8 research outputs found
The principal and parent teacher association.
- Publication venue
- Boston University
- Publication date
- 01/01/1959
- Field of study
Thesis (Ed.M.)--Boston Universit
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity
- Author
- A. Abraheem
- A. Agasou
- A. Ahmed
- A. Ali
- A. Allan
- A. Altabaibeh
- A. Alvaro
- A. Aspinwall
- A. Ayers
- A. Bamford
- A. Barron
- A. Bashyal
- A. Bellini
- A. Bociek
- A. Botello
- A. Bowes
- A. Brady
- A. Brayne
- A. Brown
- A. Brown
- A. Butler
- A. Carter
- A. Collins
- A. Cowley
- A. Cowton
- A. Cowton
- A. Cox
- A. Crew
- A. Dance
- A. Daniel
- A. Daniels
- A. Dela Rosa
- A. Drummond
- A. Durie
- A. E. Heron
- A. Easthope
- A. Easthorpe
- A. Evans.
- A. Fofano
- A. Gales
- A. Ganesan
- A. Gardner
- A. Garg
- A. Gherman
- A. Gordon
- A. Gratrix
- A. Gulati
- A. Gupta
- A. Haigh
- A. Haldeos
- A. Harrison
- A. Harvey
- A. Hayes
- A. Higham
- A. Higham
- A. Hilldrith
- A. Holden
- A. Hormis
- A. Hutcheon
- A. Javaid
- A. Joseph
- A. Kaliappan
- A. Katary
- A. Kay
- A. Kayani
- A. Kent
- A. Kirkby
- A. Knight
- A. Kubisz-Pudelko
- A. Kuravi
- A. Lewis
- A. Loveridge
- A. Lyle
- A. Mayer
- A. McAlpine
- A. McCarthy
- A. McGregor
- A. McGregor
- A. Meikle
- A. Mitchell
- A. Mitra
- A. Morris
- A. Morrison
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- A. Nicholson
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- A. Patel
- A. Pickard
- A. Price
- A. Puxty
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- A. Quinn
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- Valentina Anemoli
- Valentina Borgo
- Valentina Perticaroli
- Verena Keitel
- Veronique Vitart
- W. Harrison
- W. Khaliq
- W. Khaliq
- W. McCormick
- W. Woodyatt
- Wadha Al-Muftah
- WES/WGS Working Group Within the HGI
- Wiktoria Izdebska
- Wilna Oosthuyzen
- X. Qiu
- Xia Shen
- Y. Baird
- Y. Choudhury
- Y. Hussain
- Y. Jackson
- Y. Thirlwall
- Yanara Marincevic-Zuniga
- Yang Wu
- Yaser Al-Sarraj
- Z. Alldis
- Z. Belagodu
- Z. Bradshaw
- Z. Coton
- Z. Daly
- Z. Farzad
- Z. Fernandez
- Z. Garland
- Z. Maqsood
- Z. Omar
- Z. Prime
- Z. Scott
- Zhijian Yang
- Publication venue
- Publication date
- 01/01/2022
- Field of study
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the presence of variants in each gene. An ensemble of LASSO logistic regression models was used to identify the most informative Boolean features with respect to the genetic bases of severity. The Boolean features selected by these logistic models were combined into an Integrated PolyGenic Score that offers a synthetic and interpretable index for describing the contribution of host genetics in COVID-19 severity, as demonstrated through testing in several independent cohorts. Selected features belong to ultra-rare, rare, low-frequency, and common variants, including those in linkage disequilibrium with known GWAS loci. Noteworthily, around one quarter of the selected genes are sex-specific. Pathway analysis of the selected genes associated with COVID-19 severity reflected the multi-organ nature of the disease. The proposed model might provide useful information for developing diagnostics and therapeutics, while also being able to guide bedside disease management. © 2021, The Author(s)
Genetic mechanisms of critical illness in COVID-19.
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- A Agasou
- A Ahmed
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- A Gherman
- A Gordon
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- A Gulati
- A Gupta
- A Haigh
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- A Harrison
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- A Higham
- A Higham
- A Hilldrith
- A Holden
- A Hormis
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- A Katary
- A Kay
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- A Kent
- A Kirkby
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- A Kubisz-Pudelko
- A Kuravi
- A Lewis
- A Loveridge
- A Lyle
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- A McAlpine
- A McCarthy
- A McGregor
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- A Mitchell
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- A Morris
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- A Naranjo
- A Nicholson
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- A Nilsson
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- Achille Iolascon
- Adam Auton
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- Agnese Verzuri
- Agostino Ognibene
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- Ailsa Golightly
- Alan Maclean
- Alessandra
- Alessandra Stella
- Alessandra Vergori
- Alessia Giorli
- Alexander J Mentzer
- Alice Donati
- Alison M Meynert
- Alistair Nichol
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- Moore Shona C
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- N Ahmad
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- Openshaw Peter J M
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- Paul Klenerman
- Pereira Alexandre C
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- Pierpaolo Parravicini
- Pietro Pinoli
- Ponting Chris P
- Porteous David J
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- R Crowe
- R Cusack
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- R Doonan
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- R Gascoyne
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- R Gomez
- R Griffiths
- R Hall
- R Hamill
- R Haq
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- R Harper
- R Herdman-Grant
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- R Jacob
- R Jha
- R Johnson
- R Jones
- R Joy
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- R Kausar
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- R Kumar
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- R Loosley
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- R Marshall
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- R Paramsothy
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- R Partridge
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- R Shokkar
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- R Walker
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- Richard S Tedder
- Richmond Anne
- Riinu Pius
- Rita Perna
- Roberta Russo
- Ross Hendry
- Rossella Tita
- Rowan Kathy
- Russell Clark D
- Ruth Armstrong
- Ruth Lyons
- Ryan S Thwaites
- S Agrawal
- S Allen
- S Allibone
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- S Beavis
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- S Kimber
- S Kumar
- S Laha
- S Latham
- S Leaver
- S Lee
- S Leggett
- S MacFadyen
- S Manna
- S Marriott
- S Masuko
- S McIvor
- S McKechnie
- S Melling
- S Mellor
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- S Moore
- S Morrison
- S Moultrie
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- S Shelton
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- S Spencer
- S Srikaran
- S Stone
- S Swann
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- S Turney
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- S Wood
- S Yussuf
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- Samreen Ijaz
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- Sophie Venturelli
- Stefania Mantovani
- Stefano Baratti
- Stefano Ceri
- Stefano Rusconi
- Stella Aslibekyan
- Stephanie Roberts
- Stephen R Knight
- Summers Charlotte
- Susanna Croci
- Susanna Guerrini
- T Anderson
- T Arden
- T Baird
- T Behan
- T Bemand
- T Cosier
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- T Joefield
- T Kannan
- T Lawton
- T Marsden
- T Martin
- T McHugh
- T Newman
- T Nortcliffe
- T O Jones
- T Pogreban
- T Rees
- T Samakomva
- T Smith
- T Smith
- T Szakmany
- T Varghes
- T Williams
- T Wood
- Tammy Gilchrist
- Tenesa Albert
- Teresa Filshtein-Sonmez
- Thomas M Drake
- Thushan de Silva
- Tim Walsh
- Tom Fletcher
- Tom Solomon
- Tony Wackett
- Trevor Paterson
- Tullio Trotta
- Turtle Lance
- U Poultney
- V Amin
- V Anumakonda
- V Bastion
- V Cannons
- V Crickmore
- V Gopal
- V Irvine
- V Kasipandian
- V Krishnamurthy
- V Lake
- V Linnett
- V Martinson
- V Nagarajan
- V Page
- V Parris
- V Parris
- V Pristopan
- V Ratnam
- V Rivers
- V Sarathy
- V Thomas
- V Thwaites
- V Tuckey
- V Turner
- V Wagstaff
- V Waugh
- Valentina Anemoli
- Vanessa Sancho-Shimizu
- Victoria Shaw
- Vitart Veronique
- W Harrison
- W Khaliq
- W Khaliq
- W McCormick
- W Woodyatt
- Walker Susan
- Walsh Timothy
- Wang Bo
- Wei Shen Lim
- Wendy S Barclay
- William A Paxton
- William Greenhalf
- Wilson James F
- Wrobel Nicola
- Wu Yang
- X Qiu
- Y Baird
- Y Choudhury
- Y Hussain
- Y Jackson
- Y Thirlwall
- Yang Jian
- Yang Zhijian
- Z Alldis
- Z Belagodu
- Z Bradshaw
- Z Coton
- Z Daly
- Z Farzad
- Z Fernandez
- Z Garland
- Z Maqsood
- Z Omar
- Z Prime
- Z Scott
- Zechner Marie
- Zhai Ranran
- Zheng Chenqing
- Publication venue
- Nature
- Publication date
- 01/01/2020
- Field of study
Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 × 10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice
Ainsworth Rand Spofford, 1825-1908; a memorial meeting at the Library of Congress on Thursday, November 12, 1908, at four o'clock, the Librarian of Congress presiding.
- Author
- Anthropological Society of Washington (Washington D.C.)
- Blackwell Henry B.
- Columbia Historical Society (Washington D.C.)
- District of Columbia Library Association.
- District of Columbia. Public Library.
- Fletcher Alice C. (Alice Cunningham), 1838-1923.
- Griffin Appleton P. C. (Appleton Prentiss Clark), 1852-1926.
- Hagner Alexander Burton, 1826-
- Hough Walter, 1859-1935.
- Johnston William Dawson, 1871-1928.
- Library of Congress.
- Literary Society of Washington (Washington D.C.)
- Noyes Theodore W. (Theodore Williams), 1858-1946.
- Putnam Herbert, 1861-1955.
- Publication venue
- [New York city, Printed for the District of Columbia library association by the Webster press,
- Publication date
- Field of study
Biographical note. -- Introductory remarks by Herbert Putnam, librarian of Congress.--Dr. Spofford in Cincinnati, 1845-1860 [by] H. B. Blackwell.--Dr. Spofford and the Library of Congress, 1860-1897 [by] W. D. Johnston, president of the District of Columbia library association.--Dr. Spofford and the Public library of the District [by] T. W. Noyes, president of the trustees.--Dr. Spofford as a member of the Literary society [by] Alice C. Fletcher, of the Literary society.--Dr. Spofford as a member of the Anthropological society [by] W. Hough, president of the society.--Dr. Spofford as a member of the Historical society [by] A. B. Hagner, president of the society.--List of the writings of Dr. Spofford [by] A. P. C. Griffin, assistant librarian of Congress (p. 61-84)Mode of access: Internet
