674 research outputs found
Approaches in biotechnological applications of natural polymers
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- Publication venue
- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2016
- Field of study
Natural polymers, such as gums and mucilage, are biocompatible, cheap, easily available and non-toxic materials of native origin. These polymers are increasingly preferred over synthetic materials for industrial applications due to their intrinsic properties, as well as they are considered alternative sources of raw materials since they present characteristics of sustainability, biodegradability and biosafety. As definition, gums and mucilages are polysaccharides or complex carbohydrates consisting of one or more monosaccharides or their derivatives linked in bewildering variety of linkages and structures. Natural gums are considered polysaccharides naturally occurring in varieties of plant seeds and exudates, tree or shrub exudates, seaweed extracts, fungi, bacteria, and animal sources. Water-soluble gums, also known as hydrocolloids, are considered exudates and are pathological products; therefore, they do not form a part of cell wall. On the other hand, mucilages are part of cell and physiological products. It is important to highlight that gums represent the largest amounts of polymer materials derived from plants. Gums have enormously large and broad applications in both food and non-food industries, being commonly used as thickening, binding, emulsifying, suspending, stabilizing agents and matrices for drug release in pharmaceutical and cosmetic industries. In the food industry, their gelling properties and the ability to mold edible films and coatings are extensively studied. The use of gums depends on the intrinsic properties that they provide, often at costs below those of synthetic polymers. For upgrading the value of gums, they are being processed into various forms, including the most recent nanomaterials, for various biotechnological applications. Thus, the main natural polymers including galactomannans, cellulose, chitin, agar, carrageenan, alginate, cashew gum, pectin and starch, in addition to the current researches about them are reviewed in this article.. }To the Conselho Nacional de Desenvolvimento Cientfíico e Tecnológico (CNPq) for fellowships (LCBBC and MGCC) and the Coordenação de Aperfeiçoamento de Pessoal de Nvíel Superior (CAPES) (PBSA). This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit, the Project RECI/BBB-EBI/0179/2012 (FCOMP-01-0124-FEDER-027462) and COMPETE 2020 (POCI-01-0145-FEDER-006684) (JAT)
The disruption of proteostasis in neurodegenerative diseases
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- Yamamoto K Sato T, Matsui T, et al.
- Ye J Rawson RB, Komuro R, et al.
- Yoshida H Matsui T, Yamamoto A, et al.
- Yoshida H Oku M, Suzuki M, et al.
- Yoshida H Uemura A, Mori K
- Young JC Barral JM, Ulrich Hartl F
- Yu A Shibata Y, Shah B, et al.
- Zhang Y Lu H, Bargmann CI
- Zhao Q Wang J, Levichkin IV, et al.
- Zietkiewicz S Lewandowska A, Stocki P, et al.
- Zolkiewski M
- Zou J Guo Y, Guettouche T, et al.
- Publication venue
- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2015
- Field of study
Cells count on surveillance systems to monitor and protect the cellular proteome which, besides being highly heterogeneous, is constantly being challenged by intrinsic and environmental factors. In this context, the proteostasis network (PN) is essential to achieve a stable and functional proteome. Disruption of the PN is associated with aging and can lead to and/or potentiate the occurrence of many neurodegenerative diseases (ND). This not only emphasizes the importance of the PN in health span and aging but also how its modulation can be a potential target for intervention and treatment of human diseases.info:eu-repo/semantics/publishedVersio
Effects of rapid urbanisation on the urban thermal environment between 1990 and 2011 in Dhaka Megacity, Bangladesh
- Author
- Adams J
- Ahmed B Kamruzzaman M, Zhu X, et al.
- Artis DA Carnahan WH
- Azad A Kitada T
- Black D Henderson V
- Brown M Lewis HG, Gunn SR
- Carlson TN Arthur ST
- Carlson TN Gillies RR, Perry EM
- Carlson TN Ripley DA
- Carnahan WH Larson RC
- Chander G Markham B
- Chander G Markham BL, Helder DL
- Chen XL Zhao HM, Li P, et al.
