Theories for the Fermi Scale

I give a short review of our present understanding of new theories of the electroweak scale, with emphasis on recent progress. Plenary talk at the EPS 2007 Conference at Manchester.Comment: 14 pages, EPS 2007 Conferenc

Modelling the spectral energy distribution of galaxies. V. The dust and PAH emission SEDs of disk galaxies

We present a self-consistent model of the spectral energy distributions (SEDs) of spiral galaxies from the ultraviolet (UV) to the mid-infrared (MIR)/far-infrared (FIR)/submillimeter (submm) based on a full radiative transfer calculation of the propagation of starlight in galaxy disks. This model predicts not only the total integrated energy absorbed in the UV/optical and re-emitted in the infrared/submm, but also the colours of the dust emission based on an explicit calculation of the strength and colour of the UV/optical radiation fields heating the dust, and incorporating a full calculation of the stochastic heating of small dust grains and PAH molecules. The geometry of the translucent components of the model is empirically constrained using the results from the radiation transfer analysis of Xilouris et al. on spirals in the middle range of the Hubble sequence, while the geometry of the optically thick components is constrained from physical considerations with a posteriori checks of the model predictions with observational data. These geometrical constraints enable the dust emission to be predicted in terms of a minimum set of free parameters: the central face-on dust opacity in the B-band tau^f_B, a clumpiness factor F for the star-forming regions, the star-formation rate SFR, the normalised luminosity of the old stellar population old and the bulge-to-disk ratio B/D. We show that these parameters are almost orthogonal in their predicted effect on the colours of the dust/PAH emission. The results of the calculations are made available in the form of a large library of simulated dust emission SEDs spanning the whole parameter space of our model, together with the corresponding library of dust attenuation calculated using the same model. (see full abstract in the paper)Comment: 39 pages; accepted for publication in Astronomy & Astrophysics; For a higher resolution version of Fig.1 and Fig.20 see http://www.star.uclan.ac.uk/~ccp/index.shtm

Underwriting Apophenia and Cryptids: Are Cycles Statistical Figments of our Imagination?

This paper re-examines the evidence in favour of the existence of underwriting cycles in property and casualty insurance and their economical significance. Using a meta-analysis of published papers in the area of insurance economics, we show that the evidence supporting the existence of underwriting cycles is misleading. There is, in fact, little evidence in favour of insurance cycles with a linear autoregressive character. This means that any cyclicality in firm profitability in the property and casualty insurance industry is not predictable in a classical econometric framework. It follows that pricing in the property and casualty insurance industry is not incompatible with that of a competitive market

Chronology of the sedimentary processes during the postglacial sea level rise in two estuaries of the Algarve coast, Southern Portugal

Four profiles of estuarine sediments obtained from boreholes drilled in the Algarve, Southern Portugal were studied in order to reconstruct the process of sediment accumulation driven by the postglacial sea level rise. In addition to the sedimentological analysis, the Foraminifera Index of Marine Influence (FIMI) permitted assessment of the nature and organization of sedimentary facies in the BelicheeGuadiana and Gilão-Almargem estuaries. The Beliche- Guadiana CM5 and Almargem G2 profiles accumulated in a sheltered environment, with the former presenting an almost continuous record of the sea level rise since ca 13 000 cal yr BP. The G1 and G3 profiles from the Gilão-Almargem area represent a more discontinuous record of the last 8000 years, which accumulated in the more dynamic environment of an outer estuary. The integration of all radiocarbon ages of dated levels, led to an estimate of sediment accumulation rates. Assuming a constant position of the sediment surface with respect to the tidal range and a negligible compaction of sediment, the sea level rose at the rate of 7 mm yr ^-1 in the period from 13 000 to 7500 cal yr BP. This process slowed down to ca 0.9 mm yr 1 from 7500 cal yr BP until the present. The marked historical change in the rate of sediment accumulation in these estuaries also occurred with the accumulation of organic matter and is, therefore, important data for global biogeochemical models of carbon. The main obstacle to obtain higher temporal resolution of the sedimentary processes was the intense anaerobic respiration of organic matter via sulphate reduction, which did not allow any accumulation of peat and, furthermore, led to erasure of the palaeontological record by acid formed from the subsequent oxidation of sulphides.FORMOSE- Sources and Retention of Organic Matter in the Estuarine Zones, PRAXIS XXI program of Portuguese Science and Technology Foundation and project MEGASIG, INTERREG IIIa program of the European Union

