351 research outputs found
Significance of Aurora B overexpression in hepatocellular carcinoma. Aurora B Overexpression in HCC
- Author
- A Aihara
- Ann-Lii Cheng
- AS Befeler
- CJ Chen
- DL Satinover
- DM Parkin
- DW Hosmer
- DW Hosmer
- EC Lee
- F Girdler
- Fu-Chang Hu
- G Mountzios
- GJ Kim
- H Zhou
- HB El-Serag
- HB El-Serag
- HC Hsu
- HC Hsu
- HC Hsu
- HC Hsu
- HC Hsu
- Hey-Chi Hsu
- Hsin-Wei Tsao
- Hung-Wei Pan
- HW Pan
- J Fu
- JM Llovet
- L Wilkens
- N Keen
- O Gautschi
- P Laurent-Puig
- Po-Huang Lee
- Po-Lin Lai
- R Sorrentino
- RH Hu
- RH Yuan
- RW Wilkinson
- S Ruchaud
- S Tanaka
- S Vincent
- SH Liu
- SY Peng
- T Marumoto
- YC Shen
- YM Jeng
- Yung-Ming Jeng
- Zhong-Zhe Lin
- ZZ Lin
- Publication venue
- BioMed Central
- Publication date
- 01/01/2010
- Field of study
<p>Abstract</p> <p>Background</p> <p>To investigate the significance of Aurora B expression in hepatocellular carcinoma (HCC).</p> <p>Methods</p> <p>The <it>Aurora B </it>and <it>Aurora A </it>mRNA level was measured in 160 HCCs and the paired nontumorous liver tissues by reverse transcription-polymerase chain reaction. Mutations of the <it>p53 </it>and <it>β-catenin </it>genes were analyzed in 134 and 150 tumors, respectively, by direct sequencing of exon 2 to exon 11 of <it>p53 </it>and exon 3 of <it>β-catenin</it>. Anticancer effects of AZD1152-HQPA, an Aurora B kinase selective inhibitor, were examined in Huh-7 and Hep3B cell lines.</p> <p>Results</p> <p><it>Aurora B </it>was overexpressed in 98 (61%) of 160 HCCs and in all 7 HCC cell lines examined. The overexpression of <it>Aurora B </it>was associated with <it>Aurora A </it>overexpression (<it>P </it>= 0.0003) and <it>p53 </it>mutation (<it>P </it>= 0.002) and was inversely associated with <it>β</it>-<it>catenin </it>mutation (<it>P </it>= 0.002). <it>Aurora B </it>overexpression correlated with worse clinicopathologic characteristics. Multivariate analysis confirmed that <it>Aurora B </it>overexpression was an independent poor prognostic factor, despite its interaction with Aurora A overexpression and mutations of <it>p53 </it>and <it>β</it>-<it>catenin</it>. In Huh-7 and Hep3B cells, AZD1152-HQPA induced proliferation blockade, histone H3 (Ser10) dephosphorylation, cell cycle disturbance, and apoptosis.</p> <p>Conclusion</p> <p><it>Aurora B </it>overexpression is an independent molecular marker predicting tumor invasiveness and poor prognosis of HCC. Aurora B kinase selective inhibitors are potential therapeutic agents for HCC treatment.</p
Evolution of Resistance to Aurora Kinase B Inhibitors in Leukaemia Cells
- Author
- AJ Gifford
- AS Andersen
- C Ditchfield
- CB Andersen
- D Fancelli
- D Li
- David E. Hibbs
- E Walsby
- EA Harrington
- F Girdler
- F Girdler
- F Sessa
- GA Pihan
- GE Foley
- Glide
- Gorjana Mitic
- H Katayama
- Heba Abdel-Halim
- J Yang
- JA Engelman
- JR Bischoff
- M Talpaz
- MacroModel
- Maestro
- Maria Kavallaris
- Marjorie Liu
- ME Gorre
- N Keen
- NM Verrills
- P Meraldi
- PD Andrews
- PP Gan
- RW Wilkinson
- S Don
- S Lapenna
- Sela T. Po'uha
- ST Po'uha
- SV Sharma
- T Ikezoe
- Timothy W. Failes
- TM Gritsko
- VM Bolanos-Garcia
- Wael El-Rifai
- WL Jorgensen
- YM Jeng
- Publication venue
- Public Library of Science
- Publication date
- 16/02/2012
- Field of study
Aurora kinase inhibitors are new mitosis-targeting drugs currently in clinical trials for the treatment of haematological and solid malignancies. However, knowledge of the molecular factors that influence sensitivity and resistance remains limited. Herein, we developed and characterised an in vitro leukaemia model of resistance to the Aurora B inhibitor ZM447439. Human T-cell acute lymphoblastic leukaemia cells, CCRF-CEM, were selected for resistance in 4 µM ZM447439. CEM/AKB4 cells showed no cross-resistance to tubulin-targeted and DNA-damaging agents, but were hypersensitive to an Aurora kinase A inhibitor. Sequencing revealed a mutation in the Aurora B kinase domain corresponding to a G160E amino acid substitution. Molecular modelling of drug binding in Aurora B containing this mutation suggested that resistance is mediated by the glutamate substitution preventing formation of an active drug-binding motif. Progression of resistance in the more highly selected CEM/AKB8 and CEM/AKB16 cells, derived sequentially from CEM/AKB4 in 8 and 16 µM ZM447439 respectively, was mediated by additional defects. These defects were independent of Aurora B and multi-drug resistance pathways and are associated with reduced apoptosis mostly likely due to reduced inhibition of the catalytic activity of aurora kinase B in the presence of drug. Our findings are important in the context of the use of these new targeted agents in treatment regimes against leukaemia and suggest resistance to therapy may arise through multiple independent mechanisms
