5,837 research outputs found
Gate-Voltage Control of Chemical Potential and Weak Anti-localization in Bismuth Selenide
We report that BiSe thin films can be epitaxially grown on
SrTiO substrates, which allow for very large tunablity in carrier density
with a back-gate. The observed low field magnetoconductivity due to weak
anti-localization (WAL) has a very weak gate-voltage dependence unless the
electron density is reduced to very low values. Such a transition in WAL is
correlated with unusual changes in longitudinal and Hall resistivities. Our
results suggest much suppressed bulk conductivity at large negative
gate-voltages and a possible role of surface states in the WAL phenomena. This
work may pave a way for realizing three-dimensional topological insulators at
ambient conditions.Comment: 5 pages, 4 figures
Drug susceptibility profile and pathogenicity of H7N9 influenza virus (Anhui1 lineage) with R292K substitution
Neuraminidase inhibitors (NAIs) are the only available licensed therapeutics against human H7N9 influenza virus infections. The emergence of NAI-resistant variants of H7N9viruses with an NA R292K mutation poses a therapeutic challenge. A comprehensive understanding of the susceptibility of these viruses to clinically available NAIs, non-NAIs and their combinations is crucial for effective treatment. In this study, by using limited serial passage and plaque purification, an R292K variant of the Anhui1 lineage was isolated from a patient with clinical evidence of resistance to oseltamivir. In vitro and cell-based assays confirmed a high level of resistance conferred by the R292K mutation to oseltamivir carboxylate and a moderate level of resistance to zanamivir and peramivir. Non-NAI antivirals, such as T-705, ribavirin and NT-300, efficiently inhibited both the variant and the wild-type in cell-based assays. A combination of NAIs and non-NAIs did not exhibit a marked synergistic effect against the R292K variant. However, the combination of two non-NAIs (T-705 and ribavirin) exhibited significant synergism against the mutant virus. In experimentally infected mice, the variant showed delayed onset of symptoms, a reduced viral load and attenuated lethality compared with the wild-type. Our study suggested non-NAIs should be tested clinically for H7N9 patients with a sustained high viral load. Possible drug combination regimens, such as T-705 plus ribavirin, should be further tested in animal models. The pathogenicity and transmissibility of the R292K H7N9 variant should be further assessed with genetically well-characterized pairs of viruses and, most-desirably, with competitive fitness experiments.published_or_final_versio
An 852 nm Faraday laser with 8 kHz linewidth based on corner-cube retroreflector
A single-mode Cs atom 852 nm Faraday laser based on the corner-cube reflector
feedback is first demonstrated to our best knowledge. Using the corner-cube
reflector as external cavity feedback in Faraday laser, the robustness can be
greatly improved. This Faraday laser can always achieve laser oscillation
unless the angle between incident light and the optical axis of corner-cube
retroreflector is beyond the plus or minus 3{\deg} range. Furthermore, the
Faraday laser achieves single-mode operation within the current range of 100 mA
, and its output wavelength is automatically limited to the vicinity of the Cs
atomic transition lines. The wavelength fluctuation range is limited to plus or
minus 1.2 pm within 9 hours under +3{\deg} rotation angle. Moreover, the most
probable linewidth is 7.97 kHz measured by heterodyne beating. The Faraday
laser with high robustness as well as narrow linewidth can be widely used in
quantum precision measurement fields including quantum optics, atomic clocks,
atomic magnetometers, cold atoms, and atomic gravimeters, etc
Measurement of proton electromagnetic form factors in in the energy region 2.00-3.08 GeV
The process of is studied at 22 center-of-mass
energy points () from 2.00 to 3.08 GeV, exploiting 688.5~pb of
data collected with the BESIII detector operating at the BEPCII collider. The
Born cross section~() of is
measured with the energy-scan technique and it is found to be consistent with
previously published data, but with much improved accuracy. In addition, the
electromagnetic form-factor ratio () and the value of the
effective (), electric () and magnetic () form
factors are measured by studying the helicity angle of the proton at 16
center-of-mass energy points. and are determined with
high accuracy, providing uncertainties comparable to data in the space-like
region, and is measured for the first time. We reach unprecedented
accuracy, and precision results in the time-like region provide information to
improve our understanding of the proton inner structure and to test theoretical
models which depend on non-perturbative Quantum Chromodynamics
Search for the decay
We search for radiative decays into a weakly interacting neutral
particle, namely an invisible particle, using the produced through the
process in a data sample of
decays collected by the BESIII detector
at BEPCII. No significant signal is observed. Using a modified frequentist
method, upper limits on the branching fractions are set under different
assumptions of invisible particle masses up to 1.2 . The upper limit corresponding to an invisible particle with zero mass
is 7.0 at the 90\% confidence level
JUNO Conceptual Design Report
The Jiangmen Underground Neutrino Observatory (JUNO) is proposed to determine
the neutrino mass hierarchy using an underground liquid scintillator detector.
