69 research outputs found
Webinar: A Faculty Perspective on COIL: A Sheridan Experience!
During the winter 2021 semester, two pilot Collaborative Online International Learning(COIL) courses were conducted within Sheridan - one within the Faculty of Humanities and Social Sciences (FHASS) and the other within Pilon School of Business (PSB). This webinar aims to capitalize on the knowledge gained by our Sheridan members from those pilot courses and learn from their experiences to benefit others moving forward. We will also highlight the different services available for our faculty and staff to support them throughout their COIL journey.
Speakers: Peter Galambos, Professor, Faculty of Humanities and Social Sciences – Sheridan Mark Weaver, Professor, Pilon School of Business – Sheridan Stan Kamzol, Professor and International Academic Exchange Coordinator, Pilon School of Business – Sheridan Edwin van den Berg, Professor - Saxion University of Applied Sciences
Moderated by: Amira El Masri, Director of the Centre for Global Education and Internationalization – Sheridanhttps://source.sheridancollege.ca/cgei_events/1000/thumbnail.jp
Effect of aspirin, clopidogrel and dipyridamole on soluble markers of vascular function in normal volunteers and patients with prior ischaemic stroke
Recommended from our members
Thermotunneling Based Cooling Systems for High Efficiency Buildings
GE Global Research's overall objective was to develop a novel thermotunneling-cooling device. The end use for these devices is the replacement of vapor cycle compression (VCC) units in residential and commercial cooling and refrigeration systems. Thermotunneling devices offer many advantages over vapor cycle compression cooling units. These include quiet, reliable, non-moving parts operation without refrigerant gases. Additionally theoretical calculations suggest that the efficiency of thermotunneling devices can be 1.5-2x that of VCC units. Given these attributes it can be seen that thermotunneling devices have the potential for dramatic energy savings and are environmentally friendly. A thermotunneling device consists of two low work function electrodes separated by a sub 10 nanometer-sized gap. Cooling by thermotunneling refers to the transport of hot electrons across the gap, from the object to be cooled (cathode) to the heat rejection electrode (anode), by an applied potential. GE Global Research's goal was to model, design, fabricate devices and demonstrate cooling base on the thermotunneling technology
Optimized Phosphors for Warm White LED Light Engines
The objective of this program is to develop phosphor systems and LED light engines that have steady-state LED efficacies (using LEDs with a 60% wall-plug efficiency) of 105–120 lm/W with correlated color temperatures (CCT) ~3000 K, color rendering indices (CRI) >85, <0.003 distance from the blackbody curve (dbb), and <2% loss in phosphor efficiency under high temperature, high humidity conditions. In order to reach these goals, this involves the composition and processing optimization of phosphors previously developed by GE in combination with light engine package modification
Utilization of an Eilat Virus-Based Chimera for Serological Detection of Chikungunya Infection.
In December of 2013, chikungunya virus (CHIKV), an alphavirus in the family Togaviridae, was introduced to the island of Saint Martin in the Caribbean, resulting in the first autochthonous cases reported in the Americas. As of January 2015, local and imported CHIKV has been reported in 50 American countries with over 1.1 million suspected cases. CHIKV causes a severe arthralgic disease for which there are no approved vaccines or therapeutics. Furthermore, the lack of a commercially available, sensitive, and affordable diagnostic assay limits surveillance and control efforts. To address this issue, we utilized an insect-specific alphavirus, Eilat virus (EILV), to develop a diagnostic antigen that does not require biosafety containment facilities to produce. We demonstrated that EILV/CHIKV replicates to high titers in insect cells and can be applied directly in enzyme-linked immunosorbent assays without inactivation, resulting in highly sensitive detection of recent and past CHIKV infection, and outperforming traditional antigen preparations
Core-collapse explosions of Wolf-Rayet stars and the connection to type IIb/Ib/Ic supernovae
We present non-LTE time-dependent radiative-transfer simulations of supernova
(SN) IIb/Ib/Ic spectra and light curves, based on ~1B-energy piston-driven
ejecta, with and without 56Ni, produced from single and binary Wolf-Rayet (W-R)
stars evolved at solar and sub-solar metallicities. Our bolometric light curves
show a 10-day long post-breakout plateau with a luminosity of 1-5x10^7Lsun. In
our 56Ni-rich models, with ~3Msun ejecta masses, this plateau precedes a
20-30-day long re-brightening phase initiated by the outward-diffusing heat
wave powered by radioactive decay at depth. In low ejecta-mass models with
moderate mixing, Gamma-ray leakage starts as early as ~50d after explosion and
causes the nebular luminosity to steeply decline by ~0.02mag/d. Such
signatures, which are observed in standard SNe IIb/Ib/Ic, are consistent with
low-mass progenitors derived from a binary-star population. We propose that the
majority of stars with an initial mass ~<20Msun yield SNe II-P if 'effectively"
single, SNe IIb/Ib/Ic if part of a close binary system, and SN-less black holes
if more massive. Our ejecta, with outer hydrogen mass fractions as low as
~>0.01 and a total hydrogen mass of ~>0.001Msun, yield the characteristic SN
IIb spectral morphology at early times. However, by ~15d after the explosion,
only Halpha may remain as a weak absorption feature. Our binary models,
characterised by helium surface mass fractions of ~>0.85, systematically show
HeI lines during the post-breakout plateau, irrespective of the 56Ni abundance.
Synthetic spectra show a strong sensitivity to metallicity, which offers the
possibility to constrain it directly from SN spectroscopic modelling.Comment: 23 pages, 2 tables, 13 figures, accepted to MNRA
Chaperones convert the energy from ATP into the nonequilibrium stabilization of native proteins.