Perimembrane Aurora-A Expression is a Significant Prognostic Factor in Correlation with Proliferative Activity in Non-Small-Cell Lung Cancer (NSCLC)
- Author
- A Ewart-Toland
- A Klein
- C Sakakura
- CF Mountain
- D Li
- DM Goover
- E Tanaka
- Eiji Ogawa
- F Tanaka
- F Tanaka
- F Tanaka
- F Tanaka
- Fumihiro Tanaka
- H Katayama
- H Zhou
- Hirokazu Kotani
- Hiromi Wada
- Hiromichi Katakura
- JG Paez
- JR Bischoff
- JR Bischoff
- K Neben
- Kazumasa Takenaka
- KM Egan
- Masashi Adachi
- ME Royce
- MT Kimura
- Q Liu
- RA Dicioccio
- S Sen
- SS Chen
- T Naruke
- T Sun
- T Tong
- TJ Lynch
- TM Goepfert
- TM Gritsko
- Toshiaki Manabe
- VM Balanos-Garcia
- W Zimmerman
- X Miao
- Y Miyoshi
- YM Jeng
- Yoshinobu Toda
- Yosuke Otake
- YW Ke
- Publication venue
- Springer-Verlag
- Publication date
- 01/02/2008
- Field of study
Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Acosta D
- Acosta JG
- Acosta MV
- Adair A
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Aguilo E
- Ahmad M
- Ahmad WH
- Ahuja S
- Akchurin N
- Akgun B
- Akgun U
- Akin IV
- Alagoz E
- Albajar C
- Albayrak EA
- Albergo S
- Albrow M
- Alda Junior WL
- Alexander J
- Aliev T
- Almeida N
- Alver B
- Alverson G
- Alves GA
- Amapane N
- Amsler C
- Anagnostou G
- Anastassov A
- Anderson J
- Anderson M
- Andrea J
- Andreev V
- Andreev V
- Andreev Y
- Andrews W
- Anghel IM
- Anjos TS
- Antonelli L
- Antunes JR
- Antunovic Z
- Apanasevich L
- Apollinari G
- Appelt E
- Apresyan A
- Aranyi A
- Arce P
- Arcidiacono R
- Arenton MW
- Arfaei H
- Argiro S
- Arisaka K
- Arneodo M
- Arora S
- Asawatangtrakuldee C
- Asghar MI
- Askew A
- Assran Y
- Ata M
- Atac M
- Atramentov O
- Attikis A
- Auffray E
- Autermann C
- Auzinger G
- Avdeeva E
- Avery P
- Avetisyan A
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzolini V
- Azzurri P
- Baarmand MM
- Babb J
- Bacchetta N
- Bachtis M
- Baden A
- Baeni L
- Baesso P
- Baffioni S
- Bagliesi G
- Bai Y
- Baillon P
- Bainbridge R
- Bakhshiansohi H
- Bakirci MN
- Bakken JA
- Balazs M
- Ball AH
- Ball G
- Ban Y
- Banerjee S
- Banerjee S
- Bansal S
- Banzuzi K
- Barbagli G
- Barberis E
- Barbone L
- Bardak C
- Barfuss AF
- Bargassa P
- Barge D
- Baringer P
- Barker A
- Barnes VE
- Barnett BA
- Barney D
- Barone L
- Barrett M
- Bartalini P
- Barth C
- Basegmez S
- Basso L
- Battilana C
- Baty C
- Bauer G
- Bauerdick LAT
- Baumgartel D
- Baur U
- Bayshev I
- Bazterra VE
- Bean A
- Beauceron S
- Beaudette F
- Beaupere N
- Bedjidian M
- Beernaert K
- Behrenhoff W
- Behrens U
- Belforte S
- Beliy N
- Belknap D
- Bell AJ
- Bell KW
- Bellan P
- Bellan R
- Bellato M
- Bellinger JN
- Belotelov I
- Belyaev A
- Belyaev A
- Benaglia A
- Bencze G
- Bendavid J
- Benedetti D
- Benelli G
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- Beni N
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- Benvenuti AC
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- Bergauer T
- Berger J
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- Beri SB
- Bernardes CA
- Bernardini J
- Bernet C
- Berry D
- Berry E
- Berryhill J
- Bertl W
- Berzano U
- Besancon M
- Betchart B
- Bethani A
- Betts RR
- Beuselinck R
- Bhat PC
- Bhatnagar V
- Bhattacharya S
- Bhattacharya S
- Bhatti A
- Bialas W
- Bialkowska H
- Bian JG
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- Biino C
- Bilei GM
- Bilin B
- Bilinskas MJ
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- Bitioukov S
- Blekman F
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- Bobrovskyi S
- Boccali T
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- Bolton T
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- Bortoletto D
- Bose S
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- Chabert EC
- Chadwick M
- Chakaberia I
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- Chang S
- Chang YH
- Chang YH
- Chang YW
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- Chao Y
- Charaf O
- Charlot C
- Chasco M
- Chasserat J
- Chatrchyan S
- Chatterjee A
- Chauhan S
- Checchia P
- Chen GM
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- Cherepanov V
- Chertok M
- Chetluru V
- Cheung HWK
- Chhibra SS
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- Choi M
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- Choudhary BC
- Choudhury RK
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- Chuang SH
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- CMS Collaboration
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- Hahn KA
- Hajdu C
- Halkiadakis E
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- Heredia-de La Cruz I
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- Iashvili I
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- Ignatenko M
