O Uso da Cor no Cinema de Animação de Tim Burton

Se várias gerações passadas foram influenciadas pelas criações de Ray Harryhausen (1920-2013), as novas gerações que se interessam por animação sofrem a influência direta de Tim Burton (1958-). Não apenas pelo fascínio da técnica, como também pelos traços, cores e formas contidas na filmografia do cineasta. Uma das principais estratégias narrativas utilizadas por Burton para construir seus universos particulares e excêntricos concentra-se na concepção visual, destacando-se o recurso da cor. Interessa aqui compreender de que forma Burton concebe a utilização da cor em seus dois projetos pessoais realizados na técnica de stop-motion, a saber: O Estranho Mundo de Jack (The Nightmare Before Christmas – EUA – 1993), de Henry Selick, e A Noiva Cadáver (Corpse Bride – EUA/Reino Unido – 2005), direção de Burton e Mike Johnso

A GIARDIA LAMBLIA

A Giárdia é o mais comum e o primeiro protozoário a ser encontrado em seres humanos, ele é comumente encontrado em países emergentes onde sua população tem uma economia desestruturada com saneamento e hábitos de higiene precária. Devido sua transmissão ser por ingestão de alimentos contaminados, água tratada de maneira incorreta, os manipuladores de alimentos acaba sendo os facilitadores dessa contaminação. Essas pessoas devem passar por uma capacitação de modo que entendam a problemática em questão

MORTALIDADE MATERNA: FATORES AGRAVANTES

A morte materna ainda é um problema para a saúde pública, no Brasil e no Mundo. Segundo dados do Ministério da Saúde, há um aumento nas altas taxas de morbi-mortalidade materna. Destaca-se que em 2015, 99% das mortes maternas registradas ocorreram nos países em desenvolvimento. O Brasil, sendo um país em desenvolvimento ainda apresenta elevada Razão de Mortalidade Materna RMM, principalmente, quando consideramos o aspecto étnico-racial. Algumas pesquisas evidenciam que os piores indicadores de mortalidade, no tocante à mortalidade materna, encontram-se entre mulheres pretas e indígenas, ressaltando também a dificuldade de acesso aos serviços de saúde e tratamento para estes grupos em especial. Dessa forma, é importante a realização de pesquisas que utilizem em suas análises categorias de cor ou raça. Existem dois conceitos básicos para o entendimento de mortalidade materna: o de morte materna; e o de morte por causa materna. Existe diferença em ambos que resultam no fato de que algumas mortes por causas maternas não poderem ser consideradas mortes maternas. O estudo tem como objetivo analisar os fatores agravantes de Mortalidade Materna no Município de Quixadá – Ceará

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Morphological aspects of the ovaries of turtle Kinosternon scorpioides raised in captivity

The swear turtle "jurará" (Kinosternon scorpioides) is a mud turtle of the Amazon region exposed to disordering capture in the rural areas of Maranhão, Brazil. Despite its popularity in these areas, little meaningful information regarding the reproductive morphology is currently available, fact that impedes the adoption of policies for preservation of the species. To obtain more information, we studied the ovarian morphology adult jurará females kept in captivity by morphological and morphometric analysis in the dry and rainy season. The results revealed that all females were sexually mature and were in a vitellogenic period. The ovaries are two irregular structures composed by follicles in different stages of development (primary, secondary and tertiary) scattered in a stroma of loose connective highly vascularized tissue. The ovary weight was 6.25±4.23g and 2.27±1.42g, for the right and left one respectively. The gonadosomatic indexes were 2.06% for the dry season and 1.79% for the rainy season. The average of the follicles was 29.83 units per ovary. Microscopically, the mature ovaries revealed a basal layer composed by four cellular layers: the inner and outer theca, stratum granulosum with perivitelline membrane and zona radiata with vitelline membrane. No significant differences were observed in the ovaries either in the dry or wet period

To be or not to B27 positive: implications for the phenotypes of axial spondyloarthritis outcomes. Data from a large multiracial cohort from the Brazilian Registry of Spondyloarthritis

Abstract Background There is a remarkable variability in the frequency of HLA-B27 positivity in patients with spondyloarthritis (SpA), which may be associated with different clinical presentations worldwide. However, there is a lack of data considering ethnicity and sex on the evaluation of the main clinical and prognostic outcomes in mixed-race populations. The aim of this study was to evaluate the frequency of HLA-B27 and its correlation with disease parameters in a large population of patients from the Brazilian Registry of Spondyloarthritis (RBE). Methods The RBE is a multicenter, observational, prospective cohort that enrolled patients with SpA from 46 centers representing all five geographic regions of Brazil. The inclusion criteria were as follow: (1) diagnosis of axSpA by an expert rheumatologist; (2) age ≥18 years; (3) classification according to ASAS axial. The following data were collected via a standardized protocol: demographic data, disease parameters and treatment historical. Results A total of 1096 patients were included, with 73.4% HLA-B27 positivity and a mean age of 44.4 (±13.2) years. Positive HLA-B27 was significantly associated with male sex, earlier age at disease onset and diagnosis, uveitis, and family history of SpA. Conversely, negative HLA-B27 was associated with psoriasis, higher peripheral involvement and disease activity, worse quality of life and mobility. Conclusions Our data showed that HLA-B27 positivity was associated with a classic axSpA pattern quite similar to that of Caucasian axSpA patients around the world. Furthermore, its absence was associated with peripheral manifestations and worse outcomes, suggesting a relevant phenotypic difference in a highly miscegenated population

Characterisation of microbial attack on archaeological bone

As part of an EU funded project to investigate the factors influencing bone preservation in the archaeological record, more than 250 bones from 41 archaeological sites in five countries spanning four climatic regions were studied for diagenetic alteration. Sites were selected to cover a range of environmental conditions and archaeological contexts. Microscopic and physical (mercury intrusion porosimetry) analyses of these bones revealed that the majority (68%) had suffered microbial attack. Furthermore, significant differences were found between animal and human bone in both the state of preservation and the type of microbial attack present. These differences in preservation might result from differences in early taphonomy of the bones. © 2003 Elsevier Science Ltd. All rights reserved