On the evolution of rapidly rotating massive white dwarfs towards supernovae or collapses

A recent study by Yoon & Langer (2004a) indicated that the inner cores of rapidly accreting (Mdot > 10^{-7} M_sun/yr) CO white dwarfs may rotate differentially, with a shear rate near the threshold value for the onset of the dynamical shear instability. Such differentially rotating white dwarfs obtain critical masses for thermonuclear explosion or electron-capture induced collapse which significantly exceed the canonical Chandrasekhar limit. Here, we construct two-dimensional differentially rotating white dwarf models with rotation laws resembling those of the one-dimensional models of Yoon & Langer (2004a). We derive analytic relations between the white dwarf mass, its angular momentum, and its rotational-, gravitational- and binding energy. We show that these relations are applicable for a wide range of angular velocity profiles, including solid body rotation. We demonstrate that pre-explosion and pre-collapse conditions of both, rigidly and differentially rotating white dwarfs are well established by the present work, which may facilitate future multi-dimensional simulations of Type Ia supernova explosions and studies of the formation of millisecond pulsars and gamma-ray bursts from collapsing white dwarfs.Our results lead us to suggest various possible evolutionary scenarios for progenitors of Type Ia supernovae, leading to a new paradigm of a variable mass of exploding white dwarfs, at values well above the classical Chandrasekhar mass. Based on our 2D-models, we argue for the supernova peak brightness being proportional to the white dwarf mass, which could explain various aspects of the diversity of Type Ia supernovae, such as their variation in brightness, the dependence of their mean luminosity on the host galaxy type, and the weak correlation between ejecta velocity and peak brightness.Comment: Based on 2-D white dwarf models: 19 pages, 13 figures, A&A, accepte

Afterglow Light Curve Modulated by a Highly Magnetized Millisecond Pulsar

We investigate consequences of a continuously energy-injecting central engine of gamma-ray burst (GRB) afterglow emission, assuming that a highly magnetized pulsar is left beaming in the core of a GRB progenitor. Beaming and continuous energy-injection are natural consequences of the pulsar origin of GRB afterglows. Whereas previous studies have considered continuous energy-injection from a new-born pulsar to interpret the deviation of afterglow light curves of GRBs from those with the simple power law behavior, a beaming effect, which is one of the most important aspects of pulsar emissions, is ignored in earlier investigations. We explicitly include the beaming effect and consider a change of the beaming with time due to a dynamical evolution of a new-born pulsar. We show that the magnitude of the afterglow from this fireball indeed first decreases with time, subsequently rises, and declines again. One of the most peculiar optical afterglows light curve of GRB 970508 can be accounted for by continuous energy injection with beaming due to a highly magnetized new-born pulsar. We discuss implications on such observational evidence for a pulsar.Comment: 4 pages, 1 table, submitted to Astronomy and Astrophysics (Letters

Bone Mineral Density and Vascular Calcification in Children and Young Adults With CKD 4 to 5 or on Dialysis

Introduction: Older adults with chronic kidney disease (CKD) can have low bone mineral density (BMD) with concurrent vascular calcification. Mineral accrual by the growing skeleton may protect young people with CKD from extraosseous calcification. Our hypothesis was that children and young adults with increasing BMD do not develop vascular calcification. Methods: This was a multicenter longitudinal study in children and young people (5–30 years) with CKD stages 4 to 5 or on dialysis. BMD was assessed by tibial peripheral quantitative computed tomography (pQCT) and lumbar spine dual-energy X-ray absorptiometry (DXA). The following cardiovascular imaging tests were undertaken: cardiac computed tomography for coronary artery calcification (CAC), ultrasound for carotid intima media thickness z-score (cIMTz), pulse wave velocity z-score (PWVz), and carotid distensibility for arterial stiffness. All measures are presented as age-adjusted and sex-adjusted z-scores. Results: One hundred participants (median age 13.82 years) were assessed at baseline and 57 followed up after a median of 1.45 years. Trabecular BMD z-score (TrabBMDz) decreased (P = 0.01), and there was a nonsignificant decrease in cortical BMD z-score (CortBMDz) (P = 0.09). Median cIMTz and PWVz showed nonsignificant increase (P = 0.23 and P = 0.19, respectively). The annualized increase in TrabBMDz (ΔTrabBMDz) was an independent predictor of cIMTz increase (R2 = 0.48, β = 0.40, P = 0.03). Young people who demonstrated statural growth (n = 33) had lower ΔTrabBMDz and also attenuated vascular changes compared with those with static growth (n = 24). Conclusion: This hypothesis-generating study suggests that children and young adults with CKD or on dialysis may develop vascular calcification even as their BMD increases. A presumed buffering capacity of the growing skeleton may offer some protection against extraosseous calcification

Changes in the Frontotemporal Cortex and Cognitive Correlates in First-Episode Psychosis