During and after protein translation, molecular chaperones require ATP hydrolysis to favor the native folding of their substrates and, under stress, to avoid aggregation and revert misfolding. Why do some chaperones need ATP, and what are the consequences of the energy contributed by the ATPase cycle? Here, we used biochemical assays and physical modeling to show that the bacterial chaperones GroEL (Hsp60) and DnaK (Hsp70) both use part of the energy from ATP hydrolysis to restore the native state of their substrates, even under denaturing conditions in which the native state is thermodynamically unstable. Consistently with thermodynamics, upon exhaustion of ATP, the metastable native chaperone products spontaneously revert to their equilibrium non-native states. In the presence of ATPase chaperones, some proteins may thus behave as open ATP-driven, nonequilibrium systems whose fate is only partially determined by equilibrium thermodynamics
Protein Kinase Activity and Identification of a Toxic Effector Domain of the Target of Rapamycin TOR Proteins in Yeast
Measuring performance on the Healthcare Access and Quality Index for 195 countries and territories and selected subnational locations: A systematic analysis from the Global Burden of Disease Study 2016
Background A key component of achieving universal health coverage is ensuring that all populations have access to
quality health care. Examining where gains have occurred or progress has faltered across and within countries is
crucial to guiding decisions and strategies for future improvement. We used the Global Burden of Diseases, Injuries,
and Risk Factors Study 2016 (GBD 2016) to assess personal health-care access and quality with the Healthcare Access
and Quality (HAQ) Index for 195 countries and territories, as well as subnational locations in seven countries, from
1990 to 2016.
Methods Drawing from established methods and updated estimates from GBD 2016, we used 32 causes from which
death should not occur in the presence of effective care to approximate personal health-care access and quality by
location and over time. To better isolate potential effects of personal health-care access and quality from underlying
risk factor patterns, we risk-standardised cause-specific deaths due to non-cancers by location-year, replacing the local
joint exposure of environmental and behavioural risks with the global level of exposure. Supported by the expansion
of cancer registry data in GBD 2016, we used mortality-to-incidence ratios for cancers instead of risk-standardised
death rates to provide a stronger signal of the effects of personal health care and access on cancer survival. We
transformed each cause to a scale of 0–100, with 0 as the first percentile (worst) observed between 1990 and 2016, and
100 as the 99th percentile (best); we set these thresholds at the country level, and then applied them to subnational
locations. We applied a principal components analysis to construct the HAQ Index using all scaled cause values,
providing an overall score of 0–100 of personal health-care access and quality by location over time. We then compared
HAQ Index levels and trends by quintiles on the Socio-demographic Index (SDI), a summary measure of overall
development. As derived from the broader GBD study and other data sources, we examined relationships between
national HAQ Index scores and potential correlates of performance, such as total health spending per capita.
Findings In 2016, HAQ Index performance spanned from a high of 97·1 (95% UI 95·8–98·1) in Iceland, followed by
96·6 (94·9–97·9) in Norway and 96·1 (94·5–97·3) in the Netherlands, to values as low as 18·6 (13·1–24·4) in
the Central African Republic, 19·0 (14·3–23·7) in Somalia, and 23·4 (20·2–26·8) in Guinea-Bissau. The pace of
progress achieved between 1990 and 2016 varied, with markedly faster improvements occurring between 2000 and
2016 for many countries in sub-Saharan Africa and southeast Asia, whereas several countries in Latin America and
elsewhere saw progress stagnate after experiencing considerable advances in the HAQ Index between 1990 and 2000.
Striking subnational disparities emerged in personal health-care access and quality, with China and India having
particularly large gaps between locations with the highest and lowest scores in 2016. In China, performance ranged
from 91·5 (89·1–93·6) in Beijing to 48·0 (43·4–53·2) in Tibet (a 43·5-point difference), while India saw a 30·8-point
disparity, from 64·8 (59·6–68·8) in Goa to 34·0 (30·3–38·1) in Assam. Japan recorded the smallest range in
subnational HAQ performance in 2016 (a 4·8-point difference), whereas differences between subnational locations
with the highest and lowest HAQ Index values were more than two times as high for the USA and three times as high
for England. State-level gaps in the HAQ Index in Mexico somewhat narrowed from 1990 to 2016 (from a 20·9-point
to 17·0-point difference), whereas in Brazil, disparities slightly increased across states during this time (a 17·2-point
to 20·4-point difference). Performance on the HAQ Index showed strong linkages to overall development, with high
and high-middle SDI countries generally having higher scores and faster gains for non-communicable diseases.
Nonetheless, countries across the development spectrum saw substantial gains in some key health service areas from
2000 to 2016, most notably vaccine-preventable diseases. Overall, national performance on the HAQ Index was
positively associated with higher levels of total health spending per capita, as well as health systems inputs, but these
relationships were quite heterogeneous, particularly among low-to-middle SDI countries.
Interpretation GBD 2016 provides a more detailed understanding of past success and current challenges in improving
personal health-care access and quality worldwide. Despite substantial gains since 2000, many low-SDI and middle-
SDI countries face considerable challenges unless heightened policy action and investments focus on advancing access to and quality of health care across key health services, especially non-communicable diseases. Stagnating or
minimal improvements experienced by several low-middle to high-middle SDI countries could reflect the complexities
of re-orienting both primary and secondary health-care services beyond the more limited foci of the Millennium
Development Goals. Alongside initiatives to strengthen public health programmes, the pursuit of universal health
coverage hinges upon improving both access and quality worldwide, and thus requires adopting a more comprehensive
view—and subsequent provision—of quality health care for all populations.info:eu-repo/semantics/publishedVersio
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