- Dewan AM Yamaguchi Y
- Foley JA Defries R, Asner GP, et al.
- Giri C Pengra B, Zhu Z, et al.
- Green AA Berman M, Switzer P, et al.
- Grimm NB Faeth SH, Golubiewski NE, et al.
- Hasan S Mulamoottil G
- Hashizume M Dewan AM, Sunahara T, et al.
- Huete A Didan K, Miura T, et al.
- Jiménez-Muñoz JC Sobrino JA
- Kovats S Akhtar H
- Li J Song C, Cao L, et al.
- Li J Wang J, Ma J, et al.
- Li Y Zhang H, Kainz W
- Liu H Weng Q
- Lo CP Quattrochi DA
- Ma Y Kuang Y, Huang N
- Mackey CW Lee X, Smith RB
- Mas J
- Owen TW Carlson TN, Gillies RR
- Patz JA Olson SH
- Qin Z Karnieli A, Berliner P
- Rana MMP
- Roth M Oke TR, Emery WJ
- Saaroni H Ben-Dor E, Bitan A, et al.
- Sobrino JA Caselles V, Becker F
- Sobrino JA Jiménez-Muñoz JC, Paolini L
- Sobrino JA Jiménez-Muñoz JC, Sòria G, et al.
- Song C Woodcock CE, Seto KC
- Streutker DR
- Sun F Sun W, Chen J, et al.
- Tan KC San-Lim H, Matjafri MZ, et al.
- Voogt JA Oke TR
- Voogt JA Oke TR
- Weng Q
- Weng Q
- Weng Q Hu X, Lu D
- Weng Q Lu D
- Weng Q Lu D, Schubring J
- Wong NH Yu C
- Wu C
- Xiao H Weng Q
- Xiao R Ouyang Z, Zheng H, et al.
- Xu H Dongfeng L, Tang F
- Yang X Liu Z
- Yow DM
- Yuan F Bauer ME
- Zha Y Gao J, Ni S
- Zhang X Zhong T, Wang K, et al.
- Zhou X Wang YC
- Publication venue
- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2017
- Field of study
This study investigates the influence of land-use/land-cover (LULC) change on land surface temperature (LST) in Dhaka Megacity, Bangladesh during a period of rapid urbanisation. LST was derived from Landsat 5 TM scenes captured in 1990, 2000 and 2011 and compared to contemporaneous LULC maps. We compared index-based and linear spectral mixture analysis (LSMA) techniques for modelling LST. LSMA derived biophysical parameters corresponded more strongly to LST than those produced using index-based parameters. Results indicated that vegetation and water surfaces had relatively stable LST but it increased by around 2 °C when these surfaces were converted to built-up areas with extensive impervious surfaces. Knowledge of the expected change in LST when one land-cover is converted to another can inform land planners of the potential impact of future changes and urges the development of better management strategies
Transcriptome sequencing and analysis of major genes involved in calcium signaling pathways in pear plants (Pyrus calleryana Decne.)
