202 research outputs found
Plasma glycosaminoglycan scores in early stage renal cell carcinoma
- Publication venue
- Publication date
- 01/01/2017
- Field of study
Introduction & Objectives
No diagnostic blood biomarker for RCC is currently used in the clinical routine. Using a systems biology approach, we
previously developed a score based on circulating glycosaminoglycans (GAGs) that detected metastatic clear cell
renal cell carcinoma (RCC) with 92.6%, 93.7%, and 100% accuracy vs. healthy subjects using either plasma, urine, or
combined measurements in a validation cohort (Gatto et al., 2016, Cell Reports). It is still unknown if this test is
accurate in early stage RCC or other RCC histologies. The primary endpoint of this study was the area-under-thecurve
(AUC) in the use of plasma GAG scores to detect pre-operative RCC, any stage and any histology, versus healthy
individuals
Epigenetic Mechanisms Regulate Stem Cell Expressed Genes Pou5f1 and Gfra1 in a Male Germ Cell Line
- Author
- A Buageaw
- AH Peters
- Axel Imhof
- B Lehnertz
- BE Bernstein
- BE Bernstein
- C Chen
- C Jiang
- C Payne
- C Schmittwolf
- CB Millar
- CK Naughton
- DG de Rooij
- DG de Rooij
- E Karantzal
- E Metzger
- E Vire
- Erin May
- F Forneris
- F Forneris
- F Nantel
- F Zhao
- FW Buaas
- G Durcova-Hills
- H Kubota
- H Niwa
- H Ohta
- H Tamaru
- HH Arnold
- I Fenic
- I Svechnikova
- J Ma
- J Nichols
- J Wang
- JA Costoya
- JM Oatley
- JN Ou
- JP Jackson
- K Hayashi
- K Hubner
- K Manova
- K Ohbo
- K Yoshinaga
- L Dettin
- LD Russell
- M Bulger
- M Gardiner-Garden
- M Godmann
- M Godmann
- M Godmann
- M Hazzouri
- M Hintz
- M Kanatsu-Shinohara
- M Ohmura
- M Pesce
- M Tachibana
- M Vogelauer
- M Yoshida
- MA Hakimi
- MA Lagarkova
- Maren Godmann
- MC Hofmann
- MG Lee
- MG Lee
- MG Lee
- MS Finnin
- MW McBurney
- NS Foulkes
- P Stothard
- PO Esteve
- Q Zhu
- R Behr
- R Liu
- S Kimmins
- S Minucci
- S Vincent
- S Yeo
- Sarah Kimmins
- SJ Taylor
- SR Grimes Jr
- T Brambrink
- T Jenuwein
- T Kouzarides
- T Yoshimizu
- V Medina
- V Sorrentino
- X Meng
- X Zhong
- Y Clermont
- Y Okada
- Y Shi
- Y Tadokoro
- YI Yeom
- YJ Shi
- Z He
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
Male fertility is declining and an underlying cause may be due to environment-epigenetic interactions in developing sperm, yet nothing is known of how the epigenome controls gene expression in sperm development. Histone methylation and acetylation are dynamically regulated in spermatogenesis and are sensitive to the environment. Our objectives were to determine how histone H3 methylation and acetylation contribute to the regulation of key genes in spermatogenesis. A germ cell line, GC-1, was exposed to either the control, or the chromatin modifying drugs tranylcypromine (T), an inhibitor of the histone H3 demethylase KDM1 (lysine specific demethylase 1), or trichostatin (TSA), an inhibitor of histone deacetylases, (HDAC). Quantitative PCR (qPCR) was used to identify genes that were sensitive to treatment. As a control for specificity the Myod1 (myogenic differentiation 1) gene was analyzed. Chromatin immunoprecipitation (ChIP) followed by qPCR was used to measure histone H3 methylation and acetylation at the promoters of target genes and the control, Myod1. Remarkably, the chromatin modifying treatment specifically induced the expression of spermatogonia expressed genes Pou5f1 and Gfra1. ChIP-qPCR revealed that induction of gene expression was associated with a gain in gene activating histone H3 methylation and acetylation in Pou5f1 and Gfra1 promoters, whereas CpG DNA methylation was not affected. Our data implicate a critical role for histone H3 methylation and acetylation in the regulation of genes expressed by spermatogonia – here, predominantly mediated by HDAC-containing protein complexes
Specific Loss of Histone H3 Lysine 9 Trimethylation and HP1γ/Cohesin Binding at D4Z4 Repeats Is Associated with Facioscapulohumeral Dystrophy (FSHD)
- Author
- A Muchir
- A Muchir
- A Musio
- A Petrov
- AD Pyle
- AH Peters
- AJ Bannister
- AJ van der Kooi
- Alexander R. Ball
- Anne C. Ferguson-Smith
- April Pyle
- B Tolhuis
- B-G Ju
- BE Bernstein
- BP Chadwick