Evolution of the Late Miocene Mediterranean–Atlantic gateways and their impact on regional and global environmental change
- Author
- Abdelwahid Chakor Alami
- Abouchami
- Adams
- Aguirre
- Agustí
- Albarede
- Alfaro
- Alice Marzocchi
- Ambar
- Andersson
- Armi
- Artale
- Azdimousa
- Bache
- Baggley
- Barbieri
- Barhoun
- Baringer
- Bas van den Berg
- Bassetti
- Bassetti
- Beatriz Chacon
- Bellanca
- Benammi
- Benson
- Bertini
- Bertini
- Berástegui
- Bethoux
- Betzler
- Bigg
- Blanc
- Blanc
- Blanc-Valleron
- Boehme
- Bosmans
- Bozzano
- Brackenridge
- Bradshaw
- Braga
- Brayshaw
- Bruch
- Bryden
- Bryden
- Báldi
- Campillo
- Candela
- Capron
- Carnevale
- Carnevale
- Cesar de Castro Martíns
- Chalouan
- Chan
- Chmeleff
- Christensen
- CIESM
- Cifelli
- Clauzon
- Coiffait
- Comas
- Corbí
- Cornée
- Cunningham
- Cunningham
- Cunningham
- Curry
- Dabrio
- Dan Lunt
- de la Vara
- de Lange
- Debenedetti
- Debenedetti
- Dewey
- Di Stefano
- Diana Ochoa
- Dietrich
- Dirk Simon
- Doglioni
- Duggen
- Duggen
- Duquecaro
- Eronen
- Esteban
- Esteras
- Estrada
- Evelina Dmitrieva
- Feinberg
- Fenton
- Fernandes
- Fernández
- Flecker
- Flecker
- Flecker
- Flores
- Flower
- Fontboté
- Fortuin
- Francisco J. Sierro
- Frank
- Frank
- Frits Hilgen
- Fullea
- Garcia-Castellanos
- Garcia-Castellanos
- Garcés
- Garcés
- García
- García Lafuente
- Gargani
- Gert de Lange
- Gibert
- Gladstone
- González-Delgado
- Govers
- Govers
- Griffin
- Griffin
- Gueguen
- Guerra-Merchan
- Gutjahr
- Gutscher
- Gutscher
- Harlavan
- Hayes
- Hecht
- Henderson
- Henry
- Hernández-Molina
- Hernández-Molina
- Herold
- Hilgen
- Hilgen
- Hilgen
- Hilgen
- Hinz
- Hodell
- Hodell
- Hodell
- Hodell
- Hohenegger
- Hsü
- Hsü
- Hsü
- Hüsing
- Hüsing
- Hüsing
- Hüsing
- Iaccarino
- Iaccarino
- Iaccarino
- Ingram
- Iorga
- Iribarren
- Ivanović
- Ivanović
- Ivanović
- Ivanović
- Jacobsen
- Jaeger
- Jaeger
- James Howard
- Jan Peter Mayser
- Jiménez-Moreno
- Johanna Lofi
- John Gregory
- Jose A. Flores
- Jurado
- Kahana
- Kamikuri
- Karami
- Keigwin
- Khelifi
- Khélifi
- Koulali
- Kouwenhoven
- Kouwenhoven
- Krijgsman
- Krijgsman
- Krijgsman
- Krijgsman
- Krijgsman
- Krijgsman
- Krijgsman
- Krijgsman
- Krijgsman
- Krijgsman
- Krijgsman
- Kutzbach
- Lacan
- Larrasoaña
- Lewis
- Li
- Lisiecki
- Litto
- Llave
- Llave
- Llave
- Lofi
- Lofi
- Lofi
- Loget
- Lonergan
- Lourens
- Lozar
- Lozier
- Lozier
- Lugli
- Lugli
- Lunt
- Maillard
- Maillard
- Maillard
- Major
- Maldonado
- Manzi
- Manzi
- Manzi
- Manzi
- Marcus Gutjahr
- Maria Ochoa
- Maria Tulbure
- Marlies van der Schee
- Martín
- Martín
- Martín
- Martín
- Martín-Suárez
- Martínez-García
- Marzocchi
- Mauffret
- Mauritzen
- McArthur
- McArthur
- McCartney
- McKenzie
- MEDAR Group
- Medialdea
- Meijer
- Meijer
- Meijer
- Meijer
- Michard
- Minwer-Barakat
- Mohamed Zakaria Yousfi
- Molnar
- Montadert
- Montanari
- Moran
- Moreno
- Muiños
- Murdock
- Murphy
- Müller
- Müller
- Münch
- Münch
- Nadia Barhoun
- Naima Bachiri
- Naranjo
- Natalicchio
- Obone-Zué-Obame
- Omodeo Salé
- Orszag-Sperber
- Orszag-Sperber
- Osborne
- Paul Meijer
- Penaud
- Perez-Folgado
- Pickford
- Piepgras
- Pierre
- Platt
- Platt
- Pound
- Pound
- Prange
- Pratsch
- Price
- Price
- Puga-Bernabeu
- Pérez-Asensio
- Pérez-Asensio
- Pérez-Asensio
- Rachel Flecker
- Raffi
- Rahmstorf
- Raymo
- Reid
- Reid
- Riaza
- Rich Pancost
- Rob Govers
- Robert Ellam
- Robinson
- Roca
- Rodero
- Roger
- Rogerson
- Rogerson
- Rogerson
- Rogl
- Rohling
- Rohling
- Rohling
- Rouchy
- Rouchy
- Roveri
- Roveri
- Roveri
- Roveri
- Ryan
- Ryan
- Saint Martin
- Saint Martin
- Santarelli
- Santisteban
- Schildgen
- Schneck
- Schneider
- Schroeder
- Seidenkrantz
- Sepulchre
- Sevasti Modestou
- Sgarrella
- Sgarrella
- Shackleton
- Shackleton
- Shackleton
- Sholkovitz
- Sierro
- Sierro
- Sierro
- Sierro
- Sierro
- Sierro
- Sonnenfeld
- Soria
- Spivack
- Sprovieri
- Sprovieri
- Sprovieri
- Stephen Vincent
- Stich
- Stow
- Suc
- Suc
- Suc
- Tachikawa
- Tanja Kouwenhoven
- Thierstein
- Thomas
- Thunell
- Thunell
- Thurner
- Topper
- Topper
- Topper
- Topper
- Toto
- Tzedakis
- Utescher
- Vai
- van Assen
- van Couvering
- van Dam
- van de Poel
- van der Laan
- van der Laan
- van der Laan
- van der Made
- Van der Zwaan
- van Hinsbergen
- Vegas
- Violanti
- Vissers
- Voelker
- Walter Capella
- Warren
- Wernli
- Woodruff
- Wout Krijgsman
- Wright
- Wu
- Zachos
- Zhang
- Zhang
- Zitellini
- Zouhri
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Age and frailty are independently associated with increased COVID-19 mortality and increased care needs in survivors: Results of an international multi-centre study
- Author
- Aaliya A. M.
- Abd Elazeem H. A. S.
- Abdelhafez M. H.
- Abdelmalak A.
- Abdelwahab O. A.
- Abdulhadi O. M. A. S.
- Abdulmalek A.
- Abdulmoiz A.
- Adewole O.
- Ahmed A.
- Ahmed A.
- Aimee L.
- Albatoul M.
- Alexander C.
- Ali A.
- Alice N.
- Alsahab M.
- Avinash A.
- Azzam Y.
- Babar L.
- Babb L.
- Badh M.
- Baguiasri M.
- Baguneid C.
- Bailey E.
- Baili E.
- Baldwin S.
- Baloyiannis I.
- Bannerjee M.
- Barnard A.
- Barra F.
- Bashir H.
- Bawor M.
- Bayhan Z.
- Beishon L.
- Belcher J.
- Belgamwar R.
- Bentley C.
- Birchenough A.
- Boden R.
- Bouhuwaish A.
- Brachini G.
- Bremner L.
