25 research outputs found
Supporting business students' transition into higher education : the case of marketing downloads
- Publication venue
- 'Informa UK Limited'
- Publication date
- 12/07/2016
- Field of study
Measuring child poverty in Lesotho
- Author
- Publication venue
- Publication date
- 01/01/2006
- Field of study
EThOS - Electronic Theses Online ServiceGBUnited Kingdo
A Realist Evaluation of the Refocused School Nurse Programme within Early Adopter Sites in Scotland
- Publication venue
- Scottish Government (Scotland)
- Publication date
- 01/01/2017
- Field of study
Recommended from our members
The adaptive designs CONSORT extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design
- Author
- Altman Douglas G.
- Ando Yuki
- Ashby Deborah
- Biggs Katie
- Bunce Catey
- Cates Christopher
- Coates Elizabeth
- Collignon Olivier
- Dimairo Munyaradzi
- Gazzard Gus
- Hamasaki Toshimitsu
- Hind Daniel
- Hopewell Sally
- Jaki Thomas
- Jemiai Yannis
- Julious Steven A.
- Koenig Franz
- Lawrence David J.
- Mander Adrian P.
- Marsh Joan
- Meurer William J.
- Nicholl Jon
- Nicholl Jon P.
- Pallmann Philip
- Parke Tom
- Proschan Michael A.
- Roger James
- Scott John A.
- Sydes Matthew
- Todd Susan
- Waldron-Lynch Frank
- Walton Marc K.
- Wason James
- Weir Christopher J.
- Yap Christina
- Publication venue
- Trials
- Publication date
- 17/06/2020
- Field of study
Abstract: Adaptive designs (ADs) allow pre-planned changes to an ongoing trial without compromising the validity of conclusions and it is essential to distinguish pre-planned from unplanned changes that may also occur. The reporting of ADs in randomised trials is inconsistent and needs improving. Incompletely reported AD randomised trials are difficult to reproduce and are hard to interpret and synthesise. This consequently hampers their ability to inform practice as well as future research and contributes to research waste. Better transparency and adequate reporting will enable the potential benefits of ADs to be realised. This extension to the Consolidated Standards Of Reporting Trials (CONSORT) 2010 statement was developed to enhance the reporting of randomised AD clinical trials. We developed an Adaptive designs CONSORT Extension (ACE) guideline through a two-stage Delphi process with input from multidisciplinary key stakeholders in clinical trials research in the public and private sectors from 21 countries, followed by a consensus meeting. Members of the CONSORT Group were involved during the development process. The paper presents the ACE checklists for AD randomised trial reports and abstracts, as well as an explanation with examples to aid the application of the guideline. The ACE checklist comprises seven new items, nine modified items, six unchanged items for which additional explanatory text clarifies further considerations for ADs, and 20 unchanged items not requiring further explanatory text. The ACE abstract checklist has one new item, one modified item, one unchanged item with additional explanatory text for ADs, and 15 unchanged items not requiring further explanatory text. The intention is to enhance transparency and improve reporting of AD randomised trials to improve the interpretability of their results and reproducibility of their methods, results and inference. We also hope indirectly to facilitate the much-needed knowledge transfer of innovative trial designs to maximise their potential benefits. In order to encourage its wide dissemination this article is freely accessible on the BMJ and Trials journal websites.“To maximise the benefit to society, you need to not just do research but do it well” Douglas G Altma
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
- Author
- Abraham Roby
- Alfredsson Lars
- Ardlie Kristin
- Aubin Cristin
- Baker Amie
- Baker Katharine
- Ban Maria
- Band Gavin
- Baranzini Sergio E
- Barcellos Lisa F
- Bellenguez Céline
- Bergamaschi Laura
- Bergamaschi Roberto
- Bernstein Allan
- Berthele Achim
- Blackburn Hannah
- Blackwell Jenefer M
- Boggild Mike
- Bomfim Izaura Lima
- Booth David R
- Bradfield Jonathan P
- Bramon Elvira
- Brassat David
- Broadley Simon A
- Brown Matthew A
- Buck Dorothea
- Bumpstead Suzannah J
- Butzkueven Helmut
- Capra Ruggero
- Carroll William M
- Casas Juan P
- Cavalla Paola
- Celius Elisabeth G
- Cepok Sabine
- Chiavacci Rosetta
- Clerget-Darpoux Françoise
- Clysters Katleen
- Comabella Manuel
- Comi Giancarlo
- Compston Alastair
- Corvin Aiden
- Cossburn Mark
- Cournu-Rebeix Isabelle
- Cox Mathew B
- Cozen Wendy
- Cree Bruce AC
- Cross Anne H
- Cusi Daniele
- D'alfonso Sandra
- D'hooghe Marie Beatrice
- Daly Mark J
- Davis Emma
- de Bakker Paul IW
- De Jager Philip L
- Debouverie Marc
- Deloukas Panos
- Dilthey Alexander
- Dixon Katherine
- Dobosi Rita
- Donnelly Peter
- Dronov Serge
- Dubois Bénédicte
- Duncanson Audrey
- Edkins Sarah
- Ellinghaus David
- Elovaara Irina
- Esposito Federica
- Fontaine Bertrand
- Fontenille Claire
- Foote Simon
- Franke Andre
- Freeman Colin
- Galimberti Daniela
- Ghezzi Angelo
- Giannoulatou Eleni
- Gillman Matthew
- Glessner Joseph
- Gomez Refujia
- Goris An
- Gout Olivier
- Graham Colin
- Grant Struan FA
- Gray Emma
- Guerini Franca Rosa
- Gwilliam Rhian
- Hafler David A
- Haines Jonathan L
- Hakonarson Hakon
- Hall Per
- Hammond Naomi
- Hamsten Anders
- Harbo Hanne F
- Hartung Hans-Peter
- Hauser Stephen L
- Hawkins Clive
- Hawkins Stanley
- Heard Rob N
- Heath Simon
- Hellenthal Garrett
- Hemmer Bernhard
- Hillert Jan
- Hobart Jeremy
- Hoshi Muna
- Hunt Sarah E
- Infante-Duarte Carmen
- Ingram Gillian
- Ingram Wendy
- International Multiple Sclerosis Genetics Consortium
- Islam Talat
- Ivinson Adrian J
- Jagodic Maja
- Jankowski Janusz
- Jayakumar Alagurevathi
- Kabesch Michael
- Kemppinen Anu
- Kermode Allan G
- Kilpatrick Trevor J
- Kim Cecilia
- Klopp Norman
- Kockum Ingrid
- Koivisto Keijo
- Langford Cordelia
- Larsson Malin
- Lathrop Mark
- Lechner-Scott Jeannette S
- Leone Maurizio A
- Leppä Virpi
- Leslie Stephen
- Liddle Jennifer
- Liljedahl Ulrika
- Lincoln Robin R
- Link Jenny
- Liu Jianjun
- Lorentzen Aslaug R
- Lupoli Sara
- Macciardi Fabio
- Mack Thomas
- Markus Hugh S
- Marriott Mark
- Martin Roland
- Martinelli Boneschi Filippo
- Martinelli Vittorio
- Mason Deborah
- Mathew Christopher G
- McCann Owen T
- McCauley Jacob L
- McVean Gil
- Mentch Frank
- Mero Inger-Lise
- Mihalova Tania
- Montalban Xavier
- Mottershead John
- Moutsianas Loukas
- Mycko Marcin P
- Myhr Kjell-Morten
- Naldi Paola
- Oksenberg Jorge R
- Ollier William
- Olsson Tomas
- Oturai Annette Bang
- Page Alison
- Palmer Colin NA
- Palotie Aarno
- Patsopoulos Nikolaos A
- Pelletier Jean
- Peltonen Leena
- Perez Marc L
- Pericak-Vance Margaret A
- Piccio Laura
- Pickersgill Trevor
- Piehl Fredrik
- Pirinen Matti
- Plomin Robert
- Pobywajlo Susan
- Potter Simon C
- Quach Hong L
- Ramsay Patricia P
- Rautanen Anna
- Ravindrarajah Rathi
- Reunanen Mauri
- Reynolds Richard
- Ricketts Michelle
- Rioux John D
- Robertson Neil
- Rodegher Mariaemma
- Roesner Sabine
- Rubio Justin P
- Rückert Ina-Maria
- Saarela Janna
- Salvetti Marco
- Salvi Erika
- Santaniello Adam
- Sawcer Stephen
- Schaefer Catherine A
- Schreiber Stefan
- Schulze Christian
- Scott Rodney J
- Sellebjerg Finn
- Selmaj Krzysztof W
- Sexton David
- Shen Ling
- Simms-Acuna Brigid
- Skidmore Sheila
- Sleiman Patrick MA
- Smestad Cathrine
- Spencer Chris CA
- Spurkland Anne
- Stankovich Jim
- Stewart Graeme J
- Strange Amy
- Strange Richard C
- Su Zhan
- Sulonen Anna-Maija
- Sundqvist Emilie
- Syvänen Ann-Christine
- Søndergaard Helle Bach
- Sørensen Per Soelberg
- Taddeo Francesca
- Taylor Bruce
- Tienari Pentti
- Tourbah Ayman
- Trembath Richard C
- Tronczynska Ewa
- Tubridy Niall
