5,736 research outputs found
Genetic profiling of autoinflammatory disorders in patients with periodic fever: a prospective study
Periodic fever syndromes (PFS) are an emerging group of autoinflammatory disorders. Clinical overlap exists and multiple genetic analyses may be needed to assist diagnosis. We evaluated the diagnostic value of a 5-gene sequencing panel (5GP) in patients with undiagnosed PFS
Grey solitons in a strongly interacting superfluid Fermi Gas
The Bardeen-Cooper-Schrieffer to Bose-Einstein condensate (BCS to BEC)
crossover problem is solved for stationary grey solitons via the Boguliubov-de
Gennes equations at zero temperature. These \emph{crossover solitons} exhibit a
localized notch in the gap and a characteristic phase difference across the
notch for all interaction strengths, from BEC to BCS regimes. However, they do
not follow the well-known Josephson-like sinusoidal relationship between
velocity and phase difference except in the far BEC limit: at unitary the
velocity has a nearly linear dependence on phase difference over an extended
range. For fixed phase difference the soliton is of nearly constant depth from
the BEC limit to unitarity and then grows progressively shallower into the BCS
limit, and on the BCS side Friedel oscillations are apparent in both gap
amplitude and phase. The crossover soliton appears fundamentally in the gap; we
show, however, that the density closely follows the gap, and the soliton is
therefore observable. We develop an approximate power law relationship to
express this fact: the density of grey crossover solitons varies as the square
of the gap amplitude in the BEC limit and a power of about 1.5 at unitarity.Comment: 10 pages, 6 figures, part of New Journal of Physics focus issue
"Strongly Correlated Quantum Fluids: From Ultracold Quantum Gases to QCD
Plasmas," in pres
Prognostic and Predictive Role of Body Composition in Metastatic Neuroendocrine Tumor Patients Treated with Everolimus: A Real-World Data Analysis
Neuroendocrine tumors (NETs) are rare neoplasms frequently characterized by an up- regulation of the mammalian rapamycin targeting (mTOR) pathway resulting in uncontrolled cell proliferation. The mTOR pathway is also involved in skeletal muscle protein synthesis and in adipose tissue metabolism. Everolimus inhibits the mTOR pathway, resulting in blockade of cell growth and tumor progression. The aim of this study is to investigate the role of body composition in- dexes in patients with metastatic NETs treated with everolimus. The study population included 30 patients with well-differentiated (G1-G2), metastatic NETs treated with everolimus at the IRCCS Romagnolo Institute for the Study of Tumors (IRST) âDino Amadoriâ, Meldola (FC), Italy. The body composition indexes (skeletal muscle index [SMI] and adipose tissue indexes) were assessed by measuring on a computed tomography (CT) scan the cross-sectional area at L3 at baseline and at the first radiological assessment after the start of treatment. The body mass index (BMI) was assessed at baseline. The median progression-free survival (PFS) was 8.9 months (95% confidence interval [CI]: 3.4â13.7 months). The PFS stratified by tertiles was 3.2 months (95% CI: 0.9â10.1 months) in patients with low SMI (tertile 1), 14.2 months (95% CI: 2.3 months-not estimable [NE]) in patients with intermediate SMI (tertile 2), and 9.1 months (95% CI: 2.7 months-NE) in patients with high SMI (tertile 3) (p = 0.039). Similarly, the other body composition indexes also showed a statistically significant difference in the three groups on the basis of tertiles. The median PFS was 3.2 months (95% CI: 0.9â6.7 months) in underweight patients (BMI 18.49 kg/m2) and 10.1 months (95% CI: 3.7â28.4 months) in normal-weight patients (p = 0.011). There were no significant differences in terms of overall survival. The study showed a correlation between PFS and the body composition indexes in patients with NETs treated with everolimus, underlining the role of adipose and muscle tissue in these patients
The Fourteenth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the extended Baryon Oscillation Spectroscopic Survey and from the second phase of the Apache Point Observatory Galactic Evolution Experiment
The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in
operation since July 2014. This paper describes the second data release from
this phase, and the fourteenth from SDSS overall (making this, Data Release
Fourteen or DR14). This release makes public data taken by SDSS-IV in its first
two years of operation (July 2014-2016). Like all previous SDSS releases, DR14
is cumulative, including the most recent reductions and calibrations of all
data taken by SDSS since the first phase began operations in 2000. New in DR14
is the first public release of data from the extended Baryon Oscillation
Spectroscopic Survey (eBOSS); the first data from the second phase of the
Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2),
including stellar parameter estimates from an innovative data driven machine
learning algorithm known as "The Cannon"; and almost twice as many data cubes
from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous
release (N = 2812 in total). This paper describes the location and format of
