Zum Problem der Deskriptivität am Beispiel deutscher Verbalderivation

Eine ausführliche Analyse der Prinzipien der etikettierenden und der deskriptiven Benennung findet sich in Seiler 1975 a. [...] Wesentlich ist; daß der Term gegenüber der Paraphrase; die vermittels der Proposition, zu der er in Beziehung steht, formuliert werden kann (Lehrer = einer, der lehrt), eine Bedeutungsverengung erfährt, die in diesem Falle durch eine zusätzliche semantische Komponente 'professionell' oder 'habituell' o.ä. erfaßt werden kann. Der deskriptiven Benennung, auch charakterisierbar als "Benennen durch Aussagen", dienen diverse sprachliche Mittel oder Techniken wie Derivation, Komposition (mit der Subtechnik der Inkorporation), Absolutivbildung usw. Nicht alle Techniken kommen in jeder Sprache zur Anwendung und auch in den Sprachen, in denen sie zur Anwendung gelangen, ist diese in vielen Fällen auf bestimmte morpho-syntaktische Bereiche beschränkt. [...] Betrachten wir nun unter diesem Gesichtspunkt der Distribution deskriptiver Techniken die Verteilung von Komposition und Derivation im Deutschen. [...] Gegenstand der folgenden Überlegungen soll […] die verbale Wortbildung, und zwar im Vergleich zur nominalen, sein

Gapping, Wortstellung und Direktionalitätshypothese

Die vorliegende Arbeit ist einem Phänomen gewidmet, das in den letzten Jahren eine gewisse Rolle gespielt hat bei dem Versuch, die Anwendbarkeit des Modells der generativen Transformationsgrammatik an einer möglichst großen Anzahl unterschiedlicher Sprachen und Phänomene zu erproben. Es gehört in den umfassenderen Phänomenbereich der Koordination bzw. der Koordinationsreduktion und wird in der einschlägigen Literatur als "Gapping" bezeichnet. [...] Wir wollen koordinierte Strukturen, die ein für alle Konjunkte identisches Verb nur einmal repräsentieren, als "reduzierte Strukturen" bezeichnen, und zwar als "vorwärts"- oder "rechtsreduzierte", wenn sie es ausschließlich im ersten Konjunkt repräsentieren und als "rückwärts" oder " linksreduzierte", wenn sie es ausschließlich im zweiten bzw. (da auch mehr als zwei Sätze koordiniert werden können) im letzten Konjunkt repräsentieren. Entsprechend nennen wir koordinierte Strukturen, die das Verb in beiden bzw. allen Konjunkten repräsentieren, "nicht-reduzierte" Strukturen. [...] Beispiele zeigen, daß es Sprachen gibt, die ausschließlich vorwärtsreduzierte Varianten gestatten und solche, die nur rückwärtsreduzierte Varianten gestatten. Daraus ergibt sich folgende Fragestellung: ( i ) Welche Sprachen gestatten welche reduzierten Varianten? ( ii ) Warum gestatten bestimmte Sprachen diese, andere Sprachen jene Varianten? Diese hier noch recht grob formulierte Fragestellung wird im Laufe der Untersuchung weiter verfeinert werden. Der Schwerpunkt wird auf der Frage nach dem Warum? liegen

Ionisation by quantised electromagnetic fields: The photoelectric effect

In this paper we explain the photoelectric effect in a variant of the standard model of non relativistic quantum electrodynamics, which is in some aspects more closely related to the physical picture, than the one studied in [BKZ]: Now we can apply our results to an electron with more than one bound state and to a larger class of electron-photon interactions. We will specify a situation, where ionisation probability in second order is a weighted sum of single photon terms. Furthermore we will see, that Einstein's equality $$E_{kin}=h\nu-\bigtriangleup E>0$$ for the maximal kinetic energy $E_{kin}$ of the electron, energy $h\nu$ of the photon and ionisation gap $\bigtriangleup E$ is the crucial condition for these single photon terms to be nonzero.Comment: 59 pages, LATEX2

Deskriptive und etikettierende Benennung; Relativkonstruktionen (Ergebnisse eines Forschungsseminars über sprachliche Universalien)

