7 research outputs found
Balancing repair and tolerance of DNA damage caused by alkylating agents
- Author
- A Al-Attar
- A Bapat
- A Schambach
- A Shibata
- A Simeonov
- AE Kiltie
- AE Pegg
- AH Trainer
- AJ Deans
- AS Jaiswal
- AS Jaiswal
- B Kaina
- B Kaina
- B Kaina
- B Kaina
- B Rydberg
- B Sedgwick
- BA Kunz
- BJ Glassner
- BJ Glassner
- BP Engelward
- BP Engelward
- BP Engelward
- C Fleischmann
- CD Curtis
- CD Mol
- CE Ström
- D Ravi
- D Starcevic
- D Svilar
- D Wang
- D Wilson
- DC Cabelof
- DR Duckett
- Dragony Fu
- DW Kufe
- E Allay
- E Allay
- E Batts
- E Jelezcova
- F Calleja
- F Drablos
- F Mégnin-Chanet
- GC Stachelek
- GE Kisby
- H Bartsch
- H Farmer
- H Interthal
- H Kawate
- HE Bryant
- HY Hu
- I Casorelli
- I Kaasen
- I Rusyn
- J Dosch
- J Jelinek
- J Jiang
- J Klapacz
- J Klapacz
- J Lips
- J Paik
- J Weingart
- J-b Tang
- JA Allay
- JA Quinn
- JB Sweasy
- JC Huang
- Jennifer A. Calvo
- JH Robbins
- JK Horton
- JK Horton
- JM Bugni
- JM de Murcia
- JS Reese
- JS Reese
- JS Reese
- JT Hamilton
- JW Cardinal
- JY Choi
- K Ballschmiter
- K Becker
- K Becker
- K Becker
- K Chan
- K Ochs
- K Sakumi
- K Savitsky
- K Takenaka
- K-i Yoshioka
- KH Almeida
- KH Lauritzen
- L Gate
- L Haracska
- L Haracska
- L Haracska
- L Liu
- L Liu
- L Liu
- L Liu
- L Mirabello
- L Samson
- L Wang
- L Weissman
- L Weissman
- L Zecca
- LA Loeb
- LB Meira
- LB Meira
- Leona D. Samson
- LJ Hofseth
- LJ Rasmussen
- LJ Reha-Krantz
- LJ Stallons
- LL Dumenco
- LM Posnick
- M Briegert
- M Christmann
- M Christmann
- M Eich
- M Hewish
- M Jansen
- M Koi
- M Luo
- M Rinne
- M Rouleau
- MA Lovell
- ME Arana
- ME Hegi
- ME Moynahan
- MJ Hickman
- MJ Hickman
- ML Fishel
- ML Hegde
- ML Rinne
- MR Kelley
- MS Bobola
- MZ Zdzienicka
- N Burns
- N de Wind
- N Mojas
- N Shrivastav
- N Valeri
- NA Yamada
- NH Zaidi
- NJ Toft
- NK Kim
- OJ Sansom
- OJ Sansom
- OJ Sansom
- OK Mirzoeva
- OM Sieber
- P Branch
- P Cejka
- P Hanawalt
- P Monti
- P Monti
- P Moskwa
- P Rajesh
- P Taverna
- P Taverna
- PJ McKinnon
- R Maze
- R Maze
- R Prasad
- R Tsaryk
- RB Roth
- RC Fry
- RE Johnson
- RH Elder
- RJ Hansen
- RN Trivedi
- RW Sobol
- RW Sobol
- RW Sobol
- RW Sobol
- S Freitas
- S Hongeng
- S Kakolyris
- S Ragg
- S Wilson
- S Wirtz
- SE Andrew
- SF El-Khamisy
- SR Cerda
- SS Hecht
- SS Lange
- T Coquerelle
- T Iida
- T Iwakuma
- T Izumi
- T Moritz
- T Neff
- T Neff
- T Tsuzuki
- TF Gajewski
- TJ Begley
- TS Fenske
- V Di Maso
- V Poltoratsky
- W Lutz
- W Meikrantz
- W Xiao
- WP Roos
- WP Roos
- X Qin
- X Qin
- Y Jiang
- Y Jiang
- Y Kee
- Y Lee
- Y Nakatsuru
- ZQ Zhou
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2012
- Field of study
Alkylating agents constitute a major class of frontline chemotherapeutic drugs that inflict cytotoxic DNA damage as their main mode of action, in addition to collateral mutagenic damage. Numerous cellular pathways, including direct DNA damage reversal, base excision repair (BER) and mismatch repair (MMR), respond to alkylation damage to defend against alkylation-induced cell death or mutation. However, maintaining a proper balance of activity both within and between these pathways is crucial for a favourable response of an organism to alkylating agents. Furthermore, the response of an individual to alkylating agents can vary considerably from tissue to tissue and from person to person, pointing to genetic and epigenetic mechanisms that modulate alkylating agent toxicity
25th annual computational neuroscience meeting: CNS-2016
- Author
- Abbott L.F.
- Abeysuriya Romesh G.
- Aertsen Ad
- Agnes Everton J.
- Ahamed Tosif
- Ahmadabadi Majid Nili
- Ahn Sora
- Aihara Kazuyuki
- Aihara Kazuyuki
- Andreassen Ole A.
- Andreassen Ole A.
- Ardestani Mohammad Hovaidi
- Ardestani Mohammad Hovaidi
- Arroyo David
- Aton Sara J.
- Babichev Andrey
- Bachmann Claudia
- Badel Laurent
- Baek Hyeon-Man
- Baek JeongHun
- Baek Kwangyeol
- Bahuguna Jyotika
- Bak Ji Hyun
- Baker Chris I.
- Bakker Rembrandt
- Balaguer‑Ballester Emili
- Bard G.
- Barnett William H.
- Baroni Fabiano
- Basnayake Kanishka
- Baysal Velt
- Bennett Matthew R.
- Bernard Christophe
- Berry Hugues
- Beuth Frederick
- Bezgin` Gleb
- Bill Johannes
- Birgolias Justas
- Blackwell Justin
- Bohnenkamp Lisa
- Bojak Ingo
- Borisyuk Roman
- Bos Hannah
- Bradley Samual P.
- Breakspear Michael
- Breitwieser Oliver
- Briaire` Jeroen J.
- Briggman Kevin L
- Brinkman Braden A.
- Brown John
- Brown Ritchie E.
- Brunel Nicolas
- Buhry Laure
- Buice Michael
- Burkitt Anthony N.
- Burton Shawn D.
- Buttler Simone
- Bytschok Ilja
- Cantarelli Matteo
- Chakravarthy V.Srinivasa
- Chan Ho Ka
- Chapman Phillip D.
- Chatzikalymniou Alexandra Pierri
- Chavane Frédéric
- Chen Liang
- Chen Weiliang
- Cheung Chung Ching
- Chhabria Karishma
- Chintaluri Chaitanya
- Choe Yoonsuck
- Choi Hannah
- Choi Hansol
- Choi Ilhwan
- Choi Jee Hyun
- Choi Woochul
- Choi Yun Seo
- Choung Oh‑hyeon
- Chung SueYeon
- Clarke Eric F.
- Clements Katie
- Cloherty Shaun L.
- Clopath Claudia
- Cocchi Luca
- Cohen Yale E.
- Cook Mark
- Crook Sharon M.
