skiadaresi E
- Skou ST
- Skryabin VY
- Sliwa K
- Smith A
- Smith EUR
- Sobngwi E
- Soheili A
- Sokhan A
- Soltani S
- Somefun OD
- Soofi M
- Sorensen RJD
- Soriano JB
- Sorrie MB
- Soshnikov S
- Soyiri IN
- Spencer CN
- Spotin A
- Spurlock EE
- Sreeramareddy CT
- Srinivasan V
- Sripada K
- Stanaway JD
- Stark BA
- Steel N
- Stefan SC
- Stein C
- Stein DJ
- Steiner C
- Steiner TJ
- Steuben KM
- Stockfelt L
- Stokes MA
- Stovner LJ
- Straif K
- Stranges S
- Stubbs JL
- Suchdev PS
- Sudaryanto A
- Sufiyan MB
- Suleria HAR
- Sulo G
- Sultan I
- Swope CB
- Sykes BL
- Sylte DO
- Szocska M
- Szumowski L
- Tabares-Seisdedos R
- Tabb KM
- Tabuchi T
- Tadakamadla SK
- Taddele BW
- Tadesse DB
- Taherkhani A
- Tahir Z
- Tajdini M
- Takahashi K
- Takala JS
- Tamiru AT
- Tang M
- Tanser FC
- Tareque MI
- Tarigan IU
- Taveira N
- Taylor HJ
- Teagle WL
- Teame H
- Tediosi F
- Tefera YG
- Tehrani-Banihashemi A
- Teklehaimanot BF
- Tela FG
- Temsah M-H
- Terrason S
- Tesema GA
- Tessema ZT
- Thakur B
- Thankappan KR
- Thapar R
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- Thomson AM
- Thrift AG
- Thurston GD
- Titova MV
- Tlou B
- Tohidinik HR
- Tonelli M
- Topor-Madry R
- Topouzis F
- Toroudi HP
- Torre AE
- Touvier M
- Tovani-Palone MR
- Traini E
- Tran BX
- Travillian R
- Trias-Llimos S
- Troeger CE
- Truelsen TC
- Tsai AC
- Tsatsakis A
- Tyrovolas S
- Uddin R
- Ullah I
- Ullah S
- Umeokonkwo CD
- Undurraga EA
- Unnikrishnan B
- Upadhyay E
- Uthman OA
- Vacante M
- Vaicekonyte R
- Vakilian A
- Valdez PR
- Valli A
- Van Donkelaar A
- Vardavas C
- Varughese S
- Vasankari TJ
- Vasconcelos AMN
- Vasseghian Y
- Veisani Y
- Velasquez IM
- Venketasubramanian N
- Vidale S
- Violante FS
- Vlassov V
- Vollset SE
- Vongpradith A
- Vos T
- Vu GT
- Vujcic IS
- Vukovic A
- Vukovic R
- Waheed Y
- Wallin MT
- Walters MK
- Wamai RG
- Wang F
- Wang H
- Wang H
- Wang J
- Wang Y
- Wang Y
- Wang Y-P
- Ward JL
- Watson A
- Watson S
- Wei J
- Wei MYW
- Weintraub RG
- Weiss DJ
- Weiss J
- Welay FT
- Weldesamuel GT
- Werdecker A
- West JJ
- Westerman R
- Whisnant JL
- Whiteford HA
- Wiangkham T
- Wickramasinghe ND
- Wiens KE
- Wijeratne T
- Wilner LB
- Wilson S
- Wiysonge CS
- Wojtyniak B
- Woldu G
- Wolfe CDA
- Wondmeneh TG
- Wondmieneh AB
- Wool EE
- Wozniak SS
- Wu A-M
- Wu C
- Wu J
- Wunrow HY
- Xie Y
- Xu G
- Xu R
- Yadgir S
- Yamada T
- Yamagishi K
- Yaminfirooz M
- Yano Y
- Yaya S
- Yazdi-Feyzabadi V
- Yearwood JA
- Yeheyis TY
- Yeshitila YG
- Yilgwan CS
- Yilma MT
- Yip P
- Yonemoto N
- Yoon S-J
- York HW
- Younis MZ
- Younker TP
- Yousefi B
- Yousefi Z
- Yousefifard M