- Bridgwater H.
- Brown B.
- Bryant C.
- Budd G.
- Budd S.
- Budzikoski A.
- Bulla R.
- Buondonno A.
- Burden N.
- Burn E.
- Burton J. K.
- Butt H.
- Capoglu R.
- Caracostea A.
- Cardoso R.
- Carolyn A.
- Carr A.
- Carrasco-Prats M.
- Catherine A.
- Catherine O.
- Cattel C.
- Ceccarelli G.
- Cecere G.
- Charalabopoulos A.
- Charsley E.
- Cheney-Lowe H.
- Cheran A.
- Chevallier T.
- Choudhry A. J.
- Christina O.
- Ciccarone F.
- Cicerchia P. M.
- Cirillo B.
- Collins F. D.
- Comerford V.
- Cordie A.
- Coulter S.
- Coulthard N.
- Cox C.
- Cox N.
- Cox V.
- Crowe A.
- Cullen J.
- Cummings J.
- Cunningham N.
- Curley D.
- Currie H.
- Daly M.
- Dani M.
- Danielle L.
- Darley J.
- Dattani N.
- Davakis S.
- Davies R.
- De Paola G.
- De Toma G.
- Del Valle-Ruiz S.
- Deldar B.
- Demir H.
- Desai A.
- Desai N.
- Devaney A.
- Dew L.
- Dhesi J.
- Dias M.
- Dick G.
- Doddamani P.
- Dogra G.
- Doll T.
- Dooley H. C.
- Dost S.
- Dotchin C.
- Dowell H.
- Drghita I. M.
- Dundas J. M.
- Duranti G.
- Dusara H.
- Dwivedi R.
- Dyer A. H.
- Eastaugh A.
- Edwards E.
- Eirene Y.
- El-Shazly M.
- Elabedeen O. Z.
- Eleanor L.
- Elghazaly S. M.
- Elhadi M.
- Elmehrath A. O.
- Elrick H.
- Elsayed A.
- Eltayeb M. A.
- Emery A.
- Emily L.
- Emma L.
- Emrah A.
- Etchill E. W.
- Evans S.
- Evison F.
- Fairhead C.
- Fatih A. -S.
- Faulkner M.
- Favour N.
- Felska A.
- Fernandez A.
- Fernandez-Fernandez P. V.
- Ferraiolo A.
- Ferrero S.
- Fiori E.
- First N.
- Fisk G.
- Fleck A.
- Francesco A.
- Freshwater S.
- Gabre-Kidan F. A.
- Gabriel L.
- Gallo G.
- Gandhi R.
- Garner M.
- Gaunt V.
- Gavriella L.
- Georgiou N.
- Gerretsen H.
- Ghannam N. A. A.
- Ghobrial A.
- Ghobrial H.
- Ghufoor Z.
- Gibbon J.
- Gilbert G. F.
- Giles M.
- Gimenez-Frances C.
- Giovanni B.
- Gitanjali A.
- Gonullu E.
- Gordon A.
- Goujon M.
- Grace L.
- Gray A.
- Gray J. H.
- Green D.
- Greene C.
- Griffin E.
- Griffith K.
- Grubb A.
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- Guerero D. N.
- Gupta A.
- Gustavino C.
- Guzman L.
- Hadreiez A. K. M.
- Hajiioannou J.
- Hale M.
- Hanji D.
- Harmantepe T.
- Harrison P.
- Harsha M.
- Hart B.
- Haslam A.
- Haunton V.
- Haut E. R.
- Hayley J. B.
- Hazem A. A.
- Heinsohn T.
- Helena L.
- Hennah L.
- Hetta H. F.
- Hickman A.
- Hobill A.
- Hogan P. C. P.
- Hogan V.
- Holmes E.
- Honney K.
- Hood K.
- Hopkinson K.
- Howells L.
- Hrouda N.
- Hughes T.
- Hunsley D.
- Hurst W.
- Hussein A. R. M.
- Ibrahim E. A. A.
- Ibtida I.
- Ibukunoluwakitan A.
- Ishlek I.
- Islam A.
- Ismini P.
- Iyer R.
- Jackson K.
- Jackson R.
- Jackson T. A.
- Jade M.
- James E.
- Jarita V. S.
- Jarvis H.
- Jeffs S.
- Jelley B.
- Jenko N.
- Jessica P.
- Jeyakumar S.
- Jocelyn A.
- Jolene A.
- Kabir S.
- Kainth H.
- Kalloo J.
- Kanzaria A.
- Karapanou A.
- Kardaman N.
- Karthikeyan S.
- Karunatilleke A.
- Kelly M.
- Kelly N. I.
- Khalid H.
- Khan A.
- Khan H.
- Khan M. S.
- Khiroya H.
- King M.
- Kingsley H. A.
- Kneen T.
- Kok L.
- Kratochwila C.
- Kuzeva A.
- Lal R.
- Lapolla P.
- Lau R.
- Laura W.
- Lauren P.
- Lelt Y.
- Lia O.
- Lily L. -M.
- Lobna A. -S.
- Lochlainn M. N.
- Luigi S.
- Madden K.
- Madhavan D. H.
- Magill L.
- Manning H.
- Mantoglu B.
- Marc O.
- Martinez-Sanz N.
- Marx W.
- Masoli J.
- Masood A. E.
- Masud T.
- Maughan T.
- Mawhinney J.
- Maxfield D.
- Mayer J.
- Maynard H.
- Mccluskey L.
- Mcdonald C.
- Mcgovern A.
- Mclachlan S.
- Mcneela N.
- Medina-Manuel E.
- Meneghini S.
- Merve Y.
- Metcalf M.
- Millwood-Hargrave J.
- Mingoli A.
- Miu K.
- Mohamed Aliae S. M.
- Mohamed F.
- Mohamed H.
- Mohammad A. A.
- Mohammed A.
- Mohammed M. A.
- Mohammedseid-Nurhussien A.
- Momen M. A. A.
- Moomo F.
- Moorey H.
- Mora-Guzman I.
- Moriarty L.
- Morrin H.
- Morris C.
- Moss N.
- Moustafa M. M.
- Mpoura M.
- Mubin M.
- Muhammed A.
- Muhtaroglu A.
- Muir G.