Vorwort : Hansjakob Seiler Deskriptive und metaphorische Benennung im Bereich der deutschen Nominalformen : Rita Becker Die Anwendung des Prinzips der deskriptiven und etikettierenden Benennung auf Instrumentausdrücke im Deutschen und Ungarischen : Elisabeth Katz Etikettierende und deskriptive Benennung in Prä- und Postpositionalsystemen : Heribert Walter Das deskriptive Prinzip im Hebräischen : Edna Habel Anwendung der Prinzipien der deskriptiven und der etikettierenden Benennung auf Farbbezeichnungen im Deutschen : Charlotte Schwendy Deskriptiv vs. Etikettierend in der Fachsprache der EDV : Wolfgang Kirsch Relativkonstruktionen : Bernhard Clasen und Claudia Seip Die […] Arbeiten entstanden im Rahmen eines vom Unterzeichneten geleiteten Forschungsseminars über sprachliche Universalien im Wintersemester 1974/75. Das Interesse konzentrierte sich auf den als "deskriptive und etikettierende Benennung" bezeichneten Problembereich; die Relativkonstruktionen, hier durch eine Arbeit vertreten, hängen letztlich mit dem genannten Problembereich zusammen. Eine weitere Studie über Relativkonstruktionen sowie sonstige zur Zeit noch in Arbeit befindliche Aufsätze dieses Seminars werden vielleicht, in einem späteren Arbeitspapier Aufnahme finden

The L76V mutation in HIV-1 protease is potentially associated with hypersusceptibility to protease inhibitors Atazanavir and Saquinavir: is there a clinical advantage?

Background: Although being considered as a rarely observed HIV-1 protease mutation in clinical isolates, the L76V-prevalence increased 1998-2008 in some European countries most likely due to the approval of Lopinavir, Amprenavir and Darunavir which can select L76V. Beside an enhancement of resistance, L76V is also discussed to confer hypersusceptibility to the drugs Atazanavir and Saquinavir which might enable new treatment strategies by trying to take advantage of particular mutations. Results: Based on a cohort of 47 L76V-positive patients, we examined if there might exist a clinical advantage for L76V-positive patients concerning long-term success of PI-containing regimens in patients with limited therapy options. Genotypic- and phenotypic HIV-resistance tests from 47 mostly multi-resistant, L76V-positive patients throughout Germany were accomplished retrospectively 1999-2009. Five genotype-based drug-susceptibility predictions received from online interpretation-tools for Atazanavir, Saquinavir, Amprenavir and Lopinavir, were compared to phenotype-based predictions that were determined by using a recombinant virus assay along with a Virtual Phenotype™(Virco). The clinical outcome of the L76V-adapted follow-up therapy was determined by monitoring viral load for 96 weeks. Conclusions: In this analysis, the mostly used interpretation systems overestimated the L76V-mutation concerning Atazanavir- and SQV resistance. In fact, a clear benefit in drug susceptibility for these drugs was observed in phenotype analysis after establishment of L76V. More importantly, long-term therapy success was significantly higher in patients receiving Atazanavir and/or Saquinavir plus one L76V-selecting drug compared to patients without L76V-selecting agents (p = 0.002). In case of L76V-occurrence ATV and/or SQV may represent encouraging options for patients in deep salvage situations

Regulatory regionalism and anti-money-laundering governance in Asia

With the intensification of the Financial Action Task Force's (FATF's) worldwide campaign to promote anti-money-laundering regulation since the late 1990s, all Asian states except North Korea have signed up to its rules and have established a regional institution—the Asia/Pacific Group on Money Laundering—to promote and oversee the implementation of FATF's 40 Recommendations in the region. This article analyses the FATF regime, making two key claims. First, anti-money-laundering governance in Asia reflects a broader shift to regulatory regionalism, particularly in economic matters, in that its implementation and functioning depend upon the rescaling of ostensibly domestic agencies to function within a regional governance regime. Second, although this form of regulatory regionalism is established in order to bypass the perceived constraints of national sovereignty and political will, it nevertheless inevitably becomes entangled within the socio-political conflicts that shape the exercise of state power more broadly. Consequently, understanding the outcomes of regulatory regionalism involves identifying how these conflicts shape how far and in what manner global regulations are adopted and implemented within specific territories. This argument is demonstrated by a case study of Myanmar

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

To dissect the genetic architecture of blood pressure and assess effects on target-organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure loci, of which 17 were novel and 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantly associated with target-organ damage in multiple tissues, with minor effects in the kidney. Our findings expand current knowledge of blood pressure pathways and highlight tissues beyond the classic renal system in blood pressure regulation

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.

OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS: We have conducted a meta-analysis of genome-wide association tests of ∼2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS: Nine SNPs at eight loci were associated with proinsulin levels (P < 5 × 10(-8)). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 × 10(-4)), improved β-cell function (P = 1.1 × 10(-5)), and lower risk of T2D (odds ratio 0.88; P = 7.8 × 10(-6)). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS: We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis