2003 Synthetic Biology study

This is the final report of the 2002-2003 synthetic biology study, which brought together ~50 researchers to discuss an improved framework for engineering biology. The report itself takes the form of an annotated presentation and was written for a general technical audience. This study built upon a smaller, earlier study led by Tom Knight (unpublished at this time).Biology is a technology for processing information, materials, and energy. As a technology platform, biological systems provide access to artifacts and processes across a range of scales (e.g., the ribosome is a programmable nanoassembler, a bamboo shoot can grow 12” per day). Biology also forms the basis for human welfare (e.g., modest amounts of memory and logic, implemented as genetically encoded systems,would directly impact biological research and medicine). However, our ability to deploy biology as a technology and to interact intentionally with the living world is now limited; the charge to our study was to begin to specify enabling technologies that, if developed, would provide a general foundation for the engineering of biology and make routine the creation of synthetic biological systems that behave as predicted.N/

Strategy for Biological Risk & Security

Why do biological risks exist? Can we develop and implement a strategy for thoughtfully approaching future biological risks? This short, working report provides an abstract introduction to the problem of biological risk and outlines how technical and societal approaches should be combined in order to best address the challenge

The effect of drying and storage on the quality of cosmeceutical species Leucosidea Sericea and Greyia Flanaganii

The use of plants for cosmeceutical applications is becoming more important since “safer” and more “natural” skin products are gaining popularity. The effect of different drying methods and storage conditions on metabolite changes and biological activity of two species with cosmeceutical application namely Greyia flanaganii and Leucosidea sericea were investigated using 1H-NMR metabolomics. The multivariate analysis (PCA and OPLS-DA), and 1H-NMR sample spectra were used to analyse the significant differences (P<0.05) resulting from the different treatments. The effect of these treatments on anti-tyrosinase and anti-bacterial (against Staphylococcus aureus) activity of G.flanaganii and L.sericea ethanol leaf extracts respectively, was further investigated to assess the quality. Four different drying methods adopted were freeze drying, oven drying at 50°C, air drying at room temperature and sun drying in a greenhouse. The dried leaf extracts were stored in three different conditions of fridge, freezer and shade conditions and samples from each storage condition taken for analysis at three and six months of storage. The chemical constituents of the leaf extracts of both species were not affected by the drying method and the storage condition, but the concentrations of the metabolites changed. The treatments did not show a significant difference (P<0.05) on the biological activity of the extracts. However, G.flanaganii plant material harvested from the University of Pretoria exhibited a higher anti-tyrosinase activity than material harvested from Mothong heritage site. In G. flanaganii freshly freeze and oven dried extracts exhibited a higher anti-tyrosinase activity with fifty percent inhibitory (IC50) activity of 16.8±0.69 μg/ml and 15.73±0.85 μg/ml respectively than the activity of sun and air dried with IC50 values of 33.08±0.78 μg/ml and 36.86±2.01 μg/ml respectively. The metabolite concentrations and anti-tyrosinase activity dropped significantly after storage. Leucosidea sericea oven and freeze dried extracts, exhibited good anti-bacterial activity with a minimum inhibitory concentration (MIC) value of 0.25 μg/ml and 0.125 μg/ml respectively as compared to sun and air dried extracts with the same MIC value of 0.5 μg/ml. Freeze dried samples showed the best anti-bacterial activity (MIC 0.125 μg/ml) compared to other drying methods. Fridge and freezer storage conditions enhanced the activity of stored sample.College of Agriculture and Environmental SciencesM. Sc. (Agriculture

Perbandingan Efi kasi dan Efek Samping Antara Albendazol, Albendazol-Levamisol dan Mebendazol-Levamisol Terhadap Infeksi Soil-Transmitted Helminths pada Anak Usia Sekolah Dasar Negeri Kabupaten Deli Serdang

