Circulating angiogenic cell response to sprint interval and continuous exercise.

Although commonly understood as immune cells, certain T lymphocyte and monocyte subsets have angiogenic potential, contributing to blood vessel growth and repair. These cells are highly exercise responsive and may contribute to the cardiovascular benefits seen with exercise.Purpose: To compare the effects of a single bout of continuous (CONTEX) and sprint interval exercise (SPRINT) on circulating angiogenic cells (CAC) in healthy recreationally active adults.Methods: Twelve participants (aged 29 ±2y, BMI 25.5±0.9 kg.m-28 2, ̇O2peak 44.3±1.8 ml.kg-1.min-1; mean±SEM) participated in the study. Participants completed a 45 min bout of CONTEX at 70% peak oxygen uptake and 6x20 sec sprints on a 30 cycle ergometer, in a counterbalanced design. Blood was sampled pre-, post-, 2h and 24h post-31 exercise for quantification of CAC subsets by whole blood flow cytometric analysis. Angiogenic T lymphocytes (TANG) and angiogenic Tie2-expressing monocytes (TEM) were 33 identified by the expression of CD31 and Tie2 respectively.Results: Circulating (cells.μL-1) 34 CD3+CD31+TANG increased immediately post-exercise in both trials (

Elimination of Falciparum Malaria and Emergence of Severe Dengue:An Independent or Interdependent Phenomenon?

The global malaria burden, including falciparum malaria, has been reduced by 50% since 2000, though less so in Sub-Saharan Africa. Regional malaria elimination campaigns beginning in the 1940s, up-scaled in the 1950s, succeeded in the 1970s in eliminating malaria from Europe, North America, the Caribbean (except Haiti), and parts of Asia and South- and Central America. Dengue has grown dramatically throughout the pantropical regions since the 1950s, first in Southeast Asia in the form of large-scale epidemics including severe dengue, though mostly sparing Sub-Saharan Africa. Globally, the WHO estimates 50 million dengue infections every year, while others estimate almost 400 million infections, including 100 million clinical cases. Curiously, despite wide geographic overlap between malaria and dengue-endemic areas, published reports of co-infections have been scarce until recently. Superimposed acute dengue infection might be expected to result in more severe combined disease because both pathogens can induce shock and hemorrhage. However, a recent review found no reports on more severe morbidity or higher mortality associated with co-infections. Cases of severe dual infections have almost exclusively been reported from South America, and predominantly in persons infected by Plasmodium vivax. We hypothesize that malaria infection may partially protect against dengue – in particular falciparum malaria against severe dengue – and that this inter-species cross-protection may explain the near absence of severe dengue from the Sub-Saharan region and parts of South Asia until recently. We speculate that malaria infection elicits cross-reactive antibodies or other immune responses that infer cross-protection, or at least partial cross-protection, against symptomatic and severe dengue. Plasmodia have been shown to give rise to polyclonal B-cell activation and to heterophilic antibodies, while some anti-dengue IgM tests have high degree of cross-reactivity with sera from malaria patients. In the following, the historical evolution of falciparum malaria and dengue is briefly reviewed, and we explore early evidence of subclinical dengue in high-transmission malaria areas as well as conflicting reports on severity of co-morbidity. We also discuss examples of other interspecies interactions

Data resource profile: the Child LAnguage REpository (CLARE)

Oral language is a characteristic that defines the human species. How this ability develops underpins the health, productivity, and social well-being of individuals.1 Whereas most children acquire speech and language skills with relative ease, many do not, placing a sizeable burden on our health, education, social and economic systems.2,3 Considering this, research in the field has been chronically underfunded and fragmented, resulting in evidence gaps, limited research capacity and uncoordinated, poorly informed and often contradictory advice for policy makers and practitioners.4,5 Although language promotion and early intervention are clearly warranted, efforts to understand how and when best to target interventions have been hampered by a lack of appropriate longitudinal data. Only a few international population cohort studies have collected the detailed language measures required for accurate descriptions of the trajectories and outcomes of children’s language phenotyping.5,6 Studies measuring language in depth have been limited by small, non-representative samples, often drawn from clinical populations and/or commencing at preschool or school age,5 and thus missing the critical early years when the foundations for language are established. In addition, little is known about genetic and/or neural underpinnings, that is, the neurobiology of developmental language disorders (DLD).7Griffith Health, Menzies Health InstituteNo Full Tex