- Cserpán Dorottya
- Culmone Viviana
- Dabaghian Yuri
- Dabaghian Yuri
- Dale Anders M.
- Daly Kevin C.
- Dasgupta Sakyasingha
- Davey Neil
- Davey Neil
- Davison Andrew
- de Weerd Peter
- Deco Gustavo
- Demkó László
- Demutz Harald
- Denk Cornelia
- Destexhe Alain
- Devor Anna
- DeVuti Justin
- Diamond Alan
- Diesmann Markus
- Dillen Kim
- Doya Kenji
- Dragoi Valentin
- Draguljić Daniel
- Drew Jordan
- Drysdale Peter M.
- Duarte Renato
- Dura‑Bernal Salvador
- Dura‑Bernal Salvador
- Dura‑Bernal Salvador
- Edwards Andy
- Einevoll Gaute T.
- Elices Irene
- Elnevoll Gaute T.
- Ernst Udo A.
- Esler Timothy B.
- Esposito Elric
- Faraji Mohammad Java
- Fedorov Leonid A.
- Fenk Lisa M.
- Ferguson Katie
- Ferrario Andrea
- Filipovi Marko
- Fink Christian G.
- Fink Gereon R.
- Fishman Yonatan I.
- Fornito Alex
- Forrow Csaba
- Fouquet Coralie
- Frangou Sophia
- Freestone Dean R.
- Frijns Johan H. M.
- Fulcher Ben D.
- Fung Felix
- Gajic N. Alex Cayco
- Gallimore Andrew R.
- Gallinaro Júlia
- Gerkin Richard C.
- Gerstner Wulfram
- Giaffar Hamza
- Giese Martin
- Giese Martin
- Giese Martin A.
- Gilson Matthieu
- Gips Bart
- Gleeson Padraig
- Gliske Stephen V.
- Glomb Katharina
- Goetze Felix
- Goldsworthy Mitchell R.
- Gollo Leonardo L.
- Goncharenko Julia
- Goodarzinic Abdorreza
- Graham Bruce P.
- Grayden David B.
- Grayden David B.
- Grewe Jan
- Hadrava Michal
- Hagen Espen
- Halnes Geir
- Halnes Geir
- Hamade Khaldoun
- Hamker Fred H.
- Han Hio-Been
- Han Seung Kee
- Hansen Mads
- Harper Zachary J.
- He Hu
- Helias Moritz
- Hermann Christoph S.
- Hilgetag` Claus‑Christian
- Hines Michael L.
- Hlinka Jaroslav
- Hof Patrick R.
- Holman Katherine A.
- Hong Sungho
- Hordacre Brenton
- Howard Jr. James H.
- Huang Guang-Bin
- Huang Haiping
- Huerta Ramon
- Huh Dongsung
- Hutt Axel
- Hwang Dong‑Uk
- Hwang Eunjin
- Hye Jr. Eoon
- Iannella Nicolangelo
- Iannella Nicolangelo
- Ibbotson Michael R.
- Ionta Silvlo
- Ishii Shin
- Issa Fadi A.
- Iyer Ramakrishnan
- Jacobs Heidi
- Jang Hyun Jae
- Jang Jaeson
- Jang Jaeson
- Jensen Ole
- Jeong Jaeseung
- Jeong Jaesung
- Jeong Yong
- Jirsa Viktor K.
- Jo Sumin
- Joo Pangyu
- Josić Kresimir
- Ju Huiwen
- Jun Eunji
- Jun Sang Beom
- Jung Nam
- Jung Woo-Sung
- Jung Younginha
- Kahng B.
- Kale Penelope J.
- Kalkman Randy K.
- Kameneva Tatiana
- Kameneva Tatiana
- Kang Jiyoung
- Karoly Philippa J.
- Kasumi Ohta
- Kavalali Enge T.
- Kawato Mitsuo
- Kazama Hokto
- Kedziora David J.
- Kekona Tyler
- Keller Daniel
- Kennedy Henry
- Kepple Daniel
- Kerr Cliff C.
- Kerr Robert R.
- Kilpatrick Zachary P.
- Kim Ammo J.
- Kim Bowon
- Kim Bowon
- Kim Chang Sub
- Kim DaeEun
- Kim Hojeong
- Kim Hoon-Hee
- Kim Hyoungkyu
- Kim Jae Kyoung
- Kim Jimin
- Kim Jinseop
- Kim Juhee
- Kim Minjung
- Kim Seongkyun
- Kim Su Hyun
- Kim Sung-Phil
- Kim Sung-Phil
- Kim Tae
- Kim Taegyo
- Kim Won Sup
- Kim Youngsoo
- Kiser Seth A.
- Klanner Felix
- Kleberg Florence I.
- Klingbeil Guido
- Knösche Thomas
- Koren Veronika
- Koren Veronika
- Kotaleski Jeanette Hellgren
- Koulakov Alex
- Kralik Jerald D.
- Kringelbach Morten L.
- Kruscha Alexandra
- Kuhlmann Levin
- Kukolja Juraj
- Kumar Arvind
- Kumar Arvind
- Kundu Prantik
- Kunze Tim
- Kuravi Pradeep
- Kwag Jeehyun
- Kwon Jaehyung
- Lai Pik‑Yin
- Lakatos Peter
- Latorre Roberto
- Leahy Will
- Lee Changju
- Lee Chungho
- Lee Dan D.
- Lee Do-won
- Lee Heonsoo
- Lee Hyang Jung
- Lee Hyang Woon
- Lee Hyeonsu
- Lee Jae Woo
- Lee Jaejin
- Lee Jeungmin
- Lee Joonwon
- Lee Jung H.
- Lee Sang Wan
- Lee Sang-Hun
- Lee Seungjun
- Lee Soohyun
- Lee Sue-Hyun
- Lee Tae Ho
- Lee Won Hee
- Lee Yong‑il
- Lefebvre Baptiste
- Lefebvre Jérémie
- Leleu Timothée
- Leng Luziwei
- Levi Rafael
- Levina Anna
- Levy Brandon A.
- Li Luozheng
- Liang Guangsheng
- Lidner Benjamin
- Liedtke Joscha
- Lim Daeseob
- Lim Sewoong
- Lin Xiahoan
- Linder Benjamin
- Lines Glenn T.
- Lizler Joseph T.
- Lochmann Timm
- Lowet Eric
- Luebke Jennifer
- Lytton William W.
- Lytton William W.
- Lyu Cheng
- Ma Hailin
- Maeng Seung Eu
- Malmon Gabby
- Mandall Alekhya
- Maouene M.
- Marcelli Angelo
- Marin Boris
- Markin Sergey
- Markram Henry
- Marre Olivier
- Marsalek Petr
- Marsat Gary
- Martel Roman
- Marucci Lucia
- Maturana Matias I.
- McCarley Robert W.
- McDonnell Mark D.
- McDonnell Mark D.
- McKenna James T.
- McLauchlan Campbell
- Meffin Hamish
- Meffin Hamish
- Mehta Hima
- Meier Karlheinz
- Meijas Jorge F.
- Mellen Nick
- Memmeshei Raol-Martin
- Menzies Rosemary J.
- Merriosn-Hort Robert
- Metzner Christoph
- Mi Yuanyuan
- Mi Yuanyuan
- Mihalas Stefan
- Miller Thomas
- Moezzi Bahar
- Moezzi Bahar
- Molkov Yaroslav I.