- Iii RPK
- Iiyama Y
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- Yildirim E
- Yilmaz Y
- Yohay R
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- Yoo J
- Yoon AS
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- Yumiceva F
- Yun JC
- Zabel J
- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zang SL
- Zarubin A
- Zatserklyaniy A
- Zeinali M
- Zeise M
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang Z
- Zheng Y
- Zhokin A
- Zhu B
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- Zhukov V
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- Ziebarth EB
- Ziegler J
- Zielinski M
- Zito G
- Zoeller MH
- Zotto P
- Zou W
- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2012
- Field of study
The performance of muon reconstruction, identification, and triggering in CMS
has been studied using 40 inverse picobarns of data collected in pp collisions
at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection
criteria covering a wide range of physics analysis needs have been examined.
For all considered selections, the efficiency to reconstruct and identify a
muon with a transverse momentum pT larger than a few GeV is above 95% over the
whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4,
while the probability to misidentify a hadron as a muon is well below 1%. The
efficiency to trigger on single muons with pT above a few GeV is higher than
90% over the full eta range, and typically substantially better. The overall
momentum scale is measured to a precision of 0.2% with muons from Z decays. The
transverse momentum resolution varies from 1% to 6% depending on pseudorapidity
for muons with pT below 100 GeV and, using cosmic rays, it is shown to be
better than 10% in the central region up to pT = 1 TeV. Observed distributions
of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO
Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Acosta D
- Acosta JG
- Acosta MV
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- Prado Da Silva WL
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- Radi A
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- Ranieri R
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- Rappoccio S
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- Redondo I
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- Reyes-Santos MA
- Ribeiro PQ
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- Romeo F
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- Schoefbeck R
- Schoerner-Sadenius T
- Schott G
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- Schwick C
- Scodellaro L
- Scurlock B
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- Segala M
- Segoni I
- Seitz C
- Seixas J
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- Selvaggi G
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- Sen N
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- Sengupta S
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- Seo E
- Seo H
- Serban AT
- Serin M
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- Sexton-Kennedy E
- Sfiligoi I
- Sguazzoni G
- Shah MA
- Sharma A
- Sharma A
- Sharma S
- Sharma V
- Sharma V
- Sharp P
- Sheldon P
- Shepherd-Themistocleous CH
- Shi X
- Shipkowski SP
- Shipsey I
- Shiu JG
- Shivpuri RK
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- Shoaib M
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- Shukla P
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- Sillou D
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- Silverwood H
- Silvestre C
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- Sirois Y
- Siroli G
- Sirunyan AM
- Skhirtladze N
- Skuja A
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- Smirnov I
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- Smolin D
- Snigirev A
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- Soares MS
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- Sudano E
- Sudhakar K
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- Sultanov G
- Summers D
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- Tsang KV
- Tschudi Y
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- Ujvari B
- Ulmer KA
- Ungaro D
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- Uzun D
- Uzunian A
- Vaandering EW
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- Wissing C
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- Womersley WJ
- Won S
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- Wood JS
- Worm SD
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- Wyslouch B
- Xiao H
- Xie S
- Xu M
- Yagil A
- Yalvac M
- Yang F
- Yang M
- Yang Y
- Yang ZC
- Yazgan E
- Yelton J
- Yetkin T
- Yi K
- Yildirim E
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoo J