- Yousefinezhadi T
- Yousuf AY
- Yu C
- Yu Y
- Yuan C-W
- Yuce D
- Yusefzadeh H
- Zadey S
- Zahabi SS
- Zaidi SS
- Zaki L
- Zaki MES
- Zakzuk J
- Zamani M
- Zamanian M
- Zandian H
- Zangeneh A
- Zarafshan H
- Zastrozhin MS
- Zewdie KA
- Zhang J
- Zhang Y
- Zhang Z-J
- Zhao JT
- Zhao X-JG
- Zhao Y
- Zheleva B
- Zheng P
- Zhou M
- Zhu C
- Ziapour A
- Zimsen SRM
- Zlavog BS
- Zodpey S
- Publication venue
- 'Elsevier BV'
- Publication date
- 17/10/2020
- Field of study
Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2
- Author
- Abellán Javier
- Acosta-isaac René
- Aguado Jose María
- Aguilar Carlos
- Aguilera-albesa Sergio
- Ahmadi Sabbagh Abdolah
- Alba Jorge
- Albu Sergiu
- Alcalá-gallardo Karla A. M.
- Alcoba-florez Julia
- Alcolea Batres Sergio
- Algarin-lara Holmes Rafael
- Almadana Virginia
- Almeida Julia
- Almoguera Berta
- Alonso María R.
- Andreu-bernabeu Álvaro
- Antonijoan Maria Rosa
- Arana-arri Eunate
- Aranda Carlos
- Arango Celso
- Araque Carolina
- Araujo Izabel M. T.
- Araujo Nathalia K.
- Arcanjo Ana C.
- Arnaiz Ana
- Arnalich Fernández Francisco
- Arranz María J.
- Arribas López José Ramón
- Artiga Maria-jesús
- Avello-malaver Yubelly
- Ayuso Carmen
- Balagué-dobón Laura
- Baldion Ana María
- Ballina Martín Belén
- Baptista-rosas Raúl C.
- Barranco-díaz Andrea
- Barreda-sánchez María
- Barrera-penagos Viviana
- Belhassen-garcia Moncef
- Bernal Enrique
- Bernal-bello David
- Bezerra Joao F.
- Bezerra Marcos A. C.
- Blanca-lópez Natalia
- Blancas Rafael
- Boix-palop Lucía
- Borobia Alberto
- Bravo Elsa
- Brion María
- Brochado-kith Óscar
- Brugada Ramón
- Bustos Matilde
- Cabello Alfonso
- Calbo Esther
- Calderón Enrique J.
- Camacho Shirley
- Campos Marcela C.
- Carbonell Cristina
- Cardona-huerta Servando
- Carioca Antonio Augusto F.
- Carpio Segura Carlos
- Carracedo Ángel
- Carratto Thássia M. T.
- Carrillo-avila José Antonio
- Carvalho Maria C. C.
- Casasnovas Carlos
- Castaño Carlos F.
- Castaño Luis
- Castelao Jose E.
- Castellano Candalija Aranzazu
- Castillo María A.
- Cañadas Yolanda
- Ceballos Francisco C.
- Chaux Jessica G.
- Chaves-santiago Walter G.
- Chiquillo-gómez Sylena
- Cid-lópez Marco A.
- Cienfuegos-jiménez Óscar
- Conde-vicente Rosa
- Cordero-lorenzana M. Lourdes
- Corella Dolores
- Corrales Almudena
- Corton Marta
- Cortés-sánchez Jose L.
- Costa Tatiana X.
- Cruz Marina S.
- Cruz Raquel
- Cuesta Luisa
- Cunha Gabriela C. R.
- Cáceres Alejandro
- Cáceres-agra Juan J.
- Dalmau David
- Dantas-komatsu Raquel C. S.
- Darnaude M. Teresa
- De Andrés Raimundo
- De Araújo Jéssica N. G.
- De Juan Carmen
- De La Cruz Troca Juan J.
