America's North Coast: A Benefit-Cost Analysis of a Program to Protect and Restore the Great Lakes

Examines the baseline ecological conditions of the Great Lakes and offers a plan for the area's environmental protection and restoration. Demonstrates how a restoration program can provide economic benefits that substantially exceed its costs

Prevalence of Inadequate Hydration Levels in Aquatic Safety Personnel: A Pilot Study

Lifeguards play an important role in the security and safety of those they are hired to protect. A performance issue may arise if they succumb to circumstances that cause them to become physically or psychologically compromised. Dehydration is one issue that can result in decreased levels of workplace performance and pose personal health risks. Certified lifeguards 15 years old and older were tested for urine specific gravity (USG) to determine their place within the dehydration spectrum. Participants (N = 55) were recruited from seven test sites offering a variety of designs (indoor/outdoor, traditional/waterpark) and classifications (private, semipublic, public). Testing involved the collection of a urine specimen from participants and immediate recording of specific gravity using a reagent test strip by researchers. A brief survey to collect demographic information from subjects was also administered. The majority of participants were found to reside along the dehydration spectrum (USG ≥ 1.015), several showing results toward the severe end of the scale. The sample provided adequate demographic variability among males and females and facility classification types. No statistically significant differences were found between the demographic variables and USG scores of subjects. Since the majority of lifeguards in the sample showed some level of dehydration, this indicated a need for more information concerning lifeguards and dehydration. Despite the lack of statistically significant differences among the demographic factors within this sample, future studies should incorporate other behavioral factors and dehydration testing methods to investigate the mechanisms for preventing dehydration as well as its impact on lifeguarding performance

Effects of air pollution and the introduction of the London Low Emission Zone on the prevalence of respiratory and allergic symptoms in schoolchildren in East London: a sequential cross-sectional study

The adverse effects of traffic-related air pollution on children’s respiratory health have been widely reported, but few studies have evaluated the impact of traffic-control policies designed to reduce urban air pollution. We assessed associations between traffic-related air pollutants and respiratory/allergic symptoms amongst 8–9 year-old schoolchildren living within the London Low Emission Zone (LEZ). Information on respiratory/allergic symptoms was obtained using a parent-completed questionnaire and linked to modelled annual air pollutant concentrations based on the residential address of each child, using a multivariable mixed effects logistic regression analysis. Exposure to traffic-related air pollutants was associated with current rhinitis: NOx (OR 1.01, 95% CI 1.00–1.02), NO2 (1.03, 1.00–1.06), PM10 (1.16, 1.04–1.28) and PM2.5 (1.38, 1.08–1.78), all per μg/m3 of pollutant, but not with other respiratory/allergic symptoms. The LEZ did not reduce ambient air pollution levels, or affect the prevalence of respiratory/allergic symptoms over the period studied. These data confirm the previous association between traffic-related air pollutant exposures and symptoms of current rhinitis. Importantly, the London LEZ has not significantly improved air quality within the city, or the respiratory health of the resident population in its first three years of operation. This highlights the need for more robust measures to reduce traffic emissions

NASA Probe Study Report: Farside Array for Radio Science Investigations of the Dark ages and Exoplanets (FARSIDE)

This is the final report submitted to NASA for a Probe-class concept study of the "Farside Array for Radio Science Investigations of the Dark ages and Exoplanets" (FARSIDE), a low radio frequency interferometric array on the farside of the Moon. The design study focused on the instrument, a deployment rover, the lander and base station, and delivered an architecture broadly consistent with the requirements for a Probe mission. This notional architecture consists of 128 dipole antennas deployed across a 10 km area by a rover, and tethered to a base station for central processing, power and data transmission to the Lunar Gateway, or an alternative relay satellite. FARSIDE would provide the capability to image the entire sky each minute in 1400 channels spanning frequencies from 150 kHz to 40 MHz, extending down two orders of magnitude below bands accessible to ground-based radio astronomy. The lunar farside can simultaneously provide isolation from terrestrial radio frequency interference, auroral kilometric radiation, and plasma noise from the solar wind. This would enable near-continuous monitoring of the nearest stellar systems in the search for the radio signatures of coronal mass ejections and energetic particle events, and would also detect the magnetospheres for the nearest candidate habitable exoplanets. Simultaneously, FARSIDE would be used to characterize similar activity in our own solar system, from the Sun to the outer planets. Through precision calibration via an orbiting beacon, and exquisite foreground characterization, FARSIDE would also measure the Dark Ages global 21-cm signal at redshifts from 50-100. It will also be a pathfinder for a larger 21-cm power spectrum instrument by carefully measuring the foreground with high dynamic range