- Yoon AS
- York A
- Yu I
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- Yumiceva F
- Yun JC
- Zabel J
- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zang SL
- Zarubin A
- Zatserklyaniy A
- Zeinali M
- Zeise M
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang Z
- Zheng Y
- Zhokin A
- Zhu B
- Zhu RY
- Zhukov V
- Zhukova V
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- Zoeller MH
- Zotto P
- Zou W
- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2012
- Field of study
The performance of muon reconstruction, identification, and triggering in CMS
has been studied using 40 inverse picobarns of data collected in pp collisions
at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection
criteria covering a wide range of physics analysis needs have been examined.
For all considered selections, the efficiency to reconstruct and identify a
muon with a transverse momentum pT larger than a few GeV is above 95% over the
whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4,
while the probability to misidentify a hadron as a muon is well below 1%. The
efficiency to trigger on single muons with pT above a few GeV is higher than
90% over the full eta range, and typically substantially better. The overall
momentum scale is measured to a precision of 0.2% with muons from Z decays. The
transverse momentum resolution varies from 1% to 6% depending on pseudorapidity
for muons with pT below 100 GeV and, using cosmic rays, it is shown to be
better than 10% in the central region up to pT = 1 TeV. Observed distributions
of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO
X-ray emission from the Sombrero galaxy: discrete sources
- Author
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- Ziebarth EB
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- Zoeller MH
- Zorbilmez C
- Zotto P
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- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2010
- Field of study
We present a study of discrete X-ray sources in and around the
bulge-dominated, massive Sa galaxy, Sombrero (M104), based on new and archival
Chandra observations with a total exposure of ~200 ks. With a detection limit
of L_X = 1E37 erg/s and a field of view covering a galactocentric radius of ~30
kpc (11.5 arcminute), 383 sources are detected. Cross-correlation with Spitler
et al.'s catalogue of Sombrero globular clusters (GCs) identified from HST/ACS
observations reveals 41 X-rays sources in GCs, presumably low-mass X-ray
binaries (LMXBs). We quantify the differential luminosity functions (LFs) for
both the detected GC and field LMXBs, whose power-low indices (~1.1 for the
GC-LF and ~1.6 for field-LF) are consistent with previous studies for
elliptical galaxies. With precise sky positions of the GCs without a detected
X-ray source, we further quantify, through a fluctuation analysis, the GC LF at
fainter luminosities down to 1E35 erg/s. The derived index rules out a
faint-end slope flatter than 1.1 at a 2 sigma significance, contrary to recent
findings in several elliptical galaxies and the bulge of M31. On the other
hand, the 2-6 keV unresolved emission places a tight constraint on the field
LF, implying a flattened index of ~1.0 below 1E37 erg/s. We also detect 101
sources in the halo of Sombrero. The presence of these sources cannot be
interpreted as galactic LMXBs whose spatial distribution empirically follows
the starlight. Their number is also higher than the expected number of cosmic
AGNs (52+/-11 [1 sigma]) whose surface density is constrained by deep X-ray
surveys. We suggest that either the cosmic X-ray background is unusually high
in the direction of Sombrero, or a distinct population of X-ray sources is
present in the halo of Sombrero.Comment: 11 figures, 5 tables, ApJ in pres
Azimuthal anisotropy of charged particles at high transverse momenta in PbPb collisions at sqrt(s[NN]) = 2.76 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta JG
- Acosta MV
- Adair A
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Afanasiev S
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Aguilo E
- Ahmad M
- Ahmad WH
- Ahuja S
- Akchurin N
- Akgun B
- Akgun U
- Akin IV
- Alagoz E
- Albajar C
- Albayrak EA
- Albergo S
- Albrow M
- Alcaraz Maestre J
- Alda Junior WL
- Alexander J
- Aliev T
- Alimena J
- Almeida N
- Alverson G
- Alves GA
- Amapane N
- Amsler C
- Anagnostou G
- Anastassov A
- Anderson J
- Anderson M
- Andrea J
- Andreev V
- Andreev V
- Andreev Y
- Andrews W
- Anghel IM
- Anjos TS
- Antonelli L
- Antunovic Z
- Apanasevich L
- Appelt E
- Apresyan A
- Arce P
- Arcidiacono R
- Arenton MW
- Arfaei H
- Argiro S
- Arneodo M
- Arora S
- Asawatangtrakuldee C
- Asghar MI
- Askew A
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- Autermann C
- Auzinger G
- Avdeeva E
- Avery P
- Avetisyan A
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- Azhgirey I
- Aziz T
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- Azzolini V
- Azzurri P
- Baarmand MM
- Babb J
- Bacchetta N
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- Baden A
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- Baffioni S
- Bagliesi G
- Bai Y
- Baillon P
- Bainbridge R
- Bakhshiansohi H
- Bakirci MN
- Balazs M
- Ball AH
- Ball G
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- Banerjee S
- Banerjee S
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- Barbagli G
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- Barnett BA
- Barney D
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- Battilana C
- Bauer G
- Bauerdick LAT
- Baumgartel D
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- Bayshev I
- Bazterra VE
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- Beaudette F
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- Beernaert K
- Behr J
- Behrenhoff W
- Behrens U
- Belforte S
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- Belknap D
- Bell AJ
- Bellan R
- Belotelov I
- Belyaev A
- Belyaev A
- Benaglia A
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- Bendavid J
- Benedetti D
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- Benvenuti AC
- Beranek S
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- Berger J
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- Bhatti A
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- Bianchi G
- Bianchini L
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- Biino C
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- Yi K
- Yildirim E
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoo J
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- Yumiceva F
- Yun JC
- Zabel J
- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
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- Zarubin A
- Zatserklyaniy A
- Zeinali M
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- Zeuner WD
- Zeyrek M
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- Zumerle G
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
The azimuthal anisotropy of charged particles in PbPb collisions at
nucleon-nucleon center-of-mass energy of 2.76 TeV is measured with the CMS
detector at the LHC over an extended transverse momentum (pt) range up to
approximately 60 GeV. The data cover both the low-pt region associated with
hydrodynamic flow phenomena and the high-pt region where the anisotropies may
reflect the path-length dependence of parton energy loss in the created medium.
The anisotropy parameter (v2) of the particles is extracted by correlating
charged tracks with respect to the event-plane reconstructed by using the
energy deposited in forward-angle calorimeters. For the six bins of collision
centrality studied, spanning the range of 0-60% most-central events, the
observed v2 values are found to first increase with pt, reaching a maximum
around pt = 3 GeV, and then to gradually decrease to almost zero, with the
decline persisting up to at least pt = 40 GeV over the full centrality range
measured.Comment: Replaced with published version. Added journal reference and DO
Search for new physics with same-sign isolated dilepton events with jets and missing transverse energy
- Author
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- Abbiendi G
- Abbrescia M
- Abdullin S
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- CMS Collaboration
- Coarasa Perez JA
- Cockerill DJA
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- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
A search for new physics is performed in events with two same-sign isolated
leptons, hadronic jets, and missing transverse energy in the final state. The
analysis is based on a data sample corresponding to an integrated luminosity of
4.98 inverse femtobarns produced in pp collisions at a center-of-mass energy of
7 TeV collected by the CMS experiment at the LHC. This constitutes a factor of
140 increase in integrated luminosity over previously published results. The
observed yields agree with the standard model predictions and thus no evidence
for new physics is found. The observations are used to set upper limits on
possible new physics contributions and to constrain supersymmetric models. To
facilitate the interpretation of the data in a broader range of new physics
scenarios, information on the event selection, detector response, and
efficiencies is provided.Comment: Published in Physical Review Letter
Measurement of the Z/gamma* + b-jet cross section in pp collisions at 7 TeV
- Author
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- Abbiendi G.
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2012
- Field of study
The production of b jets in association with a Z/gamma* boson is studied
using proton-proton collisions delivered by the LHC at a centre-of-mass energy
of 7 TeV and recorded by the CMS detector. The inclusive cross section for
Z/gamma* + b-jet production is measured in a sample corresponding to an
integrated luminosity of 2.2 inverse femtobarns. The Z/gamma* + b-jet cross
section with Z/gamma* to ll (where ll = ee or mu mu) for events with the
invariant mass 60 < M(ll) < 120 GeV, at least one b jet at the hadron level
with pT > 25 GeV and abs(eta) < 2.1, and a separation between the leptons and
the jets of Delta R > 0.5 is found to be 5.84 +/- 0.08 (stat.) +/- 0.72 (syst.)
+(0.25)/-(0.55) (theory) pb. The kinematic properties of the events are also
studied and found to be in agreement with the predictions made by the MadGraph
event generator with the parton shower and the hadronisation performed by
PYTHIA.Comment: Submitted to the Journal of High Energy Physic
Performance of the CMS Cathode Strip Chambers with Cosmic Rays
- Author
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- Wenger EA
- Wengler T.
- Wenig S.
- Wenman D
- Wensveen M
- Wermes N.
- Werner JS
- Werner M.
- Werner P.
- Wertelaers P
- Werth M.
- Werthenbach U.
- Wessels M.
- Wetzel J
- Whalen K.
- White A White AE. A.
- White A.
- White M. J.
- White S.
- Whitehead S. R.
- Whiteson D.
- Whitmore J
- Whittington D.
- Whyntie T
- Wicek F.
- Wicke D.
- Wickens F. J.
- Wickens J
- Wicklund E
- Widl E
- Wiedenmann W.
- Wielers M.
- Wienemann P.
- Wiglesworth C.
- Wigmans R
- Wiik L. A. M.
- Wildauer A.
- Wildish T
- Wildt M. A.
- Wilke L
- Wilken R
- Wilkens H. G.
- Wilkinson R
- Williams E.
- Williams G
- Williams H. H.
- Williams JC
- Williams JH
- Willmott C
- Willocq S.
- Wilson A.
- Wilson J. A.
- Wilson M. G.
- Wimpenny S
- Wingerter-Seez I.
- Wingham M
- Winklmeier F.
- Winn D
- Wissing C
- Witherell M
- Wittgen M.
- Wittich P
- Wittmer B
- Wlochal M
- Wohri HK
- Wolf R
- Wolter M. W.
- Wolters H.
- Womersley WJ
- Won S
- Wood JS
- Worm SD
- Wosiek B. K.
- Wotschack J.
- Woudstra M. J.
- Wraight K.
- Wright C.
- Wright D
- Wright D.
- Wrochna G
- Wrona B.
- Wu S
- Wu S. L.
- Wu W
- Wu X.
- Wulf E.
- Wulz CE
- Wurthwein F
- Wynne B. M.
- Wyslouch B
- Xaplanteris L.
- Xella S.
- Xie S
- Xie S.
- Xie Z
- Xu D.
- Xu N.
- Xue Z
- Yagil A
- Yamada M.
- Yamamoto A
- Yan M
- Yang X
- Yang Y
- Yang ZC
- Yarba J
- Yaselli I
- Yazgan E
- Yelton J
- Yetkin T
- Yi K
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoon AS
- York A
- Yumiceva F
- Yun JC
- Yuste C
- Zabi A
- Zabolotny W
- Zachariadou A
- Zalewski P
- Zampieri A
- Zanetti M
- Zang SL
- Zarubin A
- Zatzerklyany A
- Zeidler C
- Zeinali M
- Zeise M
- Zelepoukine S
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang L
- Zhang Y
- Zhang Z
- Zheng Y
- Zhiltsov V
- Zhokin A
- Zhu B
- Zhu K
- Zhu RY
- Zhukov V
- Zhukova V
- Ziebarth EB
- Zielinski M
- Zilizi G
- Zinonos Z
- Zito G
- Zoeller MH
- Zotto P
- Zub S
- Zumerle G
- Zuranski A
- Zuyeuski R
- Zych P
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2009
- Field of study
The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device
in the CMS endcaps. Their performance has been evaluated using data taken
during a cosmic ray run in fall 2008. Measured noise levels are low, with the
number of noisy channels well below 1%. Coordinate resolution was measured for
all types of chambers, and fall in the range 47 microns to 243 microns. The
efficiencies for local charged track triggers, for hit and for segments
reconstruction were measured, and are above 99%. The timing resolution per
layer is approximately 5 ns
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