- De La Horra Carmen
- De La Hoz Ana B.
- De Martino-rodríguez Alba
- De Sousa Alves Neri Julianna Lys
- Del Campo-pérez Victor
- Delgado-cuesta Juan
- Diaz De Bustamante Aranzazu
- Dietl Beatriz
- Diz-de Almeida Silvia
- Do Monte Alves Manoella
- Domínguez-garrido Elena
- Dos Santos Katiusse A.
- Duarte Alice L.
- Díaz-caneja Covadonga M.
- Díaz-pérez Anderson
- Echave-sustaeta Jose
- Eiros Rocío
- Enciso-olivera César O.
- Escudero Gabriela
- Esko Tonu
- España Pedro Pablo
- Estigarribia Sanabria Gladys
- Fariñas María Carmen
- Fernandes Marianne R.
- Fernandez-nestosa María J.
- Fernández Martínez Yolanda
- Fernández Ramón
- Fernández Ruth
- Fernández-caballero Lidia
- Fernández-capitán Carmen
- Fernández-cruz Ana
- Fernández-ferrero Silvia
- Fernández-robelo Uxía
- Fernández-rodríguez Amanda
- Fernández-sampedro Marta
- Fernández-villa Tania
- Flores Carlos
- Flores-pérez Patricia
- Friaza Vicente
- Fuenmayor-hernández Lácides
- Fuertes-núñez Marta
- Fumadó Victoria
- Gadea Ignacio
- Gagliardi Lidia
- Gago-domínguez Manuela
- Gallego Natalia
- Galoppo Cristina
- Garcia-garcía Josefina
- García Torrejón María Carmen
- García Inés
- García Leticia
- García Mercedes
- García-cerrada Carlos
- García-de-vicuña Aitor
- García-garcía Irene
- García-ibarbia Carmen
- García-montero Andrés C.
- García-soidán Ana
- García-vázquez Elisa
- Garza-frias Emiliano
- Gentile Angela
- Gil-fournier Belén
- Gonzalez-sagrado Manuel
- Gonzalo-benito Hugo
- González Bernaldo De Quirós Fernán
- González Álvarez Beatriz
- González Juan R.
- González Juan R.
- González-montelongo Rafaela
- González-neira Anna
- González-peñas Javier
- Gorgojo-galindo Oscar
- Guaragna Florencia
- Guegel Genilson P.
- Guillén-guío Beatriz
- Guillén-navarro Encarna
- Guisado-vasco Pablo
- Gutiérrez-bautista Juan F.
- Gutiérrez-castañeda Luz D.
- Gómez Carrera Luis
- Gómez García María
- Gómez Sacristán Ángela
- Gómez-arrue Javier
- Gómez-duque Mario
- Górgolas Miguel
- Heili-frades Sara
- Hernández Estefania
- Hernández-moro Cristina
- Hernández-ortega Luis D.
- Hernández-pérez Guillermo
- Hernández-vaquero Rebeca
- Herranz M. Teresa
- Herrera María
- Herrero María José
- Herrero-gonzález Antonio
- Herráez Belén
- Horcajada Juan P.
- Imaz-ayo Natale
- Intxausti-urrutibeaskoa Maider
- Jacomo Rafael H.
- Jara Rubén
- Jiménez Pilar
- Jiménez Ángel
- Jiménez-alfaro Ignacio
- Jiménez-sousa María A.
- Jordan Iolanda
- Laguna-goya Rocío
- Laorden Daniel
- Lapunzina Pablo
- Lasa-lázaro María
- Lattig María Claudia
- Lauriente Ailen
- Liger Borja Anabel
- Llanos Lucía
- Lopez-garcia Esther
- Lopez-rodriguez Rosario
- Lorente Leonardo
- Lorenzo-salazar José M.
- Lozano José E.
- Lozano-espinosa María
- Luchessi Andre D.
- López De Heredia Miguel
- López De Heredia Miguel
- López-bernús Amparo
- López-granados Eduardo
- López-ruz Miguel A.