- Moon Jangsup
- Moon Seok-hun
- Morris Laurel S.
- Morrison Abigail
- Mosqueiro Thiago S
- Mu Shang
- Muler Eilif
- Muralidharan Vignesh
- Murray John D.
- Murray Micha M.
- Mäki‑Marttunen Tuomo
- Neymotin Samuel
- Neymotin Samuel A.
- Niry Mohammad
- Nishikawa Isao
- Nolte Max
- Nowotny Thomas
- Oba Shigeyuki
- Obermayer Klaus
- Obermayer Klaus
- Ognjanovski Nicolette
- Ouyang Guang
- Ozer Mahmut
- Paik Se-Bum
- Paik Se‑Bum
- Palmer S.E.
- Palva Matias J.
- Paninski Liam
- Pariz Aref
- Park Chang-hyun
- Park Choongseok
- Park Hae‑Jeong
- Park Ji Sung
- Park Memming
- Park Sang-Min
- Park Sol
- Parsi Shervin S.
- Parziale Antonio
- Pasupathy Anitha
- Perotti Luca
- Peterson Andre
- Petkoski Spase
- Petrovici Mihai A.
- Petterson Klas H.
- Philips Ryan T.
- Phillips Ryan S.
- Pillow Jonathan
- Pittà Maurizio De
- Plogmacher Lukas
- Podlaski William
- Pollonini Luca
- Ponce‑Alvarez Adrián
- Popp Pamela Osborn
- Preuschoff Kerstin
- Priesemann Viola
- Priesemann Viola
- Priyadharsini B. Praga
- Psarrou Maria
- Quang Le Anh
- Quintana Adrian
- Ramsey Julia
- Ranjan Rajnish
- Rankin James
- Rankin James
- Rasch Malte J.
- Rasuli Nader
- Ratnadurai‑Giridharan Shivakeshavan
- Reig Ramon
- Reimann Michael W.
- Rennle Chris J.
- Reyes Amy
- Richter René
- Ridding Michael C.
- Rieke Fred
- Rinberg Dima
- Rinzel John
- Ritter Petra
- Roach James P.
- Robb Daniel T.
- Roberts Mark J.
- Robinson Peter A.
- Robinson Peter A.
- Rodriguez Francisco B.
- Rotter Stefan
- Rubchinsky Leonid L.
- Rubinov Mikail
- Rumbell Timothy
- Rupp André
- Rybak Ilya A.
- Ryu Juhyoung
- Sadeh Sadra
- Saggio Maria L.
- Sander Leonard M.
- Sanger Terence D.
- Sanz-Leon Paula
- Sanz‑Leon Paula
- Saska Daniel
- Schaworonkow Natalie
- Schemmel Johannes
- Scheutz Matthias
- Schiff Steven J.
- Schilstra Maria
- Schilstra Marla
- Schmidt Maximilian
- Schmidt Robert
- Schottdorf Manual
- Schutter Erik De
- Schwikard Achim
- Seeholzer Alexander
- Seidenstein Alexandra
- Sejnowski Terrence J.
- Sekulić Vladisla
- Senatore Rosa
- Senk Johanna
- Seo Sat Byul
- Seung H. Sebastian
- Sharpee Tatyana O.
- Shea Steven
- Shea-Brown Eric
- Shea‑Brown Eric
- Shen Kelly
- Shiau LieJune
- Shimazaki Hideaki
- Shin Hee‑sup
- Shin In-Seob
- Shivkumar Sabyasach
- Shlizerman Eli
- Shomali Safura Rashid
- Siep Silvan F.
- Silberberg Gilad
- Silver Angus
- Silver R. Angus
- Skiker K.
- Skilling Quinton M.
- Skinner Frances K.
- Skinner Frances K.
- Smit Daniel
- Smith Brian
- Smith Jeffrey
- Soh Jaehyun
- Soman Karthik
- Somogyvári Zoltán
- Sompolinsky Haim
- Song Min
- Song Min-Ho
- Song Youngjo
- Soundry Daniel
- Sourina Olga
- Spampinato Giulia Lia Beatrice
- Spiegler Andreas
- Spinney Richard E.
- Sprecher Simon
- Stacey William C.
- Stacey William C.
- Stephens Greg
- Stern Merav
- Steuber Volker
- Steyn-Ross D. Alistair
- Steyn-Ross Moira L.
- Stimberg Marcel
- Strube‑Bloss Martin F.
- Stöckel David
- Su Jianzhong
- Sun Haoqi
- Sweeney Yann
- Tabas Alejandro
- Tahayori Bahman
- Takashima Akira
- Tam Nicoladie D.
- Tamagnini Francesco
- Tang Rongxiang
- Tang Yi-Yuan
- Tang Yi-Yuan
- Teka Wondimu
- Tetzlaff Tom
- Tezuka Taro
- Toporikova Natalia
- Torres Joaquin J.
- Toyoizumi Taro
- Tran Patricia H. P.
- Trembleau Alain
- Triesch Jochen
- Trisch Jochen
- Tsaneva‑Atanasova Krasimira
- Tsuchimoto Yoshiko
- Tuomo Maki-Martun
- Tveito Aslak
- Valizadeh Alireza
- Valizadeh Alireza
- van Albada Sacha J
- van Albada Sacha J.
- van der Eerden Jan
- Varona Pablo
- Varona Pablo
- Veale Richard
- Viriyopase Atthaphon
- Vitay Julien
- Vogels Rufin
- Vogels Tim
- Vogels Tim P.
- Vogt Simon M.
- Voon Valerie
- Voronenko Sergej O.
- Vuust Peter
- Vörös János
- Wallentin Mikkel
- Wang Dahui
- Wang Jisung
- Wang Sheng-Ju
- Wang Yuzhe
- Warburton Julia M.
- Weaver Christina M.
- Wegener Detlef
- Weidel Philipp
- Welzig Charles M.
- Werdt Stephen Van
- Wibral Michael
- Wickens Jeffery R.
- Widmer Yves
- Witek Maria A. G.
- Witting Jens
- Wolf Fred
- Wong Michael
- Wu Si
- Wu Sl
- Wójcik Daniel K.
- Xu Zhiheng
- Yamada Yasnori
- Yamamura Yorkio
- Yang Huei-Fang
- Yang Xu
- Yeon Ji Won
- Yger Pierre
- Yilmaz Ergin
- Yoo Minsu
- Yoon Sangsup
- Yoshimoto Junichiro
- Young-Ah Rho
- Yu Suin
- Zaho Yuan
- Zamora Criseida
- Zaptocky Martin
- Zhang Mingsha
- Zhang Wenhao
- Zhao Chang
- Zhao Xiaochen
- Zhao Xuelong
- Zhou Changsong
- Zochowski Michal
- Zochowski Michal R.