the publicly available data from SDSS-IV surveys. We provide references to the
important technical papers describing how these data have been taken (both
targeting and observation details) and processed for scientific use. The SDSS
website (www.sdss.org) has been updated for this release, and provides links to
data downloads, as well as tutorials and examples of data use. SDSS-IV is
planning to continue to collect astronomical data until 2020, and will be
followed by SDSS-V.Comment: SDSS-IV collaboration alphabetical author data release paper. DR14
happened on 31st July 2017. 19 pages, 5 figures. Accepted by ApJS on 28th Nov
2017 (this is the "post-print" and "post-proofs" version; minor corrections
only from v1, and most of errors found in proofs corrected
On farm agronomic and first environmental evaluation of oil crops for sustainable bioenergy chains
Energy crops, and in particular oil crops, could be an important occasion for developing new non food production
rows for a new multi-functional agriculture in Italy. In this view, the use of local biomass is a fundamental starting
point for the development of a virtuous energy chain that should pursue not only agricultural profitability, but also
chain sustainability and that is less dependent on the global market, characterized by instability in terms of biomass
availability and price. From this perspective, particular attention must be paid to crop choice on the basis of
its rusticity and of its adaptability to local growing conditions and to low input cropping systems. In this context,
alike woody and herbaceous biomasses, oil crops such as sunflower and rapeseed should be able to support local
agricultural bioenergy chain in Italy.
In addition, in a local bioenergy chain, the role of the farmers should not be limited just to grain production; but
also grain processing should be performed at farm or consortium level in oilseed extraction plants well proportioned
to the cropped surface. In this way, by means of a simple power generator, farmer could thus produce its
own thermal and electric energy from the oil, maximizing his profit. This objective could also be achieved through
the exploitation of the total biomass, including crop residues and defatted seed meals, that may be considered as
fundamental additional economic and/or environmental benefits of the chain. This paper reports some results of
three-years on-farm experiments on oil crop chain carried out in the framework of "Bioenergie" project, that was
focused to enhance farmers awareness of these criteria and to the feasibility at open field scale of low-input cultivation
of rapeseed, sunflower and Brassica carinata in seven Italian regions. In several on-farm experiences, these
crops produced more than 800 kg ha-1 of oil with good energy properties. Defatted seed meals could be interesting
as organic fertilizers and, in the case of B. carinata, as a biofumigant amendment that could offer a total or partial
alternative to some chemicals in agriculture. Furthermore, biomass soil incorporation could contribute to C sequestration,
catching CO2 from atmosphere and sinking a part in soil as stable humus. Finally, four different open
field experiences carried out again in the second year of the project, have been analysed in order to evaluate their
energy and greenhouse gasses balance after cultivation phase
Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV
The performance of muon reconstruction, identification, and triggering in CMS
has been studied using 40 inverse picobarns of data collected in pp collisions
at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection
criteria covering a wide range of physics analysis needs have been examined.
For all considered selections, the efficiency to reconstruct and identify a
muon with a transverse momentum pT larger than a few GeV is above 95% over the
whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4,
while the probability to misidentify a hadron as a muon is well below 1%. The
efficiency to trigger on single muons with pT above a few GeV is higher than
90% over the full eta range, and typically substantially better. The overall
momentum scale is measured to a precision of 0.2% with muons from Z decays. The
transverse momentum resolution varies from 1% to 6% depending on pseudorapidity
for muons with pT below 100 GeV and, using cosmic rays, it is shown to be
better than 10% in the central region up to pT = 1 TeV. Observed distributions
of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO
Search for the standard model Higgs boson in the H to ZZ to 2l 2nu channel in pp collisions at sqrt(s) = 7 TeV
A search for the standard model Higgs boson in the H to ZZ to 2l 2nu decay
channel, where l = e or mu, in pp collisions at a center-of-mass energy of 7
TeV is presented. The data were collected at the LHC, with the CMS detector,
and correspond to an integrated luminosity of 4.6 inverse femtobarns. No
significant excess is observed above the background expectation, and upper
limits are set on the Higgs boson production cross section. The presence of the
standard model Higgs boson with a mass in the 270-440 GeV range is excluded at
95% confidence level.Comment: Submitted to JHE
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