- CG Spilianakis
- CR Vakoc
- D Gabellini
- D Gabellini
- DH Cho
- DY Lee
- E Li
- ET Tonkin
- G Deidda
- G Jiang
- G Lomberk
- GD Watts
- GW Padberg
- HC Gregson
- Heather C. Gregson
- ID Krantz
- IW Duncan
- JC de Greef
- JC Rice
- JE Hewitt
- Jessica C. de Greef
- John A. Schmiesing
- JT Heale
- Judit Balog
- K Stout
- Keith D. Robertson
- KS Wendt
- Kyoko Yokomori
- Leslie F. Lock
- M Hagleitner
- M Lachner
- M Lachner
- M Weber
- MA Hakimi
- MM Tonini
- MS Lechner
- N Nonaka
- N Xu
- P Bernard
- PA Jones
- Peter J. Donovan
- PG van Overveld
- PS Masny
- R Ciosk
- R Lyle
- R Tam
- RC Su
- Richard Chien
- RJ Osborne
- RJL Lemmers
- Rune R. Frants
- S Ait-Si-Ali
- S Gruber
- S Hadjur
- S Kurukuti
- S Lomvardas
- SA Sarraf
- Sara T. Winokur
- SI Horike
- Silvère M. van der Maarel
- SM van der Maarel
- ST Winokur
- T Fischer
- T Kondo
- T Mishiro
- T Sawado
- V Parelho
- Virginia E. Kimonis
- W Stedman
- Weihua Zeng
- Xiangduo Kong
- Y Li
- Yen-Yun Chen
- Z Duan
- Publication venue
- Public Library of Science
- Publication date
- 01/07/2009
- Field of study
Facioscapulohumeral dystrophy (FSHD) is an autosomal dominant muscular dystrophy in which no mutation of pathogenic gene(s) has been identified. Instead, the disease is, in most cases, genetically linked to a contraction in the number of 3.3 kb D4Z4 repeats on chromosome 4q. How contraction of the 4qter D4Z4 repeats causes muscular dystrophy is not understood. In addition, a smaller group of FSHD cases are not associated with D4Z4 repeat contraction (termed “phenotypic” FSHD), and their etiology remains undefined. We carried out chromatin immunoprecipitation analysis using D4Z4–specific PCR primers to examine the D4Z4 chromatin structure in normal and patient cells as well as in small interfering RNA (siRNA)–treated cells. We found that SUV39H1–mediated H3K9 trimethylation at D4Z4 seen in normal cells is lost in FSHD. Furthermore, the loss of this histone modification occurs not only at the contracted 4q D4Z4 allele, but also at the genetically intact D4Z4 alleles on both chromosomes 4q and 10q, providing the first evidence that the genetic change (contraction) of one 4qD4Z4 allele spreads its effect to other genomic regions. Importantly, this epigenetic change was also observed in the phenotypic FSHD cases with no D4Z4 contraction, but not in other types of muscular dystrophies tested. We found that HP1γ and cohesin are co-recruited to D4Z4 in an H3K9me3–dependent and cell type–specific manner, which is disrupted in FSHD. The results indicate that cohesin plays an active role in HP1 recruitment and is involved in cell type–specific D4Z4 chromatin regulation. Taken together, we identified the loss of both histone H3K9 trimethylation and HP1γ/cohesin binding at D4Z4 to be a faithful marker for the FSHD phenotype. Based on these results, we propose a new model in which the epigenetic change initiated at 4q D4Z4 spreads its effect to other genomic regions, which compromises muscle-specific gene regulation leading to FSHD pathogenesis
Search for strongly interacting massive particles generating trackless jets in proton-proton collisions at s = 13 TeV
- Author
- Aarrestad TK
- Aarup Petersen H
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abercrombie D
- Acharya H
- Acosta D
- Acosta JG
- Adam W
- Adams E
- Adams MR
- Adams T
- Adloff C
- Adzic P
- Agapitos A
- Agarwal G
- Aggleton R
- Agram J-L
- Aguilar-Benitez M
- Ahmad A
- Ahmad M
- Ahmed A
- Ahuja S
- Aime C
- Akchurin N
- Akgun B
- Akpinar A
- Albajar C
- Albergo S
- Albert A
- Albrow M
- Alcaraz Maestre J
- Aldaya Martin M
- Aldá Júnior WL
- Aleksandrov A
- Alexander J
- Alhusseini M
- Alimena J
- Alison J
- Allen B
- Almond J
- Alvarez Gonzalez B
- Alverson G
- Alves GA
- Aly R
- Alyari M
- Amapane N
- Amendola C
- Amin N
- Amram O
- Amsler C
- Anagnostou G
- Andrea J
- Andreev V
- Andreev Y
- Andrews MB
- Androsov K
- Antchev G
- Antunovic Z
- Apanasevich L
- Apollinari G
- Appelt E
- Apresyan A
- Apyan A
- Araujo M
- Arcaro D
- Arcidiacono R
- Arenton MW
- Argiro S
- Arneodo M
- Aruta C
- Asavapibhop B
- Asawatangtrakuldee C
- Asenov P
- Asghar MI
- Asilar E
- Askew A
- Asmuss P
- Aspell P
- Atakisi IO
- Atanassov I
- Ather MW
- Attikis A
- Auffray E
- Aushev T
- Auzinger G
- Avati V
- Avery P
- Avila C
- Awais A
- Awan MIM
- Ayala E
- Ayala G
- Aydogmus Sen F
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzurri P
- Baarmand MM
- Babaev A
- Babounikau I
- Bacchetta N
- Bachiller I
- Bachtis M
- Backhaus M
- Baden A
- Baechler J
- Baginyan A
- Bagliesi G
- Bahinipati S
- Baillon P
- Bainbridge R
- Bakas G
- Bakhshiansohi H
- Bakirci MN
- Baldenegro Barrera C
- Ball AH
- Ban Y
- Band R
- Bandyopadhyay H
- Banerjee S
- Banerjee S
- Bansal S
- Barbagli G
- Barberis E
- Bargassa P
- Baringer P
- Barnes VE
- Barney D
- Baron O
- Barrio Luna M
- Bartek R
- Bartosik N
- Bartók M
- Bastos D
- Battilana C
- Baty A
- Bauer G
- Bauerdick LAT
- Baxter S
- Bayshev I
- Bean A
- Beauceron S
- Beaudette F
- Becerril Gonzalez H
- Bechtel J
- Bedoya CF
- Beghin D
- Behera PK
- Behera SC
- Behnke O
- Bein S
- Belchior Batista Das Chagas E
- Belforte S
- Bell KW
- Bellan R
- Belloni A
- Bellora A
- Belyaev A
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- Benaglia A
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- Bencze G
- Bendavid J
- Benecke A
- Benelli G
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- Berenguer Antequera J
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- Bermúdez Martínez A
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- Bhatnagar V
- Bhattacharya R
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- Bheesette S
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- Biasini M
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- Bilei GM
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- Bisello D
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- Blekman F
- Blinov V
- Bloch D
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- Bloom K
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- Boccali T
- Bocci A
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- Bonacorsi D
- Bonanomi M
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- Borgonovi L
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- Bossini E
- Botta C
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- Boudoul G
- Bouhali O
- Bourgatte G
- Bourilkov D
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- Braibant-Giacomelli S
- Brainerd C
- Brandao Malbouisson H
- Brandt S
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- Breeze S
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- Brinkerhoff A
- Brivio F
- Brochero Cifuentes JA
- Brom J-M
- Brondolin E
- Brooke JJ
- Brown RM
- Brunner D
- Bruno G
- Brzhechko D
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- Bucci R
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- Buchanan J
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- Buchot Perraguin A
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- Buontempo S
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- Butler JN
- Butler PH
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- Cafagna FS
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- Calderon A
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- Canelli MF
- Canepa A
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- Capeans Garrido M
- Capiluppi P
- Cappati A
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- Cardini A
- Cardwell B
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- Carlin R
- Carrera Jarrin E
- Carrillo Montoya CA
- Carrillo Moreno S
- Cartiglia N
- Carvalho Antunes De Oliveira A
- Carvalho W
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- Caspart R
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- Castaldi R
- Castaneda Hernandez A
- Castilla-Valdez H
- Castro A
- Catanesi MG
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- Ceccarelli R
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- Cepeda M
- Cerati GB
- Cerci S
- Cerminara G
- Cerrada M
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- Cetorelli F
- Chabert EC
- Chahal GS
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- Chapon E
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- Charlot C
- Chatterjee RM
- Chatterjee S
- Chaudhary G
- Chauhan S