- Zouridakis George
- Zurowski Bartosz
- Publication venue
- BMC
- Publication date
- 01/01/2016
- Field of study
The same neuron may play different functional roles in the neural circuits to which it belongs. For example, neurons in the Tritonia pedal ganglia may participate in variable phases of the swim motor rhythms [1]. While such neuronal functional variability is likely to play a major role the delivery of the functionality of neural systems, it is difficult to study it in most nervous systems. We work on the pyloric rhythm network of the crustacean stomatogastric ganglion (STG) [2]. Typically network models of the STG treat neurons of the same functional type as a single model neuron (e.g. PD neurons), assuming the same conductance parameters for these neurons and implying their synchronous firing [3, 4]. However, simultaneous recording of PD neurons shows differences between the timings of spikes of these neurons. This may indicate functional variability of these neurons. Here we modelled separately the two PD neurons of the STG in a multi-neuron model of the pyloric network. Our neuron models comply with known correlations between conductance parameters of ionic currents. Our results reproduce the experimental finding of increasing spike time distance between spikes originating from the two model PD neurons during their synchronised burst phase. The PD neuron with the larger calcium conductance generates its spikes before the other PD neuron. Larger potassium conductance values in the follower neuron imply longer delays between spikes, see Fig. 17.Neuromodulators change the conductance parameters of neurons and maintain the ratios of these parameters [5]. Our results show that such changes may shift the individual contribution of two PD neurons to the PD-phase of the pyloric rhythm altering their functionality within this rhythm. Our work paves the way towards an accessible experimental and computational framework for the analysis of the mechanisms and impact of functional variability of neurons within the neural circuits to which they belong
An essential role for Orc6 in DNA replication through maintenance of pre-replicative complexes
- Author
- Publication venue
- Publication date
- 01/01/2006
- Field of study
The heterohexameric origin recognition complex (ORC) acts as a scaffold for the G(1) phase assembly of pre-replicative complexes (pre-RC). Only the Orc1-5 subunits appear to be required for origin binding in budding yeast, yet Orc6 is an essential protein for cell proliferation. Imaging of Orc6-YFP in live cells revealed a punctate pattern consistent with the organization of replication origins into subnuclear foci. Orc6 was not detected at the site of division between mother and daughter cells, in contrast to observations for metazoans, and is not required for mitosis or cytokinesis. An essential role for Orc6 in DNA replication was identified by depleting it at specific cell cycle stages. Interestingly, Orc6 was required for entry into S phase after pre-RC formation, in contrast to previous models suggesting ORC is dispensable at this point in the cell cycle. When Orc6 was depleted in late G(1), Mcm2 and Mcm10 were displaced from chromatin, cells failed to progress through S phase, and DNA combing analysis following bromodeoxyuridine incorporation revealed that the efficiency of replication origin firing was severely compromised
Balancing repair and tolerance of DNA damage caused by alkylating agents
- Author
- A Al-Attar
- A Bapat
- A Schambach
- A Shibata
- A Simeonov
- AE Kiltie
- AE Pegg
- AH Trainer
- AJ Deans
- AS Jaiswal
- AS Jaiswal
- B Kaina
- B Kaina
- B Kaina
- B Kaina
- B Rydberg
- B Sedgwick
- BA Kunz
- BJ Glassner
- BJ Glassner
- BP Engelward
- BP Engelward
- BP Engelward
- C Fleischmann
- CD Curtis
- CD Mol
- CE Ström
- D Ravi
- D Starcevic
- D Svilar
- D Wang
- D Wilson
- DC Cabelof
- DR Duckett
- Dragony Fu
- DW Kufe
- E Allay
- E Allay
- E Batts
- E Jelezcova
- F Calleja
- F Drablos
- F Mégnin-Chanet
- GC Stachelek
- GE Kisby
- H Bartsch
- H Farmer
- H Interthal
- H Kawate
- HE Bryant
- HY Hu
- I Casorelli
- I Kaasen
- I Rusyn
- J Dosch
- J Jelinek
- J Jiang
- J Klapacz
- J Klapacz
- J Lips
- J Paik
- J Weingart
- J-b Tang
- JA Allay
- JA Quinn
- JB Sweasy
- JC Huang
- Jennifer A. Calvo
- JH Robbins
- JK Horton
- JK Horton
- JM Bugni
- JM de Murcia
- JS Reese
- JS Reese
- JS Reese
- JT Hamilton
- JW Cardinal
- JY Choi
- K Ballschmiter
- K Becker
- K Becker
- K Becker
- K Chan
- K Ochs
- K Sakumi
- K Savitsky
- K Takenaka
- K-i Yoshioka
- KH Almeida
- KH Lauritzen
- L Gate
- L Haracska
- L Haracska
- L Haracska
- L Liu
- L Liu
- L Liu
- L Liu
- L Mirabello
- L Samson
- L Wang
- L Weissman
- L Weissman
- L Zecca
- LA Loeb
- LB Meira
- LB Meira
- Leona D. Samson
- LJ Hofseth
- LJ Rasmussen
- LJ Reha-Krantz
- LJ Stallons
- LL Dumenco
- LM Posnick
- M Briegert
- M Christmann
- M Christmann
- M Eich
- M Hewish
- M Jansen
- M Koi
- M Luo
- M Rinne
- M Rouleau
- MA Lovell
- ME Arana
- ME Hegi
- ME Moynahan
- MJ Hickman
- MJ Hickman
- ML Fishel
- ML Hegde
- ML Rinne
- MR Kelley
- MS Bobola
- MZ Zdzienicka
- N Burns
- N de Wind
- N Mojas
- N Shrivastav
- N Valeri
- NA Yamada
- NH Zaidi
- NJ Toft
- NK Kim
- OJ Sansom
- OJ Sansom
- OJ Sansom
- OK Mirzoeva
- OM Sieber
- P Branch
- P Cejka
- P Hanawalt
- P Monti
- P Monti
- P Moskwa
- P Rajesh
- P Taverna
- P Taverna
- PJ McKinnon
- R Maze
- R Maze
- R Prasad
- R Tsaryk
- RB Roth
- RC Fry
- RE Johnson
- RH Elder
- RJ Hansen
- RN Trivedi
- RW Sobol
- RW Sobol
- RW Sobol
- RW Sobol
- S Freitas
- S Hongeng
- S Kakolyris
- S Ragg
- S Wilson
- S Wirtz
- SE Andrew
- SF El-Khamisy
- SR Cerda
- SS Hecht
- SS Lange
- T Coquerelle
- T Iida
- T Iwakuma
- T Izumi
- T Moritz
- T Neff
- T Neff
- T Tsuzuki
- TF Gajewski
- TJ Begley
- TS Fenske
- V Di Maso
- V Poltoratsky
- W Lutz
- W Meikrantz
- W Xiao
- WP Roos
- WP Roos
- X Qin
- X Qin
- Y Jiang
- Y Jiang
- Y Kee
- Y Lee
- Y Nakatsuru
- ZQ Zhou
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Defining the role of common variation in the genomic and biological architecture of adult human height
- Author
- Abecasis Goncalo R
- Absher Devin
- Afzal Uzma
- Albrecht Eva
- Alizadeh B
- Altshuler D
- Altshuler D
- Ambite JL
- Amin Najaf
- Amouyel Philippe
- Anand S
- Anand S
- Anderson G
- Anderson Denise
- Ardissino D
- Ardissino D
- Ardissino D
- Arnold A
- Arscott Gillian M
- Arveiler Dominique
- Asselbergs Folkert W
- Asselta R
- Assimes Themistocles L
- Avery C
- Avila PC
- Bakker Stephan J. L
- Ball SG
- Balmforth AJ
- Bandinelli Stefania
- Baron Jeffrey
- Barrett Amy
- Barroso Inês
- Basford M
- Beckmann Jacques S
- Beekman Marian
- Beilby John
- Bellis Claire
- Bennett Amanda J
- Berg R
- Berger K
- Berglund G
- Bergman Richard N
- Bergmann Sven
- Bernardi F
- BERNARDINELLI LUISA
- Berndt Sonja I
- Berne Christian
- Berzuini C
- Bielinski S
- Biffar Reiner
- Blangero John
- Blüher Matthias
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle E
- Boerwinkle Eric
- Boezen HM
- Bolton Jennifer L
- Boomsma Dorret I
- Borecki Ingrid B
- Bornstein Stefan R
- Boston J
- Bottinger Erwin P
- Bouchard Claude
- Bovet Pascal
- Boyd Heather A
- Brambilla Paolo
- Braund PS
- Brown Gentry K
- Brown Morris J
- Bruinenberg M
- Bruinenberg Marcel
- Buchkovich Martin L
- Buckley Brendan M
- Burke W
- Burnett MS
- Burtt N
- Bush WS
- Buyske S
- Buyske Steven
- Buzkova P
- Böttcher Yvonne
- Cambien F
- Campbell Harry
- Carlson C
- Carlson C
- Carrell D
- Carty C
- Casari G
- Caspersen Ida H
- Cauchi Stéphane
- Caulfield Mark J
- Celli P
- Chakravarti Aravinda
- Chambers John C
- Chanock Stephen J
- Chasman Daniel I
- Chen L
- Chen Z
- Cheng I
- Chines Peter S
- Chisholm RL
- Choudary V
- Chu Audrey Y
- Churchill LR
- Chute C
- Clarke Robert
- Claudi Boehm Simone
- Clayton E
- Cochran B
- Cole S
- Collins Francis S
- Collins Rory
- Cooper Matthew
- Cooper Richard S
- Cornfield D
- Corrocher R
- Crane P
- Crawford D
- Crawford D
- Crawford Dana C
- Croteau Chonka Damien C
- Cupples L. Adrienne
- Daly MJ
- Danesh John
- Darbar D
- Daw E. Warwick
- Day Felix R
- de Andrade M
- De Bakker Paul I. W
- de Boer RA
- De Faire Ulf
- De Groot Lisette C. P. G. M.