- Vickery Jane
- Villoslada Pablo
- Viswanathan Ananth C
- Waller Matthew J
- Wang Kai
- Wason James
- Wellcome Trust Case Control Consortium 2
- Weston Paul
- Whittaker Pamela
- Wichmann H-Erich
- Widaa Sara
- Willoughby Ernest
- Winkelmann Juliane
- Wittig Michael
- Wood Nicholas W
- Yaouanq Jacqueline
- Zajicek John
- Zhang Haitao
- Zipp Frauke
- Zuvich Rebecca
- Publication venue
- Nature Research
- Publication date
- 01/01/2011
- Field of study
Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance followed by progressive accumulation of disability. Epidemiological studies have shown that genetic factors are primarily responsible for the substantially increased frequency of the disease seen in the relatives of affected individuals, and systematic attempts to identify linkage in multiplex families have confirmed that variation within the major histocompatibility complex (MHC) exerts the greatest individual effect on risk. Modestly powered genome-wide association studies (GWAS) have enabled more than 20 additional risk loci to be identified and have shown that multiple variants exerting modest individual effects have a key role in disease susceptibility. Most of the genetic architecture underlying susceptibility to the disease remains to be defined and is anticipated to require the analysis of sample sizes that are beyond the numbers currently available to individual research groups. In a collaborative GWAS involving 9,772 cases of European descent collected by 23 research groups working in 15 different countries, we have replicated almost all of the previously suggested associations and identified at least a further 29 novel susceptibility loci. Within the MHC we have refined the identity of the HLA-DRB1 risk alleles and confirmed that variation in the HLA-A gene underlies the independent protective effect attributable to the class I region. Immunologically relevant genes are significantly overrepresented among those mapping close to the identified loci and particularly implicate T-helper-cell differentiation in the pathogenesis of multiple sclerosis
Circulating microRNAs in sera correlate with soluble biomarkers of immune activation but do not predict mortality in ART treated individuals with HIV-1 infection: A case control study
- Author
- Aagaard B.
- Abel S.
- Abeli C.
- Abgrall S.
- Aboulker J. P.
- Abrams D. I.
- Abusamra L.
- Acosta E. A.
- Adam A.
- Adams S.
- Adams S.
- Adamski A.
- Agmon-Levin N.
- Agrawal S.
- Aichelburg A.
- Aichelburg A.
- Ainsworth J. G.
- Aiuti F.
- Alcázar-Caballero R.
- Aldir M.
- Alexander I.
- Allegra D.
- Allworth A. M.
- Almeida M. M. T. B.
- Amat K.
- Ambrose P.
- Ampunpong U.
- Andersen P Lehm
- Andersen Å. Bengaard
- Anderson C.
- Anderson J.
- Anderson J.
- Anderson J. S. C.
- Andrews L.
- Andrews L.
- Aneja B.
- Angel E.
- Angel J.
- Angus B.
- Angus B. J.
- Anstead G.
- Antoniadou A.
- Antoniskis D.
- Antunes F.
- Antunes F.
- Aouba A.
- Aquilia S.
- Aquilia S.
- Aragon D. R.
- Aragon E.
- Aragon E.
- Arastéh K.
- Araujo F.
- Arduino R.
- Arduino R.
- Armishaw J.
- Arnaiz J.
- Arnaiz J.
- Arnaiz J. A.
- Arribas J.
- Arrizabalaga J.
- Arsenault M.
- Artz R.
- Artz R.
- Auchieng C.
- Auperin L.
- Baadegaard B.
- Babiker A.
- Babiker G.
- Bahia F.
- Bailowitz J.
- Bailowitz J.
- Baker D.
- Bakowska E.
- Bakowska E.
- Banks S.
- Baptista C.
- Barber T. J.
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- Barnett B. J.
- Baroni C.
- Barron M.
- Barruet R.
- Bartsch G.
- Basso C.
- Bast M.
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- Baum J.
- Baxter J.
- Baxter J. D.
- Bebchuk J.
- Bechi M.
- Bechi M.
- Beckthold B.
- Beers D.
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- Belloso W.
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- Bemenderfer null
- Benalycherif A.
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- Beral V.