- Chauhan S
- Chawla R
- Chazin Quero B
- Checchia P
- Chekhovsky V
- Chen C
- Chen GM
- Chen HS
- Chen KF
- Chen M
- Chen PH
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- Chen Z
- Chenarani S
- Cheng T
- Cheng Y
- Cherepanov V
- Chernyavskaya N
- Chertok M
- Cheung HWK
- Chhibra SS
- Chiarito B
- Chinellato J
- Chistov R
- Chlebana F
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- Choi J
- Choi S
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- Chou JP
- Choudhary BC
- Choudhury S
- Chu J
- Chudasama R
- Chwalek T
- Ciangottini D
- Ciocca C
- Ciocci MA
- Cipriani M
- Ciriolo V
- Cirkovic P
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- Cittolin S
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- Claes DR
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- Clerbaux B
- CMS Collaboration<sup>†</sup>
- Cockerill DJA
- Coelho E
- Colaleo A
- Cole JE
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- Collard C
- Colling D
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- Consuegra Rodríguez S
- Contardo D
- Conway J
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- Cooper SI
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- Cornelis T
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- Cossutti F
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- Coubez X
- Couderc F
- Cousins R
- Covarelli R
- Cox B
- Cox PT
- Cranshaw DJ
- Creanza D
- Cremonesi M
- Cristella L
- Csanád M
- Csörgő T
- Cuevas J
- Cuffiani M
- Cumalat JP
- Cummings G
- Cussans D
- Cutts D
- Czellar S
- D'Alessandro R
- D'Alfonso M
- D'Enterria D
- D'Hondt J
- Da Costa EM
- Da Rold A
- Da Silveira GG
- Dabrowski A
- Daci N
- Dalchenko M
- Dallavalle GM
- Damarseckin S
- Damgov J
- Danilov M
- Danilov V
- Daponte V
- Darwish MR
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- Dasgupta A
- Dash D
- Daskalakis G
- Dasu S
- Datta A
- Dauncey P
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- Davignon O
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- De Bruyn I
- De Castro Manzano P
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- De Iorio A
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- De La Cruz B
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- De Trocóniz JF
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- Dewanjee RK
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- Dharmaratna WGD
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- Dobur D
- Dogra S
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- Domínguez Damiani D
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- Donertas IS
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- Duarte J
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- Ecklund KM
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- Elgammal S
- Eliseev D
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- Ellis KV
- Ellithi Kamel A
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- Elmetenawee W
- Elvira VD
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- Gomber B
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- Gomez G
- Goncharov M
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- Gonzalez Lopez O
- González Fernández JR
- Gorbunov I
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- Gottschalk E
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- Gurrola A
- Gurtu A
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- Guthoff M
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- Górski M
- Gülmez E
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- Habibullah R
- Haddad Y
- Hadjiiska R
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- Hadley NJ
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- Österberg K
- Özçelik Ö
- Široký J
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
