183 research outputs found
A Genome-Wide Collection of Mos1 Transposon Insertion Mutants for the C. elegans Research Community
- Author
- A Paruzynski
- C Frokjaer-Jensen
- C Frokjaer-Jensen
- Caroline Borrel
- D Bazopoulou
- Edwige Martin
- Elisabeth Cortier
- Elodie Vallin
- EM Schwarz
- F Pauli
- I Engelmann
- JL Bessereau
- Jonathan J. Ewbank
- Joseph Gallagher
- Julien Maurizio
- Jérôme Belougne
- Karima Abouzid
- Kathrin Gieseler
- L Granger
- Laure Granger
- Laurent Ségalat
- M Gendrel
- Maité Carre-Pierrat
- N Pujol
- Patricia E. Kuwabara
- Sarah Scaglione
- SK Kim
- T Boulin
- T Stiernagle
- Todd Lamitina
- TW Harris
- V Robert
- Y Duverger
- Yohann Duverger
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
Methods that use homologous recombination to engineer the genome of C. elegans commonly use strains carrying specific insertions of the heterologous transposon Mos1. A large collection of known Mos1 insertion alleles would therefore be of general interest to the C. elegans research community. We describe here the optimization of a semi-automated methodology for the construction of a substantial collection of Mos1 insertion mutant strains. At peak production, more than 5,000 strains were generated per month. These strains were then subject to molecular analysis, and more than 13,300 Mos1 insertions characterized. In addition to targeting directly more than 4,700 genes, these alleles represent the potential starting point for the engineered deletion of essentially all C. elegans genes and the modification of more than 40% of them. This collection of mutants, generated under the auspices of the European NEMAGENETAG consortium, is publicly available and represents an important research resource
A Modified Consumer Inkjet for Spatiotemporal Control of Gene Expression
- Author
- A Ahmadzadeh
- AL Lehninger
- C Lausted
- Christophe Herman
- D Chena
- D Zicha
- Daniel J. Cohen
- DL Cohen
- EA Roth
- EM Ozbudak
- G Gurtner
- G Mayer
- GC Ellis-Davies
- H Fujikawa
- I Shestopalov
- J Ducree
- J Merrin
- JD Murray
- JH Park
- JJ Chambers
- JT Bonner
- K Amonlirdviman
- L Wolpert
- LN Jeon
- M Lutolf
- M Madou
- MC Peterman
- Michel M. Maharbiz
- MJ Dunlop
- N Yildirim
- P Wong
- PG Campbell
- RE Saunders
- RF Ismagilov
- Roberto C. Morfino
- S Basu
- S Boyden
- S Ilkhanizadeh
- T Bansal
- T Boland
- T Boland
- T Brown
- TM Keenan
- TW Engelmann
- W Gu
- W Saadi
- WJ Rosoff
- Publication venue
- Public Library of Science
- Publication date
- 18/09/2009
- Field of study
This paper presents a low-cost inkjet dosing system capable of continuous, two-dimensional spatiotemporal regulation of gene expression via delivery of diffusible regulators to a custom-mounted gel culture of E. coli. A consumer-grade, inkjet printer was adapted for chemical printing; E. coli cultures were grown on 750 µm thick agar embedded in micro-wells machined into commercial compact discs. Spatio-temporal regulation of the lac operon was demonstrated via the printing of patterns of lactose and glucose directly into the cultures; X-Gal blue patterns were used for visual feedback. We demonstrate how the bistable nature of the lac operon's feedback, when perturbed by patterning lactose (inducer) and glucose (inhibitor), can lead to coordination of cell expression patterns across a field in ways that mimic motifs seen in developmental biology. Examples of this include sharp boundaries and the generation of traveling waves of mRNA expression. To our knowledge, this is the first demonstration of reaction-diffusion effects in the well-studied lac operon. A finite element reaction-diffusion model of the lac operon is also presented which predicts pattern formation with good fidelity
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
- Acerbi E
- Acharya BS
- Adams DL
- Addy TN
- Adelman J
- Aderholz M
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akdogana T
- Akesson TPA
- Akimoto G
- Akimov AV
- Akiyama A
- Aktas A
- Alam MA
- Alam MS
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Aliyev M
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alviggi MG
- Amako K
- Amaral P
- Amelung C
- Ammosov VV
- Amorim A
- Amoros G
- Amram N
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Andrieux M-L
- Anduaga XS
- Angerami A
- Anghinolfi F
- Anh TV
- Anjos N
- Annovi A
- Antonaki A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
- Aoun S
- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Aranda CP
- Arce ATH
- Archambault JP
- Arfaoui S
- Arguin J-F
- Arik E
- Arik M
- Armbruster AJ
- Arnaez O
- Arnault C
- Artamonov A
- Artoni G
- Arutinov D
- Asai S
- Asfandiyarov R
- Ask S
- Asman B
- Asner D
- Asquith L
- Assamagan K
- Astbury A
- Astvatsatourov A
- Atoian G
- Aubert B
- Auge E
- Augsten K
- Aurousseau M
- Austin N
- Avolio G
- Avramidou R
- Axen D
- Ay C
- Azuelos G
- Azuma Y
- Baak MA
- Baccaglioni G
- Bacci C
- Bach AM
- Bachacou H
- Bachas K
- Bachy G
- Backes M
- Backhaus M
- Badescu E
- Bagnaia P
- Bahinipati S
- Bai Y
- Bailey DC
- Bain T
- Baines JT
- Baker MD
- Baker OK
- Baker S
- Banas E
- Banerjee P
- Banerjee S
- Banfi D
- Bangert A
- Bansal V
- Bansil HS
- Barajas CAC
- Barak L
- Baranov SP
- Barashkou A
- Barber T
- Barberio EL
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- Bardin DY
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- Barisonzi M
- Barklow T
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- Barnett BM
- Barnett RM
- Baroncelli A
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- Barr AJ
- Barreiro F
- Barrera CO
- Barrillon P
- Bartoldus R
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- Bednyakov VA
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- Belanger-Champagne C
- Belenguer MJ
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- Cheong ALF
- Cheplakov A
- Chepurnov VF
- Chernyatin V
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- Chromek-Burckhart D
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- Zarzhitsky P
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- Zhemchugov A
- Zheng S
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- Zitoun R
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2013
- Field of study
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of √s = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pT≥20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60≤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2≤{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration
Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector
- Author
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- Abdesselam A
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- Usai G
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- Valenta J
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- Valladolid Gallego E
- Vallecorsa S
- Valls Ferrer JA
- van der Graaf H
- van der Kraaij E
- van der Poel E
- van der Ster D
- Van Eijk B
- van Eldik N
- van Gemmeren P
- van Kesteren Z
- van Vulpen I
- Vandelli W
- Vandoni G
- Vaniachine A
- Vankov P
- Vannucci F
- Vari R
- Varnes EW
- Varouchas D
- Vartapetian A
- Varvell KE
- Vassilakopoulos VI
- Vazeille F
- Vegni G
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- Vermeulen JC
- Vertogardov L
- Vest A
- Vetterli MC
- Vichou I
- Vickey T
- Viegas FJTA
- Viehhauser GHA
- Viel S
- Villa M
- Villaplana Perez M
- Vilucchi E
- Vincter MG
- Vinek E
- Vinogradov VB
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- Virzi J
- Vitale A
- Vitells O
- Vivarelli I
- Vives Vaque F
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- Vogel A
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- von der Schmitt H
- von Loeben J
- von Radziewski H
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- Vorobel V
- Vorobiev AP
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- Vos M
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- Voss TT
- Vossebeld JH
- Vovenko AS
- Vranjes N
- Vrba V
- Vreeswijk M
- Vuillermet R
- Vukotic I
- Wagner P
- Wagner W
- Wahlen H
- Wakabayashi J
- Walbersloh J
- Walch S
- Walder J
- Walker R
- Walkowiak W
- Wall R
- Waller P
- Wang C
- Wang H
- Wang J
- Wang JC
- Wang SM
- Warburton A
- Ward CP
- Warsinsky M
- Watkins PM
- Watson AT
- Watson MF
- Watts G
- Watts S
- Waugh AT
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- Weber J
- Weber M
- Weber MS
- Weber P
- Weidberg AR
- Weingarten J
- Weiser C
- Wellenstein H
- Wells PS
- Wen M
- Wenaus T
- Wendler S
- Weng Z
- Wengler T
- Wenig S
- Wermes N
- Werner M
- Werner P
- Werth M
- Wessels M
- Whalen K
- Wheeler-Ellis SJ
- Whitaker SP
- White A
- White MJ
- White S
- Whitehead SR
- Whiteson D
- Whittington D
- Wicek F
- Wicke D
- Wickens FJ
- Wiedenmann W
- Wielers M
- Wienemann P
- Wiglesworth C
- Wiik LAM
- Wildauer A
- Wildt MA
- Wilhelm I
- Wilkens HG
- Will JZ
- Williams E
- Williams HH
- Willis W
- Willocq S
- Wilson A
- Wilson JA
- Wilson MG
- Wingerter-Seez I
- Winkelmann S
- Winklmeier F
- Wittgen M
- Wolter MW
- Wolters H
- Wooden G
- Wosiek BK
- Wotschack J
- Woudstra MJ
- Wraight K
- Wright C
- Wrona B
- Wu SL
- Wu X
- Wu Y
- Wulf E
- Wunstorf R
- Wynne BM
- Xaplanteris L
- Xella S
- Xie S
- Xie Y
- Xu C
- Xu D
- Xu G
- Yabsley B
- Yagci KD
- Yamada M
- Yamamoto A
- Yamamoto K
- Yamamoto S
- Yamamura T
- Yamaoka J
- Yamazaki T
- Yamazaki Y
- Yan Z
- Yang H
- Yang S
- Yang UK
- Yang Y
- Yang Y
- Yang Z
- Yanush S
- Yao W-M
- Yao Y
- Yasu Y
- Ye J
- Ye S
- Yildiz HD
- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Young C
- Youssef S
- Yu D
- Yu J
- Yu J
- Yuan L
- Yurkewicz A
- Zaets VG
- Zaidan R
- Zaitsev AM
- Zajacova Z
- Zalite YK
- Zanello L
- Zarzhitsky P
- Zaytsev A
- Zdrazil M
- Zeitnitz C
- Zeller M
- Zema PF
- Zemla A
- Zendler C
- Zenin AV
- Zenin O
- Zenis T
- Zenonos Z
- Zenz S
- Zerwas D
- Zhan Z
- Zhang D
- Zhang H
- Zhang J
- Zhang X
- Zhang Z
- Zhao L
- Zhao T
- Zhao Z
- Zhemchugov A
- Zheng S
- Zhong J
- Zhou B
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu Y
- Zhuang X
- Zhuravlov V
- Zieminska D
- Zilka B
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- Zolnierowski Y
- Zsenei A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/12/2010
- Field of study
The inclusive and dijet production cross-sections have been measured for jets
containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass
energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The
measurements use data corresponding to an integrated luminosity of 34 pb^-1.