- Author
- A Canovas
- A Conesa
- AJ Matlin
- AK Parida
- AL Li
- AN Dodd
- BJ Chen
- C Dubos
- C Trapnell
- C Vannini
- CY Shi
- DL Black
- E McCormack
- ET Wang
- F Liu
- F Xie
- G Liu
- G Zhang
- GK Pandey
- GT Huang
- H Jin
- H Keren
- H Shan
- H Yim
- H Zhang
- HH Huang
- J Dutkowski
- J Harrow
- J Shi
- J Wu
- J Xiong
- J Ye
- Jing Lin
- K Hashimoto
- K Matsumoto
- K Witzel
- L Kong
- LL Huang
- M Kanehisa
- M Okubo
- M Xie
- M Zhang
- MA Harris
- N Tuteja
- O Batistič
- P Cingolani
- PG Engström
- Q Guan
- Q Yu
- Qingsong Yang
- QS Wu
- R Li
- R Li
- R Munns
- R Weikard
- S Bai
- S Luan
- S Ma
- S Parvin
- S Weinl
- SA Filichkin
- SH Cheng
- T Urao
- U Kolukisaoglu
- X Kang
- Xiaogang Li
- Y Liao
- Y Liu
- Y Saijo
- Y Xu
- Y Zhao
- Y Zhou
- YH Chang
- Youhong Chang
- Yuanyuan Xu
- ZH Dang
- Zhonghua Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
A second generation human haplotype map of over 3.1 million SNPs
- Author
- Abecasis GR
- Adebamowo CA
- Adewole IF
- Ajayi I
- Altshuler D
- Altshuler D
- Altshuler D
- An D
- Aniagwu T
- Auton A
- Ballinger DG
- Barrett J
- Barry R
- Bellemare G
- Belmont JW
- Belmont JW
- Bentley DR
- Bird CP
- Birren BW
- Blumenstiel B
- Bottolo L
- Boudreau A
- Brooks LD
- Burton J
- Cai D
- Camargo A
- Cardin N
- Cardon LR
- Carter NP
- Chagnon F
- Chakravarti A
- Chee MS
- Chen PE
- Chen Z
- Chretien YR
- Chu X
- Clarke G
- Clayton EW
- Clee CM
- Collins FS
- Cox DR
- Cutler DJ
- Daly MJ
- Daly MJ
- de Bakker PI
- Defelice M
- Delgado M
- Deloukas P
- Dermitzakis ET
- Dixon M
- Donnelly P
- Evans DM
- Eyheramendy S
- Faggart M
- Fan JB
- Feolo M
- Ferretti V
- Foster MW
- Frazer KA
- Freeman C
- Fu H
- Fukushima Y
- Fulton LL
- Gabriel SB
- Gabriel SB
- Galver LM
- Gao Y
- Gibbs RA
- Gibbs RA
- Godbout M
- Goyette M
- Griffiths M
- Guan W
- Gunderson K
- Gupta S
- Guyer MS
- Gwilliam R
- Han H
- Hardenbol P
- He Y
- Hinds DA
- Holden AL
- Hu H
- Hu W
- Huang W
- Hudson TJ
- Hunt S
- Jamieson R
- Jin L
- Jones MC
- Kang L
- Kashuk CS
- Kato K
- Kawaguchi T
- Kennedy K
- Kent A
- Kitamoto T
- Knoppers BM
- Koboldt DC
- Krishnan L
- Kwok PY
- L'Archevêque P
- Leal SM
- Leboeuf M
- Leppert MF
- Li C
- Li Q
- Li Y
- Lin S
- Lin W
- Liu S
- Liu Y
- Macer DR
- Mak W
- Maller J
- Marchini J
- Marshall PA
- Matsuda I
- McCarroll S
- McEwen JE
- McLay K
- McVean G
- Miller RD
- Montpetit A
- Moore J
- Morizono T
- Morris AP
- Morrison J
- Mullikin JC
- Munro HM
- Murray SS
- Muzny D
- Myers S
- Nagashima A
- Nakamura Y
- Nazareth L
- Nguyen H
- Niikawa N
- Nkwodimmah C
- Ohnishi Y
- Oliphant AR
- Olivier JF
- Onofrio RC
- Onofrio RC
- Pan H
- Parkin M
- Pasternak S
- Patterson N
- Pawlikowska L
- Pe'er I
- Peiffer A
- Peterson JL
- Phillips MS
- Plumb RW
- Powell D
- Price A
- Purcell S
- Qin ZS
- Qiu R
- Richter DJ
- Richter DJ
- Rogers J
- Ross MT
- Rotimi CN
- Roumy S
- Roy J
- Royal CD
- Sabeti P
- Saeki K
- Sallée C
- Saxena R
- Schaffner SF
- Sekine A
- Sham PC
- Shen Y
- Shen Y
- Sherry ST
- Shi M
- Sims SK
- Skol A
- Smith AV
- Sodergren E
- Song YQ
- Spencer C
- Spiegel J
- Stahl E
- Stein LD
- Stephens M
- Stewart J
- Stranger BE
- Stuve LL
- Suda E
- Sun W
- Sung LM
- Taillon-Miller P
- Tam PK
- Tanaka T
- Tang X
- Tello-Ruiz MK
- Thomas DJ
- Thorisson GA
- Tsui LC
- Tsui SK
- Tsunoda T
- Tsunoda T
- Varilly P
- Verner A
