EVALUATION OF LOW LEVEL LASER THERAPY IN THE MANAGEMENT OF CHEMOTHERAPY-INDUCED ORAL MUCOSITIS IN PEDIATRIC AND YOUNG CANCER PATIENTS: A RANDOMIZED CLINICAL TRIAL

Backgrounds: Oral mucositis is a frequent adverse side effect of cancer chemotherapy which is associated with intense oral pain. However, it impairs the quality of life of these patients. Low Level Laser Therapy (LLLT) has been increasingly used in recent years, mostly to accelerate wound healing and to reduce pain. In cancer patients, LLLT has been shown to reduce the incidence and severity of oral mucositis. Objectives: The aim of this study is to evaluate the effect of low level laser therapy in the management of chemotherapy induced oral mucositis. Patients and Methods: The study design used was a randomized clinical trial. A total of 67 cancer patients were eligible to participate in the study. Thus, they were divided randomly into two groups: group 1 irradiated with prophylactic or active laser therapy (AlGalnAs laser diode device with a wave length of 940±15nm, 0.3mW, and a probe emitting dose of 4.2 J/cm²) and group 2 received inactive or sham laser therapy (power output equal to zero). However, for the ethical purpose, once the patients developed ulcerative mucositis, they are irradiated with active laser therapy. The oral assessment was performed daily starting from the first day of the chemotherapy by applying WHO grading system. After 24 hours, the assessment of associated oral pain was carried out every two days with visual analog scale before laser application. Consequently, the associations between variables were analyzed statistically using SPSS version 20. Results: All the patients were presented with some grade of oral mucositis. In the active or prophylactic laser group, the severity of oral mucositis was lower than the inactive or therapeutic laser group. Moreover, the incidence of grade 3 and grade 4 were less observed in the active or prophylactic laser groups than the sham or therapeutic laser groups. In addition, the mean time of healing was significantly lower in the prophylactic laser group than in the therapeutic laser groups (2.05 + 1.89 versus 4.5 + 2.4 days, p> 0,004). Prophylactic laser application was associated with significant reduction of oral pain in comparison with inactive or therapeutic laser therapy (1.18 + 1.09 versus 2.12 + 1.60, p> 0.01). Conclusions: Prophylactic laser therapy is effective in reducing the incidence of sever oral mucositis and in alleviating associated oral pain

EVALUATION OF LOW LEVEL LASER THERAPY IN THE MANAGEMENT OF CHEMOTHERAPY-INDUCED ORAL MUCOSITIS IN PEDIATRIC AND YOUNG CANCER PATIENTS: A RANDOMIZED CLINICAL TRIAL

Backgrounds: Oral mucositis is a frequent adverse side effect of cancer chemotherapy which is associated with intense oral pain. However, it impairs the quality of life of these patients. Low Level Laser Therapy (LLLT) has been increasingly used in recent years, mostly to accelerate wound healing and to reduce pain. In cancer patients, LLLT has been shown to reduce the incidence and severity of oral mucositis. Objectives: The aim of this study is to evaluate the effect of low level laser therapy in the management of chemotherapy induced oral mucositis. Patients and Methods: The study design used was a randomized clinical trial. A total of 67 cancer patients were eligible to participate in the study. Thus, they were divided randomly into two groups: group 1 irradiated with prophylactic or active laser therapy (AlGalnAs laser diode device with a wave length of 940±15nm, 0.3mW, and a probe emitting dose of 4.2 J/cm²) and group 2 received inactive or sham laser therapy (power output equal to zero). However, for the ethical purpose, once the patients developed ulcerative mucositis, they are irradiated with active laser therapy. The oral assessment was performed daily starting from the first day of the chemotherapy by applying WHO grading system. After 24 hours, the assessment of associated oral pain was carried out every two days with visual analog scale before laser application. Consequently, the associations between variables were analyzed statistically using SPSS version 20. Results: All the patients were presented with some grade of oral mucositis. In the active or prophylactic laser group, the severity of oral mucositis was lower than the inactive or therapeutic laser group. Moreover, the incidence of grade 3 and grade 4 were less observed in the active or prophylactic laser groups than the sham or therapeutic laser groups. In addition, the mean time of healing was significantly lower in the prophylactic laser group than in the therapeutic laser groups (2.05 + 1.89 versus 4.5 + 2.4 days, p> 0,004). Prophylactic laser application was associated with significant reduction of oral pain in comparison with inactive or therapeutic laser therapy (1.18 + 1.09 versus 2.12 + 1.60, p> 0.01). Conclusions: Prophylactic laser therapy is effective in reducing the incidence of sever oral mucositis and in alleviating associated oral pain

Measurement of charged particle spectra in minimum-bias events from proton-proton collisions at root s =13 TeV

Pseudorapidity, transverse momentum, and multiplicity distributions are measured in the pseudorapidity range vertical bar eta vertical bar 0.5 GeV in proton-proton collisions at a center-of-mass energy of root s = 13 TeV. Measurements are presented in three different event categories. The most inclusive of the categories corresponds to an inelastic pp data set, while the other two categories are exclusive subsets of the inelastic sample that are either enhanced or depleted in single diffractive dissociation events. The measurements are compared to predictions from Monte Carlo event generators used to describe high-energy hadronic interactions in collider and cosmic-ray physics.Peer reviewe

The Phase-2 Upgrade of the CMS Tracker

This is the final version, approved by the LHCC, of the CMS TDR devoted to the upgrade of the CMS tracker in view of the HL-LHC running

The Phase-2 Upgrade of the CMS Tracker

This is the final version, approved by the LHCC, of the CMS TDR devoted to the upgrade of the CMS tracker in view of the HL-LHC running

Search for supersymmetric partners of electrons and muons in proton–proton collisions at s=13TeV

A search for direct production of the supersymmetric (SUSY) partners of electrons or muons is presented in final states with two opposite-charge, same-flavour leptons (electrons and muons), no jets, and large missing transverse momentum. The data sample corresponds to an integrated luminosity of 35.9 fb−1 of proton–proton collisions at s=13TeV, collected with the CMS detector at the LHC in 2016. The search uses the MT2 variable, which generalises the transverse mass for systems with two invisible objects and provides a discrimination against standard model backgrounds containing W bosons. The observed yields are consistent with the expectations from the standard model. The search is interpreted in the context of simplified SUSY models and probes slepton masses up to approximately 290, 400, and 450 GeV, assuming right-handed only, left-handed only, and both right- and left-handed sleptons (mass degenerate selectrons and smuons), and a massless lightest supersymmetric particle. Limits are also set on selectrons and smuons separately. These limits show an improvement on the existing limits of approximately 150 GeV.0info:eu-repo/semantics/publishe

Search for resonant pair production of Higgs bosons decaying to bottom quark-antiquark pairs in proton-proton collisions at 13 TeV

A search for a narrow-width resonance decaying into two Higgs bosons, each decaying into a bottom quark-antiquark pair, is presented. The search is performed using proton-proton collision data corresponding to an integrated luminosity of 35.9 fb$^{-1}$ at $\sqrt{s}=$ 13 TeV recorded by the CMS detector at the LHC. No evidence for such a signal is observed. Upper limits are set on the product of the production cross section for the resonance and the branching fraction for the selected decay mode in the resonance mass range from 260 to 1200 GeV