Intestinal worm infection in particular of Soil Transmitted Helminth is still a global problem with high prevalence on the tropic and subtropic regions including Indonesia especially in the rural community. Double Blind Randomized Trial that started from April to June 2015 in which the samples are collected from public elementary school children on the Deli Serdang Regency to compare the effectivity and side effect of STH infection treatment by using Albendazole 400 mg, Albendazole 400 mg-Levamisol 50 mg/100 mg, Mebendazole 500 mg-Levamisol 50 mg/100 mg. The samples of Albendazole, Albendazole-Levamisol and Mebendazole-Levamisol groups consist of 60 children in each group in which the ones that have STH infection are Ascariasis 92 children 51.11%, Trichuriasis 37 children 20.55%, and mixed infection 51 children 28.33%. In this research, researcher doesn’t found hookworm infection in any of the groups. From the result ofstool examination, researcher found 100% of cure rate for A. lumbricoides infection on all groups, cure rate of T. trichiura infection 66.7%, 94.7%, 92.3% for each Albendazole, Albendazole-Levamisol, and Mebendazole-Levamisol groups meanwhile cure rate for mixed infection are 28.6%, 85.7%, and 66.7% for each Albendazole, Albendazole-Levamisoland Mebendazole- Levamisol groups. For mild T.trichiura infection treatment with singledose of Albendazole-Levamisolgroup is better than both of Albendazole and Mebendazole- Levamisole groups (p=0.01). In this research, researcher found nausea and diarrhea as treatment of side effect and no signifi cant difference of side effect in all groups of treatment.Infeksi cacing usus terutama yang tergolong di dalam Soil Transmitted Helminth masih merupakan masalah dunia dengan prevalensi yang cukup tinggi pada daerah tropis dan subtropis termasuk Indonesia terutama di daerah pedesaan atau rural. Uji klinik acak tersamar ganda (Double Blind Randomized Trial) sejak April-Juni 2015 terhadap anak Sekolah Dasar Negeri di Kabupaten Deli Serdang dengan membandingkan efektivitas dan efek samping antara pengobatan dengan menggunakan Albendazole dosis 400 mg, Albendazole 400 mg-Levamisol 50 mg/100 mg, dan Mebendazole 500 mg-Levamisol 50 mg/100 mg terhadap infeksi STH. Besar sampel pada kelompok Albendazol, Albendazol-Levamisol, Mebendazol-Levamisol masing-masing 60 anak. Dimana anak-anak yang terinfeksi STHterdiri dari: Ascariasis (92 anak, 51,11%), Trichuriasis (37 anak, 20,55%) dan infeksi campuran (51 anak, 28.33%). Penelitian ini tidak ditemukan infeksi cacing tambang pada tiap kelompok. Pada hasil pemeriksaan feses, didapatkan 100% kesembuhan untuk infeksi A.lumbricoides pada ketiga kelompok,infeksi T.trichiura didapat angka kesembuhan 66,7%, 94,7% dan 92,3% untuk masing-masing kelompok Albendazol, Albendazol-Levamisol dan Mebendazol-Levamisol. Sedangkan infeksi campuran didapat angka kesembuhan 28,6%, 85,7% dan 66,7% untuk masing-masing kelompok Albendazol, Albendazol-Levamisol dan Mebendazol-Levamisol. Untuk infeksi T.trichiura intensitas derajat ringan, kelompok Albendazol-Levamisol dosis tunggal lebih baik dibandingkan kelompok Albendazol dan Mebendazol-Levamisol dosis tunggal (p=0,01). Pada penelitian ini dijumpai efek samping berupa mual dan mencret dan tidak dijumpai perbedaan signifi kan efek samping pada ketiga kelompok pengobatan.Hasil penentuan efisiensi penjerapan menunjukkan formula F1 memiliki efi siensi penjerapan optimal sebesar 99,13±0,10%. Formula G1 lebih stabil selama 28 hari penyimpanan dibandingkan formula G2. Penggunaan span 40 sebagai penyusun niosom dapat meningkatkan penetrasi natrium askorbil&nbsp; fosfatdalam sediaan gel dengan jumlah kumulatif persen difusi selama 8 jam sebesar 89,04±0,01%

ANALISIS MANAJEMEN STRATEGI DI PENDIDIKAN TINGGI MENGGUNAKAN SWOT (STUDI KASUS PADA UNIVERSITAS TRUNOJOYO MADURA)

Kualitas sumber daya manusia, teknologi, dan kemampuan daya saing merupakan hal yang sangat penting agar dapat bersaing dengan negara lain di era globalisasi. Universitas Trunojoyo Madura dalam menghadapi Revolusi Industri 4.0 perlu untuk membuat rencana strategis agar visi misi yang dibuat bisa terlaksana dengan baik. Penelitian ini bertujuan untuk menganalisa faktor internal dan faktor eksternal Universitas Trunojoyo Madura menggunakan metode SWOT untuk menghasilkan strategi yang tepat agar menjadi institusi yang mampu mewujudkan lulusan yang cerdas, berdaya saing, berakhlakul karimah dan unggul dalam pendidikan serta riset berdasarkan potensi Madura. Metode penelitian deskriptif-kualitatif digunakan dalam penelitian ini. Dari penelitian ini dihasilkan strategi di bidang pembelajaran dan kemahasiswaan, Sumber Daya Manusia, penelitian dan pengabdian pada masyarakat, serta sarana dan prasarana

Modern Computer Implementation on Smart Phone with Android Platform for Smes (UMKM) in Optimization Services District Malang

The use of Android in the smartphone operating system currently used by many companies. Because of its superiority as a software that uses computer code base that can be distributed openly (open source) so many applications that can be downloaded by penggguna smartphone without paying the application fee. Believed to be a smartphone that uses the Android operating system will be less costly than a smartphone that uses the operating system are paid. Then to work the MSME sector businesses is in accordance with the condition of our society, especially people Malang. It only takes a willingness Human Resources who are committed to the implementation of SME businesses and to optimize service thoroughly and consistentl

Penerapan Multi Metode Untuk Meningkatkan Sikap dan Hasil Belajar Pencemaran Perairan Siswa Kelas III BP SUPM Sorong

The result of observations on students class 3st TBP (Aquaculture Technology) known to exist of issues cause to the low a studied attitude Water Pollution Control so impact on learning outcomes. The purpose of this research&nbsp;&nbsp; were (1) to know the increase in a studied attitude students after the application of multi methods in learning Water Pollution Control. 2) to know the increase in study results students after the application of multi methods to the process of Water Pollution Control. The research was the act of class resarch (ACR). It was done of students III TBP in application of multi methods on the learning process of water pollution control. The result of research show that 1) on the level of a change in attitude obtained value of 72.03. Based on the scoring reference criteria guide ( SRG) ) scale of five, value of 72.03 show students “ good enough” to changed a studied attitude and 2) on the outcome level student learning obtained value of 72.03 having criteria learning outcomes in the category of “moderat”. This shows that the implementation of multi methods in the learning process of water pollution control to their students &nbsp;3st TBP enough affect study results