The b-jets are identified using either a lifetime-based method, where secondary
decay vertices of b-hadrons in jets are reconstructed using information from
the tracking detectors, or a muon-based method where the presence of a muon is
used to identify semileptonic decays of b-hadrons inside jets. The inclusive
b-jet cross-section is measured as a function of transverse momentum in the
range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet
cross-section is measured as a function of the dijet invariant mass in the
range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets
and the angular variable chi in two dijet mass regions. The results are
compared with next-to-leading-order QCD predictions. Good agreement is observed
between the measured cross-sections and the predictions obtained using POWHEG +
Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet
cross-section. However, it does not reproduce the measured inclusive
cross-section well, particularly for central b-jets with large transverse
momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final
version published in European Physical Journal
6-OHDA-induced dopaminergic neurodegeneration in <i>Caenorhabditis elegans</i> is promoted by the engulfment pathway and inhibited by the transthyretin-related protein TTR-33
- Author
- A Delamarre
- A Drozdetskiy
- A Schober
- ALA Nichols
- AM Waterhouse
- Anton Gartner
- B Conradt
- B Neumann
- B Neumann
- B Thomas
- C Frøkjaer-Jensen
- C Frøkjær-Jensen
- C Klein
- C Treitz
- CM Long-Smith
- CP González-Hunt
- D Hoogewijs
- DE Shore
- DJ Hoeppner
- DL Chase
- E Lionaki
- E Neumann-haefelin
- F He
- G Minevich
- GC Brown
- H Saverwyns
- H Sies
- HL Johnsen
- I Engelmann
- J a Melo
- J Bornhorst
- J Jacob
- J Mapes
- J Sulston
- J-SS Yang
- JW Langston
- KA Wright
- Kim Caldwell
- L Hao
- L Käll
- LJ Neukomm
- M a Hibbs
- M Biasini
- M Doitsidou
- M Uno
- Massimo A. Hilliard
- MG Andrusiak
- MT Heneka
- N Guex
- O Thompson
- P Chen
- P Gerke
- P Pu
- P V Troshin
- PW Reddien
- PW Reddien
- R Dreos
- R Fu
- R Kostrzewa
- R Nass
- R Nass
- RP Oliveira
- S Arvidsson
- S Richardson
- S Sanyal
- S Schmeisser
- Sarah-Lena Offenburger
- Sean Coakley
- SJ McKay
- SW Oh
- TD Schmittgen
- Theresa Tachie-Menson
- TW Harris
- W Li
- X Wang
- X Wang
- Xue Yan Ho
- Y Kang
- Y Zhang
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2018
- Field of study
<div><p>Oxidative stress is linked to many pathological conditions including the loss of dopaminergic neurons in Parkinson’s disease. The vast majority of disease cases appear to be caused by a combination of genetic mutations and environmental factors. We screened for genes protecting <i>Caenorhabditis elegans</i> dopaminergic neurons from oxidative stress induced by the neurotoxin 6-hydroxydopamine (6-OHDA) and identified the <u>t</u>rans<u>t</u>hyretin-<u>r</u>elated gene <i>ttr-33</i>. The only described <i>C</i>. <i>elegans</i> transthyretin-related protein to date, TTR-52, has been shown to mediate corpse engulfment as well as axon repair. We demonstrate that TTR-52 and TTR-33 have distinct roles. TTR-33 is likely produced in the posterior arcade cells in the head of <i>C</i>. <i>elegans</i> larvae and is predicted to be a secreted protein. TTR-33 protects <i>C</i>. <i>elegans</i> from oxidative stress induced by paraquat or H<sub>2</sub>O<sub>2</sub> at an organismal level. The increased oxidative stress sensitivity of <i>ttr-33</i> mutants is alleviated by mutations affecting the KGB-1 MAPK kinase pathway, whereas it is enhanced by mutation of the JNK-1 MAPK kinase. Finally, we provide genetic evidence that the <i>C</i>. <i>elegans</i> cell corpse engulfment pathway is required for the degeneration of dopaminergic neurons after exposure to 6-OHDA. In summary, we describe a new neuroprotective mechanism and demonstrate that TTR-33 normally functions to protect dopaminergic neurons from oxidative stress-induced degeneration, potentially by acting as a secreted sensor or scavenger of oxidative stress.</p></div