A search for dark matter in the form of strongly interacting massive particles (SIMPs) using the CMS detector at the LHC is presented. The SIMPs would be produced in pairs that manifest themselves as pairs of jets without tracks. The energy fraction of jets carried by charged particles is used as a key discriminator to suppress efficiently the large multijet background, and the remaining background is estimated directly from data. The search is performed using proton-proton collision data corresponding to an integrated luminosity of 16.1 fb - 1 , collected with the CMS detector in 2016. No significant excess of events is observed above the expected background. For the simplified dark matter model under consideration, SIMPs with masses up to 100 GeV are excluded and further sensitivity is explored towards higher masses
Search for dark matter produced in association with a Higgs boson decaying to a pair of bottom quarks in proton-proton collisions at root s=13TeV
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- Özçelik Ö
- Publication venue
- Publication date
- 01/01/2018
- Field of study
A search for dark matter produced in association with a Higgs boson decaying to a pair of bottom quarks is performed in proton-proton collisions at a center-of-mass energy of 13 TeV collected with the CMS detector at the LHC. The analyzed data sample corresponds to an integrated luminosity of 35.9 fb(-1). The signal is characterized by a large missing transverse momentum recoiling against a bottom quark-antiquark system that has a large Lorentz boost. The number of events observed in the data is consistent with the standard model background prediction. Results are interpreted in terms of limits both on parameters of the type-2 two-Higgs doublet model extended by an additional light pseudoscalar boson a (2HDM+a) and on parameters of a baryonic Z simplified model. The 2HDM+a model is tested experimentally for the first time. For the baryonic Z model, the presented results constitute the most stringent constraints to date.Peer reviewe
Observation of the B-s(0) -> X(3872)phi Decay
- Author
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- Özçelik Ö
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Using a data sample of proton-proton collisions at root s = 13 TeV, corresponding to an integrated luminosity of 140 fb(-1) collected by the CMS experiment in 2016-2018, the B-s(0) -> X(3872)phi decay is observed. Decays into J/psi pi(+)pi(-) and K+K- are used to reconstruct, respectively, the X(3872) and phi. The ratio of the product of branching fractions B[B-s(0) -> X(3872)phi]B[X(3872) -> J/psi pi(+)pi(-)] to the product B[B-s(0) ->psi(2S)phi]B[psi(2S) -> J/psi pi(+)pi(-)] is measured to be [2.21 +/- 0.29(stat) +/- 0.17(syst)]%. The ratio B[B-s(0) -> X(3872)phi]/B[B-0 -> X(3872)K-0] is found to be consistent with one, while the ratio B[B-s(0) -> X(3872)phi]/B[B+-> X(3872)K+] is two times smaller. This suggests a difference in the production dynamics of the X(3872) in B-0 and B(0)s meson decays compared to B+. The reported observation may shed new light on the nature of the X(3872) particle.Peer reviewe
Observation of a New Excited Beauty Strange Baryon Decaying to Ξb- π+π-
- Author
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- Aarup Petersen H
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- Yohay R
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- Yoo J
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- Yu PR
- Yu SS
- Yuan L
- Yuan S
- Yumiceva F
- Yusli MN
- Zabi A
- Zacharopoulou A
- Zahid S
- Zaleski S
- Zalewski P
- Zanetti M
- Zarubin A
- Zarucki M
- Zecchinelli AG
- Zeinali M
- Zeuner WD
- Zghiche A
- Zhang F
- Zhang H
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- Zhao J
- Zhizhin I
- Zhokin A
- Zhu DH
- Zhu RY
- Ziemons T
- Zientek M
- Zlebcik R
- Zoi I
- Zolkapli Z
- Zorbakir IS
- Zorbilmez C
- Zotto P
- Zou D
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- Zuo X
- Zuolo D
- Zygala L
- Álvarez Fernández A
- Özçelik Ö
- Publication venue
- American Physical Society
- Publication date
- 01/01/2021
- Field of study
