In-Hospital Glucose Monitoring: Adequacy and Resource Management

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In-silico modelling of the mitogen-activated protein kinase (MAPK) pathway in colorectal cancer: mutations and targeted therapy

Introduction: Chemical reaction networks (CRNs) are powerful tools for describing the complex nature of cancer’s onset, progression, and therapy. The main reason for their effectiveness is in the fact that these networks can be rather naturally encoded as a dynamical system whose asymptotic solution mimics the proteins' concentration profile at equilibrium.Methods and Results: This paper relies on a complex CRN previously designed for modeling colorectal cells in their G1-S transition phase and presents a mathematical method to investigate global and local effects triggered on the network by partial and complete mutations occurring mainly in its mitogen-activated protein kinase (MAPK) pathway. Further, this same approach allowed the in-silico modeling and dosage of a multi-target therapeutic intervention that utilizes MAPK as its molecular target.Discussion: Overall the results shown in this paper demonstrate how the proposed approach can be exploited as a tool for the in-silico comparison and evaluation of different targeted therapies. Future effort will be devoted to refine the model so to incorporate more biologically sound partial mutations and drug combinations

The effects of transcutaneous spinal direct current stimulation on neuropathic pain in multiple sclerosis: clinical and neurophysiological assessment

Background: Central neuropathic pain represents one of the most common symptoms in multiple sclerosis (MS) and it seriously affects quality of life. Spinal mechanisms may contribute to the pathogenesis of neuropathic pain in MS. Converging evidence from animal models and neurophysiological and clinical studies in humans suggests a potential effect of transcranial direct current stimulation (tc-DCS) on neuropathic pain. Spinal application of DCS, i.e., transcutaneous spinal DCS (ts-DCS), may modulate nociception through inhibition of spinal reflexes. Therefore, ts-DCS could represents an effective, safe and well-tolerated treatment for neuropathic pain in MS, a largely unexplored topic. This study is a pilot randomized double-blind sham-controlled trial to evaluate the efficacy of ts-DCS on central neuropathic pain in MS patients. Methods: Thirty-three MS patients with central neuropathic pain were enrolled and randomly assigned to two groups in a double-blind sham-controlled design: anodal ts-DCS group (n = 19, 10 daily 20-min sessions, 2 mA) or sham ts-DCS group (n = 14, 10 daily 20-min sessions, 0 mA). The following clinical outcomes were evaluated before ts-DCS treatment (T0), after 10 days of treatment (T1) and 1 month after the end of treatment (T2): neuropathic pain symptoms inventory (NPSI), Ashworth Scale (AS) for spasticity and Fatigue Severity Scale (FSS). A subgroup of patients treated with anodal ts-DCS (n = 12) and sham ts-DCS (n = 11) also underwent a parallel neurophysiological study of the nociceptive withdrawal reflex (NWR) and the NWR temporal summation threshold (TST), two objective markers of pain processing at spinal level. Results: Anodal ts-DCS group showed a significant improvement in NPSI at T1, which persisted at T2, while we did not detect any significant change in AS and FSS. Sham ts-DCS group did not show any significant change in clinical scales. We observed a non-significant trend towards an inhibition of NWR responses in the anodal ts-DCS group at T1 and T2 when compared to baseline. Conclusions: Anodal ts-DCS seems to have an early and persisting (i.e., 1 month after treatment) clinical efficacy on central neuropathic pain in MS patients, probably through modulation of spinal nociception. Clinical Trial Registration: www.ClinicalTrials.gov, identifier #NCT02331654

The Effects of Transcutaneous Spinal Direct Current Stimulation on Neuropathic Pain in Multiple Sclerosis: Clinical and Neurophysiological Assessment

