Then and Now: An Analysis of Broad-based Merit Aid Initial Eligibility Policies after Twenty Years

Using Hall’s framework of policy changes, we sought to document and classify changes in initial eligibility and award provisions of broad-based merit aid scholarship programs at inception and present day. Our analysis revealed five first-order changes, two second-order changes, and only one third order change. Although the policy settings, instruments, and goals remained static in five states, the scholarship dollars in four of them have not kept up with increases in overall cost of attendance

How Principals Bridge and Buffer the New Demands of Teacher Quality and Accountability: A Mixed-Methods Analysis of Teacher Hiring

In this mixed-methods study, we examine the degree to which district-and building-level administrators accommodate teacher-quality and test-based accountability policies in their hiring practices. We find that administrators negotiated local hiring goals with characteristics emphasized by federal and state teacher-quality policies, such as knowledge of the subject and teaching skills. While district administrators and principals largely bridged to external certification requirements, some principals buffered their hiring decisions from the pressures of test-based accountability. Principals who bridged to test-based accountability gave greater weight to subject knowledge and teaching skills. We find that bridging and buffering differs by policy and cannot be easily applied to accountability policies. Specifically, separating the indirect effect of external accountability from other policies influencing principal hiring is difficult. Our analysis also highlights tensions among local, state, and federal policies regarding teacher quality and the potential of accountability to permeate noninstructional school decision making

Policy Brief MIX AND MATCH: WHAT PRINCIPALS REALLY LOOK FOR WHEN HIRING TEACHERS

Abstract The vast majority of research and policy related to teacher quality focuses on the supply of teachers and ignores teacher demand. In particular, the important role of school principals in hiring teachers is rarely considered. Using interviews of school principals in a midsized Florida school district, we provide an exploratory mixed methods analysis of the teacher characteristics principals prefer. Our findings contradict the conventional wisdom that principals undervalue content knowledge and intelligence. Principals in our study ranked content knowledge third among a list of twelve characteristics. Intelligence does appear less important at first glance, but this is apparently because principals believe all applicants who meet certification requirements meet a minimum threshold on intelligence and because some intelligent teachers have difficulty connecting with students. More generally, we find that principals prefer an "individual mix" of personal and professional qualities. They also create an "organizational mix," hiring teachers who differ from those already in the school in terms of race, gender, experience, and skills, and an "organizational match," in which teachers have similar work habits and a high propensity to remain with the school over time. Because of tenure rules, many principals also prefer less experienced (untenured) teachers, even though research suggests that they are less effective

Structure and Inhibition of Microbiome β-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity

SummaryThe selective inhibition of bacterial β-glucuronidases was recently shown to alleviate drug-induced gastrointestinal toxicity in mice, including the damage caused by the widely used anticancer drug irinotecan. Here, we report crystal structures of representative β-glucuronidases from the Firmicutes Streptococcus agalactiae and Clostridium perfringens and the Proteobacterium Escherichia coli, and the characterization of a β-glucuronidase from the Bacteroidetes Bacteroides fragilis. While largely similar in structure, these enzymes exhibit marked differences in catalytic properties and propensities for inhibition, indicating that the microbiome maintains functional diversity in orthologous enzymes. Small changes in the structure of designed inhibitors can induce significant conformational changes in the β-glucuronidase active site. Finally, we establish that β-glucuronidase inhibition does not alter the serum pharmacokinetics of irinotecan or its metabolites in mice. Together, the data presented advance our in vitro and in vivo understanding of the microbial β-glucuronidases, a promising new set of targets for controlling drug-induced gastrointestinal toxicity

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.

OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS: We have conducted a meta-analysis of genome-wide association tests of ∼2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS: Nine SNPs at eight loci were associated with proinsulin levels (P < 5 × 10(-8)). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 × 10(-4)), improved β-cell function (P = 1.1 × 10(-5)), and lower risk of T2D (odds ratio 0.88; P = 7.8 × 10(-6)). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS: We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis