A second-generation high speed civil transport: Stingray

The Stingray is the second-generation High Speed Civil Transport (HSCT) designed for the 21st Century. This aircraft is designed to be economically viable and environmentally sound transportation competitive in markets currently dominated by subsonic aircraft such as the Boeing 747 and upcoming McDonnell Douglas MD-12. With the Stringray coming into service in 2005, a ticket price of 21 percent over current subsonic airlines will cover operational costs with a 10 percent return on investment. The cost per aircraft will be $202 million with the Direct Operating Cost equal to$0.072 per mile per seat. This aircraft has been designed to be a realistic aircraft that can be built within the next ten to fifteen years. There was only one main technological improvement factor used in the design, that being for the engine specific fuel consumption. The Stingray, therefore, does not rely on technology that does not exist. The Stingray will be powered by four mixed flow turbofans that meet both nitrous oxide emissions and FAR 36 Stage 3 noise regulations. It will carry 250 passengers a distance of 5200 nautical miles at a speed of Mach 2.4. The shape of the Stingray, while optimized for supersonic flight, is compatible with all current airline facilities in airports around the world. As the demand for economical, high-speed flight increases, the Stingray will be ready and able to meet those demands

Sentinel-1 interferometric coherence as a vegetation index for agriculture

In this study, the use of Sentinel-1 interferometric coherence data as a tool for crop monitoring has been explored. For this purpose, time series of images acquired by Sentinel-1 and 2 spanning 2017 have been analysed. The study site is an agricultural area in Sevilla, Spain, where 16 different crop species were cultivated during that year. The time series of 6-day repeat-pass coherence measured at each polarimetric channel (VV and VH), as well as their difference, have been compared to the NDVI and to the backscattering ratio (VH/VV) and other indices based on backscatter. The contribution of different decorrelation sources and the effect of the bias from the space-averaged sample coherence magnitude estimation have been evaluated. Likewise, the usage of 12 days as temporal baseline was tested. The study has been carried for three different orbits, characterised by different incidence angles and acquisition times. All results support using coherence as a measure for monitoring the crop growing season, as it shows good correlations with the NDVI (R2>0.7), and its temporal evolution fits well the main phenological stages of the crops. Although each crop shows its own evolution, the performance of coherence as a vegetation index is high for most of them. VV is generally more correlated with the NDVI than VH. For crop types characterised by low plant density, this difference decreases, with VH even showing higher correlation values in some cases. For a few crop types, such as rice, the backscattering ratio outperforms the coherence in following the growth stages of the plants. Since both coherence and backscattering are directly computed from the radar images, they could be used as complementary sources of information for this purpose. Notably, the measured coherence performs well without the need of compensating the thermal noise decorrelation or the bias due to the finite equivalent number of looks.This work was supported in part by the European Space Agency under Project SEOM-S14SCI-Land (SInCohMap), and in part by the Spanish Ministry of Science and Innovation (State Agency of Research, AEI) and the European Funds for Regional Development under Project PID2020-117303GB-C22

Grounding line migration from 1992 to 2011 on Petermann Glacier, North-West Greenland

We use satellite radar interferometry to investigate changes in the location of the Petermann Glacier grounding line between 1992 and 2011. The grounding line location was identified in 17 quadruple-difference interferograms produced from European Remote Sensing (ERS)-1/2 data – the most extensive time series assembled at any ice stream to date. There is close agreement (20.6 cm) between vertical displacement of the floating ice shelf and relative tide amplitudes simulated by the Arctic Ocean Dynamics-based Tide Model 5 (AODTM-5) Arctic tide model. Over the 19 a period, the groundling line position varied by 470 m, on average, with a maximum range of 7.0 km observed on the north-east margin of the ice stream. Although the mean range (2.8 km) and variability (320 m) of the grounding line position is considerably lower if the unusually variable north-east sector is not considered, our observations demonstrate that large, isolated movements cannot be precluded, thus sparse temporal records should be analysed with care. The grounding line migration observed on Petermann Glacier is not significantly correlated with time (R2 = 0.22) despite reported ice shelf thinning and episodes of large iceberg calving, which suggests that unlike other ice streams, on the south-west margin of the Greenland ice sheet, Petermann Glacier is dynamically stable

Time Series of Sentinel-1 Interferometric Coherence and Backscatter for Crop-Type Mapping