Expert Financial Advice Neurobiologically “Offloads” Financial Decision-Making under Risk
- Author
- A Kühberger
- A Tversky
- AG Sanfey
- Alessandro Antonietti
- AN McCoy
- AN McCoy
- B King-Casas
- B Wicker
- BA Vogt
- C Camerer
- C. Monica Capra
- CD Fiorillo
- CD Frith
- CF Zink
- CF Zink
- CF Zink
- Charles Noussair
- CM Kuhnen
- D Kahneman
- D Prelec
- D Schluppeck
- DM Small
- EC Ferstl
- EM Tricomi
- F Castelli
- G Wu
- Gregory S. Berns
- GS Berns
- GS Berns
- H Fehr-Duda
- HL Gallagher
- J Derrfuss
- J Grezes
- J Mirenowicz
- J O'Doherty
- J Quiggin
- Jan B. Engelmann
- JE LeDoux
- JK Rilling
- JP Mitchell
- JP O'Doherty
- JW Kable
- K McCabe
- K Vogeley
- L Young
- LP Sugrue
- M Abdellaoui
- M Deutsch
- M Ernst
- M Matsumoto
- ME Raichle
- ML Platt
- ML Platt
- MN Shadlen
- MP Paulus
- MP Paulus
- MR Delgado
- O Hikosaka
- PN Tobler
- PW Glimcher
- R Elliott
- R Gonzalez
- R Saxe
- R Saxe
- RD Luce
- RL Buckner
- RM Birn
- RS Woodruff
- RT Schultz
- S Bonaccio
- SA Huettel
- SA Huettel
- T Ljungberg
- T Singer
- TW Robbins
- U Frith
- W Schultz
- W Schultz
- Y Cho
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2009
- Field of study
BACKGROUND: Financial advice from experts is commonly sought during times of uncertainty. While the field of neuroeconomics has made considerable progress in understanding the neurobiological basis of risky decision-making, the neural mechanisms through which external information, such as advice, is integrated during decision-making are poorly understood. In the current experiment, we investigated the neurobiological basis of the influence of expert advice on financial decisions under risk. METHODOLOGY/PRINCIPAL FINDINGS: While undergoing fMRI scanning, participants made a series of financial choices between a certain payment and a lottery. Choices were made in two conditions: 1) advice from a financial expert about which choice to make was displayed (MES condition); and 2) no advice was displayed (NOM condition). Behavioral results showed a significant effect of expert advice. Specifically, probability weighting functions changed in the direction of the expert's advice. This was paralleled by neural activation patterns. Brain activations showing significant correlations with valuation (parametric modulation by value of lottery/sure win) were obtained in the absence of the expert's advice (NOM) in intraparietal sulcus, posterior cingulate cortex, cuneus, precuneus, inferior frontal gyrus and middle temporal gyrus. Notably, no significant correlations with value were obtained in the presence of advice (MES). These findings were corroborated by region of interest analyses. Neural equivalents of probability weighting functions showed significant flattening in the MES compared to the NOM condition in regions associated with probability weighting, including anterior cingulate cortex, dorsolateral PFC, thalamus, medial occipital gyrus and anterior insula. Finally, during the MES condition, significant activations in temporoparietal junction and medial PFC were obtained. CONCLUSIONS/SIGNIFICANCE: These results support the hypothesis that one effect of expert advice is to "offload" the calculation of value of decision options from the individual's brain
Logarithmic sensing in Bacillus subtilis aerotaxis
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
Aerotaxis, the directed migration along oxygen gradients, allows many microorganisms to locate favorable oxygen concentrations.
