Prospective validation of the CLIP score: a new prognostic system for patient with cirrhosis and hepatocellular carcinoma

Prognosis of patients with cirrhosis and hepatocellular carcinoma (HCC) depends on both residual liver function and tumor extension. The CLIP score includes Child-Pugh stage, tumor morphology and extension, serum alfa-fetoprotein (AFP) levels, and portal vein thrombosis. We externally validated the CLIP score and compared its discriminatory ability and predictive power with that of the Okuda staging system in 196 patients with cirrhosis and HCC prospectively enrolled in a randomized trial. No significant associations were found between the CLIP score and the age, sex, and pattern of viral infection. There was a strong correlation between the CLIP score and the Okuda stage, As of June 1999, 150 patients (76.5%) had died. Median survival time was 11 months, overall, and it was 36, 22, 9, 7, and 3 months for CLIP categories 0, 1, 2, 3, and 4 to 6, respectively. In multivariate analysis, the CLIP score had additional explanatory power above that of the Okuda stage. This was true for both patients treated with locoregional therapy or not. A quantitative estimation of 2-year survival predictive power showed that the CLIP score explained 37% of survival variability, compared with 21% explained by Okuda stage. In conclusion, the CLIP score, compared with the Okuda staging system, gives more accurate prognostic information, is statistically more efficient, and has a greater survival predictive power. It could be useful in treatment planning by improving baseline prognostic evaluation of patients with RCC, and could be used in prospective therapeutic trials as a stratification variable, reducing the variability of results owing to patient selection

An embedding technique to determine ττ backgrounds in proton-proton collision data

An embedding technique is presented to estimate standard model tau tau backgrounds from data with minimal simulation input. In the data, the muons are removed from reconstructed mu mu events and replaced with simulated tau leptons with the same kinematic properties. In this way, a set of hybrid events is obtained that does not rely on simulation except for the decay of the tau leptons. The challenges in describing the underlying event or the production of associated jets in the simulation are avoided. The technique described in this paper was developed for CMS. Its validation and the inherent uncertainties are also discussed. The demonstration of the performance of the technique is based on a sample of proton-proton collisions collected by CMS in 2017 at root s = 13 TeV corresponding to an integrated luminosity of 41.5 fb(-1).Peer reviewe

Performance of missing transverse momentum reconstruction in proton-proton collisions at root s=13 TeV using the CMS detector

The performance of missing transverse momentum ((p) over right arrow (miss)(T)) reconstruction algorithms for the CMS experiment is presented, using proton-proton collisions at a center-of-mass energy of 13 TeV, collected at the CERN LHC in 2016. The data sample corresponds to an integrated luminosity of 35.9 fb(-1). The results include measurements of the scale and resolution of (p) over right arrow (miss)(T), and detailed studies of events identified with anomalous (p) over right arrow (miss)(T). The performance is presented of a (p) over right arrow (miss)(T) reconstruction algorithm that mitigates the effects of multiple proton-proton interactions, using the "pileup per particle identification" method. The performance is shown of an algorithm used to estimate the compatibility of the reconstructed (p) over right arrow (miss)(T) with the hypothesis that it originates from resolution effects.Peer reviewe

Measurement of electroweak production of a W boson in association with two jets in proton-proton collisions at s=\sqrt{s}= 13 TeV

A measurement is presented of electroweak (EW) production of a W boson in association with two jets in proton-proton collisions at $\sqrt{s}=$ 13 TeV. The data sample was recorded by the CMS Collaboration at the LHC and corresponds to an integrated luminosity of 35.9 fb$^{-1}$. The measurement is performed for the $\ell\nu$jj final state (with $\ell\nu$ indicating a lepton-neutrino pair, and j representing the quarks produced in the hard interaction) in a kinematic region defined by invariant mass $m_\mathrm{jj} >$ 120 GeV and transverse momenta $p_\mathrm{T j} >$ 25 GeV. The cross section of the process is measured in the electron and muon channels yielding $\sigma_\mathrm{EW}($Wjj$)=$ 6.23$\pm$0.12 (stat)$\pm$ 0.61 (syst) pb per channel, in agreement with leading-order standard model predictions. The additional hadronic activity of events in a signal-enriched region is studied, and the measurements are compared with predictions. The final state is also used to perform a search for anomalous trilinear gauge couplings. Limits on anomalous trilinear gauge couplings associated with dimension-six operators are given in the framework of an effective field theory. The corresponding 95% confidence level intervals are $-$2.3 $< c_{\mathrm{WWW}}/\Lambda^2 <$ 2.5 TeV$^{-2}$, $-$8.8 $< c_{\mathrm{W}}/\Lambda^2 <$ 16 TeV$^{-2}$, and $-$45 $< c_{\mathrm{B}}/\Lambda^2 <$ 46 TeV$^{-2}$. These results are combined with the CMS EW Zjj analysis, yielding the most stringent limit to date on the $c_{\mathrm{WWW}}$ coupling: $-$1.8 $< c_{\mathrm{WWW}}/\Lambda^2 <$ 2.0 TeV$^{-2}$