Background: Central neuropathic pain represents one of the most common symptoms in multiple sclerosis (MS) and it seriously affects quality of life. Spinal mechanisms may contribute to the pathogenesis of neuropathic pain in MS. Converging evidence from animal models and neurophysiological and clinical studies in humans suggests a potential effect of transcranial direct current stimulation (tc-DCS) on neuropathic pain. Spinal application of DCS, i.e., transcutaneous spinal DCS (ts-DCS), may modulate nociception through inhibition of spinal reflexes. Therefore, ts-DCS could represents an effective, safe and well-tolerated treatment for neuropathic pain in MS, a largely unexplored topic. This study is a pilot randomized double-blind sham-controlled trial to evaluate the efficacy of ts-DCS on central neuropathic pain in MS patients.Methods: Thirty-three MS patients with central neuropathic pain were enrolled and randomly assigned to two groups in a double-blind sham-controlled design: anodal ts-DCS group (n = 19, 10 daily 20-min sessions, 2 mA) or sham ts-DCS group (n = 14, 10 daily 20-min sessions, 0 mA). The following clinical outcomes were evaluated before ts-DCS treatment (T0), after 10 days of treatment (T1) and 1 month after the end of treatment (T2): neuropathic pain symptoms inventory (NPSI), Ashworth Scale (AS) for spasticity and Fatigue Severity Scale (FSS). A subgroup of patients treated with anodal ts-DCS (n = 12) and sham ts-DCS (n = 11) also underwent a parallel neurophysiological study of the nociceptive withdrawal reflex (NWR) and the NWR temporal summation threshold (TST), two objective markers of pain processing at spinal level.Results: Anodal ts-DCS group showed a significant improvement in NPSI at T1, which persisted at T2, while we did not detect any significant change in AS and FSS. Sham ts-DCS group did not show any significant change in clinical scales. We observed a non-significant trend towards an inhibition of NWR responses in the anodal ts-DCS group at T1 and T2 when compared to baseline.Conclusions: Anodal ts-DCS seems to have an early and persisting (i.e., 1 month after treatment) clinical efficacy on central neuropathic pain in MS patients, probably through modulation of spinal nociception.Clinical Trial Registration:www.ClinicalTrials.gov, identifier #NCT02331654

The Post-Eocene Evolution of the Doruneh Fault Region (Central Iran): The Intraplate Response to the Reorganization of the Arabia-Eurasia Collision Zone

The Cenozoic deformation history of Central Iran has been dominantly accommodated by the activation of major intracontinental strike-slip fault zones, developed in the hinterland domain of the Arabia-Eurasia convergent margin. Few quantitative temporal and kinematic constraints are available from these strike-slip deformation zones, hampering a full assessment of the style and timing of intraplate deformation in Iran and the understanding of the possible linkage to the tectonic reorganization of the Zagros collisional zone. This study focuses on the region to the north of the active trace of the sinistral Doruneh Fault. By combing structural and low-temperature apatite fission track (AFT) and (U-Th)/He (AHe) thermochronology investigations, we provide new kinematic and temporal constraints to the deformation history of Central Iran. Our results document a post-Eocene polyphase tectonic evolution dominated by dextral strike-slip tectonics, whose activity is constrained since the early Miocene in response to an early, NW-SE oriented paleo-σ1 direction. A major phase of enhanced cooling/exhumation is constrained at the Miocene/Pliocene boundary, caused by a switch of the maximum paleo-σ1 direction to N-S. When integrated into the regional scenario, these data are framed into a new tectonic reconstruction for the Miocene-Quaternary time lapse, where strike-slip deformation in the intracontinental domain of Central Iran is interpreted as guided by the reorganization of the Zagros collisional zone in the transition from an immature to a mature stage of continental collision

