Sketch-n-Sketch: Output-Directed Programming for SVG

For creative tasks, programmers face a choice: Use a GUI and sacrifice flexibility, or write code and sacrifice ergonomics? To obtain both flexibility and ease of use, a number of systems have explored a workflow that we call output-directed programming. In this paradigm, direct manipulation of the program's graphical output corresponds to writing code in a general-purpose programming language, and edits not possible with the mouse can still be enacted through ordinary text edits to the program. Such capabilities provide hope for integrating graphical user interfaces into what are currently text-centric programming environments. To further advance this vision, we present a variety of new output-directed techniques that extend the expressive power of Sketch-n-Sketch, an output-directed programming system for creating programs that generate vector graphics. To enable output-directed interaction at more stages of program construction, we expose intermediate execution products for manipulation and we present a mechanism for contextual drawing. Looking forward to output-directed programming beyond vector graphics, we also offer generic refactorings through the GUI, and our techniques employ a domain-agnostic provenance tracing scheme. To demonstrate the improved expressiveness, we implement a dozen new parametric designs in Sketch-n-Sketch without text-based edits. Among these is the first demonstration of building a recursive function in an output-directed programming setting.Comment: UIST 2019 Paper + Appendi

Azimuthal anisotropy of charged jet production in root s(NN)=2.76 TeV Pb-Pb collisions

We present measurements of the azimuthal dependence of charged jet production in central and semi-central root s(NN) = 2.76 TeV Pb-Pb collisions with respect to the second harmonic event plane, quantified as nu(ch)(2) (jet). Jet finding is performed employing the anti-k(T) algorithm with a resolution parameter R = 0.2 using charged tracks from the ALICE tracking system. The contribution of the azimuthal anisotropy of the underlying event is taken into account event-by-event. The remaining (statistical) region-to-region fluctuations are removed on an ensemble basis by unfolding the jet spectra for different event plane orientations independently. Significant non-zero nu(ch)(2) (jet) is observed in semi-central collisions (30-50% centrality) for 20 <p(T)(ch) (jet) <90 GeV/c. The azimuthal dependence of the charged jet production is similar to the dependence observed for jets comprising both charged and neutral fragments, and compatible with measurements of the nu(2) of single charged particles at high p(T). Good agreement between the data and predictions from JEWEL, an event generator simulating parton shower evolution in the presence of a dense QCD medium, is found in semi-central collisions. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Peer reviewe

Forward-central two-particle correlations in p-Pb collisions at root s(NN)=5.02 TeV

Two-particle angular correlations between trigger particles in the forward pseudorapidity range (2.5 2GeV/c. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B. V.Peer reviewe

Event-shape engineering for inclusive spectra and elliptic flow in Pb-Pb collisions at root(NN)-N-S=2.76 TeV

Peer reviewe

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Pseudorapidity and transverse-momentum distributions of charged particles in proton-proton collisions at root s=13 TeV

The pseudorapidity (eta) and transverse-momentum (p(T)) distributions of charged particles produced in proton-proton collisions are measured at the centre-of-mass energy root s = 13 TeV. The pseudorapidity distribution in vertical bar eta vertical bar <1.8 is reported for inelastic events and for events with at least one charged particle in vertical bar eta vertical bar <1. The pseudorapidity density of charged particles produced in the pseudorapidity region vertical bar eta vertical bar <0.5 is 5.31 +/- 0.18 and 6.46 +/- 0.19 for the two event classes, respectively. The transverse-momentum distribution of charged particles is measured in the range 0.15 <p(T) <20 GeV/c and vertical bar eta vertical bar <0.8 for events with at least one charged particle in vertical bar eta vertical bar <1. The evolution of the transverse momentum spectra of charged particles is also investigated as a function of event multiplicity. The results are compared with calculations from PYTHIA and EPOS Monte Carlo generators. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Peer reviewe

Elliptic flow of muons from heavy-flavour hadron decays at forward rapidity in Pb-Pb collisions at root s(NN)=2.76TeV

