Study abroad: Exploring the pre-departure preparation provided to students, staff and host communities

Student pre-departure preparation has been identified as essential if study abroad programs involving work integrated learning are to deliver the numerous benefits they intend, while mitigating the many risks they involve. However, little is known about what preparation is provided to the academic and professional staff who implement these programs, and the community members who host the students. Interviews with 16 academic and professional staff involved in preparing students, staff, and host communities for Australian study abroad programs reveal inconsistencies in the preparation provided to students, and very limited preparation to staff and host communities. The limited preparation that is offered, is designed and developed in an organic (not structured) and inconsistent manner. Our findings suggest that institutions should consider implementing a more structured, consistent and institutionally driven approach to preparation for students, staff, and host communities to reduce the substantial risks associated with these programs while maximizing the benefits

Development and validation of an assessment tool for higher education learning abroad programs:A qualitative Delphi study

Background: Higher education learning abroad programs provide many benefits to healthcare students. However, inadequate preparation prior to their international travel, and misdirected motivations for their participation, can jeopardise the benefits and increase the risks. While it is pivotal to objectively evaluate pre-departure student preparation and the impact the programs have on students, existing assessment questionnaires fail to inform these aspects. Objectives: To develop an assessment tool (two surveys) to holistically evaluate learning abroad programs for higher education healthcare students. Design: A qualitative Delphi technique. Participants: A total of 24 experts who had designed, managed, participated in, hosted, funded, and/or researched Australian learning abroad programs for higher education students. Methods: The study was conducted over a 4-month period. An initial set of pre-departure and post-program questions was developed through a review of the existing literature and from a post-program survey previously used at an Australian higher education institution. Subsequently, experts provided constructive and practical feedback on the questions to be included in the two surveys. Results: The experts reached consensus on the 26 questions to be included in the pre-departure survey and the 16 questions in the post-program survey after three Delphi rounds. Key areas of interest to the experts were mitigating student risk, improving effectiveness of pre-departure briefings, gaining a better insight into student motivations for participation, and understanding the impact the programs have on students. Conclusions: The development of this valid assessment tool (two surveys) will provide higher education institutions and program leaders with the ability to better evaluate the effectiveness of the pre-departure preparation they provide to students, understand the motivations of students who participate, as well as assessing the impact these programs have on students. The insights gathered can be used to improve future program offerings and maximise the benefits to healthcare students while reducing the risks.</p

Socioeconomic inequalities in pregnancy outcome associated with Down syndrome: a population-based study.

OBJECTIVE: To investigate socioeconomic inequalities in outcome of pregnancy associated with Down syndrome (DS) compared with other congenital anomalies screened for during pregnancy. DESIGN AND SETTING: Retrospective population-based registry study (East Midlands & South Yorkshire in England). PARTICIPANTS: All registered cases of DS and nine selected congenital anomalies with poor prognostic outcome (the UK Fetal Anomaly Screening Programme (FASP)9) with an end of pregnancy date between 1 January 1998 and 31 December 2007. MAIN OUTCOME MEASURES: Poisson regression models were used to explore outcome measures, including socioeconomic variation in rates of anomaly; antenatal detection; pregnancy outcome; live birth incidence and neonatal mortality. Deprivation was measured using the Index of Multiple Deprivation 2004 at super output area level. RESULTS: There were 1151 cases of DS and 1572 cases of the nine severe anomalies combined. The overall rate of antenatal detection was 57% for DS, which decreased with increasing deprivation (rate ratio comparing the most deprived tenth with the least deprived: 0.76 (0.60 to 0.97)). Antenatal detection rates were considerably higher for FASP9 anomalies (86%), with no evidence of a trend with deprivation (0.99 95% CI (0.84 to 1.17)). The termination of pregnancy rate following antenatal diagnosis was higher for DS (86%) than the FASP9 anomalies (70%). Both groups showed wide socioeconomic variation in the termination of pregnancy rate (rate ratio: DS: 0.76 (0.58 to 0.99); FASP9 anomalies: 0.80 (0.65 to 0.97)). Consequently, socioeconomic inequalities in live birth and neonatal mortality rates associated with these anomalies arise that were not observed in utero. CONCLUSIONS: Socioeconomic inequalities exist in the antenatal detection of DS, and subsequent termination rates are much higher for DS than other anomalies. Termination rates for all anomalies are lower in more deprived areas leading to wide socioeconomic inequalities in live born infants with a congenital anomaly, particularly DS, and subsequent neonatal mortality

Multiband Studies of the Optical Periodic Modulation in the X-Ray Binary SAX~J1808.4-3658 during Its Quiescence and 2008 Outburst

