88 research outputs found
Understanding Third Mission Activities as Services to Cooperatively Design the Non-Academic Environment
The UNESCO World Action Program on ESD assumes that universities bear social responsibility by generating and transferring knowledge and innovations (BMBF 2022) to their non-academic environment. Those activities are often referred to as Third Mission Activities (TMA) besides the two initial university missions research and education. In this paper it is investigated whether considering TMA as âservices offered by universitiesâ is an adequate option for the analysis and management of those activities.
In problem-centered interviews conducted between 2019 and 2020, 127 university members at three German universities presented detailed information about various TMA, which was examined in a qualitative content analysis. In this investigation, properties of classic and complex service types were compared to the characteristics of the TMA by deductive category formation. Inductive category formation additionally enabled a more detailed analysis of knowledge-intensive and cooperative service sub-types. As a result, it can be shown that classic, complex, knowledge-intensive and cooperative service types exhibit strong parallels with TMA
Serum lipoprotein(a) and 3-year outcomes in patients undergoing percutaneous coronary intervention.
BACKGROUND AND AIMS
We aimed at addressing the association between serum lipoprotein (a) levels and clinical outcomes of consecutive patients undergoing PCI.
METHODS
We used consecutive patients undergoing PCI at the Heart Center University of Freiburg, Bad Krozingen in Germany between January 2005 and November 2013. A total of 6679 patients [men (nâ=â5391) and women (nâ=â1288)] mean aged 67.5â(± 11.1) years were assessed at baseline and prospectively followed for 3 years. Lp(a) measurement were performed at hospital admission as a routine laboratory parameter.
RESULTS
Approximately 30% of PCI patients show an elevated Lp(a) value of more than 50mg/dL. In total, 736 Patients died during the follow-up, thereof 189 (11.3%) in the first quartile, 186 (10.7%) in the second quartile, 183 (11.5%) in the third quartile and 178 (10.7%) in the last quartile (p value 0.843 from LogRank test). The MACE rate showed consistent results with 409 (24.4%), 385 (22.1%), 395 (24.7%) and 419 (25.3%) in the different respective quartiles (p value 0.125 from LogRank test).
CONCLUSION
In this large non-selected cohort of patients undergoing PCI followed by moderate intensity statin therapy, higher Lp(a) levels were not associated with worse clinical outcomes during a follow-up of 3 years
SARS-CoV-2 infects human cardiomyocytes promoted by inflammation and oxidative stress
INTRODUCTION
The respiratory illness triggered by severe acute respiratory syndrome virus-2 (SARS-CoV-2) is often particularly serious or fatal amongst patients with pre-existing heart conditions. Although the mechanisms underlying SARS-CoV-2-related cardiac damage remain elusive, inflammation (i.e. 'cytokine storm') and oxidative stress are likely involved.
METHODS AND RESULTS
Here we sought to determine: 1) if cardiomyocytes are targeted by SARS-CoV-2 and 2) how inflammation and oxidative stress promote the viral entry into cardiac cells. We analysed pro-inflammatory and oxidative stress and its impact on virus entry and virus-associated cardiac damage from SARS-CoV-2 infected patients and compared it to left ventricular myocardial tissues obtained from non-infected transplanted hearts either from end stage heart failure or non-failing hearts (donor group). We found that neuropilin-1 potentiates SARS-CoV-2 entry into human cardiomyocytes, a phenomenon driven by inflammatory and oxidant signals. These changes accounted for increased proteases activity and apoptotic markers thus leading to cell damage and apoptosis.
CONCLUSION
This study provides new insights into the mechanisms of SARS-CoV-2 entry into the heart and defines promising targets for antiviral interventions for COVID-19 patients with pre-existing heart conditions or patients with co-morbidities
A phase I trial investigating the Aurora B kinase inhibitor BI 811283 in combination with cytarabine in patients with acute myeloid leukaemia
WspĂłĆczesne zagadnienia zarzÄ dzania: przedsiÄbiorstwo - biznes - region
Praca recenzowana / peer-reviewed pape
ZarzÄ dzanie procesami rynkowymi
Ze wstÄpu: "Opracowanie niniejsze przekazywane do rÄ
k czytelnikĂłw to plon dziaĆalnoĆci
naukowej pracownikĂłw WydziaĆu ZarzÄ
dzania i Marketingu Krakowskiej
SzkoĆy WyĆŒszej im. Andrzeja Frycza Modrzewskiego oraz pracownikĂłw innych
uczelni z Polski i Europy. DuĆŒe zrĂłĆŒnicowanie tematyczne wynika m. in.
z rozwoju Uczelni, WydziaĆu i poszerzenia wspĂłĆpracy krajowej i miÄdzynarodowej
z innymi jednostkami naukowymi. Pomimo tego, iĆŒ wiele artykuĆĂłw ze
wzglÄdu na podejmowane w nich problemy trudno jednoznacznie zakwalifikowaÄ
do jednej wÄ
skiej dziedziny, zdecydowano o podziale materiaĆu na trzy
czÄĆci: zarzÄ
dzanie, finanse i marketing. O zakwalifikowaniu opracowania do
poszczegĂłlnych czÄĆci zadecydowaĆa nie tylko istota rozwaĆŒanego tematu, ale
takĆŒe czÄsto bardzo interesujÄ
ce i odkrywcze powiÄ
zania z innymi dziedzinami
szeroko pojÄtego zarzÄ
dzania i ekonomii. StÄ
d teĆŒ publikacja jest recenzowana
przez trzech niezaleĆŒnych recenzentĂłw."(...
Author Correction: The FLUXNET2015 dataset and the ONEFlux processing pipeline for eddy covariance data
The FLUXNET2015 dataset and the ONEFlux processing pipeline for eddy covariance data
The FLUXNET2015 dataset provides ecosystem-scale data on CO2, water, and energy exchange between the biosphere and the atmosphere, and other meteorological and biological measurements, from 212 sites around the globe (over 1500 site-years, up to and including year 2014). These sites, independently managed and operated, voluntarily contributed their data to create global datasets. Data were quality controlled and processed using uniform methods, to improve consistency and intercomparability across sites. The dataset is already being used in a number of applications, including ecophysiology studies, remote sensing studies, and development of ecosystem and Earth system models. FLUXNET2015 includes derived-data products, such as gap-filled time series, ecosystem respiration and photosynthetic uptake estimates, estimation of uncertainties, and metadata about the measurements, presented for the first time in this paper. In addition, 206 of these sites are for the first time distributed under a Creative Commons (CC-BY 4.0) license. This paper details this enhanced dataset and the processing methods, now made available as open-source codes, making the dataset more accessible, transparent, and reproducible.Peer reviewe
A novel 72-kDa leukocyte-derived osteoglycin enhances the activation of toll-like receptor 4 and exacerbates cardiac inflammation during viral myocarditis
Lokaler technischer Fortschritt und intra-industrielle Strukturen
Lokaler technischer Fortschritt und intra-industrielle Strukturen : e. Data Envelopment Analyse. - Aachen : Shaker, 1996. - 246, XII, X S. - (Berichte aus der Volkswirtschaft). - Zugl.: Augsburg, Univ., Diss., 199
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