Heavy quarkonium: progress, puzzles, and opportunities

A golden age for heavy quarkonium physics dawned a decade ago, initiated by the confluence of exciting advances in quantum chromodynamics (QCD) and an explosion of related experimental activity. The early years of this period were chronicled in the Quarkonium Working Group (QWG) CERN Yellow Report (YR) in 2004, which presented a comprehensive review of the status of the field at that time and provided specific recommendations for further progress. However, the broad spectrum of subsequent breakthroughs, surprises, and continuing puzzles could only be partially anticipated. Since the release of the YR, the BESII program concluded only to give birth to BESIII; the $B$-factories and CLEO-c flourished; quarkonium production and polarization measurements at HERA and the Tevatron matured; and heavy-ion collisions at RHIC have opened a window on the deconfinement regime. All these experiments leave legacies of quality, precision, and unsolved mysteries for quarkonium physics, and therefore beg for continuing investigations. The plethora of newly-found quarkonium-like states unleashed a flood of theoretical investigations into new forms of matter such as quark-gluon hybrids, mesonic molecules, and tetraquarks. Measurements of the spectroscopy, decays, production, and in-medium behavior of c\bar{c}, b\bar{b}, and b\bar{c} bound states have been shown to validate some theoretical approaches to QCD and highlight lack of quantitative success for others. The intriguing details of quarkonium suppression in heavy-ion collisions that have emerged from RHIC have elevated the importance of separating hot- and cold-nuclear-matter effects in quark-gluon plasma studies. This review systematically addresses all these matters and concludes by prioritizing directions for ongoing and future efforts.Comment: 182 pages, 112 figures. Editors: N. Brambilla, S. Eidelman, B. K. Heltsley, R. Vogt. Section Coordinators: G. T. Bodwin, E. Eichten, A. D. Frawley, A. B. Meyer, R. E. Mitchell, V. Papadimitriou, P. Petreczky, A. A. Petrov, P. Robbe, A. Vair

Gravity-mediated (or composite) Dark Matter confronts astrophysical data

We consider the astrophysical bounds on a new form of dark matter, the so called Gravity-mediated Dark Matter. In this scenario, dark matter communicates with us through a mediator sector composed of gravitational resonances, namely a new scalar (radion) and a massive spin-two resonance (massive graviton). We consider specific models motivated by natural electroweak symmetry breaking or weak-scale dark matter in the context of models in warped extra-dimensions and their composite duals. The main Dark Matter annihilation mechanism is due to the interactions of KK gravitons to gauge bosons that propagate in bulk. We impose the bounds on monochromatic or continuum photons from Fermi-LAT and HESS. We also explore scenarios in which the Fermi gamma-ray line could be a manifestation of Gravity-mediated Dark Matter

Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation : Data From ROCKET AF

M. Kaste on työryhmän ROCKET AF Steering Comm jäsen.Background-Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all-cause mortality may guide interventions. Methods and Results-In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) study, patients with nonvalvular atrial fibrillation were randomized to rivaroxaban or dose-adjusted warfarin. Cox proportional hazards regression with backward elimination identified factors at randomization that were independently associated with all-cause mortality in the 14 171 participants in the intention-to-treat population. The median age was 73 years, and the mean CHADS(2) score was 3.5. Over 1.9 years of median follow-up, 1214 (8.6%) patients died. Kaplan-Meier mortality rates were 4.2% at 1 year and 8.9% at 2 years. The majority of classified deaths (1081) were cardiovascular (72%), whereas only 6% were nonhemorrhagic stroke or systemic embolism. No significant difference in all-cause mortality was observed between the rivaroxaban and warfarin arms (P=0.15). Heart failure (hazard ratio 1.51, 95% CI 1.33-1.70, P= 75 years (hazard ratio 1.69, 95% CI 1.51-1.90, P Conclusions-In a large population of patients anticoagulated for nonvalvular atrial fibrillation, approximate to 7 in 10 deaths were cardiovascular, whereasPeer reviewe

Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).

Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)

Convergent genetic and expression data implicate immunity in Alzheimer's disease

Background Late–onset Alzheimer's disease (AD) is heritable with 20 genes showing genome wide association in the International Genomics of Alzheimer's Project (IGAP). To identify the biology underlying the disease we extended these genetic data in a pathway analysis. Methods The ALIGATOR and GSEA algorithms were used in the IGAP data to identify associated functional pathways and correlated gene expression networks in human brain. Results ALIGATOR identified an excess of curated biological pathways showing enrichment of association. Enriched areas of biology included the immune response (p = 3.27×10-12 after multiple testing correction for pathways), regulation of endocytosis (p = 1.31×10-11), cholesterol transport (p = 2.96 × 10-9) and proteasome-ubiquitin activity (p = 1.34×10-6). Correlated gene expression analysis identified four significant network modules, all related to the immune response (corrected p 0.002 – 0.05). Conclusions The immune response, regulation of endocytosis, cholesterol transport and protein ubiquitination represent prime targets for AD therapeutics