- Mulhern S.
- Muller D.
- Murphy D. C.
- Muzammil B.
- Nadkarni V.
- Nasreldin K.
- Natalie W.
- Nawaz W.
- Nee Y.
- Nguyen H.
- Ni C.
- Nikolaos S.
- Nirantharakumar K.
- Okoth K.
- Olebu O.
- Omoteniola O.
- Osuafor C. N.
- Passby C.
- Pastor-Perez P.
- Patel H.
- Patel S.
- Patterson K.
- Pearson G. M. E.
- Pedro L.
- Penfold R.
- Perinpanathan R.
- Perivoliotis K.
- Perra T.
- Perry R.
- Pettitt M.
- Pigott J.
- Pinkney M.
- Pinkney T.
- Pinotti E.
- Porcu A.
- Price A.
- Pugliese F.
- Puri P.
- Pytraczy S.
- Qaiser Y.
- Quinn T.
- Qurashi M.
- Rachael A.
- Radenkovic D.
- Rajeswaran T.
- Rand A.
- Rapaport S. F.
- Razzak T.
- Rebecca W.
- Reilly L.
- Reynolds A.
- Reynolds P.
- Richardson A.
- Richardson S.
- Roberts A.
- Roberts-Rhodes C.
- Robinson T.
- Rocca A.
- Ross-Skinner E.
- Ruiz-Marin M.
- Ryall R.
- Saad A. M.
- Saad M. M.
- Sadiq A.
- Sally T. A.
- Sammarco G.
- Sampanis M. A.
- Samuel N.
- Sanghvi H.
- Sanyal N.
- Sapienza P.
- Sarah M.
- Sayers R.
- Scott L.
- Seed A.
- Sen M.
- Shaban M. A. A.
- Shakespeare K. T.
- Shaw E.
- Shaw H.
- Sheldrake J.
- Shivam P.
- Sinead O.
- Sivarajan S. S.
- Sleeman I.
- Smith J.
- Soo C.
- Speranza F.
- Spice C.
- Stafford A.
- Stambollouian K.
- Stephanie W.
- Stephen L.
- Stevens K. A.
- Steves C.
- Stewart J.
- Strain W. D.
- Stratton E.
- Street H.
- Surtees M.
- Suvira L.
- Swinnerton E.
- Sylvia A.
- Taha A.
- Taher A. S. A.
- Tait C.
- Taylor A.
- Taylor J.
- Thake M.
- Theodore L.
- Thin K.
- Thould H.
- Thyn T.
- To B.
- Tobiss H.
- Toppley K.
- Torsney K.
- Townsend L.
- Tullo E.
- Tzovaras G.
- Umeadi A.
- Vaidya H.
- Valero-Soriano M.
- Varden R.
- Vergani V.
- Vervoort D.
- Vescio G.
- Vettasseri M.
- Virk M.
- Vyas V.
- Wagland J.
- Wallis S.
- Warner C.
- Watkins E.
- Watson H.
- Webb R.
- Welch C.
- Welsh S. H.
- West R.
- Whelan E.
- Whitney J.
- Whitsey M.
- Wilcock C.
- Wilkinson I.
- Williams D.
- Williamson M.
- Willott R. H.
- Wilson D.
- Wimalasundera M.
- Witham M.
- Yang S.
- Yasin Y.
- Yasmin N.
- Yee K.
- Yesim M. A.
- Yildiz A.
- Yusuf H.
- Zambon M.
- Zaw H.
- Zeinab M.
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2021
- Field of study
Age and frailty are independently associated with increased COVID-19 mortality and increased care needs in survivors: results of an international multi-centre study
- Author
- Aaliya Mohammed (12499327)
- Abdulkader Mohammad (12499324)
- Abdulmalek Aljafari (12498697)
- Abdulmoiz Aljafari (12498700)
- Abigail Hobill (12499126)
- Abigail Reynolds (9119102)
- Adam Budzikoski (12498805)
- Adam Gordon (825422)
- Adam H Dyer (12498967)
- Adam Seed (2367799)
- Agnieszka Felska (12499003)
- Ahmad Bouhuwaish (9757988)
- Ahmed A Momen (12499330)
- Ahmed Cordie (12498865)
- Ahmed KM Hadreiez (12499093)
- Ahmed O Elmehrath (12498979)
- Ahmed SA Taher (12499558)
- Ahmed Y Azzam (12229460)
- Aidan Haslam (12499108)
- Aimee Leadbetter (12499234)
- Aina Ibukunoluwakitan (12499159)
- Aine McGovern (10174331)
- Akhil Kanzaria (12499198)
- Alberto Porcu (5473763)
- Aldo Rocca (10650326)
- Alexander Emery (12498988)
- Alexander Hickman (12499123)
- Alexander Noar (12499387)
- Alexandra Richardson (12499465)
- Alexandros Charalabopoulos (12498838)
- Alexis Carr (12498829)
- Ali Ali (3510386)
- Ali Muhtaroglu (12499357)
- Aliae AR Mohamed Hussein (12499321)
- Alice Devaney (12498922)
- Alice O'Docherty (12499393)
- Alison Eastaugh (12498970)
- Almontacer EB Masood (12499279)
- Alodia Gabre-Kidan (12499027)
- Alshaimaa M Saad (12499483)
- Amalia Karapanou (12499201)
- Amanda Stafford (12499537)
- Ambreen Sadiq (12499489)
- Amelia Roberts (12499468)
- Amir Abdelmalak (12498673)
- Amy Birchenough (12498781)
- Amy Gray (4541533)
- Amybel Taylor (12499564)
- Andra Caracostea (12498823)
- Andrea Mingoli (11397024)
- Andrew Crowe (450839)
- Andrew Ghobrial (12499045)
- Aneliya Kuzeva (12499228)
- Angeline Price (10174343)
- Anna Barnard (1987999)
- Anna Fleck (12499021)
- Anne Karunatilleke (12499210)
- Anthony Grubb (12499081)
- Anthony Umeadi (12499591)
- Antia Fernandez (12499006)
- Antonella Ferraiolo (696685)
- Antonio Buondonno (12498811)
- Arjun Desai (12498919)
- Asad J Choudhry (12498850)
- Asma Khan (8140407)
- Avinash Aujayeb (12229442)
- Awolkhier Mohammedseid-Nurhussien (12498631)
- Ayushi Gupta (9031847)
- Baguiasri Mandane (12499264)
- Barbara Hart (12499105)
- Baris Mantoglu (12499270)
- Benjaman To (12499579)
- Benjamin Jelley (12498613)
- Benyamin Deldar (12498916)
- Bruno Cirillo (9503960)
- Bryony Brown (12498586)
- Bushra Muzammil (12499369)
- Carly Welch (6206861)
- Caroline Tait (12499561)
- Carolyn Akladious (12498694)
- Cassandra Fairhead (12498997)
- Caterina Cattel (12498835)
- Catherine Atkin (12498733)
- Catherine Bryant (5072462)
- Catherine Dotchin (5983973)
- Catherine O'Mahony (12499405)