- Mahillo Ignacio
- Mancebo Esther
- Mar Carmen
- Marcelo Calvo Cristina
- Marcos Miguel
- Marcos-delgado Alba
- Mariscal-aguilar Pablo
- Martin-fernandez Marta
- Martin-pedraza Laura
- Martinez Amalia
- Martinez-paz Pedro
- Martín María Dolores
- Martín María M.
- Martín Vicente
- Martín-lópez Caridad
- Martín-oterino José-Ángel
- Martín-vicente María
- Martínez Juan José
- Martínez Ricardo
- Martínez Silvia
- Martínez-aquino Eleno
- Martínez-gonzález Óscar
- Martínez-lópez Iciar
- Martínez-nieto Óscar
- Martínez-pérez Ángel
- Martínez-ramas Andrea
- Martínez-reséndez Michel F.
- Martínez-robles Violeta
- Marzal Laura
- Marín-candón Alicia
- Maya Belén Rodríguez
- Mazzeu Juliana F.
- Medeiros Jeane F. P.
- Medeiros Kelliane A.
- Medrano Francisco J.
- Meijome Xose M.
- Mejuto-montero Natalia
- Mendes Ingrid
- Mendoza Charris Humberto
- Merayo Macías Eleuterio
- Mercadillo Fátima
- Mercado-sesma Arieh R.
- Molina Antonio J. J.
- Molina-roldán Elena
- Montoya Juan José
- Moraes Vitor M. S.
- Moreira-escriche Patricia
- Morelos-arnedo Xenia
- Moreno Cuerda Víctor
- Moreno Fernández Alberto
- Moreno Rocío
- Moreno-docón Antonio
- Moreno-escalante Junior
- Morilla Rubén
- Muñoz García Patricia
- Méndez-echevarría Ana
- Mínguez Pablo
- Neira Pablo
- Nevado Julián
- Nieto-gañán Israel
- Nunes Joana F. R.
- Nuñez-torres Rocío
- Obrador-hevia Antònia
- Ocejo-vinyals J. Gonzalo
- Olivar Virginia
- Oliveira Silviene F.
- Olivera María Rubio
- Ondo Lorena
- Orfao Alberto
- Ortega Luis
- Ortega-paino Eva
- Ortiz-flores Fernando
- Ortiz-lópez Rocío
- Oteo José A.
- Pacheco Manuel
- Pacheco-miranda Fredy Javier
- Padilla-conejo Irene
- Panadero-fajardo Sonia
- Parellada Mara
- Pariente-rodríguez Roberto
- Paz-artal Estela
- Peces-barba Germán
- Pedromingo Kus Miguel S.
- Perales Celia
- Perucho Teresa
- Pichardo Lisbeth A.
- Pinho Susana M. T.
- Pinsach-abuin Mel·lina
- Pinzón Luz Adriana
- Pita Guillermo
- Pla-juncà Francesc
- Planas-serra Laura
- Pompa-mera Ericka N.
- Porras-hurtado Gloria L.
- Pujol Aurora
- Pérez Alexandra
- Pérez César
- Pérez María Jazmín
- Pérez Patricia
- Pérez-de-nanclares Gustavo
- Pérez-garcía Felipe
- Pérez-jurado Luis A.
- Pérez-matute Patricia
- Pérez-tomás M. Elena
- Quevedo-chávez María Eugenia
- Quijada Maria Angeles
- Quintela Inés
- Quintela Inés
- Ramiro-león Soraya
- Rascado Sedes Pedro
- Recalde Delia
- Recio-fernández Emma
- Resino Salvador
- Riancho José A.
- Ribeiro Adriana P.
- Rivadeneira-chamorro Carlos S.
- Roa-agudelo Diana
- Robelo Pardo Montserrat
- Rodriguez Marilyn Johanna
- Rodriguez-nicolas Antonio
- Rodriguez-palmero Agustí
- Rodriguez-urrego Paula A.
- Rodríguez-artalejo Fernando
- Rodríguez-ferrer Marena
- Rodríguez-gallego Carlos
- Rodríguez-garcía José A.
- Rodríguez-hernández María A.