- De Jong Pim A
- Dedoussis George
- Deelen Joris
- Deelman E
- Delgado Graciela
- Deloukas P
- Deloukas Panos
- Demirkan Ayse
- Den Ruijter Hester M
- Denny JC
- Denny Josh C
- Devaney J
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- Dimitriou Maria
- Ding K
- Do R
- Doney Alex S. F
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- Duga S
- Duggan D
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- Durda P
- Dörr Marcus
- Ehret Georg B
- Eklund Niina
- Elosua R
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- Engert JC
- Engert JC
- Epstein SE
- Erbel Raimund
- Erdmann J
- Erdmann J
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- Erdmann J
- Erdmann Jeanette
- Eriksson Johan G
- Esko Tonu
- Estrada Karol
- Eury Elodie
- Fall Tove
- Farrall Martin
- Feenstra Bjarke
- Fehrmann Rudolf
- Feitosa Mary F
- Ferrannini Ele
- Ferrario M
- Ferreira Teresa
- Ferrières Jean
- Ferrucci Luigi
- Fetiveau R
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- Fischer M
- Fischer Krista
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- Ford Ian
- Fornage M
- Forouhi Nita G
- Forrester Terrence
- Fost N
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- Fox Caroline S
- Franceschini N
- Franke L
- Franke Lude
- Franks Paul W
- Fraser Ross M
- Frayling Timothy M
- Friedlander Y
- Froguel Philippe
- Fullerton SM
- Gabriel SB
- Galli M
- Gansevoort Ron T
- Garcia Melissa E
- Gejman Pablo V
- Geller Frank
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- Giedraitis Vilmantas
- Gieger Christian
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- Goddard Michael E
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- Goodloe R
- Gottesman Omri
- Graff M
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- Greenland P
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- Grosshennig A
- Grosshennig A
- Groves Christopher J
- Gräßler Jürgen
- Grönberg Henrik
- Gudnason Vilmundur
- Guiducci C
- Gustafsson Stefan
- Gyllensten Ulf
- Haas David W
- Haessler J
- Haessler Jeffrey
- Haiman C
- Haiman Christopher A
- Haines J
- Haines JL
- Hakonarson HH
- Hall AS
- Hall Alistair S
- Hall Per
- Haller Toomas
- Hallmans Goran
- Hamsten Anders
- Hannemann Anke
- Harris Tamara B
- Hart G
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- Hassinen Maija
- Hattersley Andrew T
- Havulinna AS
- Hayes M
- Hayes M. Geoffrey
- Hayward Caroline
- Heard Costa Nancy L
- Heath Andrew C
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- Heiss G
- Helmer Quinta
- Hemani Gibran
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- Henderson B
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- Henriksen J
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- Hillege Hans L
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- Hindorff Lucia A
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- Hirschhorn JN
- Hirschhorn Joel N
- Hlatky Mark A
- Hoffmann Per
- Hoffmann Wolfgang
- Hofman Albert
- Holmen Oddgeir
- Houwing Duistermaat Jeanine J
- Hovingh G. Kees
- Huge A
- Hui Jennie
- Humowiecki J
- Humphries Steve E
- Hunt Steven C
- Hunter David J
- Hutchinson F
- Hveem Kristian
- Hypponen Elina
- Hólm H
- Illig Thomas
- Ingelsson Erik
- Isaacs Aaron
- Jackson R
- Jackson Anne U
- Jacobs Kevin B
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- Jarvik G
- Jeff J
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- Johansen Berit
- Johansson Åsa
- Jolley Jennifer
- Jousilahti Pekka
- Jukema J. Wouter
- Jula Antti M
- Juliusdottir Thorhildur
- Junttila Juhani
- Justice Anne E
- Kanoni Stavroula
- Kao L
- Kaplan Robert C
- Kaprio Jaakko
- Karjalainen Juha
- Kastelein John J. P
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- Kayser Manfred
- Kee Frank
- Keinanen Kiukaanniemi Sirkka M
- Kent KM
- Kho A
- Kho Abel N
- Kibbe WA
- Kiemeney Lambertus A
- Kinnunen Leena
- Kitchner T
- Kivimaki Mika
- Kleber Marcus E
- Klopp Norman
- Knouff CW
- Kocarnik J
- Kocher Thomas
- Koenig B
- Kolonel L
- Kooner Jaspal S
- Kooperberg C
- Kooperberg Charles
- Korn JM
- Koskinen Seppo
- Kovacs Peter
- Kraja Aldi T
- Kratzer Wolfgang
- Kristiansson Kati
- Kuh Diana
- Kuller L.
- Kullo I
- Kumari Meena
- Kutalik Zoltán
- Kuusisto Johanna
- König I
- König IR
- Laakso Markku
- LaCroix A
- Lakka Timo A
- Langenberg Claudia
- Larson EB
- Law M
- Le Marchand L
- Le Marchand Loic
- Leach Irene Mateo
- Lehtimäki Terho
- Lemke AA
- Lettre Guillaume
- Li M
- Lichtner Peter
- Lieb W
- Lieb W
- Lim U
- Lim Unhee
- Lin D
- Lin Y
- Lind Lars
- Lindgren Cecilia M
- Lindsay JM
- Lindström Jaana
- Linneman J
- Linsel Nitschke P
- Linsel Nitschke P
- Liu Yongmei
- Lo Ken Sin
- Lobbens Stéphane
- Locke Adam E
- Loos Ruth J. F
- Lorentzon Mattias
- Lotay Vaneet
- Lowe WL
- Lu Yingchang
- Luan Jian'An
- Lucas G
- Lucas G
- Ludman E
- Lui Julian C
- Lupoli Sara
- Lyssenko Valeriya
- MacCluer J
- MacRae CA
- Madden Pamela A. F
- Magnusson Patrik K. E
- Mahajan Anubha
- Maillard Marc
- Malin BA
- Malinowski J
- Mangino Massimo
- Mannucci PM
- Mannucci PM
- Mannucci PM
- Manolio T
- Manunta Paolo
- Marette André
- Marrugat J
- Martin Nicholas G
- Martinelli N
- Marziliano N
- Masys DR
- Matise T
- Matise Tara C
- Matthai W
- Mcardle Wendy L
- McCarroll SA
- Mccarthy Mark I
- McCarty CA
- McDavid A
- Mckenzie Colin A
- McKeown PP
- McKeown PP
- Mcknight Barbara
- Mclachlan Stela
- Mclaren Paul J
- Medina Gomez Carolina
- Meigs JB
- Meitinger Thomas
- Melander O
- Melander O
- Melander O
- Melbye Mads
- Menni Cristina
- Merger Sigrun
- Merlini PA
- Metspalu Andres
- Mihailov Evelin
- Milani Lili
- Miller A
- Mirel D
- Mitchell SL
- Moayyeri Alireza
- Moebus Susanne
- Mohlke Karen L
- Moll Frans L
- Monda Keri L
- Monroe K
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- Mooser V
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- Murdock D
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- Männistö Satu
- März Winfried
- Müller Nurasyid Martina
- Müller Gabriele
- Nalls Michael A
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- Nato A
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- Navis G
- Nelis Mari
- Nemesh J
- Newton K
- Njølstad Inger
- Nolte Ilja M
- North KE
- North Kari E
- Nyholt Dale R
- Nöthen Markus M
- O'Connell Jeffrey R
- O'Donnell CJ
- O'Donnell CJ
- O'Donnell CJ
- Oetjens M
- Ohlsson Claes
- Oldehinkel Albertine J
- Olivieri O
- Ong Ken K
- Oostra Ben A
- Oozageer Laticia
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- Ouwehand Willem H
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- Palbicki J
- Palmer Cameron D
- Palmer Colin N. A
- Pankow J
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- Parkin M
- Pasko Dorota
- Pasterkamp Gerard
- Pathak J
- Patsy B
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- Patterson CC
- Pechlivanis Sonali
- Pedersen Nancy L
- Peissig P
- Peltonen L
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- Peltonen L
- Pendergrass S
- Perola Markus
- Pers Tune H
- Person S
- Peters U
- Peters Annette
- Peters Ulrike
- Peyvandi F
- Piazza A
- Pichard AD
- Pilz Stefan
- Porcu Eleonora
- Postma DS
- Powell Joseph E
- Power Chris
- Pramstaller Peter P
- Prentice R
- Preuss M
- Preuss M
- Price Alkes L
- Price Jackie F
- Prokopenko Inga
- Pulley J
- Purcell S
- Purcell S
- Purcell S
- Pérusse Louis
- Qasim A
- Qi Lu
- Quertermous Thomas
- Quibrera M
- Rader DJ
- Rader DJ
- Raitakari Olli T
- Ramirez AH
- Ramos R
- Randall Joshua C
- Rankinen Tuomo
- Rao D. C.
- Rasmussen L
- Rauramaa Rainer
- Rayner Nigel W
- Reeser J
- Reilly MP
- Reilly MP
- Reinmaa Eva
- Renstrom Frida
- Restrepo N
- Ribichini F
- Rice Treva K
- Ridker Paul M
- Ried Janina S
- Ripke Stephan
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- Ritchie M
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- Ritchie Marylyn
- Rivadeneira Fernando
- Robertson Neil R
- Roden DM
- Rose Lynda M
- Rosmalen JG
- Rosse S
- Rossi M
- Rotter Jerome I
- Roussel Ronan
- Rudan Igor
- Saaristo Timo E
- Sala J
- Saleheen Danish
- Salomaa V
- Salomaa V
- Salomaa V
- Salomaa Veikko
- Samani NJ
- Samani NJ
- Samani NJ
- Samani NJ
- Samani Nilesh J
- Sanna Serena
- Saramies Jouko
- Sarzynski Mark A
- Satler L
- Savova G
- Scharnagl Hubert
- Scheffold T
- Scherag André
- Schildcrout JS
- Schlessinger David
- Scholtens Salome
- Scholz M
- Schreiber S
- Schreiber S
- Schumacher F
- Schumacher Fredrick R
- Schunkert H
- Schunkert H
- Schunkert H
- Schunkert I
- Schunkert Heribert
- Schwartz SM
- Schwartz SM
- Schwartz SM
- Schwartz SM
- Schwarz Peter E. H
- Scott Robert A
- Sebert Sylvain
- Sehmi Joban
- Seufferlein Thomas
- Sever Peter
- Shi Jianxin
- Shohet R
- Shuldiner Alan R
- Shungin Dmitry
- Silventoinen Karri
- Sinisalo Juha
- Siscovick D
- Siscovick DS
- Siscovick DS
- Slaets JP
- Slagboom P. Eline
- Smit Johannes H
- Smith ME
- Smith Albert Vernon
- Smolonska Joanna
- Snieder H
- Snieder Harold
- Spangler L
- Spector Tim D
- Speliotes Elizabeth K
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- Spreafico M
- Stancáková Alena
- Stanton Alice V
- Stark K
- Stark K
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- Stefansson K
- Stefansson Kari
- Steinthorsdottir Valgerdur
- Stirrups Kathleen
- Stolk RP
- Stolk Ronald P
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- Strawbridge Rona J
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- Subirana I
- Subirana I
- Sundström Johan
- Sung Yun Ju
- Surti A
- Swertz Morris A
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- Tanaka Toshiko
- Tardif Jean Claude
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- Tayo Bamidele O
- Teumer Alexander
- Thompson JR
- Thompson WK
- Thorleifsson G
- Thorleifsson Gudmar
- Thornton Wells T
- Thorsteinsdottir U
- Thorsteinsdottir Unnur
- Tiirikainen M
- Tremblay Angelo
- Tremoli Elena
- Trinidad SB
- Trompet Stella
- Tubaro M
- Tuomilehto Jaakko
- Tyrer Jonathan P
- Tönjes Anke
- Uitterlinden André G
- Umans J
- Uusitupa Matti
- van der Harst P
- Van Der Harst Pim
- van der Klauw MM
- Van Der Laan Sander W
- Van Der Velde Nathalie
- Van Dijk Suzanne
- Van Duijn Cornelia M
- Van Heemst Diana
- Van Oort Floor V. A
- Van Schoor Natasja M
- Van Setten Jessica
- Van Vliet Ostaptchouk Jana V
- Vedantam Sailaja
- Vermeulen Sita H
- Verweij Niek
- Vinkhuyzen Anna A. E
- Virtamo Jarmo
- Visscher Peter M.