The elliptic flow, v(2), of muons from heavy-flavour hadron decays at forward rapidity (2.5 <y <4) is measured in Pb-Pb collisions at root s(NN)= 2.76TeVwith the ALICE detector at the LHC. The scalar product, two- and four-particle Q cumulants and Lee-Yang zeros methods are used. The dependence of the v(2) of muons from heavy-flavour hadron decays on the collision centrality, in the range 0-40%, and on transverse momentum, p(T), is studied in the interval 3 <p(T)<10 GeV/c. A positive v(2) is observed with the scalar product and two-particle Q cumulants in semi-central collisions (10-20% and 20-40% centrality classes) for the p(T) interval from 3 to about 5GeV/c with a significance larger than 3 sigma, based on the combination of statistical and systematic uncertainties. The v(2) magnitude tends to decrease towards more central collisions and with increasing pT. It becomes compatible with zero in the interval 6 <p(T)<10 GeV/c. The results are compared to models describing the interaction of heavy quarks and open heavy-flavour hadrons with the high-density medium formed in high-energy heavy-ion collisions. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V.Peer reviewe

Was sagt die LAC-Depressionsstudie wirklich aus? Eine methodenkritische Betrachtung.

Mit großem Interesse haben wir daher die erneute Publikation (Leuzinger-Bohleber, Hautzinger, Keller, et al., 2019) der Ergebnisse der Studie zu Langzeitbehandlungen bei chronisch depressiven Patienten (kurz: LAC-Studie) gelesen. Bislang haben die Autoren die regelmäßig veröffentlichten „Tranchen“ des sicherlich beträchtlichen Datensatzes dieses Forschungsprojektes lediglich im kleinen Kreis diskutiert. Da dieses Mal auch in Medien für interessierte Laien (Padberg, 2019) darüber berichtet wurde und die Studie als Beleg für eine vergleichbare Effektivität von Psychoanalyse und kognitiver Verhaltenstherapie verwendet wird, würden wir gerne die Gelegenheit wahrnehmen, diese zu kommentieren

Was sagt die LAC-Depressionsstudie wirklich aus?

Hintergrund Kognitiv-behaviorale und psychodynamische Therapieverfahren befinden sich in einem Konkurrenzverhältnis, was den Nachweis ihrer Wirksamkeit angeht. Obwohl es bereits vergleichende Wirksamkeitsstudien gab, bilden diese oft nicht die Versorgungssituation in Deutschland ab. Anfang des Jahres wurden die Ergebnisse der „LAC-Depressionsstudie“ vorgelegt, die diese beiden Verfahren in einem naturalistischen Studiendesign vergleicht. Diese Ergebnisse suggerieren die gleiche Effektivität von kognitiver Verhaltenstherapie (KVT) und psychoanalytischer Therapie (PAT). Material und Methode Methodenkritische Betrachtung mehrerer, aus den Ergebnissen der LAC-Depressionsstudie publizierter Forschungsberichte, alternative Darstellung der primären Ergebnismaße relativ zur Anzahl der Behandlungssitzungen. Ergebnisse Die LAC-Depressionsstudie wich an entscheidenden Stellen vom vorher veröffentlichten Versuchsprotokoll ab. Die KVT erreicht die gleichen Ergebnisse mit deutlich weniger Therapiesitzungen. Das Versuchsdesign sowie die erreichte Stichprobengröße sind ungeeignet, um die in den Hypothesen vermuteten Effekte nachzuweisen. Schlussfolgerungen Aufgrund von methodischen Problemen, teils deutlichen Abweichungen vom Studienprotokoll und gravierenden Dosis-Wirkung-Unterschieden können die Ergebnisse dieser Studie jedoch nicht als Beleg für eine vermeintlich gleiche Effektivität von PAT und KVT gewertet werden.(VLID)459315

燒津鰹漁業に於ける船仲組織(上) - 本邦漁業に特異なる勞働組織の一例 -

We report on the measurement of freeze-out radii for pairs of identical-charge pions measured in Pb-Pb collisions at √sNN = 2.76 TeV as a function of collision centrality and the average transverse momentum of the pair kT. Three-dimensional sizes of the system (femtoscopic radii), as well as direction-averaged onedimensional radii are extracted. The radii decrease with kT, following a power-law behavior. This is qualitatively consistent with expectations from a collectively expanding system, produced in hydrodynamic calculations. The radii also scale linearly with _dNch/dη_1/3. This behavior is compared to world data on femtoscopic radii in heavy-ion collisions. While the dependence is qualitatively similar to results at smaller √sNN, a decrease in the ratio Rout/Rside is seen, which is in qualitative agreement with a specific prediction from hydrodynamic models: a change from inside-out to outside-in freeze-out configuration. The results provide further evidence for the production of a collective, strongly coupled system in heavy-ion collisions at the CERN Large Hadron Collider