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- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2015
- Field of study
Introduction: The use of anti-retroviral therapy (ART) has dramatically reduced HIV-1 associated morbidity and mortality. However, HIV-1 infected individuals have increased rates of morbidity and mortality compared to the non-HIV-1 infected population and this appears to be related to end-organ diseases collectively referred to as Serious Non-AIDS Events (SNAEs). Circulating miRNAs are reported as promising biomarkers for a number of human disease conditions including those that constitute SNAEs. Our study sought to investigate the potential of selected miRNAs in predicting mortality in HIV-1 infected ART treated individuals. Materials and Methods: A set of miRNAs was chosen based on published associations with human disease conditions that constitute SNAEs. This case: control study compared 126 cases (individuals who died whilst on therapy), and 247 matched controls (individuals who remained alive). Cases and controls were ART treated participants of two pivotal HIV-1 trials. The relative abundance of each miRNA in serum was measured, by RTqPCR. Associations with mortality (all-cause, cardiovascular and malignancy) were assessed by logistic regression analysis. Correlations between miRNAs and CD4+ T cell count, hs-CRP, IL-6 and D-dimer were also assessed. Results: None of the selected miRNAs was associated with all-cause, cardiovascular or malignancy mortality. The levels of three miRNAs (miRs -21, -122 and -200a) correlated with IL-6 while miR-21 also correlated with D-dimer. Additionally, the abundance of miRs -31, -150 and -223, correlated with baseline CD4+ T cell count while the same three miRNAs plus miR- 145 correlated with nadir CD4+ T cell count. Discussion: No associations with mortality were found with any circulating miRNA studied. These results cast doubt onto the effectiveness of circulating miRNA as early predictors of mortality or the major underlying diseases that contribute to mortality in participants treated for HIV-1 infection
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos Ane
- Abbas Ahmed M.
- Abbas Mostafa
- Abbasi Mujeeb
- Abbott Tom
- Abd Karim Muhammad Fairuz Shah
- Abdalaal Ibrahim
- Abdel-Galil Khalid
- Abdelemam Rania
- Abdelgawad Abdalrahman
- Abdelkarim Maryam
- Abdelkhalek Mohamed
- Abdelmageed Abdelfatah
- Abdelmawgoud Sherif
- Abdelmohsen Sarah
- Abdelrahman Ahmed Saber
- Abdelrahman Mostafa
- Abdelwahab Khaled
- Abdou Hossam
- Abdulai Darling Ramatu
- Abdulkhaleq Marwa
- Abdullah Bahiyah
- Abdulsalam Khalifa
- Abdulsalam Shuaib
- Abdur-Rahman Lukman
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abebrese John Tabiri
- Abeldaño Ariel
- Abou-Khalil Jad
- Abou-Taleb Hisham
- Abozid Anwaar
- Abozied Hesham
- Abrate Alberto
- Abu-Zaid Ahmed
- Abubakar Mohammed Kabir
- Abud Burçin
- Abuzaid Mohammed
- Adam Albushra Altayeb
- Adamina Michel
- Adamou Harissou
- Adamu Auwal
- Adamu Kabir Musa
- Adanu Kekeli
- Adebara Idowu
- Adebola Oluwaseyi
- Ademuyiwa Adesoji
- Adeniran Abiodun
- Adepiti Akinfolarin
- Aderogba Adeleke Akeem
- Adesunkanmi Abdulhafiz
- Adeyeye Ademola
- Adisa Adewale
- Adjeso Theophilus Justus Kofi
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adu-Aryee Nii Armah
- Adumah Collins
- Afzal Irrum
- Agapov Mikhail
- Agarwal Gaurav
- Agarwal Ravi
- Agbeko Anita Eseenam
- Agbeno Evans Kofi
- Agbonrofo Peter
- Agboola Oluseyi
- Aggarwal Gaurav
- Aghadi Ifeanyi
- Aghtarafi Natasha
- Agrawal Amit
- Agresta Ferdinando
- Aguado Héctor J.
- Aguilera-Arevalo Maria-Lorena
- Aherne Thomas
- Ahmad Aline
- Ahmad Maleeha
- Ahmad Misbahu
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- Ahmed Khalid
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- Aisuodionoe-Shadrach Oseremen
- Aitken Sarah
- Ajenifuja Kayode
- Ajiya Abdulrazak
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- Akinyemi Tosin
- Akrida Ioanna
- Aktokmakyan Talar Vartanoglu
- Akwaisah Ayoub
- Al Bettar Osama
- Al-Badawi Ismail A.
