Simulation of Building Physics for Beginning Design Students

Concepts such as heat transfer, stack effect, natural ventilation, and other problems related to building physics are taught to beginning design students through architectural examples, deterministic diagrams, and rules of thumb. Unlike the approach to teaching form, which involves exploration and iteration within a studio environment, often suspending disbelief to allow exploration, these exercises see architecture through the lenses of optimization, equilibrium, and objective outcomes. They are taught as steady state concepts. Instead of leaning on teaching techniques derived from an engineering standpoint, often technocratic and deterministic, it would serve beginning design students well to explore these concepts through experimentation and scaled built models that demonstrate the intended atmosphere effect. Can we ask the students to think compositionally about an architectural atmosphere in the way we ask them to think about form, proportion, sequence, and hierarchy? The goal then is to have students learn to think about atmosphere and energy from a design standpoint. As Kiel Moe notes, this point of view comes from an understanding of architecture and energy as one of magnificence and not of management. (Moe, 2017) With the help of students at the University of Wisconsin – Milwaukee, this research looks to explore reciprocal design techniques that allow students to iterate within an open system of their design. This ongoing investigation looks to grow the rigor and accessibility of scaled physical simulation of atmosphere and energy in buildings within a beginning design student studio

The Effect of Bone Quality on Treatment of Intertrochanteric Fractures with Helical Blade Versus Lag Screw Fixation in Cephalomedulary Nails

Introduction. The specific aim of this retrospective study was to determine whether bone quality has any effect on the complication rates or overall survivorship between helical blades and lag screws in cephalomedullary nails used for intertrochanteric hip fractures. Methods. Clinical charts and radiographic studies of patients between Jan 2012 through July 2019 were reviewed. Radiographic images (pre-, intra-, and post-operative) were reviewed to evaluate fracture fixation type, fracture reduction grade, and post-operative complications. DEXA scan results (T-score) and serum alkaline phosphatase (ALP) isoenzyme activity values were collected to evaluate patient bone quality. Results. 303 (helical: 197, screw: 106) cases were included. Complications were found in 31 helical blade cases (16%) and 23 lag screw cases (22%). No statistically significant difference was detected when comparing complication rates to patient bone quality between these two groups. These two groups had similar one-year implant survivorship with respect to T-score, the low ALP level group, and normal ALP level group. The helical blade had higher implant survivorship compared to lag screw in five-year survival rate with respect to osteoporotic group, high ALP level group, and normal ALP level group. (Osteoporotic: 77% vs 69%, High ALP: 73% vs 67%, normal ALP: 70% vs 64%). Conclusions. Similar complication rates were observed between helical blade and lag screw constructs in cephalomedullary femoral nails when accounting for patient bone quality. However, the bone quality had positive influence on the initial post-operative fracture reduction grade, and the five-year implant survivorship

Talking quiescence: a rigorous theory that supports parallel composition, action hiding and determinisation

The notion of quiescence - the absence of outputs - is vital in both behavioural modelling and testing theory. Although the need for quiescence was already recognised in the 90s, it has only been treated as a second-class citizen thus far. This paper moves quiescence into the foreground and introduces the notion of quiescent transition systems (QTSs): an extension of regular input-output transition systems (IOTSs) in which quiescence is represented explicitly, via quiescent transitions. Four carefully crafted rules on the use of quiescent transitions ensure that our QTSs naturally capture quiescent behaviour. We present the building blocks for a comprehensive theory on QTSs supporting parallel composition, action hiding and determinisation. In particular, we prove that these operations preserve all the aforementioned rules. Additionally, we provide a way to transform existing IOTSs into QTSs, allowing even IOTSs as input that already contain some quiescent transitions. As an important application, we show how our QTS framework simplifies the fundamental model-based testing theory formalised around ioco.Comment: In Proceedings MBT 2012, arXiv:1202.582

Myeloid Cell Sirtuin-1 Expression Does Not Alter Host Immune Responses to Gram-Negative Endotoxemia or Gram-Positive Bacterial Infection