El derecho a la salud mental: viejos problemas, nuevos desafíos

Fil: Arnao, Magdalena. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Filosofía; Argentina.Fil: Arnao, Magdalena. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Arnao, Magdalena. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Szlejcher, Anna. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Archivología; Argentina.Fil: Szlejcher, Anna. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Bocco, Graciela. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades; Argentina.Fil: Bocco, Graciela. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Bocco, Graciela. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Caminada, María Paz. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Caminada, María Paz. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Buhlman, Soledad. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Buhlman, Soledad. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Burijovich, Jacinta. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Burijovich, Jacinta. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Carpio, Sol de. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Carpio, Sol del. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Chena, Marina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Chena, Marina. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Ase, Iván. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Ase, Iván. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Yoma, Solana. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Yoma, Solana. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Blanes, Paola. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Blanes. Paola. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Barrault, Omar. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Barrault, Omar. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Herranz, Melisa. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Herranz, Melisa. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Berra, Cecilia. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Berra, Cecilia. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Miretti, Jeremías. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Miretti, Jeremías. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Díaz, Rodrigo. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Díaz, Rodrigo. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Costa, Maricel. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Costa, Maricel. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Lesta, Liz. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Lesta, Liz. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Castagno, Mariel. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Castagno, Mariel. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Correa, Ana. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Correa, Ana. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Atala, Laura. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Atala, Laura. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Carrizo, Cecilia. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Carrizo, Cecilia. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Gómez, Agustina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Gómez, Agustina. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Merlo, Virginia. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Merlo, Virginia. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Moreno, Liliana. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Moreno, Liliana. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Fonseca, Federico. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Fonseca, Federico. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Illanes, Mariana. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Illanes, Mariana. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Scorza, Diana. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Scorza, Diana. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Se refieren las continuidades en torno a la vulneración de los derechos de las personas confinadas en los hospitales psiquiátricos y se profundiza sobre otros problemas existentes en el campo de la salud mentalhttp://www.unc.edu.ar/extension/vinculacion/observatorio-ddhh/informe-mirar-tras-los-muros-2014-1/informe-mirar-tras-los-muros-2014Fil: Arnao, Magdalena. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Filosofía; Argentina.Fil: Arnao, Magdalena. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Arnao, Magdalena. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Szlejcher, Anna. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Archivología; Argentina.Fil: Szlejcher, Anna. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Bocco, Graciela. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades; Argentina.Fil: Bocco, Graciela. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Bocco, Graciela. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Caminada, María Paz. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Caminada, María Paz. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Buhlman, Soledad. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Buhlman, Soledad. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Burijovich, Jacinta. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Burijovich, Jacinta. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Carpio, Sol de. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Carpio, Sol del. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Chena, Marina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Chena, Marina. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Ase, Iván. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Ase, Iván. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Yoma, Solana. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Yoma, Solana. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Blanes, Paola. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Blanes. Paola. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Barrault, Omar. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Barrault, Omar. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Herranz, Melisa. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Herranz, Melisa. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Berra, Cecilia. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Berra, Cecilia. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Miretti, Jeremías. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Miretti, Jeremías. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Díaz, Rodrigo. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Díaz, Rodrigo. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Costa, Maricel. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Costa, Maricel. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Lesta, Liz. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Lesta, Liz. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Castagno, Mariel. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Castagno, Mariel. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Correa, Ana. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Correa, Ana. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Atala, Laura. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Atala, Laura. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Carrizo, Cecilia. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Carrizo, Cecilia. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Gómez, Agustina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Gómez, Agustina. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Merlo, Virginia. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Merlo, Virginia. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Moreno, Liliana. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Moreno, Liliana. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Fonseca, Federico. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Fonseca, Federico. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Illanes, Mariana. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Illanes, Mariana. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Fil: Scorza, Diana. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Scorza, Diana. Mesa de Salud Mental y Derechos Humanos. Observatorio de Salud Mental y Derechos Humanos; Argentina.Ciencia Polític

Contrasting styles of (U)HP rock exhumation along the Cenozoic Adria-Europe plate boundary (Western Alps, Calabria, Corsica)

