11 research outputs found
Ultra- and Hyper-compact HII regions at 20 GHz
We present radio and infrared observations of 4 hyper-compact HII regions and
4 ultra-compact HII regions in the southern Galactic plane. These objects were
selected from a blind survey for UCHII regions using data from two new radio
surveys of the southern sky; the Australia Telescope 20 GHz survey (AT20G) and
the 2nd epoch Molonglo Galactic Plane Survey (MGPS-2) at 843 MHz. To our
knowledge, this is the first blind radio survey for hyper- and ultra-compact
HII regions.
We have followed up these sources with the Australia Telescope Compact Array
to obtain H70-alpha recombination line measurements, higher resolution images
at 20 GHz and flux density measurements at 30, 40 and 95 GHz. From this we have
determined sizes and recombination line temperatures as well as modeling the
spectral energy distributions to determine emission measures. We have
classified the sources as hyper-compact or ultra-compact on the basis of their
physical parameters, in comparison with benchmark parameters from the
literature.
Several of these bright, compact sources are potential calibrators for the
Low Frequency Instrument (30-70 GHz) and the 100-GHz channel of the High
Frequency Instrument of the Planck satellite mission. They may also be useful
as calibrators for the Australia Telescope Compact Array, which lacks good
non-variable primary flux calibrators at higher frequencies and in the Galactic
plane region. Our spectral energy distributions allow the flux densities within
the Planck bands to be determined, although our high frequency observations
show that several sources have excess emission at 95 GHz (3 mm) that can not be
explained by current models.Comment: 13 pages, 7 figures, accepted for publication in MNRA
Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium
Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be convenient alternatives for evaluating osteoporosis and fracture risk. We performed a meta-analysis of genome-wide association (GWA) studies to assess the genetic determinants of heel broadband ultrasound attenuation (BUA; n = 14 260), velocity of sound (VOS; n = 15 514) and BMD (n = 4566) in 13 discovery cohorts. Independent replication involved seven cohorts with GWA data (in silico n = 11 452) and new genotyping in 15 cohorts (de novo n = 24 902). In combined random effects, meta-analysis of the discovery and replication cohorts, nine single nucleotide polymorphisms (SNPs) had genome-wide significant (P < 5 × 10(-8)) associations with heel bone properties. Alongside SNPs within or near previously identified osteoporosis susceptibility genes including ESR1 (6q25.1: rs4869739, rs3020331, rs2982552), SPTBN1 (2p16.2: rs11898505), RSPO3 (6q22.33: rs7741021), WNT16 (7q31.31: rs2908007), DKK1 (10q21.1: rs7902708) and GPATCH1 (19q13.11: rs10416265), we identified a new locus on chromosome 11q14.2 (rs597319 close to TMEM135, a gene recently linked to osteoblastogenesis and longevity) significantly associated with both BUA and VOS (P < 8.23 × 10(-14)). In meta-analyses involving 25 cohorts with up to 14 985 fracture cases, six of 10 SNPs associated with heel bone properties at P < 5 × 10(-6) also had the expected direction of association with any fracture (P < 0.05), including three SNPs with P < 0.005: 6q22.33 (rs7741021), 7q31.31 (rs2908007) and 10q21.1 (rs7902708). In conclusion, this GWA study reveals the effect of several genes common to central DXA-derived BMD and heel ultrasound/DXA measures and points to a new genetic locus with potential implications for better understanding of osteoporosis pathophysiology
ECFS best practice guidelines: the 2018 revision
Developments in managing CF continue to drive dramatic improvements in survival. As newborn screening rolls-out across Europe, CF centres are increasingly caring for cohorts of patients who have minimal lung disease on diagnosis. With the introduction of mutation-specific therapies and the prospect of truly personalised medicine, patients have the potential to enjoy good quality of life in adulthood with ever-increasing life expectancy. The landmark Standards of Care published in 2005 set out what high quality CF care is and how it can be delivered throughout Europe. This underwent a fundamental re-write in 2014, resulting in three documents; center framework, quality management and best practice guidelines. This document is a revision of the latter, updating standards for best practice in key aspects of CF care, in the context of a fast-moving and dynamic field.
In continuing to give a broad overview of the standards expected for newborn screening, diagnosis, preventative treatment of lung disease, nutrition, complications, transplant/end of life care and psychological support, this consensus on best practice is expected to prove useful to clinical teams both in countries where CF care is developing and those with established CF centres. The document is an ECFS product and endorsed by the CF Network in ERN LUNG and CF Europe
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Proposal to DOE Basic Energy Sciences: Ultrafast X-ray science facility at the Advanced Light Source
We propose to develop a true user facility for ultrafast x-ray science at the Advanced Light Source. This facility will be unique in the world, and will fill a critical need for the growing ultrafast x-ray research community. The development of this facility builds upon the expertise from long-standing research efforts in ultrafast x-ray spectroscopy and the development of femtosecond x-ray sources and techniques at both the Lawrence Berkeley National Laboratory and at U.C. Berkeley. In particular, the technical feasibility of a femtosecond x-ray beamline at the ALS has already been demonstrated, and existing ultrafast laser technology will enable such a beamline to operate near the practical limit for femtosecond x-ray flux and brightness from a 3rd generation synchrotron