- Wallenburg JC
- Wang H
- Wang H
- Wang J
- Wang R
- Wang VO
- Wang W
- Wang Y
- Wang Y
- Wang Z
- Watkin J
- Waye MM
- Weinstock GM
- Weir BS
- Wheeler DA
- Wheeler DA
- Whittaker P
- Willey DL
- Willis TD
- Wilson RK
- Winchester E
- Wong JT
- Xiao M
- Xiong X
- Xu L
- Xue H
- Yakub I
- Yang H
- Yao Z
- Yu F
- Yu J
- Zacharia LF
- Zeng C
- Zeng C
- Zhang B
- Zhang H
- Zhang Q
- Zhao H
- Zhao H
- Zhao H
- Zhou J
- Ziaugra L
- Ziaugra L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2007
- Field of study
We describe the Phase II HapMap, which characterizes over 3.1 million human single nucleotide polymorphisms (SNPs) genotyped in 270 individuals from four geographically diverse populations and includes 25-35% of common SNP variation in the populations surveyed. The map is estimated to capture untyped common variation with an average maximum r(2) of between 0.9 and 0.96 depending on population. We demonstrate that the current generation of commercial genome-wide genotyping products captures common Phase II SNPs with an average maximum r(2) of up to 0.8 in African and up to 0.95 in non-African populations, and that potential gains in power in association studies can be obtained through imputation. These data also reveal novel aspects of the structure of linkage disequilibrium. We show that 10-30% of pairs of individuals within a population share at least one region of extended genetic identity arising from recent ancestry and that up to 1% of all common variants are untaggable, primarily because they lie within recombination hotspots. We show that recombination rates vary systematically around genes and between genes of different function. Finally, we demonstrate increased differentiation at non-synonymous, compared to synonymous, SNPs, resulting from systematic differences in the strength or efficacy of natural selection between populations.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/62863/1/nature06258.pd
Biological processes, properties and molecular wiring diagrams of candidate low-penetrance breast cancer susceptibility genes
- Author
- A Cox
- A Ewart-Toland
- A Ewart-Toland
- A Komiya
- A Subramanian
- A Subramanian
- AC Antoniou
- AG Renehan
- AL Barabasi
- AL Dixon
- AL Richardson
- Antoni Berenguer
- B Pasche
- B Song
- BD Cuevas
- BW Zanke
- CA Haiman
- CM Perou
- D Hanahan
- DF Easton
- DG Cox
- DG Cox
- DJ Hunter
- DJ Hunter
- EL Hsu
- ET Liu
- F Al-Shahrour
- F Al-Shahrour
- F Lerebours
- G Untergasser
- H Guo
- H Kitano
- H Kitano
- HS Bachmann
- HY Chang
- I Carvalho
- I Tomlinson
- Ignacio Medina
- J Gudmundsson
- J Loscalzo
- Javier Díez
- JF Rual
- Joaquín Dopazo
- JS Witte
- JT Chang
- JX Yu
- K Chin
- K Rennstam
- K Wang
- K Wennmalm
- KA Frazer
- KS Pollard
- L Kruglyak
- LA Garraway
- LC Freeman
- LC Walker
- LJ van 't Veer
- LM Greene
- LT Amundadottir
- M Ashburner
- M Kanehisa
- M Unoki
- M Vidal
- M Xu
- M Yeager
- MA Pujana
- Miguel Angel Pujana
- MJ van de Vijver
- MK Wendt
- ML Freedman
- ML Yaremko
- Núria Bonifaci
- Oscar Reina
- P Shannon
- R Development Core Team
- R Shen
- S Durinck
- S Forbes
- S Furuta
- S Furuta
- S Hassan
- S Lee
- S Seitz
- SJ Chanock
- SM Pupa
- SN Stacey
- T Chen
- T Sun
- U Stelzl
- V Vuaroqueaux
- VG Kaklamani
- VG Kaklamani
- VP Eswarakumar
- Víctor Moreno
- Y Benjamini
- YL Lo
- Z Zhang