- Vohl Marie Claude
- Voight B
- Voight BF
- Voight BF
- Vonk Judith M
- Völzke Henry
- Waite Lindsay L
- Waksman R
- Waldenberger Melanie
- Walker MC
- Walker Mark
- Wang H
- Wang Zhaoming
- Wareham Nicholas J
- Waterworth DM
- Watkins Hugh
- Waudby C
- Weedon Michael N
- Wennauer Roman
- Westra Harm Jan
- Wichmann HE
- Wichmann HE
- Wichmann H. Erich
- Wijmenga C
- Wilensky R
- Wilke RA
- Wilkens L
- Wilkens Lynne R
- Willenborg Christina
- Willer Cristen J
- Williams G
- Williams R
- Wilsgaard Tom
- Wilson S
- Wilson James F
- Winkler Thomas W
- Wojczynski Mary K
- Wolf WA
- Wolffenbuttel BH
- Wong Andrew
- Wood Andrew R
- Workalemahu Tsegaselassie
- Wright BJ
- Wright Alan F
- Wu C
- Wu J
- Xie C
- Xu H
- Yang Jian
- Yee J
- Yee J
- Yengo Loïc
- Young A
- Zanen Pieter
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zheng W
- Ziegler A
- Ziegler A
- Zonzin P
- Ärnlöv Johan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ∼2,000, ∼3,700 and ∼9,500 SNPs explained ∼21%, ∼24% and ∼29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/β-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants
Analysis of Outcomes in Ischemic vs Nonischemic Cardiomyopathy in Patients With Atrial Fibrillation A Report From the GARFIELD-AF Registry
- Author
- A'Court Christine
- Abdel-Qader Muwafeg
- Abe Masahiko
- Abe Masatake
- Abe Mitsunori
- Abe Sumihisa
- Abe Yukihiko
- Abhayaratna Walter
- Accogli Michele
- Adachi Susumu
- Adachi Toru
- Adak Dhriti
- Adam Matthew
- Adriaansen Henk
- Aegerter Emanuel
- Ageta Masato
- Aggarwala Anil
- Agnelli Giancarlo
- AgnieszkaMetzgier-Gumiela AgnieszkaMetzgier-Gumiela
- Ahlmark Hakan
- Ahmad Kamran
- Ahmad Shahid
- Ahmed Fayzal
- Ahn Jung Joo
- Akers Lori
- Akiyama Masahiro
- Al Mahmeed Wael
- Al-Khalili Faris
- Alberts Mark
- Alborough Elizabeth
- Aldegather Jehad
- Aleksandrova Elena
- Alexandre Almeida Carlos
- Ali Amar
- Ali Gholam
- Alia Pilar Montero
- Allasia Bartolomeo
- Alonso Carmela
- Alonso Concepcion
- Altun Armagan
- Alunni Massimo
- Alvarez Garcia Pere
- Alvarez Douglas
- Alvarez Miguel
- Alzogaray Maria Fernanda
- Amarenco Pierre
- Amaro Marisol
- Ambicka Monika
- Ambrosino Pasquale
- Ambrosio Giuseppe
- Amin Joseph
- Amrhein Diana
- Amstutz Daniela
- An Hae Jung
- Andere Natalia
- Andersson Agneta
- Andersson Lisbeth
- Ando Hiroshi
- Ando Shinichi
- Andrzejewski Dariusz
- Angaran Paul
- Ansoult Nadege
- Antonova Petra
- Antonsen Hege
- Aoki Kenji
- Aoyama Takuma
- Appleby Nigel
- Appleby Nigel
- Aracil Villar Joaquin
- Arai Hidekazu
- Araminowicz Joanna
- Aras Funda
- Arcocha Torres Maria Fe
- Argena Antonio
- Arima Shinichi
- Armangau Pauline
- Arstall Margaret
- Asafu-Adjaye Nana
- Asano Hiroshi
- Asano Taku
- Ashraf M. Javed
- Assagay Maharajh S.
- Assouline Serge
- Astridge Penny
- Atar Dan
- Atar Dan
- Ausen Karin
- Austria Aileen
- Aves Theresa
- Avinc Gamze
- Avinc Gamze
- Avinc Gamze
- Axthelm Christoph
- Ayar Ozge
- Aydinlar Ali
- Ayres Bronte
- Azakami Shiro
- Aziz Michael
- Azuma Junya
- Baba Takao
- Babjakova Zuzana
- Babyesiza Adyeri
- Bae Sang Cheol
- Baek Ae Lee
- Baglioni Gregorio
- Bai Chunlin
- Baksh Farisha
- Balaraju Swathi
- Ball Kelly
- Bamungpong Panthipa
- Banfi Elena
- Barbarash Olga
- Barbeira Pablo Saleta
- Barkowski Timothy
- Barnes Dylan
- Barnes Dylan
- Baron Esquivias Gonzalo
- Barraquer Feu Edelmira
- Barreau Angeline
- Barreda Maria
- Barretto Antonio Carlos Pereira
- Barrow Susan
- Barry Lisa
- Bartkowiak Radoslaw
- Bartlett Melialoha
- Bartnik Jerzy
- Basiak Marcin
- Basily Wagdy
- Bassand Jean-Pierre
- Bassand Jean-Pierre
- Bassand Jean-Pierre
- Bassand Jean-Pierre
- Bastani Lisa
- Baszak Jacek
- Batalov Roman
- Batlle Javier
- Batta Claire
- Batta Claire
- Baumbach Sylvia
- Baumgartner Philipp
- Baweja Paramdeep
- Bayat Junaid
- Beattie Andre
- Becerra Munoz Victor
- Begum Haseena
- Bekieszczuk Ewa
- Belenkova Yulia
- Belenky Dmitry
- Bengtsberg Daniel
- Bennett James
- Berardi Mario
- Berg-Johansen Berg-Johansen
- Berge Eivind
- Berge Trude
- Berit Anne
- Berman Sofia Graciela
- Bernat Lukasz
- Berneau Jean-Baptiste
- Best Peggy
- Beton Osman
- Betsuyaku Tetsuo
- Beveridge Rosemary
- Bezrodna Larysa
- Bhargava Kartikeya
- Biagioli Viviana
- Bianchi Alfredo
- Biedrzycka Malgorzata
- Biedrzycka Malgorzata
- Biedrzycki Lukasz
- Biernacka Anita
- Bigcanoe Julie
- Bignell Nanci
- Bilas Roman
- Bilecen Sinan
- Billger Annelie
- Bindig Hans-Walter
- Binnekamp Maurits
- Bird Nigel
- Bireciklioglu Mustafa Fehmi
- Birhan MEHMET BİRHAN
- Bitakova Fatima
- Black Andrew
- Blenkhorn Adam
- Blinkova Marina
- Blombery Peter
- Blumberg Edwin
- Bockova Lucie
- Boda Zoltan
- Boehme Stefanie
- Boen Rigmor
- Boersma Misannia
- Boggian Giulio
- Bonet Jorge
- Bongaerts Maarten
- Bongiorni Maria Grazia
- Bonin Kerstin
- Bonkowski Grzegorz
- Bonner Michelle
- Bonnetain Anne
- Boon Jannie
- Boonyapisit Warangkana
- Boos Laura
- Booysen Maria
- Borjesson Ulf
- Borras Ana Domenech
- Boshoff Cecilia
- Bosman Femmy
- Bosschaert Mike
- Bossolasco Pierdomenico
- Botha Margo
- Bottarelli Maria Luisa
- Bouzamayor Maria Belen Lage
- Bowen-Simpkins Emma
- Bowers Suzanne
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- Goldhaber Samuel Z.
