Cosmology, Particles, and the Unity of Science

During the last three decades, there has been a growing realization among physicists and cosmologists that the relation between particle physics and cosmology may constitute yet another successful example of the unity of science. However, there are important conceptual problems in the unification of the two disciplines, e.g. in connection with the cosmological constant and the conjecture of inflation. The present article will outline some of these problems, and argue that the victory for the unity of science in the context of cosmology and particle physics is still far from obvious.Comment: 23 pages, no figures. To appear in Studies in History and Philosophy of Modern Physic

Transplantation tolerance from a historical perspective

Although transplantation immunology as a distinctive field began with the development of experimental models that showed the feasibility of bone marrow transplantation, organ engraftment was accomplished first in humans, and was thought for many years to occur by drastically different mechanisms. Here, we present our view of the concepts of allograft acceptance and acquired tolerance from a historical perspective, and attempt to amalgamate them into simple and unifying rules that might guide improvements in clinical therapy

Weyl's principle, cosmic time and quantum fundamentalism

We examine the necessary physical underpinnings for setting up the cosmological standard model with a global cosmic time parameter. In particular, we discuss the role of Weyl's principle which asserts that cosmic matter moves according to certain regularity requirements. After a brief historical introduction to Weyl's principle we argue that although the principle is often not explicitly mentioned in modern standard texts on cosmology, it is implicitly assumed and is, in fact, necessary for a physically well-defined notion of cosmic time. We finally point out that Weyl's principle might be in conflict with the wide-spread idea that the universe at some very early stage can be described exclusively in terms of quantum theory.Comment: To appear in the section on "Physical and philosophical perspectives on probability and time" in S. Hartmann et al. (eds.) "Explanation, Prediction and Confirmation", Springer's The Philosophy of Science in a European Perspective book serie

The cytolytic T lymphocyte response to the murine cytomegalovirus

During the acute cytolytic T lymphocyte (CTL) response of mice to infection with the murine cytomegalovirus two independent populations of activated interleukin-receptive CTL precursors can be demonstrated. One population is specific for cell membrane-incorporated viral structural antigens, whereas the second population detects an antigen, whose appearance is correlated with the synthesis of viral immediate early proteins. Since this new type of antigen is only defined by lymphocyte recognition, it is referred to as the lymphocyte-detected immediate early antigen (LYDIEA). Expression of immediate early antigen precedes the production of viral progeny and, therefore, it is possible that LYDIEA-specific CTL could serve as indicator cells for the very first activities of the viral genome, even during nonproductive infection

Lysis mediated by T cells and restricted by H-2 antigen of target cells infected with vaccinia virus

VARIOUS virus infections lead to the formation of cytotoxic lymphocytes (CL), which are capable of killing virus-infected target cells1−4. Specific lysis of target cells infected with 51Cr-labelled vaccinia virus could be observed when investigating the cell-mediated cytotoxic reaction to vaccinia virus5; the CL could be characterised as a T cell. The sensitised lymphocytes from C3H mice could only kill syngeneic L929 cells infected with vaccinia virus, whereas lysis by sensitised lymphocytes derived from DBA/2 mice was restricted to the syngeneic infected mastocytoma P815X2 cells. In the lymphocytic choriomeningitis infection the target cell lysis was shown to be restricted by H-2 antigen6. We report here experiments with primary fibroblasts of the mouse strains C3H, DBA/2 and the (C3H DBA/2)F1 generation were designed to affirm that the effector phase of virus-specific lysis of target cells mediated by T cells is restricted by H-2 antigen even in the vaccinia virus infection. Further experiments with H-2 alloantisera were performed to indicate the close local relationship between H-2 antigens and viral surface antigens

Back to the future

Sin resume

Immunological memory≠protective immunity

So-called ‘immunological memory' is, in my view, a typical example where a field of enquiry, i.e. to understand long-term protection to survive reexposure to infection, has been overtaken by ‘l'art pour l'art' of ‘basic immunology'. The aim of this critical review is to point out some key differences between academic text book-defined immunological memory and protective immunity as viewed from a co-evolutionary point of view, both from the host and the infectious agents. A key conclusion is that ‘immunological memory' of course exists, but only in particular experimental laboratory models measuring ‘quicker and better' responses after an earlier immunization. These often do correlate with, but are not the key mechanisms of, protection. Protection depends on pre-existing neutralizing antibodies or pre-activated T cells at the time of infection—as documented by the importance of maternal antibodies around birth for survival of the offspring. Importantly, both high levels of antibodies and of activated T cells are antigen driven. This conclusion has serious implications for our thinking about vaccines and maintaining a level of protection in the population to deal with old and new infectious disease

The philosophy behind Quantum Gravity

This paper investigates some of the philosophical and conceptual issues raised by the search for a quantum theory of gravity. It is critically discussed wheter such a theory is necessary in the first place, and how much would be accomplished if it is eventually constructed. I argu that the motivations behind, and expectations to, a theory of quantum gravity are entangled with central themes in the philosophy of science, in particular unification, reductionism, and the interpretation of quantum mechanics. I further argue that there are - contrary to claims made on behalf of string theory - no good reasons to think that a quantum theory of gravity, if constructed, will provide a theory of everything, that is, a fundamental theory from which all physics ini principle can be derive