Despite oxygen’s fundamental role for life, even key aspects of aerotaxis remain poorly understood. In Bacillus subtilis, for example,
there is conflicting evidence of whether migration occurs to the maximal oxygen concentration available or to an optimal
intermediate one, and how aerotaxis can be maintained over a broad range of conditions. Using precisely controlled oxygen
gradients in a microfluidic device, spanning the full spectrum of conditions from quasi-anoxic to oxic (60 n mol/l–1 m mol/l), we
resolved B. subtilis’ ‘oxygen preference conundrum’ by demonstrating consistent migration towards maximum oxygen
concentrations (‘monotonic aerotaxis’). Surprisingly, the strength of aerotaxis was largely unchanged over three decades in oxygen
concentration (131 n mol/l–196 μ mol/l). We discovered that in this range B. subtilis responds to the logarithm of the oxygen
concentration gradient, a rescaling strategy called ‘log-sensing’ that affords organisms high sensitivity over a wide range of
conditions. In these experiments, high-throughput single-cell imaging yielded the best signal-to-noise ratio of any microbial taxis
study to date, enabling the robust identification of the first mathematical model for aerotaxis among a broad class of alternative
models. The model passed the stringent test of predicting the transient aerotactic response despite being developed on steadystate
data, and quantitatively captures both monotonic aerotaxis and log-sensing. Taken together, these results shed new light on
the oxygen-seeking capabilities of B. subtilis and provide a blueprint for the quantitative investigation of the many other forms of
microbial taxis
High intravascular tissue factor—but not extracellular microvesicles—in septic patients is associated with a high SAPS II score
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Measurement of the cross-section for b-jets produced in association with a Z boson at root s=7 TeV with the ATLAS detector ATLAS Collaboration
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
- Acerbi E
- Acharya BS
- Adams DL
- Addy TN
- Adelman J
- Aderholz M
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akdogan T
- Akesson TPA
- Akimoto G
- Akimov AV
- Akiyama A
- Alam MA
- Alam MS
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Aliyev M
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alviggi MG
- Amako K
- Amaral P
- Amelung C
- Ammosov VV
- Amorim A
- Amoros G
- Amram N
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Andrieux M-L
- Anduaga XS
- Angerami A
- Anghinolfi F
- Anh TV
- Anjos N
- Annovi A
- Antonaki A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
- Aoun S
- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Arce ATH
- Archambault JP
- Arfaoui S
- Arguin J-F
- Arik E
- Arik M
- Armbruster AJ
- Arnaez O
- Arnault C
- Artamonov A
- Artoni G
- Arutinov D
- Asai S
- Asfandiyarov R
- Ask S
- Asman B
- Asquith L
- Assamagan K
- Astbury A
- Astvatsatourov A
- Atoian G
- Aubert B
- Auge E
- Augsten K
- Aurousseau M
- Austin N
- Avolio G
- Avramidou R
- Axen D
- Ay C
- Azuelos G
- Azuma Y
- Baak MA
- Baccaglioni G
- Bacci C
- Bach AM
- Bachacou H
- Bachas K
- Bachy G
- Backes M
- Backhaus M
- Badescu E
- Bagnaia P
- Bahinipati S
- Bai Y
- Bailey DC
- Bain T
- Baines JT
- Baker MD
- Baker OK
- Baker S
- Banas E
- Banerjee P
- Banerjee S
- Banfi D
- Bangert A
- Bansal V
- Bansil HS
- Barajas CAC
- Barak L
- Baranov SP
- Barashkou A
- Barber T
- Barberio EL
- Barberis D