An embedding technique to determine ττ\tau\tau backgrounds in proton-proton collision data

An embedding technique is presented to estimate standard model $\tau\tau$ backgrounds from data with minimal simulation input. In the data, the muons are removed from reconstructed $\mu\mu$ events and replaced with simulated tau leptons with the same kinematic properties. In this way a set of hybrid events is obtained that does not rely on simulation except for the decay of the tau leptons. The challenges in describing the underlying event or the production of associated jets in the simulation are avoided. The technique described in this paper was developed for CMS. Its validation and the inherent uncertainties are also discussed. The demonstration of the performance of the technique is based on a sample of proton-proton collisions collected by CMS in 2017 at $\sqrt{s}=$ 13 TeV corresponding to an integrated luminosity of 41.5 fb$^{-1}$

Constraints on anomalous HVV couplings from the production of Higgs bosons decaying to τ\tau lepton pairs

A study is presented of anomalous HVV interactions of the Higgs boson, including its CP properties. The study uses Higgs boson candidates produced mainly in vector boson fusion and gluon fusion that subsequently decay to a pair of $\tau$ leptons. The data were recorded by the CMS experiment at the LHC in 2016 at a center-of-mass energy of 13 TeV and correspond to an integrated luminosity of 35.9 fb$^{-1}$. A matrix element technique is employed for the analysis of anomalous interactions. The results are combined with those from the $\mathrm{H}\to 4\ell$ decay channel presented earlier, yielding the most stringent constraints on anomalous Higgs boson couplings to electroweak vector bosons expressed as effective cross-section fractions and phases: the CP-violating parameter $f_{a3}\cos(\phi_{a3})=(0.00 \pm 0.27 )\times10^{-3}$ and the CP-conserving parameters $f_{a2}\cos(\phi_{a2})=(0.08^{+1.04}_{-0.21})\times10^{-3}$, $f_{\Lambda1}\cos(\phi_{\Lambda1})=(0.00^{+0.53}_{-0.09})\times10^{-3}$, and $f_{\Lambda1}^{\mathrm{Z}\gamma}\cos(\phi_{\Lambda1}^{\mathrm{Z}\gamma})=(0.0^{+1.1}_{-1.3})\times10^{-3}$. The current data set does not allow for precise constraints on CP properties in the gluon fusion process. The results are consistent with standard model expectations.A study is presented of anomalous HVV interactions of the Higgs boson, including its CP properties. The study uses Higgs boson candidates produced mainly in vector boson fusion and gluon fusion that subsequently decay to a pair of τ leptons. The data were recorded by the CMS experiment at the LHC in 2016 at a center-of-mass energy of 13 TeV and correspond to an integrated luminosity of 35.9  fb-1. A matrix element technique is employed for the analysis of anomalous interactions. The results are combined with those from the H→4ℓ decay channel presented earlier, yielding the most stringent constraints on anomalous Higgs boson couplings to electroweak vector bosons expressed as effective cross section fractions and phases: the CP-violating parameter fa3cos(ϕa3)=(0.00±0.27)×10-3 and the CP-conserving parameters fa2cos(ϕa2)=(0.08-0.21+1.04)×10-3, fΛ1cos(ϕΛ1)=(0.00-0.09+0.53)×10-3, and fΛ1Zγcos(ϕΛ1Zγ)=(0.0-1.3+1.1)×10-3. The current dataset does not allow for precise constraints on CP properties in the gluon fusion process. The results are consistent with standard model expectations.A study is presented of anomalous HVV interactions of the Higgs boson, including its $CP$ properties. The study uses Higgs boson candidates produced mainly in vector boson fusion and gluon fusion that subsequently decay to a pair of $\tau$ leptons. The data were recorded by the CMS experiment at the LHC in 2016 at a center-of-mass energy of 13 TeV and correspond to an integrated luminosity of 35.9 fb$^{-1}$. A matrix element technique is employed for the analysis of anomalous interactions. The results are combined with those from the H $\to 4\ell$ decay channel presented earlier, yielding the most stringent constraints on anomalous Higgs boson couplings to electroweak vector bosons expressed as effective cross section fractions and phases: the $CP$-violating parameter $f_{a3}\cos(\phi_{a3})$ $=$ $(0.00 \pm 0.27) \times 10^{-3}$ and the $CP$-conserving parameters $f_{a2}\cos(\phi_{a2})$ $=$ $(0.08 ^{+1.04}_{-0.21}) \times 10^{-3}$, $f_{\Lambda1}\cos(\phi_{\Lambda1})$ $=$ $(0.00 ^{+0.53}_{-0.09}) \times 10^{-3}$, and $f_{\Lambda1}^{\mathrm{Z}\gamma}\cos(\phi_{\Lambda1}^{\mathrm{Z}\gamma})$ $=$ $(0.0 ^{+1.1}_{-1.3}) \times 10^{-3}$. The current dataset does not allow for precise constraints on $CP$ properties in the gluon fusion process. The results are consistent with standard model expectations