The role of sirtuin-1 (SIRT1) in innate immunity, and in particular the influence of SIRT1 on antimicrobial defense against infection, has yet to be reported but is important to define since SIRT1 inhibitors are being investigated as therapeutic agents in the treatment of cancer, Huntington’s disease, and autoimmune diseases. Given the therapeutic potential of SIRT1 suppression, we sought to characterize the role of SIRT1 in host defense. Utilizing both pharmacologic methods and a genetic knockout, we demonstrate that SIRT1 expression has little influence on macrophage and neutrophil antimicrobial functions. Myeloid SIRT1 expression does not change mortality in gram-negative toxin-induced shock or gram-positive bacteremia, suggesting that therapeutic suppression of SIRT1 may be done safely without suppression of myeloid cell-specific immune responses to severe bacterial infections.American Asthma Foundation (Stephen Silberstein Senior Fellowship Awards

School-related experience and performance with inflammatory bowel disease: results from a cross-sectional survey in 675 children and their parents

Objective We describe school performance and experience in children with inflammatory bowel disease (IBD) across Germany and Austria. Predictors of compromised performance and satisfaction were evaluated to identify subgroups of increased risk. Design This cross-sectional analysis was based on a postal survey in children aged 10-15 with Crohn's disease, ulcerative colitis or unclassified IBD and their families. Multivariate regression analysis was used to assess influential factors on parental satisfaction with school, attending advanced secondary education (ASE), having good marks and having to repeat a class. Satisfaction was assessed based on the Child Healthcare-Satisfaction, Utilisation and Needs instrument (possible range 1.00-5.00). Results Of 1367 families contacted, 675 participated in the study (49.4%). Sixty-eight participants (10.2%) had repeated a year, 312 (46.2%) attended ASE. The median school satisfaction score was 2.67 (IQR 2.00-3.33). High socioeconomic status (SES) and region within Germany were predictive for ASE (OR high SES 8.2, 95% CI 4.7 to 14.2). SES, female sex and region of residence predicted good marks. Grade retention was associated with an active disease course (OR 2.7, 95% CI 1.4 to 5.3) and prolonged periods off school due to IBD (OR 3.9, 95% CI 1.8 to 8.6). Conclusions A severe disease course impacted on the risk of grade retention, but not on type of school attended and school marks. Low satisfaction of parents of chronically ill children with the school situation underlines the need for a more interdisciplinary approach in health services and health services research in young people

Simultaneous Multi-Wavelength Observations of Sgr A* during 2007 April 1-11

We report the detection of variable emission from Sgr A* in almost all wavelength bands (i.e. centimeter, millimeter, submillimeter, near-IR and X-rays) during a multi-wavelength observing campaign. Three new moderate flares are detected simultaneously in both near-IR and X-ray bands. The ratio of X-ray to near-IR flux in the flares is consistent with inverse Compton scattering of near-IR photons by submillimeter emitting relativistic particles which follow scaling relations obtained from size measurements of Sgr A*. We also find that the flare statistics in near-IR wavelengths is consistent with the probability of flare emission being inversely proportional to the flux. At millimeter wavelengths, the presence of flare emission at 43 GHz (7mm) using VLBA with milli-arcsecond spatial resolution indicates the first direct evidence that hourly time scale flares are localized within the inner 30$\times$70 Schwarzschild radii of Sgr A*. We also show several cross correlation plots between near-IR, millimeter and submillimeter light curves that collectively demonstrate the presence of time delays between the peaks of emission up to three hours. The evidence for time delays at millimeter and submillimeter wavelengths are consistent with the source of emission being optically thick initially followed by a transition to an optically thin regime. In particular, there is an intriguing correlation between the optically thin near-IR and X-ray flare and optically thick radio flare at 43 GHz that occurred on 2007 April 4. This would be the first evidence of a radio flare emission at 43 GHz delayed with respect to the near-IR and X-ray flare emission.Comment: replaced with revised version 57 pages, 28 figures, ApJ (in press

The Lick AGN Monitoring Project: Alternate Routes to a Broad-line Region Radius

It is now possible to estimate black hole masses across cosmic time, using broad emission lines in active galaxies. This technique informs our views of how galaxies and their central black holes coevolve. Unfortunately, there are many outstanding uncertainties associated with these "virial" mass estimates. One of these comes from using the accretion luminosity to infer a size for the broad-line region. Incorporating the new sample of low-luminosity active galaxies from our recent monitoring campaign at Lick Observatory, we recalibrate the radius-luminosity relation with tracers of the accretion luminosity other than the optical continuum. We find that the radius of the broad-line region scales as the square root of the X-ray and Hbeta luminosities, in agreement with recent optical studies. On the other hand, the scaling appears to be marginally steeper with narrow-line luminosities. This is consistent with a previously observed decrease in the ratio of narrow-line to X-ray luminosity with increasing total luminosity. The radius of the broad-line region correlates most tightly with Hbeta luminosity, while the X-ray and narrow-line relations both have comparable scatter of a factor of two. These correlations provide useful alternative virial BH masses in objects with no detectable optical/UV continuum emission, such as high-redshift galaxies with broad emission lines, radio-loud objects, or local active galaxies with galaxy-dominated continua.Comment: 8 pages, 1 figure, accepted for publication in Ap