- Publication venue
- BioMed Central
- Publication date
- 01/01/2008
- Field of study
Background: Recent advances in whole-genome association studies (WGASs) for human cancer risk are beginning to provide the part lists of low-penetrance susceptibility genes. However, statistical analysis in these studies is complicated by the vast number of genetic variants examined and the weak effects observed, as a result of which constraints must be incorporated into the study design and analytical approach. In this scenario, biological attributes beyond the adjusted statistics generally receive little attention and, more importantly, the fundamental biological characteristics of low-penetrance susceptibility genes have yet to be determined. Methods: We applied an integrative approach for identifying candidate low-penetrance breast cancer susceptibility genes, their characteristics and molecular networks through the analysis of diverse sources of biological evidence. Results: First, examination of the distribution of Gene Ontology terms in ordered WGAS results identified asymmetrical distribution of Cell Communication and Cell Death processes linked to risk. Second, analysis of 11 different types of molecular or functional relationships in genomic and proteomic data sets defined the 'omic' properties of candidate genes: i/ differential expression in tumors relative to normal tissue; ii/ somatic genomic copy number changes correlating with gene expression levels; iii/ differentially expressed across age at diagnosis; and iv/ expression changes after BRCA1 perturbation. Finally, network modeling of the effects of variants on germline gene expression showed higher connectivity than expected by chance between novel candidates and with known susceptibility genes, which supports functional relationships and provides mechanistic hypotheses of risk. Conclusion: This study proposes that cell communication and cell death are major biological processes perturbed in risk of breast cancer conferred by low-penetrance variants, and defines the common omic properties, molecular interactions and possible functional effects of candidate genes and proteins
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adachi S
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adersberger M
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Ahmed WS
- Ai X
- Aielli G
- Akatsuka S
- Akesson TPA
- Akilli E
- Akimov A
- Al Khoury K
- Alberghi GL
- Albert J
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
- Ali B
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alvarez Estevez M
- Alviggi MG
- Amaral Coutinho Y
- Ambler A
- Ambroz L
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amoroso S
- Amrouche CS
- An F
- Anastopoulos C
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Andreazza A
- Andrei V
- Anelli CR
- Angelidakis S
- Angerami A
- Anisenkov A
- Annovi A
- Antel C
- Anthony MT
- Antipov E
- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aparisi Pozo JA
- Araque JP
- Araujo Ferraz V
- Araujo Pereira R
- Araya ST
- Arcangeletti C
- Arce ATH
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Arling J-H
- Armbruster AJ
- Armstrong A
- Arnaez O
- Arnold H
- Artoni G
- Artz S
- Asai S
- Asawatavonvanich T
- Asbah N
- Asimakopoulou EM
- Asquith L
- Assahsah J
- Assamagan K