- Rodríguez-novoa German Ezequiel
- Rodríguez-ruiz Emilio
- Rojas-martinez Augusto
- Rojo Federico
- Romero-coronado Andrea
- Rondón-garcía Filomeno
- Rosa Lidia S.
- Rosales-castillo Antonio
- Rubio Cladelis
- Ruiz Montserrat
- Ruiz-cabello Francisco
- Ruiz-casares Eva
- Ruiz-cubillan Juan J.
- Ruiz-hornillos Javier
- Ryan Pablo
- Salamanca Hector D.
- Salazar-garcía Lorena
- Salgueiro-origlia Giorgina Gabriela
- Sancho-sainz Cristina
- Sande Esther
- Sangil Anna
- Santos Arnoldo
- Santos Ney P. C.
- Schlüter Agatha
- Scourge Cohort Group
- Segovia Sonia
- Serra-llovich Alex
- Sevil-puras Fernando
- Sevilla-porras Marta
- Sicolo Miguel A.
- Silbiger Vivian N.
- Silva Fabiola T. C.
- Silva Gabriela V.
- Silva Nayara S.
- Silván-fuentes Cristina
- Solé-violán Jordi
- Soria José Manuel
- Sorlí Jose V.
- Sousa Renata R.
- Souto Juan Carlos
- Souza Karla S. C.
- Souza Vanessa S.
- Sprockel John J.
- Suárez-rama José Javier
- Suárez-zamora David A.
- Sánchez López Antonio J.
- Sánchez Pedro-luis
- Sánchez-carpintero Abad María
- Sánchez-pablo Clara
- Sánchez-pernaute Olga
- Sánchez-prados María Concepción
- Sánchez-real Javier
- Sánchez-redondo Jorge
- Taboada-fraga Xiana
- Tamayo Eduardo
- Tamayo-velasco Alvaro
- Taracido-fernández Juan Carlos
- Tavares Nathali A. C.
- Tellería Carlos
- Tenorio-castaño Jair Antonio
- Teper Alejandro
- Torres-gutiérrez Ronald P.
- Torres-macho Juan
- Torres-tobar Lilian
- Troya Jesús
- Urioste Miguel
- Valencia-ramos Juan
- Valido Agustín
- Vargas-gallo Juan Pablo
- Varón Belén
- Vasconcelos Romero H. T.
- Vega Tomas
- Velasco-quirce Santiago
- Vidán-estévez Julia
- Vieitez-santiago Miriam
- Vilches Carlos
- Villalobos Lavinia
- Villar Felipe
- Villar-garcia Judit
- Villaverde Cristina
- Villoslada-blanco Pablo
- Virseda-berdices Ana
- Vélez-santamaría Valentina
- Víctor Virginia
- Yáñez Zuleima
- Zapatero-gaviria Antonio
- Zarate Ruth
- Zazo Sandra
- Álvarez Nuria
- Álvarez-benítez Yady
- Álvarez-navia Felipe
- Álvarez-sala Walther Rodolfo
- Íñigo-campos Antonio
- Íñiguez María
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 08/05/2024
- Field of study
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality
Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950-2019 : a comprehensive demographic analysis for the Global Burden of Disease Study 2019
- Author
- Abbafati Cristiana
- Abbas Kaja M.
- Abbasi Mohammad
- Abbasi-Kangevari Mohsen
- Abbasifard Mitra
- Abbastabar Hedayat
- Abd-Allah Foad
- Abdelalim Ahmed
- Abdollahi Mohammad
- Abdollahpour Ibrahim
- Abedi Aidin
- Abedi Parisa
- Abegaz Kedir H.
- Abolhassani Hassan
- Abosetugn Akine E.
- Aboyans Victor
- Abrams Elissa M.
- Abreu Lucas G.
- Abrigo Michael R. M.
- Abu Haimed Abdulaziz K.
- Abu-Gharbieh Eman
- Abu-Raddad Laith J.
- Abualhasan Ahmed
- Abushouk Abdelrahman I.