- Barbero M
- Bardin DY
- Barillari T
- Barisonzi M
- Barklow T
- Barlow N
- Barnett BM
- Barnett RM
- Baroncellia A
- Barone G
- Barr AJ
- Barreiro F
- Barrera CO
- Barrillon P
- Bartoldus R
- Barton AE
- Bartsch D
- Bartsch V
- Bates RL
- Batkovaa L
- Batley JR
- Battaglia A
- Battistin M
- Battistonia G
- Bauer F
- Bawa HS
- Beare B
- Beau T
- Beauchemin PH
- Beccherlea R
- Bechtle R
- Beck HP
- Beckingham M
- Becks KH
- Beddallc A
- Beddallc AJ
- Bedikian S
- Bednyakov VA
- Bee CP
- Begel M
- Behera PK
- Beimforde M
- Belanger-Champagne C
- Belenguer MJ
- Bell PJ
- Bell WH
- Bella G
- Bella LA
- Bellagambaa L
- Bellina F
- Bellomo M
- Belloni A
- Beloborodova O
- Belotskiy K
- Beltramello O
- Ben Ami S
- Benary O
- Benchekrouna D
- Benchouk C
- Bendel M
- Benekos N
- Benhammou Y
- Benjamin DP
- Benoit M
- Bensinger JR
- Benslama K
- Bentvelsen S
- Berge D
- Berger N
- Berghaus F
- Berglund E
- Beringer J
- Bernardet K
- Bernat P
- Bernhard R
- Bernius C
- Berry T
- Bertina A
- Bertinelli F
- Bertoluccia F
- Besanaa MI
- Besson N
- Bethke S
- Bhimji W
- Bianchi RM
- Biancoa M
- Biebel O
- Bieniek SR
- Bierwagen K
- Biesiada J
- Bigliettia M
- Bilokon H
- Bindia M
- Binet S
- Bingulc A
- Binia C
- Biscarat C
- Bitenc U
- Black KM
- Blair RE
- Blanchard J-B
- Blanchot G
- Blazeka T
- Blocker C
- Blocki J
- Blondel A
- Blum W
- Blumenschein U
- Bobbink GJ
- Bobrovnikov VB
- Bocchetta SS
- Bocci A
- Boddy CR
- Boehler M
- Boek J
- Boelaert N
- Boeriu OEV
- Boeser S
- Bogaerts JA
- Bogdanchikov A
- Bogouch A
- Bohma C
- Boisvert V
- Bold T
- Boldeaa V
- Bolnet NM
- Bona M
- Bondarenko VG
- Bondioli M
- Boonekamp M
- Boorman G
- Booth CN
- Bordoni S
- Borer C
- Borisov A
- Borissov G
- Borjanovica I
- Borronia S
- Bos K
- Boscherinia D
- Bosman M
- Boterenbrood H
- Botterill D
- Bouchami J
- Boudreau J
- Bouhova-Thacker EV
- Bourdarios C
- Bousson N
- Boveia A
- Boyd J
- Boyko IR
- Bozhko NI
- Bozovic-Jelisavcicb I
- Bracinik J
- Braem A
- Branchinia P
- Brandenburg GW
- Brandt A
- Brandt G
- Brandt O
- Bratzler U
- Brau B
- Brau JE
- Braun HM
- Brelier B
- Bremer J
- Brenner R
- Bressler S
- Breton D
- Britton D
- Brochu FM
- Brock I
- Brock R
- Brodbeck TJ
- Brodet E
- Broggia F
- Bromberg C
- Brooijmans G
- Brooksb WK
- Brown G
- Brown H
- Bruckman de Renstrom PA
- Bruncko D
- Bruneliere R
- Brunet S
- Brunia A
- Brunia G
- Bruschia M
- Buanes T
- Bucci F
- Buchanan J
- Buchanan NJ
- Buchholz P
- Buckingham RM
- Buckley AG
- Budaa SI
- Budagov IA
- Budick B
- Buescher V
- Bueso XP
- Bugge L
- Buira-Clark D
- Bulekov O
- Bunse M
- Buran T
- Burckhart H
- Burdin S
- Burgess T
- Burke S
- Busato E
- Bussey P
- Buszello CP
- Butin F
- Butler B
- Butler JM
- Buttar CM
- Butterworth JM
- Buttinger W
- Byatt T
- Cabrera Urban S
- Caforioa D
- Cakir IT
- Cakira O
- Calafiura P
- Calderini G
- Calfayan P
- Calkins R
- Calobaa LP
- Caloia R
- Calvet D
- Calvet S
- Camarri P
- Cambiaghia M
- Cameron D
- Camillocci ES
- Campana S
- Campanelli M
- Canalea V
- Canelli F
- Canepaa A
- Cantero J
- Capassoa L
- Caprinia I
- Caprinia M
- Capriotti D
- Capuaa M
- Caputo R
- Cardarelli R
- Carli T
- Carlinoa G
- Carminatia L
- Caron S
- Carona B
- Carter AA
- Carter JR
- Carvalhoa J
- Casadei D
- Casado MP
- Cascellaa M
- Casoa C
- Castaneda-Miranda E
- Castanheira MTD
- Castillo Gimenez V
- Castillo LRF
- Castro NF
- Cataldia G
- Cataneo F
- Catinaccio A
- Catmore JR
- Cattai A
- Cattani G
- Caughron S
- Cauza D
- Cavalcanti TP
- Cavalleri P