Search for charged Higgs bosons in the H±^{\pm} →\to τ±ντ\tau^{\pm}\nu_\tau decay channel in proton-proton collisions at s=\sqrt{s} = 13 TeV

A search is presented for charged Higgs bosons in the $\mathrm{H}^{\pm} \to \tau^{\pm}\nu_\tau$ decay mode in the hadronic final state and in final states with an electron or muon. The search is based on proton-proton collision data recorded by the CMS experiment in 2016 at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 35.9 fb$^{-1}$. The results agree with the background expectation from the standard model. Upper limits at 95% confidence level are set on the production cross section times branching fraction to $\tau^{\pm}\nu_\tau$ for an $\mathrm{H}^{\pm}$ in the mass range of 80 GeV to 3 TeV, including the region near the top quark mass. The observed limit ranges from 6 pb at 80 GeV to 5 fb at 3 TeV. The limits are interpreted in the context of the minimal supersymmetric standard model ${m_{\mathrm{h}}^\text{mod-}}$ scenario.A search is presented for charged Higgs bosons in the H$^{±}$ → τ$^{±}$ν$_{τ}$ decay mode in the hadronic final state and in final states with an electron or a muon. The search is based on proton-proton collision data recorded by the CMS experiment in 2016 at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 35.9 fb$^{−1}$. The results agree with the background expectation from the standard model. Upper limits at 95% confidence level are set on the production cross section times branching fraction to τ$^{±}$ν$_{τ}$ for an H$^{±}$ in the mass range of 80GeV to 3TeV, including the region near the top quark mass. The observed limit ranges from 6 pb at 80 GeV to 5 fb at 3 TeV. The limits are interpreted in the context of the minimal supersymmetric standard model m$_{h}^{hod −}$ scenario.A search is presented for charged Higgs bosons in the H$^{\pm}$ $\to$ $\tau^{\pm}\nu_\tau$ decay mode in the hadronic final state and in final states with an electron or muon. The search is based on proton-proton collision data recorded by the CMS experiment in 2016 at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 35.9 fb$^{-1}$. The results agree with the background expectation from the standard model. Upper limits at 95% confidence level are set on the production cross section times branching fraction to $\tau^{\pm}\nu_\tau$ for an H$^{\pm}$ in the mass range of 80 GeV to 3 TeV, including the region near the top quark mass. The observed limit ranges from 6 pb at 80 GeV to 5 fb at 3 TeV. The limits are interpreted in the context of the minimal supersymmetric standard model $m_\mathrm{h}^\mathrm{mod-}$ scenario

Search for supersymmetry in final states with photons and missing transverse momentum in proton-proton collisions at 13 TeV

Results are reported for a search for supersymmetry in final states with photons and missing transverse momentum in proton-proton collisions at the LHC. The data sample corresponds to an integrated luminosity of 35.9 fb$^{-1}$ collected at a center-of-mass energy of 13 TeV using the CMS detector. The results are interpreted in the context of models of gauge-mediated supersymmetry breaking. Production cross section limits are set on gluino and squark pair production in this framework. Gluino masses below 1.86 TeV and squark masses below 1.59 TeV are excluded at 95% confidence level