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- Afshari Mahdi
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- Quazi Syed Zahiruddin
- Rabiee Mohammad
- Rabiee Navid
- Radfar Amir
- Rafiee Ata
- Rafiei Alireza
- Raggi Alberto
- Rahim Fakher
- Rahimi-Movaghar Afarin
- Rahman Mohammad H.
- Rahman Muhammad A.
- Rajabpour-Sanati Ali
- Rajati Fatemeh
- Rakovac Ivo
- Ram Pradhum
- Ramezanzadeh Kiana
- Rana Saleem M.
- Ranabhat Chhabi L.
- Ranta Annemarei
- Rao Puja C.
- Rao Sowmya J.
- Rasella Davide
- Rashedi Vahid
- Rastogi Prateek
- Rath Goura K.
- Rathi Priya
- Rawaf David L.
- Rawaf Salman
- Rawal Lal
- Rawassizadeh Reza
- Rawat Ramu
- Razo Christian
- Redford Sofia B.
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- Reiner Robert C.
- Reinig Nickolas
- Reitsma Marissa B.
- Remuzzi Giuseppe
- Renjith Vishnu
- Renzaho Andre M. N. (R17978)
- Ärnlöv Johan
- Øverland Simon
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2020
- Field of study
Background: Accurate and up-to-date assessment of demographic metrics is crucial for understanding a wide range of social, economic, and public health issues that affect populations worldwide. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 produced updated and comprehensive demographic assessments of the key indicators of fertility, mortality, migration, and population for 204 countries and territories and selected subnational locations from 1950 to 2019.
Methods: 8078 country-years of vital registration and sample registration data, 938 surveys, 349 censuses, and 238 other sources were identified and used to estimate age-specific fertility. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate age-specific fertility rates for 5-year age groups between ages 15 and 49 years. With extensions to age groups 10–14 and 50–54 years, the total fertility rate (TFR) was then aggregated using the estimated age-specific fertility between ages 10 and 54 years. 7417 sources were used for under-5 mortality estimation and 7355 for adult mortality. ST-GPR was used to synthesise data sources after correction for known biases. Adult mortality was measured as the probability of death between ages 15 and 60 years based on vital registration, sample registration, and sibling histories, and was also estimated using ST-GPR. HIV-free life tables were then estimated using estimates of under-5 and adult mortality rates using a relational model life table system created for GBD, which closely tracks observed age-specific mortality rates from complete vital registration when available. Independent estimates of HIV-specific mortality generated by an epidemiological analysis of HIV prevalence surveys and antenatal clinic serosurveillance and other sources were incorporated into the estimates in countries with large epidemics. Annual and single-year age estimates of net migration and population for each country and territory were generated using a Bayesian hierarchical cohort component model that analysed estimated age-specific fertility and mortality rates along with 1250 censuses and 747 population registry years. We classified location-years into seven categories on the basis of the natural rate of increase in population (calculated by subtracting the crude death rate from the crude birth rate) and the net migration rate. We computed healthy life expectancy (HALE) using years lived with disability (YLDs) per capita, life tables, and standard demographic methods. Uncertainty was propagated throughout the demographic estimation process, including fertility, mortality, and population, with 1000 draw-level estimates produced for each metric. Findings: The global TFR decreased from 2·72 (95% uncertainty interval [UI] 2·66–2·79) in 2000 to 2·31 (2·17–2·46) in 2019. Global annual livebirths increased from 134·5 million (131·5–137·8) in 2000 to a peak of 139·6 million (133·0–146·9) in 2016. Global livebirths then declined to 135·3 million (127·2–144·1) in 2019. Of the 204 countries and territories included in this