- Catherine Wilcock (12499639)
- Catrin Cox (12498874)
- Charlotte Greene (12499072)
- Charlotte Roberts-Rhodes (12499471)
- Chee Soo (12498658)
- Cheran Anandarajah (12498721)
- Chiara Kratochwila (12499225)
- Chloe Warner (12499618)
- Christina Page (12499414)
- Christopher N Osuafor (12498634)
- Claire McDonald (627409)
- Claire Morris (2019940)
- Claire Spice (12499534)
- Claire Steves (5144204)
- Clara Gimenez-Frances (12499063)
- Clare Baguneid (12498754)
- Claudio Gustavino (12499087)
- Cliona Ni Cheallaigh (9617430)
- Corrina Bentley (12498778)
- Daisy Wilson (6011324)
- Daniel Curley (12498886)
- Daniel Muller (3244128)
- Daniel N Guerero (12499084)
- Danielle Hunsley (12499150)
- Danielle Lis (12499240)
- David Williams (229939)
- Declan C Murphy (12499366)
- Deepthy Hari Madhavan (12499102)
- Deevia Hanji (12499099)
- Deirdre Green (12499069)
- Dina Radenkovic (4676860)
- Dominic Maxfield (12499288)
- Dominique Vervoort (8468494)
- Efstratia Baili (12258342)
- Eirene Yeung (210321)
- Eleanor Lunt (12499252)
- Eleanor Watkins (12499621)
- Elinor Burn (12498589)
- Elinor Edwards (12498973)
- Elisha Whelan (12499630)
- Elizabeth Holmes (12499135)
- Ellanna Griffin (12499075)
- Ellen James (12499174)
- Ellen Tullo (2880158)
- Ellie Shaw (12499513)
- Elliott R Haut (12499111)
- Elsayed M Awad (12498736)
- Eltayeb A Ahmed (12498685)
- Emily Bailey (5754929)
- Emily Lyon (12499255)
- Emily Ross-Skinner (12499474)
- Emma Livesey (12499243)
- Emma Stratton (12499546)
- Emma Swinnerton (12499555)
- Emre Gonullu (12258426)
- Enrico Fiori (12499012)
- Enrico Pinotti (12499438)
- Eric W Etchill (12498991)
- Esther Medina-Manuel (12499300)
- Evelyn Charsley (12498841)
- Fabio Barra (12229463)
- Fabio Speranza (3594422)
- Farhana Moomo (12499333)
- Fatih Altintoprak (12467228)
- Fatma D Collins (12498859)
- Favour Nwolu (12499390)
- Fawsiya Mohamed (12499315)
- Felicity Evison (12498994)
- Flavia Ciccarone (12498853)
- Francesco Alessandri (6787682)
- Francesco Pugliese (792375)
- Gabriel Lee (838259)
- Gabrielle Budd (12498799)
- Gaetano Gallo (6173327)
- Gavriella Levinson (12499237)
- George Tzovaras (12499588)
- Georgia F Gilbert (12499057)
- Georgina Muir (12499360)
- Giancarlo Ceccarelli (648611)
- Gilda De Paola (12498907)
- Gioia Brachini (12498790)
- Giorgio De Toma (12498910)
- Giovanni B Fonsi (12499024)
- Gitanjali Amaratungaz (12498709)
- Giulia Duranti (12498958)
- Giuseppe Cecere (1928059)
- Giuseppe Sammarco (575750)
- Giuseppina Vescio (12499600)
- Gordon Dick (12498934)
- Grace Lewis (6813344)
- Grace ME Pearson (12498640)
- Gracie Fisk (12499018)
- Gurinder Dogra (12498940)
- Hakan Demir (1454902)
- Hamilton Morrin (12499342)
- Hanna Nguyen (12499384)
- Hannah Bashir (12498766)
- Hannah Bridgwater (12498796)
- Hannah C Dooley (8214468)
- Hannah Cheney-Lowe (12498844)
- Hannah Currie (12498889)
- Hannah Dowell (12498949)
- Hannah Gerretsen (12499039)
- Hannah Moorey (3548264)
- Hannah Shaw (12499516)
- Hannah Street (12499549)
- Hannah Thould (12499573)
- Hannah Tobiss (12499582)
- Hannah Watson (71406)
- Haris Khan (8748504)
- Harjinder Kainth (12499192)
- Harnish Patel (3532901)
- Harsha Malapati (11091047)
- Hayley Jarvis (12499177)
- Hayley R Boden (12498787)
- Hazel Sanghvi (12499495)
- Hazem Ahmed (2734090)
- Hedra Ghobrial (12499048)
- Heena Khiroya (12498616)
- Hein Zaw (5772269)
- Hejab Butt (12498817)
- Helal F Hetta (12499120)
- Helena Lee (7481552)
- Henry Maynard (12499294)
- Hesham Khalid (12499213)
- Hiren Dusara (12498961)
- Hope Elrick (12498982)
- Hossam Aldein S Abd Elazeem (12498667)
- Hrisheekesh Vaidya (4241539)
- Humza Yusuf (12499666)
- Iain Wilkinson (11210310)
- Ioan M Draghita (12498952)
- Ioannis Baloyiannis (12498760)
- Irem Ishlek (12499162)
- Ishmam Ibtida (9849214)
- Islam A Ahmed (12498688)
- Ismael Mora-Guzman (12499336)
- Ismini Panayotidis (4778079)
- Isobel Sleeman (12498655)
- Jack Cullen (12498877)
- Jack Stewart (11781983)
- Jade Man (12499261)
- Jake Gibbon (12499054)
- James Belcher (12498772)
- James M Dundas (12498955)
- Jamie Mawhinney (12499285)
- Jane Masoli (3540020)
- Jarita Sivam (12499528)
- Jason Kalloo (12499195)
- Jay Darley (12498895)
- Jean Cummings (12498880)
- Jenni K Burton (12498592)
- Jennifer Pigott (12498649)
- Jennifer Smith (172056)
- Jessica Parkin (12499420)
- Jiannis Hajiioannou (12499096)
- Joanne Taylor (49271)
- Joanne Wagland (12499612)
- Jocelyn Amer (12498712)
- John Millwood-Hargrave (12499309)
- Jolene Atia (3172896)
- Jonathan Sheldrake (12499519)
- Jordan Mayer (12499291)
- Joshua H Gray (12499066)
- Jugdeep Dhesi (12498928)
- Julie Whitney (12499633)
- Kar Yee Law (12499231)
- Karl Jackson (12499168)
- Karla Griffith (12499078)
- Katharine Hood (12499138)
- Katharine Stambollouian (12499540)
- Katherine Hopkinson (12499141)
