1,954 research outputs found

    Immune-related adverse events in the treatment of non-Hodgkin lymphoma with immune checkpoint inhibitors

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    Immune checkpoint inhibitors (ICIs) show efficacy in the treatment of non-Hodgkin lymphomas (NHL). However, these agents are associated with a unique group of side effects called immune-related adverse events (irAEs). We conducted an observational retrospective/prospective study on patients with relapsed/refractory NHL treated with ICI to determine the incidence of irAEs assessing the type, severity, and timing of onset, outcome and relationship with study drugs of these events. Thirty-two patients underwent ICI as single agent (N = 20) or in combination (N = 12). Ten patients (31.3%) developed at least one irAE for a total of 17 irAEs. Median time to presentation of irAEs was 69 days (range 0–407) with a median resolution time of 16 days (range 0–98). Progression free survival at 24 months for patients who developed an irAE was 40% and 31.8% for who did not. Overall survival for the two groups did not differ (at 24 months 40.0% and 62.5% for patients without and with irAE, respectively), but the median for who developed an irAE was not reached. The incidence of irAEs was associated with better long-term survival in NHL treated with ICIs but patients’ disease conditions need to be carefully evaluated to decide the optimal management

    Response of microchannel plates in ionization mode to single particles and electromagnetic showers

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    Hundreds of concurrent collisions per bunch crossing are expected at future hadron colliders. Precision timing calorimetry has been advocated as a way to mitigate the pileup effects and, thanks to their excellent time resolution, microchannel plates (MCPs) are good candidate detectors for this goal. We report on the response of MCPs, used as secondary emission detectors, to single relativistic particles and to electromagnetic showers. Several prototypes, with different geometries and characteristics, were exposed to particle beams at the INFN-LNF Beam Test Facility and at CERN. Their time resolution and efficiency are measured for single particles and as a function of the multiplicity of particles. Efficiencies between 50% and 90% to single relativistic particles are reached, and up to 100% in presence of a large number of particles. Time resolutions between 20ps and 30ps are obtained.Comment: 20 pages, 9 figures. Paper submitted to NIM

    Aprovechamiento sustentable de los recursos hídricos en el desarrollo de los yacimientos de hidrocarburos no convencionales

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    Fil: Scatizza, Carlos F.. Hidroar S.A. Calle 67 N 1474, (1900) La Plata. Buenos Aires; ArgentinaFil: Hernández, Mario Alberto. Cátedra de Hidrogeología. Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; ArgentinaFil: Preiato, Sergio. Hidroar S.A. Calle 67 N 1474, (1900) La Plata. Buenos Aires; ArgentinaFil: Di Lorenzo, Cintia. Hidroar S.A. Calle 67 N 1474, (1900) La Plata. Buenos Aires; ArgentinaFil: Wocca, Marcos. Hidroar S.A. Calle 67 N 1474, (1900) La Plata. Buenos Aires; Argentin

    Aprovechamiento sustentable de los recursos hídricos en el desarrollo de los yacimientos de hidrocarburos no convencionales

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    Desde fines de los ‘90 Argentina declinó sus reservas hidrocarburíferas en coincidencia con la progresiva disminución de la producción nacional de gas y petróleo. Sin embargo, estudios geológicos-geofísicos posicionan mundialmente al país dentro de los seis con mayores reservas de hidrocarburos no convencionales. Para el desarrollo de estos yacimientos es preciso contar con importantes volúmenes de agua, transformando rocas de baja permeabilidad (pelitas-esquistos) en rocas permeables capaces de transmitir gas o petróleo mediante la técnica “fracking” (fracturación de las rocas por medio de inyección de fluidos a altas presiones hidráulicas). Una cantidad importante de estos reservorios se ubican en regiones áridas de Argentina (Provincias de Neuquén, Mendoza, Chubut, Santa Cruz), donde los recursos hídricos suelen escasear o distan de los yacimientos, siendo los recursos subterráneos una alternativa para exploración. Este trabajo describe las necesidades hídricas para perforación y desarrollo de esta tecnología basado en experiencias de yacimientos no convencionales maduros, describiendo ventajas y problemáticas, particularmente en relación a los recursos hídricos.Since the late '90s Argentina hydrocarbon reserves have declined coinciding with the gradual decline in national production of oil and gas. However, geological-geophysical studies globally positioned the country within six with major unconventional hydrocarbon reserves. For exploration and development of these resources is necessary to have large volumes of water to transform low-permeability rocks (shales, schists) in permeable rocks capable of transmitting gas or oil using the technique "fracking" (fracking rock for injecting fluids at high pressures hydraulic). Significant amount of these reservoirs are located in arid regions of Argentina (Provincia of Neuquén, Mendoza, Chubut, Santa Cruz), where water resources are scarce or far from the deposits, being an alternative underground resources exploration. This paper describes the water requirements for drilling and development of this technology based on experiences of mature unconventional reservoirs, describing advantages and problems, particularly in relation to water resources.Universidad Nacional de La Plat

    Search for supersymmetry in events with photons and missing transverse energy in pp collisions at 13 TeV

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    Search for top squark pair production in pp collisions at root s=13 TeV using single lepton events

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    Observation of Charge-Dependent Azimuthal Correlations in p-Pb Collisions and Its Implication for the Search for the Chiral Magnetic Effect

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    Search for new physics with dijet angular distributions in proton-proton collisions at root S = 13 TeV

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    Search for resonances in the mass spectrum of muon pairs produced in association with b quark jets in proton-proton collisions at root 8 and 13 TeV

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    A search for resonances in the mass range 12-70 GeV produced in association with a b quark jet and a second jet, and decaying to a muon pair, is reported. The analysis is based on data from proton-proton collisions at center-of-mass energies of 8 and 13 TeV, collected with the CMS detector at the LHC and corresponding to integrated luminosities of 19.7 and 35.9 fb(-1), respectively. The search is carried out in two mutually exclusive event categories. Events in the first category are required to have a b quark jet in the central region (|| 2.4) and at least one jet in the forward region (|| > 2.4). Events in the second category are required to have two jets in the central region, at least one of which is identified as a b quark jet, no jets in the forward region, and low missing transverse momentum. An excess of events above the background near a dimuon mass of 28 GeV is observed in the 8 TeV data, corresponding to local significances of 4.2 and 2.9 standard deviations for the first and second event categories, respectively. A similar analysis conducted with the 13 TeV data results in a mild excess over the background in the first event category corresponding to a local significance of 2.0 standard deviations, while the second category results in a 1.4 standard deviation deficit. The fiducial cross section measurements and 95% confidence level upper limits on those for a resonance consistent with the 8 TeV excess are provided at both collision energies

    Search for Evidence of the Type-III Seesaw Mechanism in Multilepton Final States in Proton-Proton Collisions at root s=13 TeV

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