Near infrared flares of Sagittarius A*: Importance of near infrared polarimetry

We report on the results of new simulations of near-infrared (NIR) observations of the Sagittarius A* (Sgr A*) counterpart associated with the super-massive black hole at the Galactic Center. The observations have been carried out using the NACO adaptive optics (AO) instrument at the European Southern Observatory's Very Large Telescope and CIAO NIR camera on the Subaru telescope (13 June 2004, 30 July 2005, 1 June 2006, 15 May 2007, 17 May 2007 and 28 May 2008). We used a model of synchrotron emission from relativistic electrons in the inner parts of an accretion disk. The relativistic simulations have been carried out using the Karas-Yaqoob (KY) ray-tracing code. We probe the existence of a correlation between the modulations of the observed flux density light curves and changes in polarimetric data. Furthermore, we confirm that the same correlation is also predicted by the hot spot model. Correlations between intensity and polarimetric parameters of the observed light curves as well as a comparison of predicted and observed light curve features through a pattern recognition algorithm result in the detection of a signature of orbiting matter under the influence of strong gravity. This pattern is detected statistically significant against randomly polarized red noise. Expected results from future observations of VLT interferometry like GRAVITY experiment are also discussed.Comment: 26 pages, 38 figures, accepted for publication by A&

Statistical Characterization of the Chandra Source Catalog

The first release of the Chandra Source Catalog (CSC) contains ~95,000 X-ray sources in a total area of ~0.75% of the entire sky, using data from ~3,900 separate ACIS observations of a multitude of different types of X-ray sources. In order to maximize the scientific benefit of such a large, heterogeneous data-set, careful characterization of the statistical properties of the catalog, i.e., completeness, sensitivity, false source rate, and accuracy of source properties, is required. Characterization efforts of other, large Chandra catalogs, such as the ChaMP Point Source Catalog (Kim et al. 2007) or the 2 Mega-second Deep Field Surveys (Alexander et al. 2003), while informative, cannot serve this purpose, since the CSC analysis procedures are significantly different and the range of allowable data is much less restrictive. We describe here the characterization process for the CSC. This process includes both a comparison of real CSC results with those of other, deeper Chandra catalogs of the same targets and extensive simulations of blank-sky and point source populations.Comment: To be published in the Astrophysical Journal Supplement Series (Fig. 52 replaced with a version which astro-ph can convert to PDF without issues.

M Protein and Hyaluronic Acid Capsule Are Essential for In Vivo Selection of covRS Mutations Characteristic of Invasive Serotype M1T1 Group A Streptococcus

The initiation of hyperinvasive disease in group A Streptococcus (GAS) serotype M1T1 occurs by mutation within the covRS two-component regulon (named covRS for control of virulence regulatory sensor kinase), which promotes resistance to neutrophil-mediated killing through the upregulation of bacteriophage-encoded Sda1 DNase. To determine whether other virulence factors contribute to this phase-switching phenomenon, we studied a panel of 10 isogenic GAS serotype M1T1 virulence gene knockout mutants. While loss of several individual virulence factors did not prevent GAS covRS switching in vivo, we found that M1 protein and hyaluronic acid capsule are indispensable for the switching phenotype, a phenomenon previously attributed uniquely to the Sda1 DNase. We demonstrate that like M1 protein and Sda1, capsule expression enhances survival of GAS serotype M1T1 within neutrophil extracellular traps. Furthermore, capsule shares with M1 protein a role in GAS resistance to human cathelicidin antimicrobial peptide LL-37. We conclude that a quorum of GAS serotype M1T1 virulence genes with cooperative roles in resistance to neutrophil extracellular killing is essential for the switch to a hyperinvasive phenotype in vivo