- Astalos R
- Astigarraga MEP
- Atkin RJ
- Atkinson M
- Atlay NB
- Atmani H
- Augsten K
- Avolio G
- Ayoub MK
- Azuelos G
- Bachacou H
- Bachas K
- Backes M
- Backman F
- Bagnaia P
- Bahmani M
- Bahrasemani H
- Bailey AJ
- Bailey VR
- Baines JT
- Bakalis C
- Baker OK
- Bakker PJ
- Balaji S
- Baldin EM
- Balek P
- Balli F
- Balunas WK
- Balz J
- Banas E
- Bandyopadhyay A
- Banerjee S
- Bannoura AAE
- Barak L
- Barbe WM
- Barberio EL
- Barberis D
- Barbero M
- Barbour G
- Barillari T
- Barisits M-S
- Barkeloo J
- Barklow T
- Barnea R
- Barnett BM
- Barnett RM
- Barnovska-Blenessy Z
- Baroncelli A
- Barone G
- Barr AJ
- Barreiro F
- Barsov S
- Bartoldus R
- Bartolini G
- Barton AE
- Bartos P
- Basalaev A
- Basan A
- Bassalat A
- Basso MJ
- Bates RL
- Batlamous S
- Batley JR
- Batool B
- Battaglia M
- Bauce M
- Bauer F
- Bauer KT
- Bawa HS
- Beacham JB
- Beau T
- Beauchemin PH
- Becherer F
- Bechtle P
- Beck HC
- Beck HP
- Becker K
- Becot C
- Beddall A
- Beddall AJ
- Bednyakov VA
- Bedognetti M
- Beermann TA
- Begalli M
- Begel M
- Behera A
- Behr JK
- Beisiegel F
- Bell AS
- Bella G
- Bella LA
- Bellagamba L
- Bellerive A
- Bellos P
- Beloborodov K
- Belotskiy K
- Belyaev NL
- Benchekroun D
- Benekos N
- Benhammou Y
- Benjamin DP
- Benoit M
- Bensinger JR
- Bentvelsen S
- Beresford L
- Beretta M
- Berge D
- Berger N
- Bergmann B
- Bergsten LJ
- Beringer J
- Berlendis S
- Berlingen JM
- Bernardi G
- Bernius C
- Bernlochner FU
- Berry T
- Berta P
- Bertella C
- Bertram IA
- Besson N
- Bethani A
- Bethke S
- Betti A
- Bevan AJ
- Beyer J
- Bhattacharya DS
- Bhattarai P
- Bi R
- Bianchi RM
- Biebel O
- Biedermann D
- Bielski R
- Bierwagen K
- Biesuz N
- Biglietti M
- Billoud TR
- Bindi M
- Bingul A
- Bini C
- Biondi S
- Birman M
- Bisanz T
- Biswal JP
- Biswas D
- Bitadze A
- Bittrich C
- Bjorke K
- Blazek T
- Bloch I
- Blocker C
- Blue A
- Blumenschein U
- Bobbink GJ
- Bobrovnikov VS
- Bocchetta SS
- Bocci A
- Boeriu OEV
- Boerner D
- Bogavac D
- Bogdanchikov AG
- Bohm C
- Boisvert V
- Bokan P
- Bold T
- Bolz AE
- Bomben M
- Bona M
- Bonilla JS
- Boonekamp M
- Booth CD
- Borecka-Bielska HM
- Borgna LS
- Borisov A
- Borissov G
- Bortfeldt J
- Bortoletto D
- Boscherini D
- Bosman M
- Bostanabad MG
- Bouaouda K
- Boudreau J
- Bouhova-Thacker E
- Boumediene D
- Bourdarios CA
- Boutle SK
- Boveia A
- Boyd J
- Boye D
- Boyko IR
- Bozson AJ
- Bracinik J
- Brahimi N
- Brandt G
- Brandt O
- Braren F
- Brau B
- Brau JE
- Brendlinger K
- Brenner L
- Brenner R
- Bressler S
- Bret MC
- Brickwedde B
- Briglin DL
- Britton D
- Britzger D
- Brock I
- Brock R
- Brooijmans G
- Brooks WK
- Brost E
- Broughton JH
- Bruncko D
- Bruni A
- Bruni G
- Bruni LS
- Bruno S
- Bruschi M
- Bruscino N
- Bryant P
- Bryngemark L
- Buanes T
- Buat Q
- Buchholz P
- Buckley AG
- Budagov IA
- Buehrer F
- Buescher V
- Bugge MK
- Bulekov O
- Burch TJ
- Burdin S
- Burgard CD
- Burger AM
- Burghgrave B
- Burr JTP
- Burton CD
- Burzynski JC
- Buschmann E
- Bussey PJ
- Butler JM
- Buttar CM
- Butterworth JM
- Butti P
- Buttinger W
- Buzatu A
- Buzykaev AR
- Bylund OB
- Cabras G
- Cabrera Urban S
- Caforio D
- Cai H
- Cairo VMM
- Cakir IT
- Cakir O
- Calace N
- Calafiura P
- Calandri A
- Calderini G
- Calfayan P
- Callea G
- Caloba LP
- Caltabiano A
- Calvente Lopez S
- Calvet D
- Calvet S
- Calvet TP
- Calvetti M