Efficient use of water for irrigation in the upper midwest

The objectives of this multidisciplinary interinstitutional regional study on the efficient use of water for irrigation in the upper Midwest were: (1) to determine parameters needed for existing or improved models of crop response; (2) to relate yield response to costs and revenues by assessing the water demand for irrigation; and (3) to study the demand for irrigation, present and projected, and its availability as related to public allocation decisions. From this series of studies it was concluded that: (1) There are many areas of the Midwest with sufficient groundwater and surface water resources to support the development of irrigation. (2) Soil moisture models indicate that only moderate yield response to irrigation can be expected on high moisture soils; on lighter soils and claypan soils, yield response is significant, even in regions with relatively high precipitation. (3) Irrigation and drainage on claypan soils can dramatically increase corn yields. (4) It appears economically worthwhile for the individual farmer operating on moderate soils or on claypan soils to evaluate capital investments in irrigation along with other capital investments. (5) Increases in yields and persistence of alfalfa due to irrigation appear to be insignificant when compared to conventional management practices; further research is needed. A potential, however, appears to exist for improving adaptation of a1 fa1 fa varieties to soil water deficits.U.S. Geological SurveyU.S. Department of the InteriorOpe

Interplanetary CubeSats: Opening the Solar System to a Broad Community at Lower Cost

Interplanetary CubeSats could enable small, low-cost missions beyond low Earth orbit. This class is defined by mass < ~ 10 kg, cost < $30 M, and durations up to 5 years. Over the coming decade, a stretch of each of six distinct technology areas, creating one overarching architecture, could enable comparatively low-cost Solar System exploration missions with capabilities far beyond those demonstrated in small satellites to date. The six technology areas are: (1) CubeSat electronics and subsystems extended to operate in the interplanetary environment, especially radiation and duration of operation; (2) Optical telecommunications to enable very small, low-power uplink/downlink over interplanetary distances; (3) Solar sail propulsion to enable high !V maneuvering using no propellant; (4) Navigation of the Interplanetary Superhighway to enable multiple destinations over reasonable mission durations using achievable !V; (5) Small, highly capable instrumentation enabling acquisition of high-quality scientific and exploration information; and (6) Onboard storage and processing of raw instrument data and navigation information to enable maximum utility of uplink and downlink telecom capacity, and minimal operations staffing. The NASA Innovative Advanced Concepts (NIAC) program in 2011 selected Interplanetary CubeSats for further investigation, some results of which are reported here for Phase 1

Social Class

Discussion of class structure in fifth-century Athens, historical constitution of theater audiences, and the changes in the comic representation of class antagonism from Aristophanes to Menander