The potential use of the interferometric coherence measured with Sentinel-1 satellites as input feature for crop classification is explored in this study. A one-year time series of Sentinel-1 images acquired over an agricultural area in Spain, in which 17 crop species are present, is exploited for this purpose. Different options regarding temporal baselines, polarisation, and combination with radiometric data (backscattering coefficient) are analysed. Results show that both radiometric and interferometric features provide notable classification accuracy when used individually (overall accuracy lies between 70% and 80%). It is found that the shortest temporal baseline coherences (6 days) and the use of all available intensity images perform best, hence proving the advantage of the 6-day revisit time provided by the Sentinel-1 constellation with respect to longer revisit times. It is also shown that dual-pol data always provide better classification results than single-pol ones. More importantly, when both coherence and backscattering coefficient are jointly used, a significant increase of accuracy is obtained (greater than 7% in overall accuracy). Individual accuracies of all crop types are increased, and an overall accuracy above 86% is reached. This proves that both features provide complementary information, and that the combination of interferometric and radiometric radar data constitute a solid information source for this application.This work was supported in part by the European Space Agency via the ESA SEOM Program ITT under Grant AO/1-8306/15/I-NB “SEOM-S14SCI Land,” and in part by the Spanish Ministry of Science, Innovation and Universities, the State Agency of Research (AEI), and the European Funds for Regional Development (EFRD) under Project TEC2017-85244-C2-1-P

Selection criteria of diluents of tri-n-butyl phosphate for recovering neodymium(III) from nitrate solutions

The selection of a proper diluent should be based on several criteria such as the distribution ratio, phase disengagement time, cost, safety and environmental impact of the process. The effect of different diluents on the solvent extraction of Nd(III) by the neutral extractant tri-n-butylphosphate (TBP) from nitrate feed solutions was studied. The nature of the diluent had little effect on the extraction kinetics of Nd(III) by TBP above 2.5 min. In general, phase disengagement times were relatively shorter for aromatic diluents compared to aliphatic diluents. Conversely, extraction efficiencies were the highest for aliphatic diluents, slightly lower for mixed aliphatic-aromatic diluents and much lower for aromatic diluents. The poorer extraction efficiencies of aromatic diluents maybe due to the lower concentration of free extractant as a result of the stronger interactions of the diluent with water and/or of the diluent with the extractant. Under the experimental conditions, the differences in extraction between aliphatic and aromatic diluents decreased with increasing the salting-out effect of nitrate ions in the feed. At nitrate concentrations of 4.5 mol L−1 or more, the different diluents had a limited influence on the metal extraction with 1 mol L−1 TBP from feed solutions of 1 g L−1 Nd(III). Thus, under these conditions, the selection of the diluent can be preferably based on its cost, safety and biodegradability rather than on its physico-chemical properties

Consumer-Led Screening for Atrial Fibrillation: Frontier Review of the AF-SCREEN International Collaboration.

The technological evolution and widespread availability of wearables and handheld ECG devices capable of screening for atrial fibrillation (AF), and their promotion directly to consumers, has focused attention of health care professionals and patient organizations on consumer-led AF screening. In this Frontiers review, members of the AF-SCREEN International Collaboration provide a critical appraisal of this rapidly evolving field to increase awareness of the complexities and uncertainties surrounding consumer-led AF screening. Although there are numerous commercially available devices directly marketed to consumers for AF monitoring and identification of unrecognized AF, health care professional-led randomized controlled studies using multiple ECG recordings or continuous ECG monitoring to detect AF have failed to demonstrate a significant reduction in stroke. Although it remains uncertain if consumer-led AF screening reduces stroke, it could increase early diagnosis of AF and facilitate an integrated approach, including appropriate anticoagulation, rate or rhythm management, and risk factor modification to reduce complications. Companies marketing AF screening devices should report the accuracy and performance of their products in high- and low-risk populations and avoid claims about clinical outcomes unless improvement is demonstrated in randomized clinical trials. Generally, the diagnostic yield of AF screening increases with the number, duration, and temporal dispersion of screening sessions, but the prognostic importance may be less than for AF detected by single-time point screening, which is largely permanent, persistent, or high-burden paroxysmal AF. Consumer-initiated ECG recordings suggesting possible AF always require confirmation by a health care professional experienced in ECG reading, whereas suspicion of AF on the basis of photoplethysmography must be confirmed with an ECG. Consumer-led AF screening is unlikely to be cost-effective for stroke prevention in the predominantly young, early adopters of this technology. Studies in older people at higher stroke risk are required to demonstrate both effectiveness and cost-effectiveness. The direct interaction between companies and consumers creates new regulatory gaps in relation to data privacy and the registration of consumer apps and devices. Although several barriers for optimal use of consumer-led screening exist, results of large, ongoing trials, powered to detect clinical outcomes, are required before health care professionals should support widespread adoption of consumer-led AF screening