- Camarda S
- Camarero Munoz D
- Camarri P
- Camelia EA
- Cameron D
- Camincher C
- Campana S
- Campanelli M
- Camplani A
- Campoverde A
- Canale V
- Canesse A
- Cantero J
- Cao T
- Cao Y
- Capua M
- Cardarelli R
- Cardillo F
- Carducci G
- Carli I
- Carli T
- Carlino G
- Carlson BT
- Carminati L
- Carney RMD
- Caron S
- Carquin E
- Carra S
- Carter JWS
- Casado MP
- Casha AF
- Casper DW
- Castelijn R
- Castillo Garcia L
- Castillo Gimenez V
- Castillo FL
- Castillo LRF
- Castro NF
- Catinaccio A
- Catmore JR
- Cattai A
- Cavaliere V
- Cavallaro E
- Cavalli-Sforza M
- Cavasinni V
- Celebi E
- Cerda Alberich L
- Cerny K
- Cerqueira AS
- Cerri A
- Cerrito L
- Cerutti F
- Cervelli A
- Cetin SA
- Chadi Z
- Chakraborty D
- Chan J
- Chan WS
- Chan WY
- Chapman JD
- Chargeishvili B
- Charlton DG
- Charman TP
- Chau CC
- Che S
- Chekanov S
- Chekulaev S
- Chelkov GA
- Chen B
- Chen C
- Chen CH
- Chen H
- Chen J
- Chen S
- Chen SJ
- Chen X
- Chen Y-H
- Cheng HC
- Cheng HJ
- Cheplakov A
- Cheremushkina E
- Cheu E
- Cheung K
- Chevalerias TJA
- Chevalier L
- Chiarella V
- Chiarelli G
- Chiodini G
- Chisholm AS
- Chitan A
- Chiu I
- Chiu YH
- Chizhov M
- Choi K
- Chomont AR
- Chouridou S
- Chow YS
- Chu MC
- Chu X
- Chudoba J
- Chwastowski JJ
- Chytka L
- Cieri D
- Ciesla KM
- Cinca D
- Cindro V
- Cioara IA
- Ciocio A
- Cirotto F
- Citron ZH
- Citterio M
- Ciubotaru DA
- Ciungu BM
- Clark A
- Clark MR
- Clark PJ
- Clement C
- Coadou Y
- Cobal M
- Coccaro A
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- Zhemchugov A
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- Zinonos Z
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- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
Search for the neutral Higgs bosons of the minimal supersymmetric standard model in pp collisions at root s=7 TeV with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdinov O
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Acharya BS
- Adam ER
- Adamczyk L
- Adams DL
- Addy TN
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- Publication venue
- Publication date
- 01/02/2013
- Field of study
A search for neutral Higgs bosons of the Minimal Supersymmetric Standard Model (MSSM) is reported. The analysis is based on a sample of proton-proton collisions at a centre-of-mass energy of 7TeV recorded with the ATLAS detector at the Large Hadron Collider. The data were recorded in 2011 and correspond to an integrated luminosity of 4.7 fb-1 to 4.8 fb-1. Higgs boson decays into oppositely-charged muon or τ lepton pairs are considered for final states requiring either the presence or absence of b-jets. No statistically significant excess over the expected background is observed and exclusion limits at the 95% confidence level are derived. The exclusion limits are for the production cross-section of a generic neutral Higgs boson, φ, as a function of the Higgs boson mass and for h/A/H production in the MSSM as a function of the parameters mA and tan β in the mhmax scenario for mA in the range of 90GeV to 500 GeV. Copyright CERN
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
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- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2013
- Field of study