The Ξb-π+π- invariant mass spectrum is investigated with an event sample of proton-proton collisions at s=13 TeV, collected by the CMS experiment at the LHC in 2016-2018 and corresponding to an integrated luminosity of 140 fb-1. The ground state Ξb- is reconstructed via its decays to J/ψΞ- and J/ψΛK-. A narrow resonance, labeled Ξb(6100)-, is observed at a Ξb-π+π- invariant mass of 6100.3±0.2(stat)±0.1(syst)±0.6(Ξb-) MeV, where the last uncertainty reflects the precision of the Ξb- baryon mass. The upper limit on the Ξb(6100)- natural width is determined to be 1.9 MeV at 95% confidence level. The low Ξb(6100)- signal yield observed in data does not allow a measurement of the quantum numbers of the new state. However, following analogies with the established excited Ξc baryon states, the new Ξb(6100)- resonance and its decay sequence are consistent with the orbitally excited Ξb- baryon, with spin and parity quantum numbers JP=3/2-
Measurement of the inclusive and differential Higgs boson production cross sections in the decay mode to a pair of τ Leptons in pp collisions at sqrt[s]=13 TeV
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- Yao Y
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- Yumiceva F
- Yusli MN
- Zabi A
- Zacharopoulou A
- Zahid S
- Zaleski S
- Zalewski P
- Zanetti M
- Zarubin A
- Zarucki M
- Zecchinelli AG
- Zeinali M
- Zeuner WD
- Zghiche A
- Zhang F
- Zhang H
- Zhang J
- Zhang L
- Zhang W
- Zhang Y
- Zhang Y
- Zhang Z
- Zhao J
- Zhizhin I
- Zhokin A
- Zhu DH
- Zhu RY
- Ziemons T
- Zoi I
- Zolkapli Z
- Zorbakir IS
- Zorbilmez C
- Zotto P
- Zotz A
- Zou D
- Zou R
- Zucchetta A
- Zumerle G
- Zuo X
- Zuolo D
- Zygala L
- Álvarez Fernández A
- Özçelik Ö
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2022
- Field of study
Measurements of the inclusive and differential fiducial cross sections of the Higgs boson are presented, using the τ lepton decay channel. The differential cross sections are measured as functions of the Higgs boson transverse momentum, jet multiplicity, and transverse momentum of the leading jet in the event, if any. The analysis is performed using proton-proton collision data collected with the CMS detector at the LHC at a center-of-mass energy of 13 TeV and corresponding to an integrated luminosity of 138 fb^{-1}. These are the first differential measurements of the Higgs boson cross section in the final state of two τ leptons. In final states with a large jet multiplicity or with a Lorentz-boosted Higgs boson, these measurements constitute a significant improvement over measurements performed in other final states
Driver mutations of cancer epigenomes
- Author
- A Balakrishnan
- A Borodovsky
- A Chaturvedi
- A Dolnik
- A El-Osta
- A Fujimoto
- A Green
- A Hermann
- A Kirmizis
- A Mamo
- A Nekrutenko
- A Pais
- A Renneville
- A Saha
- A Tefferi
- A Tefferi
- A Tefferi
- A Yokoyama
- A Yokoyama
- AA Hakimi
- AA Hakimi
- AD Riggs
- AD Trobaugh-Lotrario
- AE Burrows
- AE Smith
- AF Ghiam
- AH Shain
- AH Shain
- AH Shih
- AJ Bannister
- AJ Kuo
- AJ Sievert
- AL Kung
- AM Fontebasso
- AM Jankowska
- AP Bracken
- AP Feinberg
- AR Grassian
- AS Ho
- AV Krivtsov
- B Luo
- B Vogelstein
- B Wiestler
- BC Mobley
- BG Mar
- BG Wilson
- BG Wilson
- BS Winkler
- BT Yuen
- BV Geisbrecht
- C Bodor
- C Bodor
- C Chen
- C Hartmann
- C Holz-Schietinger
- C Holz-Schietinger
- C Love
- C Lu
- C Lu
- C Morales Torres
- C Peng
- C Perez
- C Plass
- C Quivoron
- Cancer Genome Atlas Research Network
- CD DiNardo
- CG Joseph
- CG Kleer
- CG Lian
- CG Mullighan
- CH Arrowsmith
- CJ Guidi
- CJ Pirozzi
- CJ Sneeringer
- CK Schmidt
- CL Hanigan
- CL Hsieh
- CM Hughes
- CR Majer
- CR Vakoc
- CW Roberts
- D Capello
- D Capper
- D Hanahan
- D Jia
- D Matsubara
- D Reisman
- D Rotili
- D Sturm
- DA Khuong-Quang
- DB Yap
- DN Reisman
- DR Borger
- DW Parsons
- DW Parsons
- E Cerami
- E Martinez-Garcia
- E Pronier
- E Sanchez-Tillo
- EA Minor
- ED Rubery
- EL Greer
- ER Mardis
- ER Plimack
- F Chedin
- F Delhommeau
- F Delhommeau
- F Fuks
- F Fuks
- F Li
- F Petrij
- F Stegelmann
- F Thol
- F Thol
- F Traina
- F Viguie
- FE Bleeker
- FX Schaub
- G Duns
- G Duns
- G Haaften van
- G Manceau
- G Marcucci
- G Nikoloski
- G Robinson
- G Wu
- G Yan
- GA Challen
- GL Dalgliesh
- GM Poage
- H Inoue
- H Makishima
- H Noushmehr
- H Ogiwara
- H Shen
- H Wu
- H Yan
- H Zhao
- HA Hou
- HM Herz
- I Christiaans
- I Issaeva
- I Oruetxebarria
- I Panagopoulos
- I Suetake
- I Varela
- I Versteege
- J Balss
- J Borrow
- J Caramel
- J Cheng
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- J Datta