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- Rickard Jennifer
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- Rokohl Alexander Christopher
- Roland Christina L
- Rolinger Jens
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- Yusefi Hossein
- Zabaleta Jon
- Zabkiewicz Catheriner
- Zaccaria Giulia
- Zacharia Bincy
- Zafar Syed Nabeel
- Zago Mauro
- Zaheen Zakia
- Zahid Zahra
- Zaimis Tilemachos
- Zakaria Andee Dzulkarnaen
- Zambon Martina
- Zamora Lindsey
- Zampogna Biagio
- Zancana Giuseppa
- Zani Augusto
- Zanin Luca
- Zanini Nicola
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarif Pierre
- Zaránd Attila
- Zehnder Philipp
- Zenger Serkan
- Zenha Horácio
- Zhu Michael Z. L.
- Ziemann Sebastian
- Zimak Danijela Mrazovac
- Zimak Zoran
- Zivkovic Dragana
- Zizzo Maurizio
- Zucker Benjamin
- Zwain Yasir
- Zyskowski Michael
- Ávila Clara Castro
- Älgå Andreas
- Çakici Mehmet Çaǧlar
- Çelik Enes
- Çelik Meryem Nur
- Özçay Necdet
- Şevik Hüsnü
- Šantak Goran
- Šimko Kristián
- Žatecký Jan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2023
- Field of study
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries
Development and Validation of a Risk Score for Chronic Kidney Disease in HIV Infection Using Prospective Cohort Data from the D:A:D Study
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- Publication venue
- Publication date
- 01/01/2015
- Field of study
Ristola M. on työryhmien DAD Study Grp ; Royal Free Hosp Clin Cohort ; INSIGHT Study Grp ; SMART Study Grp ; ESPRIT Study Grp jäsen.Background Chronic kidney disease (CKD) is a major health issue for HIV-positive individuals, associated with increased morbidity and mortality. Development and implementation of a risk score model for CKD would allow comparison of the risks and benefits of adding potentially nephrotoxic antiretrovirals to a treatment regimen and would identify those at greatest risk of CKD. The aims of this study were to develop a simple, externally validated, and widely applicable long-term risk score model for CKD in HIV-positive individuals that can guide decision making in clinical practice. Methods and Findings A total of 17,954 HIV-positive individuals from the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study with >= 3 estimated glomerular filtration rate (eGFR) values after 1 January 2004 were included. Baseline was defined as the first eGFR > 60 ml/min/1.73 m2 after 1 January 2004; individuals with exposure to tenofovir, atazanavir, atazanavir/ritonavir, lopinavir/ritonavir, other boosted protease inhibitors before baseline were excluded. CKD was defined as confirmed (>3 mo apart) eGFR In the D:A:D study, 641 individuals developed CKD during 103,185 person-years of follow-up (PYFU; incidence 6.2/1,000 PYFU, 95% CI 5.7-6.7; median follow-up 6.1 y, range 0.3-9.1 y). Older age, intravenous drug use, hepatitis C coinfection, lower baseline eGFR, female gender, lower CD4 count nadir, hypertension, diabetes, and cardiovascular disease (CVD) predicted CKD. The adjusted incidence rate ratios of these nine categorical variables were scaled and summed to create the risk score. The median risk score at baseline was -2 (interquartile range -4 to 2). There was a 1: 393 chance of developing CKD in the next 5 y in the low risk group (risk score = 5, 505 events), respectively. Number needed to harm (NNTH) at 5 y when starting unboosted atazanavir or lopinavir/ritonavir among those with a low risk score was 1,702 (95% CI 1,166-3,367); NNTH was 202 (95% CI 159-278) and 21 (95% CI 19-23), respectively, for those with a medium and high risk score. NNTH was 739 (95% CI 506-1462), 88 (95% CI 69-121), and 9 (95% CI 8-10) for those with a low, medium, and high risk score, respectively, starting tenofovir, atazanavir/ritonavir, or another boosted protease inhibitor. The Royal Free Hospital Clinic Cohort included 2,548 individuals, of whom 94 individuals developed CKD (3.7%) during 18,376 PYFU (median follow-up 7.4 y, range 0.3-12.7 y). Of 2,013 individuals included from the SMART/ESPRIT control arms, 32 individuals developed CKD (1.6%) during 8,452 PYFU (median follow-up 4.1 y, range 0.6-8.1 y). External validation showed that the risk score predicted well in these cohorts. Limitations of this study included limited data on race and no information on proteinuria. Conclusions Both traditional and HIV-related risk factors were predictive of CKD. These factors were used to develop a risk score for CKD in HIV infection, externally validated, that has direct clinical relevance for patients and clinicians to weigh the benefits of certain antiretrovirals against the risk of CKD and to identify those at greatest risk of CKD.Peer reviewe
Marketing downloads: a student-centred learning and assessment innovation
- Publication venue
- Publication date
- 01/01/2015
- Field of study