Since the first discovery of ultrahigh pressure (UHP) rocks 30 years ago in the Western Alps, the mechanisms for exhumation of (U)HP terranes worldwide are still debated. In the western Mediterranean, the presently accepted model of synconvergent exhumation (e.g., the channel-flow model) is in conflict with parts of the geologic record. We synthesize regional geologic data and present alternative exhumation mechanisms that consider the role of divergence within subduction zones. These mechanisms, i.e., (i) the motion of the upper plate away from the trench and (ii) the rollback of the lower plate, are discussed in detail with particular reference to the Cenozoic Adria-Europe plate boundary, and along three different transects (Western Alps, Calabria-Sardinia, and Corsica-Northern Apennines). In the Western Alps, (U)HP rocks were exhumed from the greatest depth at the rear of the accretionary wedge during motion of the upper plate away from the trench. Exhumation was extremely fast, and associated with very low geothermal gradients. In Calabria, HP rocks were exhumed from shallower depths and at lower rates during rollback of the Adriatic plate, with repeated exhumation pulses progressively younging toward the foreland. Both mechanisms were active to create boundary divergence along the Corsica-Northern Apennines transect, where European southeastward subduction was progressively replaced along strike by Adriatic northwestward subduction. The tectonic scenario depicted for the Western Alps trench during Eocene exhumation of (U)HP rocks correlates well with present-day eastern Papua New Guinea, which is presented as a modern analog of the Paleogene Adria-Europe plate boundary

Beta-Blocker Use in Older Hospitalized Patients Affected by Heart Failure and Chronic Obstructive Pulmonary Disease: An Italian Survey From the REPOSI Register

Beta (β)-blockers (BB) are useful in reducing morbidity and mortality in patients with heart failure (HF) and concomitant chronic obstructive pulmonary disease (COPD). Nevertheless, the use of BBs could induce bronchoconstriction due to β2-blockade. For this reason, both the ESC and GOLD guidelines strongly suggest the use of selective β1-BB in patients with HF and COPD. However, low adherence to guidelines was observed in multiple clinical settings. The aim of the study was to investigate the BBs use in older patients affected by HF and COPD, recorded in the REPOSI register. Of 942 patients affected by HF, 47.1% were treated with BBs. The use of BBs was significantly lower in patients with HF and COPD than in patients affected by HF alone, both at admission and at discharge (admission, 36.9% vs. 51.3%; discharge, 38.0% vs. 51.7%). In addition, no further BB users were found at discharge. The probability to being treated with a BB was significantly lower in patients with HF also affected by COPD (adj. OR, 95% CI: 0.50, 0.37-0.67), while the diagnosis of COPD was not associated with the choice of selective β1-BB (adj. OR, 95% CI: 1.33, 0.76-2.34). Despite clear recommendations by clinical guidelines, a significant underuse of BBs was also observed after hospital discharge. In COPD affected patients, physicians unreasonably reject BBs use, rather than choosing a β1-BB. The expected improvement of the BB prescriptions after hospitalization was not observed. A multidisciplinary approach among hospital physicians, general practitioners, and pharmacologists should be carried out for better drug management and adherence to guideline recommendations

Masterplan Aeropuerto Internacional Rosario "Islas Malvinas"

A partir de las ventajas locacionales del AMR, se propone potenciar el rol de nodo logístico con el desarrollo de un centro de intercambio aeroportuario, entendido como un área destinada a la realización de actividades relacionadas fundamentalmente con usos productivos, de transporte y distribución comercial. La composición general del parque consiste en la configuración de espacios abiertos y equipamientos que se alternan con zonas de vegetación existente. Es por estos espacios donde discurren los flujos peatonales interactuando con el sentido de percepción del espacio al largo de toda su extensión en a medida que uno se va acercando a la nueva terminal. La terminal se presenta como un elemento conector entre el parque/ciudad y la experiencia de volar, así como una puerta de entrada y salida, disponiendo a su vez de llegadas a través de distintos medios de transporte independientes pero pertenecientes a un mismo sistema.Fil: Abalos, Juan Pablo. Universidad Nacional de Rosario. Facultad de Arquitectura, Planeamiento y Diseño; Argentina.Fil: Colombo Berra, Federico. Universidad Nacional de Rosario. Facultad de Arquitectura, Planeamiento y Diseño; Argentina