Entrepreneurship based empowerment among fisherwomen self help groups of Kerala

The present study was conducted to analyse the extent of empowerment achieved by fisherwomen through participation in the entrepreneurial activities of self help groups (SHGs) functioning in the fisheries sector. Data were collected from 180 SHG members in the Kollam, Ernakulam and Kasargod districts of Kerala. Aquaculture (55.5%) and value addition of fish (45.5%) were the entrepreneurial activities adopted by fisherwomen SHGs. Empowerment level of each SHG member was quantified by modifying the existing empowerment dimensions into an Empowerment Index (EI), consisting of 8 sub-dimensions. Extent of empowerment was found out by taking the difference of empowerment index before and after joining the SHG. Among the eight empowerment dimensions, higher difference was observed in confidence building (0.43) followed by economic empowerment (0.42) and decision making pattern (0.41). The study revealed that the level of involvement in entrepreneurial activity has increased the empowerment in terms of confidence building, self-esteem, decision making pattern, psychological and economic empowerment. However, the existing fisheries extension interventions through extension contact and training were found to be associated with only self esteem and psychological empowerment. Therefore, new and innovative extension interventions are suggested in the paper to influence other sub-dimensions like economic empowerment, confidence building and decision making pattern

Entrepreneurship based empowerment among fisherwomen self help groups of Kerala

The present study was conducted to analyse the extent of empowerment achieved by fisherwomen through participation in the entrepreneurial activities of self help groups (SHGs) functioning in the fisheries sector. Data were collected from 180 SHG members in the Kollam, Ernakulam and Kasargod districts of Kerala. Aquaculture (55.5%) and value addition of fish (45.5%) were the entrepreneurial activities adopted by fisherwomen SHGs. Empowerment level of each SHG member was quantified by modifying the existing empowerment dimensions into an Empowerment Index (EI), consisting of 8 sub-dimensions. Extent of empowerment was found out by taking the difference of empowerment index before and after joining the SHG. Among the eight empowerment dimensions, higher difference was observed in confidence building (0.43) followed by economic empowerment (0.42) and decision making pattern (0.41). The study revealed that the level of involvement in entrepreneurial activity has increased the empowerment in terms of confidence building, self-esteem, decision making pattern, psychological and economic empowerment. However, the existing fisheries extension interventions through extension contact and training were found to be associated with only self esteem and psychological empowerment. Therefore, new and innovative extension interventions are suggested in the paper to influence other sub-dimensions like economic empowerment, confidence building and decision making pattern

Performance of Activity Group under the Swarnjayanti Gram Swarozgar Yojana (SGSY) in Kerala

Fisherwomen contribute significantly to fisheries growth in Kerala. To enhance the participation of women in agriculture and allied fields, Government of India has implemented several developmental programmes.The Swarnjayanti Gram Swarozgar Yojana (SGSY) is implemented in Kerala to assist poor families (Swarozgaries) living below the poverty line by ensuring appreciable sustained income through micro enterprises. The present study was conducted in 7 Panchayats in the Ernakulam district of Kerala. Majority (88%) started the new micro enterprise in 2008 and 12 per cent in 2010. About 60 per cent of the group seek technical advice on financial transactions from the funding agency/ Micro Financial Institutes (MFIs) and 40 per cent groups take own decisions. All the groups conduct meetings either weekly or monthly for discussing their records on the sales. Decision making in the group is by all the members. The study includes detailed findings about the economic performance of the group, group profile and constraints faced by the group

Formulation of plant nutrient with synbiotic enhancement

Oleochemical wastewater discharge from the industry into water sources is one of the main causes of water pollution. A proper treatment is required before the effluent is discharged to the environment. Since the oleochemical wastewater contains nutrients and probiotics that are good for plants, it could be used as a nutrient provider for the plants instead. Therefore, the formulation of synbiotic plant nutrients from this effluent is an effective way of using the oleochemical effluent. This study aimed to formulate the plant nutrients by using industrial wastewater, which contains the synbiotic enhancement and validating the significance of the formulated plant nutrients into three types of plants; Abelmoschus esculentus (Okra), Solanum Melongena (Brinjal), and Capsicum annuum (Chilli peppers). Synbiotic is a combination of both prebiotics and probiotics that benefit the host by stimulating the growth of a limited number of health-promoting bacteria. To formulate the plant nutrient, the wastewater was filtered using a cotton cloth before the pre-biotics solution was added. Sample A (filtered wastewater was mixed with Sample B (prebiotics solution) by different percentages, namely F1 (100%:0%), F2 (75%:25%), F3 (50%:50%), F3 (25%:75%), 0%:100% (Sample A to Sample B respectively) and lastly, 50%:50% (Sample C (unfiltered wastewater) to Sample B respectively). The height of the plant and the number of leaves are measured weekly for four months. From the data, it can be seen that F3 gave significant results for the okra plant, in which it gains the highest height of plant compared to the other two plants. On the other hand, F6 give the best results for both the brinjal and the chilli plant where their leaves grow the highest from the second until the fourth month of plant growth. Hence, this research gives an added value to the wastewater, whereas the wastewater is used as the synbiotic plant nutrient enhancer and work best for the plants

Performance of the CMS Cathode Strip Chambers with Cosmic Rays

The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device in the CMS endcaps. Their performance has been evaluated using data taken during a cosmic ray run in fall 2008. Measured noise levels are low, with the number of noisy channels well below 1%. Coordinate resolution was measured for all types of chambers, and fall in the range 47 microns to 243 microns. The efficiencies for local charged track triggers, for hit and for segments reconstruction were measured, and are above 99%. The timing resolution per layer is approximately 5 ns

Large-eddy simulation sensitivities to variations of configuration and forcing parameters in canonical boundary-layer flows for wind energy applications

The sensitivities of idealized large-eddy simulations (LESs) to variations of model configuration and forcing parameters on quantities of interest to wind power applications are examined. Simulated wind speed, turbulent fluxes, spectra and cospectra are assessed in relation to variations in two physical factors, geostrophic wind speed and surface roughness length, and several model configuration choices, including mesh size and grid aspect ratio, turbulence model, and numerical discretization schemes, in three different code bases. Two case studies representing nearly steady neutral and convective atmospheric boundary layer (ABL) flow conditions over nearly flat and homogeneous terrain were used to force and assess idealized LESs, using periodic lateral boundary conditions. Comparison with fast-response velocity measurements at 10 heights within the lowest 100&thinsp;m indicates that most model configurations performed similarly overall, with differences between observed and predicted wind speed generally smaller than measurement variability. Simulations of convective conditions produced turbulence quantities and spectra that matched the observations well, while those of neutral simulations produced good predictions of stress, but smaller than observed magnitudes of turbulence kinetic energy, likely due to tower wakes influencing the measurements. While sensitivities to model configuration choices and variability in forcing can be considerable, idealized LESs are shown to reliably reproduce quantities of interest to wind energy applications within the lower ABL during quasi-ideal, nearly steady neutral and convective conditions over nearly flat and homogeneous terrain.</p

Performance and Operation of the CMS Electromagnetic Calorimeter

The operation and general performance of the CMS electromagnetic calorimeter using cosmic-ray muons are described. These muons were recorded after the closure of the CMS detector in late 2008. The calorimeter is made of lead tungstate crystals and the overall status of the 75848 channels corresponding to the barrel and endcap detectors is reported. The stability of crucial operational parameters, such as high voltage, temperature and electronic noise, is summarised and the performance of the light monitoring system is presented

The Identification of Protein Kinase C Iota as a Regulator of the Mammalian Heat Shock Response Using Functional Genomic Screens

BACKGROUND: The heat shock response is widely used as a surrogate of the general protein quality control system within the cell. This system plays a significant role in aging and many protein folding diseases as well as the responses to other physical and chemical stressors. METHODS/PRINCIPAL FINDINGS: In this study, a broad-based functional genomics approach was taken to identify potential regulators of the mammalian heat shock response. In the primary screen, a total of 13724 full-length genes in mammalian expression vectors were individually co-transfected into human embryonic kidney cells together with a human HSP70B promoter driving firefly luciferase. A subset of the full-length genes that showed significant activation in the primary screen were then evaluated for their ability to hyper-activate the HSP70B under heat shock conditions. Based on the results from the secondary assay and gene expression microarray analyses, eight genes were chosen for validation using siRNA knockdown. Of the eight genes, only PRKCI showed a statistically significant reduction in the heat shock response in two independent siRNA duplexes compared to scrambled controls. Knockdown of the PRKCI mRNA was confirmed using quantitative RT-PCR. Additional studies did not show a direct physical interaction between PRKCI and HSF1. CONCLUSIONS/SIGNIFICANCE: The results suggest that PRKCI is an indirect co-regulator of HSF1 activity and the heat shock response. Given the underlying role of HSF1 in many human diseases and the response to environmental stressors, PRKCI represents a potentially new candidate for gene-environment interactions and therapeutic intervention

Identification of Novel Mt-Guab2 Inhibitor Series Active against M. tuberculosis

Tuberculosis (TB) remains a leading cause of mortality worldwide. With the emergence of multidrug resistant TB, extensively drug resistant TB and HIV-associated TB it is imperative that new drug targets be identified. The potential of Mycobacterium tuberculosis inosine monophosphate dehydrogenase (IMPDH) as a novel drug target was explored in the present study. IMPDH exclusively catalyzes the conversion of inosine monophosphate (IMP) to xanthosine monophosphate (XMP) in the presence of the cofactor nicotinamide adenine dinucleotide (NAD+). Although the enzyme is a dehydrogenase, the enzyme does not catalyze the reverse reaction i.e. the conversion of XMP to IMP. Unlike other bacteria, M. tuberculosis harbors three IMPDH-like genes, designated as Mt-guaB1, Mt-guaB2 and Mt-guaB3 respectively. Of the three putative IMPDH's, we previously confirmed that Mt-GuaB2 was the only functional ortholog by characterizing the enzyme kinetically. Using an in silico approach based on designed scaffolds, a series of novel classes of inhibitors was identified. The inhibitors possess good activity against M. tuberculosis with MIC values in the range of 0.4 to 11.4 µg mL−1. Among the identified ligands, two inhibitors have nanomolar Kis against the Mt-GuaB2 enzyme

Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target.

The human pathogen Mycobacterium tuberculosis is the causative agent of pulmonary tuberculosis (TB), a disease with high worldwide mortality rates. Current treatment programs are under significant threat from multi-drug and extensively-drug resistant strains of M. tuberculosis, and it is essential to identify new inhibitors and their targets. We generated spontaneous resistant mutants in Mycobacterium bovis BCG in the presence of 10× the minimum inhibitory concentration (MIC) of compound 1, a previously identified potent inhibitor of mycobacterial growth in culture. Whole genome sequencing of two resistant mutants revealed in one case a single nucleotide polymorphism in the gene aspS at 535GAC>535AAC (D179N), while in the second mutant a single nucleotide polymorphism was identified upstream of the aspS promoter region. We probed whole cell target engagement by overexpressing either M. bovis BCG aspS or Mycobacterium smegmatis aspS, which resulted in a ten-fold and greater than ten-fold increase, respectively, of the MIC against compound 1. To analyse the impact of inhibitor 1 on M. tuberculosis AspS (Mt-AspS) activity we over-expressed, purified and characterised the kinetics of this enzyme using a robust tRNA-independent assay adapted to a high-throughput screening format. Finally, to aid hit-to-lead optimization, the crystal structure of apo M. smegmatis AspS was determined to a resolution of 2.4 Å