We report on time-resolved optical imaging of the X-ray binary SAX J1808.4-3658 during its quiescent state and 2008 outburst. The binary, containing an accretion-powered millisecond pulsar, has a large sinusoidal-like modulation in its quiescent optical emission. We employ a Markov chain Monte Carlo technique to fit our multi-band light curve data in quiescence with an irradiated star model, and derive a tight constraint of $50^{+6}_{-5}$ deg on the inclination angle $i$ of the binary system. The pulsar and its companion are constrained to have masses of 0.97^{+0.31}_{-0.22} M_{\sun} and 0.04^{+0.02}_{-0.01} M_{\sun} (both 1$\sigma$ ranges), respectively. The dependence of these results on the measurements of the companion's projected radial velocity is discussed. We also find that the accretion disk had nearly constant optical fluxes over a $\sim$500 day period in the quiescent state our data covered, but started brightening 1.5 months before the 2008 outburst. Variations in modulation during the outburst were detected in our four observations made 7-12 days after the start of the outburst, and a sinusoidal-like modulation with 0.2 mag amplitude changed to have a smaller amplitude of 0.1 mag. The modulation variations are discussed. We estimate the albedo of the companion during its quiescence and the outburst, which was approximately 0 and 0.8 (for isotropic emission), respectively. This large difference probably provides additional evidence that the neutron star in the binary turns on as a radio pulsar in quiescence.Comment: 13 pages, 9 figures, 1 table, accepted for publication in Ap

Pharmacokinetic/pharmacodynamic integration and modelling of florfenicol for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida

Pharmacokinetic-pharmacodynamic (PK/PD) integration and modelling were used to predict dosage schedules for florfenicol for two pig pneumonia pathogens, Actinobacillus pleuropneumoniae and Pasteurella multocida. Pharmacokinetic data were pooled for two bioequivalent products, pioneer and generic formulations, administered intramuscularly to pigs at a dose rate of 15 mg/kg. Antibacterial potency was determined in vitro as minimum inhibitory concentration (MIC) and Mutant Prevention Concentration in broth and pig serum, for six isolates of each organism. For both organisms and for both serum and broth MICs, average concentration:MIC ratios over 48 h were similar and exceeded 2.5:1 and times greater than MIC exceeded 35 h. From in vitro time-kill curves, PK/PD modelling established serum breakpoint values for the index AUC24h/MIC for three levels of inhibition of growth, bacteriostasis and 3 and 4log10 reductions in bacterial count; means were 25.7, 40.2 and 47.0 h, respectively, for P. multocida and 24.6, 43.8 and 58.6 h for A. pleuropneumoniae. Using these PK and PD data, together with literature MIC distributions, doses for each pathogen were predicted for: (1) bacteriostatic and bactericidal levels of kill; (2) for 50 and 90% target attainment rates (TAR); and (3) for single dosing and daily dosing at steady state. Monte Carlo simulations for 90% TAR predicted single doses to achieve bacteriostatic and bactericidal actions over 48 h of 14.4 and 22.2 mg/kg (P. multocida) and 44.7 and 86.6 mg/kg (A. pleuropneumoniae). For daily doses at steady state, and 90% TAR bacteriostatic and bactericidal actions, dosages of 6.2 and 9.6 mg/kg (P. multocida) and 18.2 and 35.2 mg/kg (A. pleuropneumoniae) were required. PK/PD integration and modelling approaches to dose determination indicate the possibility of tailoring dose to a range of end-points

Modelling the spectral energy distribution of galaxies. V. The dust and PAH emission SEDs of disk galaxies

We present a self-consistent model of the spectral energy distributions (SEDs) of spiral galaxies from the ultraviolet (UV) to the mid-infrared (MIR)/far-infrared (FIR)/submillimeter (submm) based on a full radiative transfer calculation of the propagation of starlight in galaxy disks. This model predicts not only the total integrated energy absorbed in the UV/optical and re-emitted in the infrared/submm, but also the colours of the dust emission based on an explicit calculation of the strength and colour of the UV/optical radiation fields heating the dust, and incorporating a full calculation of the stochastic heating of small dust grains and PAH molecules. The geometry of the translucent components of the model is empirically constrained using the results from the radiation transfer analysis of Xilouris et al. on spirals in the middle range of the Hubble sequence, while the geometry of the optically thick components is constrained from physical considerations with a posteriori checks of the model predictions with observational data. These geometrical constraints enable the dust emission to be predicted in terms of a minimum set of free parameters: the central face-on dust opacity in the B-band tau^f_B, a clumpiness factor F for the star-forming regions, the star-formation rate SFR, the normalised luminosity of the old stellar population old and the bulge-to-disk ratio B/D. We show that these parameters are almost orthogonal in their predicted effect on the colours of the dust/PAH emission. The results of the calculations are made available in the form of a large library of simulated dust emission SEDs spanning the whole parameter space of our model, together with the corresponding library of dust attenuation calculated using the same model. (see full abstract in the paper)Comment: 39 pages; accepted for publication in Astronomy & Astrophysics; For a higher resolution version of Fig.1 and Fig.20 see http://www.star.uclan.ac.uk/~ccp/index.shtm

Evolutionary process of Bos taurus cattle in favourable versus unfavourable environments and its implications for genetic selection

The evolutionary processes that have enabled Bos taurus cattle to establish around the globe are at the core to the future success of livestock production. Our study focuses on the history of cattle domestication including the last 60 years of B. taurus breeding programmes in both favourable and unfavourable environments and its consequences on evolution and fitness of cattle. We discuss the emergence of ‘production diseases’ in temperate production systems and consider the evolutionary genetics of tropical adaptation in cattle and conclude that the Senepol, N'Dama, Adaptaur and Criollo breeds, among others with similar evolutionary trajectories, would possess genes capable of improving the productivity of cattle in challenging environments. Using our own experimental evidence from northern Australia, we review the evolution of the Adaptaur cattle breed which has become resistant to cattle tick. We emphasize that the knowledge of interactions between genotype, environment and management in the livestock systems will be required to generate genotypes for efficient livestock production that are both economically and environmentally sustainable. Livestock producers in the 21st century will have less reliance on infrastructure and veterinary products to alleviate environmental stress and more on the animal's ability to achieve fitness in a given production environment

Dynamical masses of a nova-like variable on the edge of the period gap

We present the first dynamical determination of the binary parameters of an eclipsing SW Sextantis star in the 3–4 h orbital period range during a low state. We obtained time-resolved optical spectroscopy and photometry of HS 0220+0603 during its 2004–2005 low-brightness state, as revealed in the combined Small & Moderate Aperture Research Telescope System, IAC80 and M1 Group long-term optical light curve. The optical spectra taken during primary eclipse reveal a secondary star spectral type of M5.5 ± 0.5 as derived from molecular band-head indices. The spectra also provide the first detection of a DAB white dwarf in a cataclysmic variable. By modelling its optical spectrum we estimate a white dwarf temperature of 30 000 ± 5000 K. By combining the results of modelling the white dwarf eclipse from ULTRACAM light curves with those obtained by simultaneously fitting the emission- and absorption-line radial velocity curves and I-band ellipsoidal light curves, we measure the stellar masses to be M1 = 0.87 ± 0.09 M⊙ and M2 = 0.47 ± 0.05 M⊙ for the white dwarf and the M dwarf, respectively, and an inclination of the orbital plane of i ≈ 79°. A radius of 0.0103 ± 0.0007 R⊙ is obtained for the white dwarf. The secondary star in HS 0220+0603 is likely too cool and undersized for its mass

Prediction of marbofloxacin dosage for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida by pharmacokinetic/pharmacodynamic modelling

PK/PD integration data. (DOCX 7 kb

Bright OB stars in the Galaxy - III. Constraints on the radial stratification of the clumping factor in hot star winds from a combined Halpha, IR and radio analysis

Recent results strongly challenge the canonical picture of massive star winds: various evidence indicates that currently accepted mass-loss rates, Mdot, may need to be revised downwards significantly. This is because the most commonly used mass-loss diagnostics are affected by ``clumping'' (small-scale density inhomogeneities), influencing our interpretation of observed spectra and fluxes. Such downward revisions would have dramatic consequences for the evolution of, and feedback from, massive stars, and thus robust determinations of the clumping properties and mass-loss rates are urgently needed. Here, we present a first attempt to constrain the radial stratification of the so-called clumping factor. To this end, we have analyzed a sample of 19 Galactic O-type supergiants/giants, by combining data for Halpha, IR, mm and radio fluxes, and using appropriate analysis methods. Clumping has been included into our analysis in the ``conventional'' way, by assuming the inter-clump matter to be void. Because (almost) all our diagnostics depends on the square of density, we cannot derive absolute clumping factors, but only factors normalized to a certain minimum. This minimum was usually found to be located in the outermost, radio-emitting region, i.e., the radio mass-loss rates are the lowest ones, compared to Mdot derived from Halpha and the IR. The radio rates agree well with those predicted by theory, but are only upper limits, due to unknown clumping in the outer wind. Our most important result concerns a (physical) difference between denser and thinner winds: for denser winds, the innermost region is more strongly clumped than the outermost one (with a normalized clumping factor of 4.1+/-1.4), whereas thinner winds have similar clumping properties in the inner and outer regions.Comment: 40 pages, 17 figures, accepted by A&