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of √s = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pT≥20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60≤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2≤{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration
Tumor Transcriptome Sequencing Reveals Allelic Expression Imbalances Associated with Copy Number Alterations
- Author
- A Gabory
- A Jemal
- A Mortazavi
- Adam J. Broomer
- AE Al Moustafa
- AP Feinberg
- AP Feinberg
- Asim S. Siddiqui
- Brian B. Tuch
- C Leethanakul
- C Mayr
- C Wissmann
- CH Chen
- Christina B. Chung
- Cinna K. Monighetti
- CJ Kang
- CN Henrichsen
- D Lipson
- D Tsafrir
- David I. Smith
- DM Parkin
- DR Bentley
- DY Chiang
- E Dehan
- E Schuuring
- Eric J. Moore
- ET Wang
- F Tang
- Francisco M. De La Vega
- G Clement
- GH Perry
- H Cui
- H Sasaki
- I Alevizos
- IF Tsui
- IJ Matouk
- J Gil
- J Herrick
- J Kim
- J Miyazawa
- J Sebat
- JA Lee
- Jan L. Kasperbauer
- JC Marioni
- Jian Gu
- JK Kim
- K Freier
- K Willert
- K Yoshinaga
- Kerry D. Olsen
- L Xu
- LA Liotta
- M Egeblad
- M Johnsen
- Matthew W. Muller
- Melissa A. Barker
- MR Stratton
- N Adachi
- ND Trinklein
- O Ogawa
- P Cahan
- P Krimpenfort
- P Lopez
- Pius M. Brzoska
- PJ Campbell
- PM Haverty
- R Nusse
- Rebecca R. Laborde
- RK Thomas
- Ruoying Tan
- S Ghaemmaghami
- S Ortega
- S Rainier
- S Wachi
- SA McCarroll
- Sarah J. Stanley
- Scott Kuersten
- SP Bohen
- ST Sherry
- T Beissbarth
- T LaFramboise
- Timothy Ravasi
- TJ Belbin
- TJ Ley
- TM Holm
- Xing Xu
- Y Du
- Y Hosokawa
- Y Zhang
- Yan W. Asmann
- YH Yu
- Yongming Sun
- YS Lee
- Z Wang
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
Due to growing throughput and shrinking cost, massively parallel sequencing is rapidly becoming an attractive alternative to microarrays for the genome-wide study of gene expression and copy number alterations in primary tumors. The sequencing of transcripts (RNA-Seq) should offer several advantages over microarray-based methods, including the ability to detect somatic mutations and accurately measure allele-specific expression. To investigate these advantages we have applied a novel, strand-specific RNA-Seq method to tumors and matched normal tissue from three patients with oral squamous cell carcinomas. Additionally, to better understand the genomic determinants of the gene expression changes observed, we have sequenced the tumor and normal genomes of one of these patients. We demonstrate here that our RNA-Seq method accurately measures allelic imbalance and that measurement on the genome-wide scale yields novel insights into cancer etiology. As expected, the set of genes differentially expressed in the tumors is enriched for cell adhesion and differentiation functions, but, unexpectedly, the set of allelically imbalanced genes is also enriched for these same cancer-related functions. By comparing the transcriptomic perturbations observed in one patient to his underlying normal and tumor genomes, we find that allelic imbalance in the tumor is associated with copy number mutations and that copy number mutations are, in turn, strongly associated with changes in transcript abundance. These results support a model in which allele-specific deletions and duplications drive allele-specific changes in gene expression in the developing tumor
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