study, in 2019, 102 had a TFR lower than 2·1, which is considered a good approximation of replacement-level fertility. All countries in sub-Saharan Africa had TFRs above replacement level in 2019 and accounted for 27·1% (95% UI 26·4–27·8) of global livebirths. Global life expectancy at birth increased from 67·2 years (95% UI 66·8–67·6) in 2000 to 73·5 years (72·8–74·3) in 2019. The total number of deaths increased from 50·7 million (49·5–51·9) in 2000 to 56·5 million (53·7–59·2) in 2019. Under-5 deaths declined from 9·6 million (9·1–10·3) in 2000 to 5·0 million (4·3–6·0) in 2019. Global population increased by 25·7%, from 6·2 billion (6·0–6·3) in 2000 to 7·7 billion (7·5–8·0) in 2019. In 2019, 34 countries had negative natural rates of increase; in 17 of these, the population declined because immigration was not sufficient to counteract the negative rate of decline. Globally, HALE increased from 58·6 years (56·1–60·8) in 2000 to 63·5 years (60·8–66·1) in 2019. HALE increased in 202 of 204 countries and territories between 2000 and 2019
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
- Author
- Aase Handberg
- Abhijna R Ballal
- Abhimanyu Thakur
- Abuelreich Sarah
- Achille Anselmo
- Adam L Maddox
- Adityas Purnianto
- Adrian E Morelli
- Adrian L Harris
- Adriana F Paes Leme
- Adriana T Larregina
- Afrodité Németh
- Afsareen Bano
- Agnieszka Razim
- Agustin Enciso-Martinez
- Ahmed Ge Ibrahim
- Ahmed Somaida
- Aija Linē
- Ainhoa Alberro
- Ajay P Singh
- Akbar L Marzan
- Akhil Srivastava
- Akira Yokoi
- Al Charest
- Alain R Brisson
- Alan J Zimmerman
- Albano Cáceres-Verschae
- Aled Clayton
- Aleksandra Inic-Kanada
- Aleksei Tikhonov
- Alena Ivanova
- Alessandra Ciullo
- Alessandro Gori
- Alessio Noghero
- Alex J Rai
- Alexander Otahal
- Alexander R Ivanov
- Alexis G Murillo Carrasco
- Alice Gualerzi
- Alicia Galinsoga
- Alicia Llorente
- Aliosha I Figueroa-Valdés
- Alireza Fazeli
- Alissa M Weaver
- Alok Raghav
- Alvaro Compañ-Bertomeu
- Amanda Khoo
- Amanda Salviano-Silva
- Amandine Bonifay
- Amankeldi A Salybekov
- Amélie Nadeau
- Amin Zakeri
- Amirmohammad Nasiri Kenari
- Amit K Srivastava
- Amy A Baxter
- Amy C Kauffman
- Amy H Buck
- An Hendrix
- Ana C Torrecilhas
- Ana I Salazar-Puerta
- Ana O'Loghlen
- Anabela Cordeiro-da-Silva
- Anaïs Bécot
- Anders T Boysen
- Andras G Miklosi
- Andras Saftics
- András I Försönits
- Andre J van Wijnen
- Andrea Galisova
- Andrea Ridolfi
- Andrea Zendrini
- Andreas Möller
- Andreia M Silva
- Andreina Schoeberlein
- Andreu Matamoros-Angles
- Andrew Devitt
- Andrew F Hill
- Andrew Lai
- Andrew Rowland
- André Cronemberger-Andrade
- André Görgens
- Andries Zijlstra
- Angela M Zivkovic
- Angelica Ortiz
- Angelo Musicò
- Ann M Wehman
- Anna Antoniou
- Anna C Berardi
- Anna Cifuentes-Rius
- Anna D Krasnodembskaya
- Anna Koncz
- Anna M Schmid
- Anna Romolo
- Annaïg J Rozo
- Annalisa Radeghieri
- Annie Frelet-Barrand
- Annika Pfeiffer
- Anthony W Ferrante Jr
- Antje M Zickler
- Antoine Karoichan
- Antonella Bongiovanni
- Antonia Hufnagel
- Antonia Reale
- Antonio da Silva Novaes
- Antonio Marcilla
- Apolonija Bedina-Zavec
- Apurba Dev
- Asa M Wheelock
- Ashish Kumar
- Ashley E Russell
- Ashok K Shetty
- Asima Bhattacharyya
- Attila Oláh
- Augusto Zani
- Aurelia Rughetti
- Aurelio Lorico
- Aurélie Ledreux
- Avital A Rodal
- Ayesha Saleem
- Ákos M Lőrincz
- Áurea M Gabriel
- Bagabas Reem
- Baharak Hosseinkhani
- Bahnisikha Barman
- Bairen Pang
- Bas Wm van Balkom
- Batuhan T Bozkurt
- Beate Vestad
- Benedetta Bussolati
- Benjamin Jurek
- Benjamin Mary
- Bergese Paolo
- Berglind E Benediktsdóttir
- Bernadett R Bodnár
- Bernd Giebel
- Bert Dhondt
- Berta Puig
- Beth Coyle
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- Biao Lu
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- Blenkiron Cherie
- Bo Li
- Bojana Milutinovic
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- Bonita H Powell
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- Burger Dylan
- Bussolati Benedetta
- Buzas Edit I.
- Byeong Hyeon Choi
- Cai Houjian
- Camille Ettelaie
- Camille V Trinidad
- Cansu Gorgun
- Carla Mazzeo
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- Claudia M Radu
- Cláudio Pinheiro
- Clémence Belleannée
- Clotilde Billottet
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- Colin L Hisey
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- Daniela Boselli
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- Daniela L Papademetrio
- Daniele D'Arrigo
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- David P Al-Adra
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- David Rf Carter
- David Rufino-Ramos
- David W Greening
- Davide Zocco
- Deanna F Shea
- Deborah Ci Goberdhan
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- Denis Corbeil
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- Dilara C Ozkocak
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- Dorian Forte
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- Emilia Scharrig
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- Enis Kostallari
- Eqbal Mohamadi
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- Indira Prasadam
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- Jascinta P Santavanond
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- van der Pol Edwin
- van Herwijnen Martijn J. C.
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- Vasiliki Mahairaki
- Vasiliy S Chernyshev
- Vatsal Deliwala
- Veer Bala Gupta
- Vendula Pospichalova
- Vengala Rao Yenuganti
- Venkatesh Kumar Chetty
- Vera A Tang
- Vera Mugoni
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- Verity J Ford
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- Veronica Huber
- Veronika Kralj-Iglic
- Veronika Stoka
- Victor Bodart-Santos
- Vijaya Sunkara
- Vikramsingh Gujar
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- Viktoria Weber
- Vincent Hyenne
- Vincent Yeung
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- Violaine Moreau
- Vito G D'Agostino
- Vivek Kumar Gupta
- Vladimir Bokun
- Vroniqa Ku'ulei-Lyn Faustino
- Vytautas Žėkas
- Wai-Leng Lee
- Wanessa F Altei
- Wauben Marca H. M.
- Wehman Ann M.
- Wei Duan
- Wei Guo
- Wei Seong Toh
- Welsh Joshua A.
- Wen-Wei Chang
- Wilfrid Boireau
- Wilfried W Bazié
- Willem Stoorvogel
- Williams Sarah
- Witwer Kenneth W.
- Wolfgang Holnthoner
- Wyatt N Vreeland
- Xabier Osteikoetxea
- Xandra O Breakefield
- Xavier Loyer
- Xiaomei Yan
- Xiaoqin Wang
- Xinhua Lei
- Xinlei Li
- Xiuming Liang
- Yagmur Yildizhan
- Yang You
- Yasuo Inoshima
- Yi Wen
- Yinghong Zhou
- Yingtang Gao
- Yiyao Huang
- Yoel Sadovsky
- Yohan Kim
- Yong Song Gho
- Yongkang Yang
- Yonis Bare
- Yoon-Kyoung Cho
- Yoshinobu Takakura
- Young-Gyun Park
- Yu Fujita
- Yu Xiao
- Yuki Yamamoto
- Yumi Kumagai
- Yunjie Wu
- Yunxi Chen
- Yusuke Yamamoto
- Yusuke Yoshioka
- Yvan Courageux
- Yvonne Couch
- Zach Troyer
- Zendrini Andrea
- Zheng Lei
- Zheng Zhao
- Zijlstra Andries
- Zimmerman Alan J.
- Zivile Useckaite
- Zoltan Varga
- Zoltán Varga
- Zoltán Wiener
- Zucai Suo
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly
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