It is located 53 km away from both Yangjiang and Taishan Nuclear Power Plants
in Guangdong, China. The experimental hall, spanning more than 50 meters, is
under a granite mountain of over 700 m overburden. Within six years of running,
the detection of reactor antineutrinos can resolve the neutrino mass hierarchy
at a confidence level of 3-4, and determine neutrino oscillation
parameters , , and to
an accuracy of better than 1%. The JUNO detector can be also used to study
terrestrial and extra-terrestrial neutrinos and new physics beyond the Standard
Model. The central detector contains 20,000 tons liquid scintillator with an
acrylic sphere of 35 m in diameter. 17,000 508-mm diameter PMTs with high
quantum efficiency provide 75% optical coverage. The current choice of
the liquid scintillator is: linear alkyl benzene (LAB) as the solvent, plus PPO
as the scintillation fluor and a wavelength-shifter (Bis-MSB). The number of
detected photoelectrons per MeV is larger than 1,100 and the energy resolution
is expected to be 3% at 1 MeV. The calibration system is designed to deploy
multiple sources to cover the entire energy range of reactor antineutrinos, and
to achieve a full-volume position coverage inside the detector. The veto system
is used for muon detection, muon induced background study and reduction. It
consists of a Water Cherenkov detector and a Top Tracker system. The readout
system, the detector control system and the offline system insure efficient and
stable data acquisition and processing.Comment: 328 pages, 211 figure
Confirmation of a charged charmoniumlike state in with double tag
We present a study of the process
using data samples of 1092~pb at ~GeV and 826~pb
at ~GeV collected with the BESIII detector at the BEPCII storage
ring. With full reconstruction of the meson pair and the bachelor
in the final state, we confirm the existence of the charged
structure in the system in the two
isospin processes and . By
performing a simultaneous fit, the statistical significance of
signal is determined to be greater than 10, and its pole mass and width
are measured to be
=(3881.71.6(stat.)1.6(syst.))~MeV/ and
=(26.62.0(stat.)2.1(syst.))~MeV, respectively.
The Born cross section times the branching fraction
() is measured to be
at
~GeV and
at
~GeV. The polar angular distribution of the
- system is consistent with the expectation of a
quantum number assignment of for
Faraday laser pumped cesium beam clock
We realize a high-performance compact optically pumped cesium beam clock
using Faraday laser simultaneously as pumping and detection lasers. The Faraday
laser, which is frequency stabilized by modulation transfer spectroscopy (MTS)
technique, has narrow linewidth and superior frequency stability. Measured by
optical heterodyne method between two identical systems, the linewidth of the
Faraday laser is 2.5 kHz after MTS locking, and the fractional frequency
stability of the Faraday laser is optimized to
. Based on this high-performance Faraday
laser, the cesium beam clock realizes a signal-to-noise ratio (SNR) in 1 Hz
bandwidth of when the cesium oven temperature is 130{\deg}C.
Frequency-compared with Hydrogen maser, the fractional frequency stability of
the Faraday laser pumped cesium beam clock can reach
and drops to at 10000 s
when the cesium oven temperature is 110{\deg}C. %, which is the best reported
result compared with other cesium beam clocks. This Faraday laser pumped cesium
beam clock demonstrates its excellent performance, and its great potential in
the fields of timekeeping, navigation, and communication. Meanwhile, the
Faraday laser, as a high-performance optical frequency standard, can also
contribute to the development of other applications in quantum metrology,
precision measurement and atomic physics
Search for squarks and gluinos with the ATLAS detector in final states with jets and missing transverse momentum using √s=8 TeV proton-proton collision data
A search for squarks and gluinos in final states containing high-p T jets, missing transverse momentum and no electrons or muons is presented. The data were recorded in 2012 by the ATLAS experiment in s√=8 TeV proton-proton collisions at the Large Hadron Collider, with a total integrated luminosity of 20.3 fb−1. Results are interpreted in a variety of simplified and specific supersymmetry-breaking models assuming that R-parity is conserved and that the lightest neutralino is the lightest supersymmetric particle. An exclusion limit at the 95% confidence level on the mass of the gluino is set at 1330 GeV for a simplified model incorporating only a gluino and the lightest neutralino. For a simplified model involving the strong production of first- and second-generation squarks, squark masses below 850 GeV (440 GeV) are excluded for a massless lightest neutralino, assuming mass degenerate (single light-flavour) squarks. In mSUGRA/CMSSM models with tan β = 30, A 0 = −2m 0 and μ > 0, squarks and gluinos of equal mass are excluded for masses below 1700 GeV. Additional limits are set for non-universal Higgs mass models with gaugino mediation and for simplified models involving the pair production of gluinos, each decaying to a top squark and a top quark, with the top squark decaying to a charm quark and a neutralino. These limits extend the region of supersymmetric parameter space excluded by previous searches with the ATLAS detector
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
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