- Cavalli-Sforza M
- Cavallia D
- Cavasinnia V
- Ceradinia F
- Cerqueiraa AS
- Cerri A
- Cerrito L
- Cerutti F
- Cetinb SA
- Ceveninia F
- Chafaqa A
- Chakraborty D
- Chan K
- Chapleau B
- Chapman JD
- Chapman JW
- Chareyre E
- Charlton DG
- Chavda V
- Cheatham S
- Chekanov S
- Chekulaeva SV
- Chelkov GA
- Chelstowska MA
- Chen C
- Chen H
- Chen X
- Chenc S
- Chenc T
- Chenga S
- Cheong ALF
- Cheplakov A
- Chepurnov VF
- Cherkaoui El Moursli R
- Chernyatin V
- Cheu E
- Cheung SL
- Chevalier L
- Chiefaria G
- Chikovani L
- Childersa JT
- Chilingarov A
- Chiodinia G
- Chizhov MV
- Choudalakis G
- Chouridou S
- Christidi IA
- Christov A
- Chromek-Burckhart D
- Chu ML
- Chudoba J
- Ciapettia G
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- Ciftcia AK
- Ciftcia R
- Cinca D
- Cindro V
- Ciobotaru MD
- Cioccaa C
- Ciocio A
- Cirilli M
- Ciubancana M
- Clark A
- Clark PJ
- Cleland W
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- Zimmermann S
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- Zitoun R
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- Zmouchko VV
- Zobernig G
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- Zolnierowski Y
- Zsenei A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2011
- Field of study
A measurement is presented of the inclusive cross-section for b-jet production in association with a Z boson in pp collisions at a centre-of-mass energy of root s = 7 TeV. The analysis uses the data sample collected by the ATLAS experiment in 2010, corresponding to an integrated luminosity of approximately 36 pb(-1). The event selection requires a Z boson decaying into high P-T electrons or muons, and at least one b-jet, identified by its displaced vertex, with transverse momentum p(T) > 25 GeV and rapidity vertical bar y vertical bar < 2.1. After subtraction of background processes, the yield is extracted from the vertex mass distribution of the candidate b-jets. The ratio of this cross-section to the inclusive Z cross-section (the average number of b-jets per Z event) is also measured. Both results are found to be in good agreement with perturbative QCD predictions at next-to-leading order
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
- A Abbott
- A Abou-Raya
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- W Tungwiwat
- WA Cass
- WB Dunn
- WB Ershler
- WB Kannel
- WI Leong
- WJ Jo
- WK Adkins
- WL Neeley
- WM Campana
- WR Farwell
- WR Markesbery
- WR Markesbery
- WS Jeong
- WS Yang
- WW Huber
- WW Wong
- WY Ong
- X Chen
- X Chen
- X He
- X Huang
- X Huang
- X Huang
- X Li
- X Zhang
- X Zhu
- X Zhu
- XD Huang
- XJ Li
- XM Yuan
- XM Yuan
- XP Huang
- Y Almog
- Y Avramovich-Tirosh
- Y Bao
- Y Bdolah
- Y Chen
- Y Christen
- Y Curin
- Y Deugnier
- Y Deugnier
- Y Engin-Üstün
- Y Ge
- Y Gilgun-Sherki
- Y Haruna
- Y Honda
- Y Hua
- Y Ikeda
- Y Jiao
- Y Jung
- Y Ke
- Y Ke
- Y Kohgo
- Y Kohgo
- Y Levites
- Y Li
- Y Okatani
- Y Okatani
- Y Sai
- Y Sai
- Y Sun
- Y Takada
- Y Wang
- Y Wang
- Y Wei
- Y Wei
- Y Wu
- Y Wu
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhao
- Y Zheng
- YE Henrotin
- YF Chu
- YH Lee
- YH Suh
- YH Wei
- YJ Surh
- YJ Surh
- YJ Surh
- YK Wu
- YM Kim
- YS Keum
- YS Sohn
- YX Ma
- YZ Fang
- Z Cai
- Z Cai
- Z Cheng
- Z Pei
- Z Serdar
- Z Tong
- Z Tong
- Z Yu
- Z Zhang
- ZD Liu
- ZD Liu
- ZE Karanjawala
- ZE Suntres
- ZI Cabantchik
- ZZ Chong
- ZZ Chong
- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
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