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- J Lindberg
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- J Yamazaki
- J Zhang
- JA Losman
- JC Reyes
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- JD Jaffe
- JF Dimartino
- JG Herman
- JG Kim
- JG Lohr
- JJ Lee
- JK Wang
- JL Lai
- JM Foulks
- JN Wu
- JP Patel
- JS You
- JU Guo
- JW Edmunds
- K Blaschke
- K Helin
- K Hussein
- K Moran-Crusio
- K Wang
- KB Shpargel
- KC Wiegand
- KE Bachman
- KE Bisling
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- KM Chan
- KM Chan
- KM Mann
- KW Trotter
- L Bjerke
- L Dang
- L Ellis
- L Pasqualucci
- L Pasqualucci
- L Shi
- L Wang
- M Brecqueville
- M Chesi
- M Ehrlich
- M Endo
- M Esteller
- M Ewalt
- M Gessi
- M Huang
- M Kaneda
- M Ko
- M Ko
- M Neumann
- M New
- M Oka
- M Okano
- M Peifer
- M Sasaki
- M Sausen
- M Tahiliani
- M Tsikitis
- MA Dawson
- MA Gama-Sosa
- ME Figueroa
- MF Amary
- MF Berger
- MF Kane
- MG Lee
- MJ Thirman
- MJ Walter
- ML Veigl
- MM Purdy
- MR Kang
- MR Stratton
- MS Isakoff
- MT McCabe
- MT McCabe
- N Konstandin
- N Shiama
- N Singhal
- N Stransky
- ND Heintzman
- NG Iyer
- NG Nagl Jr
- O Abdel-Wahab
- O Abdel-Wahab
- O Kosmider
- O Nibourel
- O Witt
- O Yildirim
- P Asp
- P Guglielmelli
- P Guilhamon
- P Kapur
- P Paschka
- P Vella
- P Wang
- P Zou
- PA Croonquist
- PA Jones
- PA Jones
- PA Jones
- PA Kreiger
- PB Dallas
- PP Medina
- PS Ward
- PW Lewis
- Q Chen
- Q Feng
- R Deplus
- R Eckner
- R Holliday
- R Margueron
- R Margueron
- R Pawlowski
- R Yin
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- RB Lorsbach
- RD Morin
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- SN Khan
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- T Bosse
- T Ernst
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- T Nakajima
- T Oike
- T Shibata
- T Sjoblom
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- TJ Hulsebos
- TJ Ley
- TJ Pugh
- TJ Wigle
- V Grossmann
- V Grossmann
- V Senyuk
- V Valinluck
- W Beguelin
- W Gu
- W Timp
- W Wang
- W Xia
- W Xu
- WC Chou
- WC Chou
- WC Chou
- WD Li
- WM Grady
- X Fu
- X Gao
- X Niu
- X Wang
- X Wang
- X Xu
- XJ Yan
- XS Li
- Y Attieh
- Y Costa
- Y Gui
- Y Li
- Y Shi
- Y Tadokoro
- Y Watanabe
- Y Yamashita
- YA Yang
- YF He
- YQ Li
- YW Cho
- YZ Ge
- Z Jagani
- Z Kan
- Z Nie
- Z Wang
- ZJ Zang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Recommended from our members
Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c
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- Abbasi-Kangevari M
- Abu-Rmeileh NM
- Adambekov S
- Adams RJ
- Aekplakorn W
- Agdeppa IA
- Aghazadeh-Attari J
- Aguilar-Salinas CA
- Agyemang C
- Ahmad NA
- Ahmadi A
- Ahmadi N
- Ahmadi N
- Ahmed SH
- Ajlouni K
- Al Asfoor D
- Al Nsour M
- Al Qaoud NM
- Al-Hinai H
- Al-Lahou B
- Al-Lawati JA
- Alarouj M
- AlBuhairan F
- AlDhukair S
- Aldwairji MA
- Ali MM
- Alinezhad F
- Alkandari A
- Alomirah HF
- Aly E
- Amarapurkar DN
- Andersen LB
- Anderssen SA
- Andrade DS
- Anjana RM
- Ansari-Moghaddam A
- Aounallah-Skhiri H
- Aris T
- Arlappa N
- Aryal KK
- Assah FK
- Assembekov B
- Auvinen J
- Avdicova M
- Azad K
- Azimi-Nezhad M
- Azizi F
- Bacopoulou F
- Balakrishna N
- Bamoshmoosh M
- Banach M
- Bandosz P
- Banegas JR
- Barbagallo CM
- Barcelo A
- Baretic M
- Barrera L
- Basit A
- Batieha AM
- Batista AP
- Baur LA
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- Belavendra A
- Ben Romdhane H
- Ben S
- Benchekor SM
- Benet M
- Bennett JE
- Berkinbayev S
- Bernabe-Ortiz A
- Berrios Carrasola X
- Bettiol H
- Beybey AF
- Bhargava SK
- Bikbov MM
- Bista B
- Bjerregaard P
- Bjertness E
- Bjertness MB
- Bjorkelund C
- Bloch KV
- Blokstra A
- Bo S
- Bobak M
- Boggia JG
- Bonaccio M
- Bonilla-Vargas A
- Borghs H
- Bovet P
- Brajkovich I
- Brenner H
- Brewster LM
- Brian GR
- Briceno Y
- Brito M
- Bugge A
- Buntinx F
- Cabrera de Leon A
- Caixeta RB
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- Candido APC
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- Capuano E
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- Cheraghian B
- Chirlaque M-D
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- Cirillo M
- Cisneros JZ
- Claessens F
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- Cowan MJ
- Cowell C
- Crujeiras AB
- Cruz JJ
- Cureau FV
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- Eddie R
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- Salonen JT
- Salvetti M
- Sanchez-Abanto J
- Santos Silva DA
- Santos DA
- Santos LC
- Santos MP
- Santos TR
- Saramies JL
- Sardinha LB
- Sarrafzadegan N
- Saum K-U
- Savin S
- Sbaraini M
- Scazufca M
- Schaan BD
- Scheidt-Nave C
- Schipf S
- Schmidt CO
- Schramm S
- Sebert S
- Sedaghattalab M
- Sein AA
- Sepanlou SG
- Sewpaul R
- Shamah-Levy T
- Shamshirgaran SM
- Sharafkhah M
- Sharma SK
- Sharman A
- Shaw JE
- Shayanrad A
- Shayesteh AA
- Sheffer KE
- Shimizu-Furusawa H
- Shiri R
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- Si-Ramlee K
- Simon M
- Simons J
- Simons LA
- Singleton RK
- Sjostrom M
- Slowikowska-Hilczer J
- Slusarczyk P
- Smeeth L
- Sobngwi E
- Soderberg S
- Soemantri A
- Sofat R
- Solfrizzi V
- Somi MH
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- Soumare A
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- Sparrenberger K
- Staessen JA
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- Sylva RC
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- Tarqui-Mamani CB
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- Thankappan KR
- Theobald H
- Theodoridis X
- Thet TM
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- Thrift AG
- Timmermans EJ
- Tjandrarini DH
- Tolonen HK
- Tolstrup JS
- Tomaszewski M
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- Traissac P
- Tran QB
- Triantafyllou A
- Tuitele J
- Tuliakova AM
- Tulloch-Reid MK
- Tuomainen T-P
- Tzala E
- Tze PN
- Tzourio C
- Ueda P
- Ugel E
- Ukoli FAM
- Ulmer H
- Uusitalo HMT
- Valdivia G
- Van den Born B-J
- Van der Heyden J
- van Rossem L
- Van Schoor NM
- van Valkengoed IGM
- van Zutphen EM
- Vander Hoorn S
- Vanderschueren D
- Vanuzzo D
- Vasan SK
- Vega T
- Velasquez-Melendez G
- Verstraeten R
- Viet L
- Villalpando S
- Vioque J
- Virtanen JK
- Viswanathan B
- Voutilainen A
- Vrkic TZ
- Wade AN
- Wang C
- Wang N
- Wang Q
- Wang Y-W
- Wang YX
- Wannamethee SG
- Webster-Kerr K
- Wedderkopp N
- Wei W
- Westbury LD
- Whincup PH
- Widhalm K
- Widyahening IS
- Wiecek A
- Wilks RJ
- Willeit J
- Willeit P
- Wilsgaard T
- Wojtyniak B
- Wong A
- Wong EB
- Wong NI
- Woodward M
- Wu FC
- Xu H
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- Yaacob NA
- Yan L
- Yan W
- Yoosefi M
- Yoshihara A
- Younger-Coleman NO
- Yu Y
- Yu Y-L
- Yusoff AF
- Yusoff MFM
- Zainuddin AA
- Zamani F
- Zambon S
- Zampelas A
- Zaw KK
- Zdrojewski T
- Zeng Y
- Zhang Z-Y
- Zholdin B
- Zhou B
- Zimmet P
- Zitt E
- Zoghlami N
- Publication venue
- Nature Research
- Publication date
- 09/11/2023
- Field of study
Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) are both used to diagnose diabetes, but these measurements can identify different people as having diabetes. We used data from 117 population-based studies and quantified, in different world regions, the prevalence of diagnosed diabetes, and whether those who were previously undiagnosed and detected as having diabetes in survey screening, had elevated FPG, HbA1c or both. We developed prediction equations for estimating the probability that a person without previously diagnosed diabetes, and at a specific level of FPG, had elevated HbA1c, and vice versa. The age-standardized proportion of diabetes that was previously undiagnosed and detected in survey screening ranged from 30% in the high-income western region to 66% in south Asia. Among those with screen-detected diabetes with either test, the age-standardized proportion who had elevated levels of both FPG and HbA1c was 29–39% across regions; the remainder had discordant elevation of FPG or HbA1c. In most low- and middle-income regions, isolated elevated HbA1c was more common than isolated elevated FPG. In these regions, the use of FPG alone may delay diabetes diagnosis and underestimate diabetes prevalence. Our prediction equations help allocate finite resources for measuring HbA1c to reduce the global shortfall in diabetes diagnosis and surveillance
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