Background: Loss of cortical volume in frontotemporal regions has been reported in patients with schizophrenia and their relatives. Cortical area and thickness are determined by different genetic processes, and measuring these parameters separately may clarify disturbances in corticogenesis relevant to schizophrenia. Our study also explored clinical and cognitive correlates of these parameters.Methods: Thirty-seven patients with first-episode psychosis (34 schizophrenia, 3 schizoaffective disorder) and 38 healthy control subjects matched for age and sex took part in the study. Imaging was performed on an magnetic resonance imaging 1.5-T scanner. Area and thickness of the frontotemporal cortex were measured using a surface-based morphometry method (Freesurfer). All subjects underwent neuropsychologic testing that included measures of premorbid and current IQ, working and verbal memory, and executive function.Results: Reductions in cortical area, more marked in the temporal cortex, were present in patients. Overall frontotemporal cortical thickness did not differ between groups, although regional thinning of the right superior temporal region was observed in patients. There was a significant association of both premorbid IQ and IQ at disease onset with area, but not thickness, of the frontotemporal cortex, and working memory span was associated with area of the frontal cortex. These associations remained significant when only patients with schizophrenia were considered.Conclusions: Our results suggest an early disruption of corticogenesis in schizophrenia, although the effect of subsequent environmental factors cannot be excluded. In addition, cortical abnormalities are subject to regional variations and differ from those present in neurodegenerative diseases

Recent advances in Leishmania reverse genetics : Manipulating a manipulative parasite

In this review we describe the expanding repertoire of molecular tools with which to study gene function in Leishmania. Specifically we review the tools available for studying functions of essential genes, such as plasmid shuffle and DiCre, as well as the rapidly expanding portfolio of available CRISPR/Cas9 approaches for large scale gene knockout and endogenous tagging. We include detail on approaches that allow the direct manipulation of RNA using RNAi and protein levels via Tet or DiCre induced overexpression and destabilization domain mediated degradation. The utilisation of current methods and the development of more advanced molecular tools will lead to greater understanding of the role of essential genes in the parasite and thereby more robust drug target validation, thereby paving the way for the development of novel therapeutics to treat this important disease

Quantum Creation of an Open Inflationary Universe

We discuss a dramatic difference between the description of the quantum creation of an open universe using the Hartle-Hawking wave function and the tunneling wave function. Recently Hawking and Turok have found that the Hartle-Hawking wave function leads to a universe with Omega = 0.01, which is much smaller that the observed value of Omega > 0.3. Galaxies in such a universe would be about $10^{10^8}$ light years away from each other, so the universe would be practically structureless. We will argue that the Hartle-Hawking wave function does not describe the probability of the universe creation. If one uses the tunneling wave function for the description of creation of the universe, then in most inflationary models the universe should have Omega = 1, which agrees with the standard expectation that inflation makes the universe flat. The same result can be obtained in the theory of a self-reproducing inflationary universe, independently of the issue of initial conditions. However, there exist two classes of models where Omega may take any value, from Omega > 1 to Omega << 1.Comment: 23 pages, 4 figures. New materials are added. In particular, we show that boundary terms do not help to solve the problem of unacceptably small Omega in the new model proposed by Hawking and Turok in hep-th/9803156. A possibility to solve the cosmological constant problem in this model using the tunneling wave function is discusse

Roadmap on Li-ion battery manufacturing research

Growth in the Li-ion battery market continues to accelerate, driven primarily by the increasing need for economic energy storage for electric vehicles. Electrode manufacture by slurry casting is the first main step in cell production but much of the manufacturing optimisation is based on trial and error, know-how and individual expertise. Advancing manufacturing science that underpins Li-ion battery electrode production is critical to adding to the electrode manufacturing value chain. Overcoming the current barriers in electrode manufacturing requires advances in materials, manufacturing technology, in-line process metrology and data analytics, and can enable improvements in cell performance, quality, safety and process sustainability. In this roadmap we explore the research opportunities to improve each stage of the electrode manufacturing process, from materials synthesis through to electrode calendering. We highlight the role of new process technology, such as dry processing, and advanced electrode design supported through electrode level, physics-based modelling. Progress in data driven models of electrode manufacturing processes is also considered. We conclude there is a growing need for innovations in process metrology to aid fundamental understanding and to enable feedback control, an opportunity for electrode design to reduce trial and error, and an urgent imperative to improve the sustainability of manufacture

Stable reference genes for the measurement of transcript abundance during larval caste development in the honeybee

Many genes are differentially regulated by caste development in the honeybee. Identifying and understanding these differences is key to discovering the mechanisms underlying this process. To identify these gene expression differences requires robust methods to measure transcript abundance. RT-qPCR is currently the gold standard to measure gene expression, but requires stable reference genes to compare gene expression changes. Such reference genes have not been established for honeybee caste development. Here, we identify and test potential reference genes that have stable expression throughout larval development between the two female castes. In this study, 15 candidate reference genes were examined to identify the most stable reference genes. Three algorithms (GeNorm, Bestkeeper and NormFinder) were used to rank the candidate reference genes based on their stability between the castes throughout larval development. Of these genes Ndufa8 (the orthologue of a component of complex one of the mitochondrial electron transport chain) and Pros54 (orthologous to a component of the 26S proteasome) were identified as being the most stable. When these two genes were used to normalise expression of two target genes (previously found to be differentially expressed between queen and worker larvae by microarray analysis) they were able to more accurately detect differential expression than two previously used reference genes (awd and RpL12). The identification of these novel reference genes will be of benefit to future studies of caste development in the honeybee