Mass balance of the Greenland Ice Sheet from 1992 to 2018

In recent decades, the Greenland Ice Sheet has been a major contributor to global sea-level rise1,2, and it is expected to be so in the future3. Although increases in glacier flow4–6 and surface melting7–9 have been driven by oceanic10–12 and atmospheric13,14 warming, the degree and trajectory of today’s imbalance remain uncertain. Here we compare and combine 26 individual satellite measurements of changes in the ice sheet’s volume, flow and gravitational potential to produce a reconciled estimate of its mass balance. Although the ice sheet was close to a state of balance in the 1990s, annual losses have risen since then, peaking at 335 ± 62 billion tonnes per year in 2011. In all, Greenland lost 3,800 ± 339 billion tonnes of ice between 1992 and 2018, causing the mean sea level to rise by 10.6 ± 0.9 millimetres. Using three regional climate models, we show that reduced surface mass balance has driven 1,971 ± 555 billion tonnes (52%) of the ice loss owing to increased meltwater runoff. The remaining 1,827 ± 538 billion tonnes (48%) of ice loss was due to increased glacier discharge, which rose from 41 ± 37 billion tonnes per year in the 1990s to 87 ± 25 billion tonnes per year since then. Between 2013 and 2017, the total rate of ice loss slowed to 217 ± 32 billion tonnes per year, on average, as atmospheric circulation favoured cooler conditions15 and as ocean temperatures fell at the terminus of Jakobshavn Isbræ16. Cumulative ice losses from Greenland as a whole have been close to the IPCC’s predicted rates for their high-end climate warming scenario17, which forecast an additional 50 to 120 millimetres of global sea-level rise by 2100 when compared to their central estimate

Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).

Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Improved risk stratification of patients with atrial fibrillation: an integrated GARFIELD-AF tool for the prediction of mortality, stroke and bleed in patients with and without anticoagulation.

OBJECTIVES: To provide an accurate, web-based tool for stratifying patients with atrial fibrillation to facilitate decisions on the potential benefits/risks of anticoagulation, based on mortality, stroke and bleeding risks. DESIGN: The new tool was developed, using stepwise regression, for all and then applied to lower risk patients. C-statistics were compared with CHA2DS2-VASc using 30-fold cross-validation to control for overfitting. External validation was undertaken in an independent dataset, Outcome Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF). PARTICIPANTS: Data from 39 898 patients enrolled in the prospective GARFIELD-AF registry provided the basis for deriving and validating an integrated risk tool to predict stroke risk, mortality and bleeding risk. RESULTS: The discriminatory value of the GARFIELD-AF risk model was superior to CHA2DS2-VASc for patients with or without anticoagulation. C-statistics (95% CI) for all-cause mortality, ischaemic stroke/systemic embolism and haemorrhagic stroke/major bleeding (treated patients) were: 0.77 (0.76 to 0.78), 0.69 (0.67 to 0.71) and 0.66 (0.62 to 0.69), respectively, for the GARFIELD-AF risk models, and 0.66 (0.64-0.67), 0.64 (0.61-0.66) and 0.64 (0.61-0.68), respectively, for CHA2DS2-VASc (or HAS-BLED for bleeding). In very low to low risk patients (CHA2DS2-VASc 0 or 1 (men) and 1 or 2 (women)), the CHA2DS2-VASc and HAS-BLED (for bleeding) scores offered weak discriminatory value for mortality, stroke/systemic embolism and major bleeding. C-statistics for the GARFIELD-AF risk tool were 0.69 (0.64 to 0.75), 0.65 (0.56 to 0.73) and 0.60 (0.47 to 0.73) for each end point, respectively, versus 0.50 (0.45 to 0.55), 0.59 (0.50 to 0.67) and 0.55 (0.53 to 0.56) for CHA2DS2-VASc (or HAS-BLED for bleeding). Upon validation in the ORBIT-AF population, C-statistics showed that the GARFIELD-AF risk tool was effective for predicting 1-year all-cause mortality using the full and simplified model for all-cause mortality: C-statistics 0.75 (0.73 to 0.77) and 0.75 (0.73 to 0.77), respectively, and for predicting for any stroke or systemic embolism over 1 year, C-statistics 0.68 (0.62 to 0.74). CONCLUSIONS: Performance of the GARFIELD-AF risk tool was superior to CHA2DS2-VASc in predicting stroke and mortality and superior to HAS-BLED for bleeding, overall and in lower risk patients. The GARFIELD-AF tool has the potential for incorporation in routine electronic systems, and for the first time, permits simultaneous evaluation of ischaemic stroke, mortality and bleeding risks. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier for GARFIELD-AF (NCT01090362) and for ORBIT-AF (NCT01165710)