- Katherine Patterson (12498637)
- Kathleen T Shakespeare (12499510)
- Kathryn Toppley (12499585)
- Katie Honney (7799858)
- Katie Thin (12499570)
- Katy Madden (12498622)
- Kelli Torsney (12498664)
- Kelvin Miu (12499312)
- Kelvin Okoth (10307754)
- Kent A Stevens (12499543)
- Kingsley Appiah (12498730)
- Konstantinos Perivoliotis (12499432)
- Krishnarajah Nirantharakumar (154539)
- Lara Howells (12499144)
- Lara Reilly (12499462)
- Laura Babb (12498748)
- Laura Bremner (12498793)
- Laura Magill (4399846)
- Laura Winter (12499651)
- Lauren C Passby (12499423)
- Lauren McCluskey (12498625)
- Laurenny Guzman (12499090)
- Laxmi Babar (12498745)
- Li Kok (12499222)
- Lia Orlando (12499408)
- Liam Townsend (9617403)
- Lily Lowes (12499249)
- Lindsay Hennah (12499117)
- Lindsey Dew (12498925)
- Lizzie Moriarty (12499339)
- Lobna Al-Sodani (12498706)
- Luca Scott (12499501)
- Lucy Beishon (7298981)
- Luigi Simonelli (12499525)
- Madeleine Daly (12498892)
- Madeleine Garner (12499033)
- Madiha Virk (12499606)
- Mahmoud M Saad (12499486)
- Mairead Kelly (346537)
- Manpreet Badh (12498751)
- Marc Osterdahl (12499411)
- Margherita Faulkner (12499000)
- Maria Dias (12498931)
- Maria Mpoura (12499351)
- Maria Qurashi (12499450)
- Maria Valero-Soriano (12499594)
- Mariam Albatoul Nageh (12499375)
- Marie Giles (12499060)
- Marie Goujon (12498604)
- Mark Vettasseri (12499603)
- Mark Whitsey (12499636)
- Martha Pinkney (12499435)
- Martina Zambon (12499669)
- Mary Ni Lochlainn (11419458)
- Matthew Hale (9045264)
- Matthew King (782718)
- Megan Williamson (11996525)
- Melanie Dani (6397982)
- Mertcan Akcay (12498691)
- Merve Yigit (12499660)
- Mettha Wimalasundera (12499645)
- Michael Sen (12499504)
- Michael Surtees (12499552)
- Michail A Sampanis (12499492)
- Michala Pettitt (12498646)
- Michelle Metcalf (12499306)
- Miguel Ruiz-Marin (12499477)
- Milagros Carrasco-Prats (12498832)
- Miles Witham (4355218)
- Miriam Thake (12499567)
- Mohamed Eltaher AA Ibrahim (12499156)
- Mohamed M Moustafa (12499348)
- Mohammad T Azam (12498739)
- Mohammed A Azab (12229448)
- Mohammed Ahmad (9120880)
- Mohammed Al-Sadawi (12498703)
- Mohammed H Abdelhafez (12498670)
- Mohammed Mubin (12499354)
- Monica Bawor (516749)
- Mosab AA Shaban (12499507)
- Mostafa El-Shazly (12498985)
- Moulinath Bannerjee (12498763)
- Muhammad S Khan (12499216)
- Muhammed Elhadi (9689965)
- Muhammed H Ansari (12498727)
- Mustafa Alsahab (12498583)
- Natalie Cox (12498595)
- Natalie McNeela (12498628)
- Natalie Yeo (12499657)
- Nathan Jenko (12499183)
- Necattin Firat (12499015)
- Niamh Cunningham (12498883)
- Nicholas Moss (12499345)
- Nick Coulthard (12498871)
- Nicola Kelly (9194178)
- Nicole Burden (12498814)
- Nicole Hrouda (12499147)
- Nik Sanyal (12498652)
- Nikhita Dattani (12498898)
- Nikolaos Georgiou (12499036)
- Nikolaos Sipsas (8687409)
- Nirali Desai (10956418)
- Nourhan AA Ghannam (12499042)
- Nuha Kardaman (12499204)
- Nuria Martinez-Sanz (12499273)
- Olebu Ogochukwu (12499402)
- Olubayode Adewole (12498682)
- Omar A Abdelwahab (12498676)
- Omar Zein Elabedeen (12499672)
- Omoteniola Odutola (12499396)
- Osama MAS Abdulhadi (12498679)
- Paolo Sapienza (11397021)
- Parveen Doddamani (12498937)
- Patricia Pastor-Perez (12499426)
- Patrick CP Hogan (12499129)
- Patrick Harrison (11805810)
- Paul Reynolds (382180)
- Pedro Fernandez-Fernandez (12499009)
- Pedro Lopez-Morales (12499246)
- Pierfrancesco Lapolla (10232340)
- Pierfranco M Cicerchia (12498856)
- Prabhleen Puri (12499441)
- Rachael Anders (12498724)
- Rachael Webb (12499624)
- Rajesh Dwivedi (12498964)
- Rajni Lal (12498619)
- Rand A Hussein (12499153)
- Ratnam Gandhi (12499030)
- Ravindra Belgamwar (12498775)
- Rebecca Lau (3664084)
- Rebecca Ryall (12499480)
- Rebecca Wright (12339118)
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- Reem Bulla (12498808)
- Rifa Cardoso (12498826)
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- Rita Perry (12498643)
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- Rose Penfold (7537139)
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- Rowan Davies (12498904)
- Rupini Perinpanathan (12499429)
- Ruth H Willott (12499642)
- Ruth West (8003159)
- Sally Aziz (12498742)
- Samiullah Dost (12498946)
- Samuel North (4070647)
- Sandeep Karthikeyan (12499207)
- Sarah Baldwin (12498757)
- Sarah Evans (270764)
- Sarah F Rapaport (12499456)
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- Sarah Richardson (698187)
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- Shahriar Kabir (12499189)
- Sharon Budd (12498802)
- Shefali Patel (11154648)
- Shivam Pancholi (12499417)
- Shrouk M Elghazaly (12498976)
- Simona Meneghini (12499303)
- Simone Ferrero (4614157)
- Sinead O'Dwyer (12499399)
- Sing Yang Sim (12499522)
- Siobhan Coulter (12498868)