Gravitational Waves From Known Pulsars: Results From The Initial Detector Era

We present the results of searches for gravitational waves from a large selection of pulsars using data from the most recent science runs (S6, VSR2 and VSR4) of the initial generation of interferometric gravitational wave detectors LIGO (Laser Interferometric Gravitational-wave Observatory) and Virgo. We do not see evidence for gravitational wave emission from any of the targeted sources but produce upper limits on the emission amplitude. We highlight the results from seven young pulsars with large spin-down luminosities. We reach within a factor of five of the canonical spin-down limit for all seven of these, whilst for the Crab and Vela pulsars we further surpass their spin-down limits. We present new or updated limits for 172 other pulsars (including both young and millisecond pulsars). Now that the detectors are undergoing major upgrades, and, for completeness, we bring together all of the most up-to-date results from all pulsars searched for during the operations of the first-generation LIGO, Virgo and GEO600 detectors. This gives a total of 195 pulsars including the most recent results described in this paper.United States National Science FoundationScience and Technology Facilities Council of the United KingdomMax-Planck-SocietyState of Niedersachsen/GermanyAustralian Research CouncilInternational Science Linkages program of the Commonwealth of AustraliaCouncil of Scientific and Industrial Research of IndiaIstituto Nazionale di Fisica Nucleare of ItalySpanish Ministerio de Economia y CompetitividadConselleria d'Economia Hisenda i Innovacio of the Govern de les Illes BalearsNetherlands Organisation for Scientific ResearchPolish Ministry of Science and Higher EducationFOCUS Programme of Foundation for Polish ScienceRoyal SocietyScottish Funding CouncilScottish Universities Physics AllianceNational Aeronautics and Space AdministrationOTKA of HungaryLyon Institute of Origins (LIO)National Research Foundation of KoreaIndustry CanadaProvince of Ontario through the Ministry of Economic Development and InnovationNational Science and Engineering Research Council CanadaCarnegie TrustLeverhulme TrustDavid and Lucile Packard FoundationResearch CorporationAlfred P. Sloan FoundationAstronom

The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of hematologic malignancies: multiple myeloma, lymphoma, and acute leukemia

Increasing knowledge concerning the biology of hematologic malignancies as well as the role of the immune system in the control of these diseases has led to the development and approval of immunotherapies that are resulting in impressive clinical responses. Therefore, the Society for Immunotherapy of Cancer (SITC) convened a hematologic malignancy Cancer Immunotherapy Guidelines panel consisting of physicians, nurses, patient advocates, and patients to develop consensus recommendations for the clinical application of immunotherapy for patients with multiple myeloma, lymphoma, and acute leukemia. These recommendations were developed following the previously established process based on the Institute of Medicine’s clinical practice guidelines. In doing so, a systematic literature search was performed for high-impact studies from 2004 to 2014 and was supplemented with further literature as identified by the panel. The consensus panel met in December of 2014 with the goal to generate consensus recommendations for the clinical use of immunotherapy in patients with hematologic malignancies. During this meeting, consensus panel voting along with discussion were used to rate and review the strength of the supporting evidence from the literature search. These consensus recommendations focus on issues related to patient selection, toxicity management, clinical endpoints, and the sequencing or combination of therapies. Overall, immunotherapy is rapidly emerging as an effective therapeutic strategy for the management of hematologic malignances. Evidence-based consensus recommendations for its clinical application are provided and will be updated as the field evolves

Contributions of Dopamine-Related Genes and Environmental Factors to Highly Sensitive Personality: A Multi-Step Neuronal System-Level Approach

Traditional behavioral genetic studies (e.g., twin, adoption studies) have shown that human personality has moderate to high heritability, but recent molecular behavioral genetic studies have failed to identify quantitative trait loci (QTL) with consistent effects. The current study adopted a multi-step approach (ANOVA followed by multiple regression and permutation) to assess the cumulative effects of multiple QTLs. Using a system-level (dopamine system) genetic approach, we investigated a personality trait deeply rooted in the nervous system (the Highly Sensitive Personality, HSP). 480 healthy Chinese college students were given the HSP scale and genotyped for 98 representative polymorphisms in all major dopamine neurotransmitter genes. In addition, two environment factors (stressful life events and parental warmth) that have been implicated for their contributions to personality development were included to investigate their relative contributions as compared to genetic factors. In Step 1, using ANOVA, we identified 10 polymorphisms that made statistically significant contributions to HSP. In Step 2, these polymorphism's main effects and interactions were assessed using multiple regression. This model accounted for 15% of the variance of HSP (p<0.001). Recent stressful life events accounted for an additional 2% of the variance. Finally, permutation analyses ascertained the probability of obtaining these findings by chance to be very low, p ranging from 0.001 to 0.006. Dividing these loci by the subsystems of dopamine synthesis, degradation/transport, receptor and modulation, we found that the modulation and receptor subsystems made the most significant contribution to HSP. The results of this study demonstrate the utility of a multi-step neuronal system-level approach in assessing genetic contributions to individual differences in human behavior. It can potentially bridge the gap between the high heritability estimates based on traditional behavioral genetics and the lack of reproducible genetic effects observed currently from molecular genetic studies