- Goldhaber Samuel Z.
- Goldhaber Samuel Z.
- Goldhaber Samuel Z.
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- Kaat Josine Te
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- Kakkar Ajay K.
- Kakkar Ajay K.
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- Koeniger Praxis Dr
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- Mantovani Lorenzo G.
- Mantovani Lorenzo G.
- Mantovani Lorenzo G.
- Manzanal Rey Aranza
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- Mntla Pindile
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- Modi Mayank H.
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- Mostovoy Yuriy
- Motero Carrasco Juan
- Motylev Igor
- Moure Gonzalez Maria
- Moustafa Moustafa
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- Turpie Alexander G. G.
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- Tybura Sebastian
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- Verheugt Freek W. A.
- Vertes Andras
- Vicic Judy
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- Wada Masamichi
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- Wakeling John
- Wakeman Anne
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- Wang Y.
- Wang Yong
- Warke A.
- Wastling Rebecca
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- Yamasawa Masanori
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- Yamazoe Masahiro
- Yang Jingshan
- Yang Lingli
- Yang Zhiming
- Yawila Suree
- Yildirim Rifat
- Yilmaz Faruk
- Yilmaz Ozcan
- Yokota Naoto
- Yokoyama Yasuhiro
- Yoon Eunji
- Yoon Jung Han
- Yoshida Keiki
- Yoshida Tetsuro
- Yoshida Tomohiro
- Yoshida Tomoki
- Yoshimura Akira
- Yoshizawa Naoto
- Yu HyunJu
- Yu Ting
- Yusuf Huma
- Yuyang Tan
- Zaatout Eman
- Zaitsu Ryuji
- Zak Jan
- Zakutynska-Kowalczyk Karolina
- Zaluska Roman
- Zaman Kashif
- Zateyshchikov Dmitry
- Zauzig Heinz-Dieter
- Zdrowotnej Zespol Opieki
- Zecca Cinzia
- Zemlianskaia Oksana
- Zhai Hong
- Zhan Qiong
- Zhang Guoshan
- Zhang Huaiqin
- Zhang Ran
- Zhang Yi
- Zhao Yusheng
- Zhuravleva Evgeniya
- Zidek Milan
- Zidkova Eva
- Zika Jiri
- Zillo Mariana
- Zimmett Leon
- Zimny Hans-Hermann
- Zincke Stephanie
- Zinka Elzbieta
- Zinka Elzbieta
- Zotova Irina
- Zubeeva Galina
- Zuber Mathieu
- Zutz Stefan
- Zwenkau Schwarz
- Zyczynska Malgorzata
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 01/06/2019
- Field of study
IMPORTANCE Congestive heart failure (CHF) is commonly associated with nonvalvular atrial fibrillation (AF), and their combination may affect treatment strategies and outcomes
Genetic studies of body mass index yield new insights for obesity biology
- Author
- Aasarød K
- Abecasis G
- Abecasis GR
- Abecasis GR
- Abecasis Gonçalo R.
- Absher D
- Absher D
- Absher Devin
- Adair LS
- Adair LS
- Adair LS
- Adair Linda S.
- Adam M
- Adeyemo A
- Ahlqvist E
- Ahmadi KR
- Ahola A
- Ainali C
- Akylbekova E
- Ala-Korpela M
- Alavere H
- Albrecht E
- Albrecht E
- Albrecht Eva
- Alexander M
- Alhenc-Gelas F
- Alizadeh BZ
- Alizadeh BZ
- Altshuler D
- Altshuler D
- Altshuler D
- Altshuler D
- Ambite JL
- Amin N
- Amin N
- Amin Najaf
- Amouyel P
- Amouyel Philippe
- An P
- Anand S
- Anand S
- Anderson CA
- Anderson G
- Anderson Denise
- Andrews JS
- Andrews JS
- Antonella M
- Antti J
- Ardissino D
- Ardissino D
- Ardissino D
- Arking DE
- Arking DE
- Arnold A
- Arnold AM
- Arora P
- Arscott Gillian M.
- Artigas MS
- Arveiler D
- Arveiler D
- Arveiler Dominique
- Asiki G
- Aspelund T
- Aspelund T
- Aspelund T
- Aspelund T
- Aspelund T
- Asselbergs Folkert W.
- Asselta R
- Assimes TL
- Assimes TL
- Assimes Themistocles L.
- Atalay M
- Atkinson EJ
- Atkinson EJ
- Attwood Antony P.
- Aulchenko Y
- Aulchenko YS
- Avery C
- Bain SC
- Bakker SJ
- Bakker SJ
- Bakker SJ
- Bakker Stephan J.L.
- Balkau B
- Ball SG
- Balmforth AJ
- Balmforth AJ
- Bandinelli S
- Bandinelli S
- Bandinelli S
- Bandinelli S
- Bandinelli S
- Bandinelli Stefania
- Barbalic M
- Barrett A
- Barrett Amy
- Barroso I
- Barroso I
- Barroso I
- Barroso I
- Barroso I
- Barroso Inɥs
- Bas Isabelita N.
- Basart H
- Basart HV
- Bataille V
- Baumert J
- Beckmann JS
- Beckmann JS
- Beckmann JS
- Beckmann JS
- Beckmann JS
- Beckmann Jacques S.
- Beekman Marian
- Been LF
- Beilby JP
- Beilby JP
- Beilby John
- Bell JT
- Bellis Claire
- Bennett F
- Bennett Amanda J.
- Berenson GS
- Berger K
- Berglund G
- Bergman RN
- Bergman RN
- Bergman Richard N.
- Bergmann S
- Bergmann S
- Bergmann S
- Bergmann S
- Bernardi F
- Bernardinelli L
- Berndt Sonja I.
- Berne Christian
- Berzuini C
- Bielak LF
- Bierut LJ
- Biffar R
- Biffar R
- Bis JC
- Blackburn H
- Blagieva Roza
- Blangero John
- Blankenberg SS
- Blüher Matthias
- Boban M
- Boban M
- Bochud M
- Bochud M
- Bochud M
- Bochud M
- Bochud M
- Bochud Murielle
- Boehm BO
- Boehm BO
- Boehm BO
- Boehm Bernhard O.
- Boehnke M
- Boehnke M
- Boehnke M
- Boehnke M
- Boehnke Michael
- Boerwinkle E
- Boerwinkle E
- Boerwinkle E
- Boerwinkle E
- Boerwinkle E
- Boerwinkle E
- Boerwinkle E
- Boerwinkle E
- Boerwinkle Eric
- Boezen HM
- Bolton JA
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- Zhang W
- Zhang Qunyuan
- Zhang Weihua
- Zhao JH
- Zhao JH
- Zhao JH
- Zhao JH
- Zhao W
- Zhao Jing Hua
- Zhao Wei
- Zheng W
- Zheng Wei
- Zhu H
- Zhu X
- Zhuang WV
- Zhuang WV
- Ziegler A
- Ziegler A
- Ziegler A
- Zillikens MC
- Zillikens M. Carola
- Zimmermann ME
- Zitting P
- Zondervan KT
- Zondervan KT
- Zondervan Krina T.
- Zonzin P
- Zukowska-Szczechowska E
- Zygmunt M
- Ärnlöv J
- Ärnlöv Johan
- Österholm AM
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Note: A full list of authors and affiliations appears at the end of the article.
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P 20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.</p