- Soha M Mohamed (12499318)
- Sophie Jeffs (12499180)
- Sophie Mclachlan (12499297)
- Spyridon Davakis (12498901)
- Sri Sivarajan (12499531)
- Stephanie Mulhern (12499363)
- Stephanie Wallis (12499615)
- Stephanie Worrall (12499654)
- Stephen Lim (149062)
- Suvira Madan (12499258)
- Sylvia Amini (12498715)
- Sylvia Pytraczyk (12499444)
- Taha Amir (12498718)
- Tahir Masud (804313)
- Tahmina Razzak (12499459)
- Tanya Robinson (11016672)
- Terence Quinn (3717607)
- Teresa Perra (12258519)
- Terry Hughes (12498607)
- Theodore Chevallier (12498847)
- Theodore Liakakos (3475031)
- Thomas A Jackson (12498610)
- Thomas Kneen (12499219)
- Thomas Pinkney (467511)
- Thurkka Rajeswaran (12499453)
- Thyn Thyn (12499576)
- Tina Doll (12498943)
- Tom Maughan (12499282)
- Torben Heinsohn (12499114)
- Vaishali Vyas (12499609)
- Varun Nadkarni (12499372)
- Vesna Hogan (12499132)
- Victoria Comerford (12498862)
- Victoria Cox (325585)
- Victoria Gaunt (12498601)
- Victoria Haunton (7755344)
- Vittoria Vergani (4846690)
- W David Strain (12498661)
- Wasim Nawaz (12499381)
- William Hurst (4229008)
- William Marx (12499276)
- Yasin A Yildiz (12499663)
- Yasmin K NasrEldin (12499378)
- Yen Nee J Bo (12498784)
- Yu Lelt Win (12499648)
- Yue Guan (2178228)
- Yusra Qaiser (12499447)
- Zaynub Ghufoor (12499051)
- Zeinab Majid (9957176)
- Zulfu Bayhan (12498769)
- Publication venue
- Publication date
- 05/02/2021
- Field of study
Introduction: Increased mortality has been demonstrated in older adults with coronavirus disease 2019 (COVID-19), but the effect of frailty has been unclear.
Methods: This multi-centre cohort study involved patients aged 18 years and older hospitalised with COVID-19, using routinely collected data. We used Cox regression analysis to assess the impact of age, frailty and delirium on the risk of inpatient mortality, adjusting for sex, illness severity, inflammation and co-morbidities. We used ordinal logistic regression analysis to assess the impact of age, Clinical Frailty Scale (CFS) and delirium on risk of increased care requirements on discharge, adjusting for the same variables.
Results: Data from 5,711 patients from 55 hospitals in 12 countries were included (median age 74, interquartile range [IQR] 54–83; 55.2% male). The risk of death increased independently with increasing age (>80 versus 18–49: hazard ratio [HR] 3.57, confidence interval [CI] 2.54–5.02), frailty (CFS 8 versus 1–3: HR 3.03, CI 2.29–4.00) inflammation, renal disease, cardiovascular disease and cancer, but not delirium. Age, frailty (CFS 7 versus 1–3: odds ratio 7.00, CI 5.27–9.32), delirium, dementia and mental health diagnoses were all associated with increased risk of higher care needs on discharge. The likelihood of adverse outcomes increased across all grades of CFS from 4 to 9.
Conclusion: Age and frailty are independently associated with adverse outcomes in COVID-19. Risk of increased care needs was also increased in survivors of COVID-19 with frailty or older age.</p
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdelrazik Marwa
- Abdollahi Hamed
- Abdullah T.
- Abecasis Goncalo
- Abedalthagafi M.
- Abel Lynn
- Abernathy C.
- Abraheem Azmeralde
- Abul-Husn Noura S.
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- Aksentijevich Alexandra
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- Åsvold Bjørn Olav
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Altres ajuts: Department of Health and Social Care (DHSC); Illumina; LifeArc; Medical Research Council (MRC); UKRI; Sepsis Research (the Fiona Elizabeth Agnew Trust); the Intensive Care Society, Wellcome Trust Senior Research Fellowship (223164/Z/21/Z); BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070, BBS/E/D/30002275); UKRI grants (MC_PC_20004, MC_PC_19025, MC_PC_1905, MRNO2995X/1); UK Research and Innovation (MC_PC_20029); the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z); the Edinburgh Clinical Academic Track (ECAT) programme; the National Institute for Health Research, the Wellcome Trust; the MRC; Cancer Research UK; the DHSC; NHS England; the Smilow family; the National Center for Advancing Translational Sciences of the National Institutes of Health (CTSA award number UL1TR001878); the Perelman School of Medicine at the University of Pennsylvania; National Institute on Aging (NIA U01AG009740); the National Institute on Aging (RC2 AG036495, RC4 AG039029); the Common Fund of the Office of the Director of the National Institutes of Health; NCI; NHGRI; NHLBI; NIDA; NIMH; NINDS.Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care or hospitalization after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes-including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)-in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease