4,545 research outputs found
CHEMDNER: The drugs and chemical names extraction challenge
Natural language processing (NLP) and text mining technologies for the chemical domain (ChemNLP or chemical
text mining) are key to improve the access and integration of information from unstructured data such as patents
or the scientific literature. Therefore, the BioCreative organizers posed the CHEMDNER (chemical compound and
drug name recognition) community challenge, which promoted the development of novel, competitive and
accessible chemical text mining systems. This task allowed a comparative assessment of the performance of various
methodologies using a carefully prepared collection of manually labeled text prepared by specially trained
chemists as Gold Standard data. We evaluated two important aspects: one covered the indexing of documents
with chemicals (chemical document indexing - CDI task), and the other was concerned with finding the exact
mentions of chemicals in text (chemical entity mention recognition - CEM task). 27 teams (23 academic and
4 commercial, a total of 87 researchers) returned results for the CHEMDNER tasks: 26 teams for CEM and 23 for the
CDI task. Top scoring teams obtained an F-score of 87.39% for the CEM task and 88.20% for the CDI task, a very
promising result when compared to the agreement between human annotators (91%). The strategies used to
detect chemicals included machine learning methods (e.g. conditional random fields) using a variety of features,
chemistry and drug lexica, and domain-specific rules. We expect that the tools and resources resulting from this
effort will have an impact in future developments of chemical text mining applications and will form the basis to
find related chemical information for the detected entities, such as toxicological or pharmacogenomic properties
Graph Metrics for Temporal Networks
Temporal networks, i.e., networks in which the interactions among a set of
elementary units change over time, can be modelled in terms of time-varying
graphs, which are time-ordered sequences of graphs over a set of nodes. In such
graphs, the concepts of node adjacency and reachability crucially depend on the
exact temporal ordering of the links. Consequently, all the concepts and
metrics proposed and used for the characterisation of static complex networks
have to be redefined or appropriately extended to time-varying graphs, in order
to take into account the effects of time ordering on causality. In this chapter
we discuss how to represent temporal networks and we review the definitions of
walks, paths, connectedness and connected components valid for graphs in which
the links fluctuate over time. We then focus on temporal node-node distance,
and we discuss how to characterise link persistence and the temporal
small-world behaviour in this class of networks. Finally, we discuss the
extension of classic centrality measures, including closeness, betweenness and
spectral centrality, to the case of time-varying graphs, and we review the work
on temporal motifs analysis and the definition of modularity for temporal
graphs.Comment: 26 pages, 5 figures, Chapter in Temporal Networks (Petter Holme and
Jari Saram\"aki editors). Springer. Berlin, Heidelberg 201
Primary Angioplasty in a Catastrophic Presentation: Acute Left Main Coronary Total OcclusionâThe ATOLMA Registry
Objectives. To determine the outcome predictors of in-hospital mortality in acute total occlusion of the left main coronary artery (ATOLMA) patients referred to emergent angioplasty and to describe the clinical presentation and the long-term outcome of these patients.Background. ATOLMA is an uncommon angiographic finding that usually leads to a catastrophic presentation. Limited and inconsistent data have been previously reported regarding true ATOLMA, yet comprehensive knowledge remains scarce.Methods. This is a multicenter retrospective cohort that includes patients presenting with myocardial infarction due to a confirmed ATOLMA who underwent emergency percutaneous coronary intervention (PCI).Results. In the period of the study, 7930 emergent PCI were performed in the five participating centers, and 46 of them had a true ATOLMA (0.58%). At admission, cardiogenic shock was present in 89% of patients, and cardiopulmonary resuscitation was required in 67.4%. All the patients had right dominance. Angiographic success was achieved in 80.4% of the procedures, 13 patients (28.2%) died during the catheterization, and the in-hospital mortality rate was 58.6% (27/46). At one-year and at the final follow-up, 18 patients (39%) were alive, including four cases successfully transplanted. Multivariate analysis showed that postprocedural TIMI flow was the only independent predictor of in-hospital mortality (OR 0.23, (95% CI 0.1-0.36),p<0.001).Conclusions. Our study confirms that the clinical presentation of ATOLMA is catastrophic, presenting a high in-hospital mortality rate; nevertheless, primary angioplasty in this setting is feasible. Postprocedural TIMI flow resulted as the only independent predictor of in-hospital mortality. In-hospital survivors presented an encouraging outcome. ATOLMA and left dominance could be incompatible with life
Precise measurement of the W-boson mass with the CDF II detector
We have measured the W-boson mass MW using data corresponding to 2.2/fb of
integrated luminosity collected in proton-antiproton collisions at 1.96 TeV
with the CDF II detector at the Fermilab Tevatron collider. Samples consisting
of 470126 W->enu candidates and 624708 W->munu candidates yield the measurement
MW = 80387 +- 12 (stat) +- 15 (syst) = 80387 +- 19 MeV. This is the most
precise measurement of the W-boson mass to date and significantly exceeds the
precision of all previous measurements combined
Search for the standard model Higgs boson in the H to ZZ to 2l 2nu channel in pp collisions at sqrt(s) = 7 TeV
A search for the standard model Higgs boson in the H to ZZ to 2l 2nu decay
channel, where l = e or mu, in pp collisions at a center-of-mass energy of 7
TeV is presented. The data were collected at the LHC, with the CMS detector,
and correspond to an integrated luminosity of 4.6 inverse femtobarns. No
significant excess is observed above the background expectation, and upper
limits are set on the Higgs boson production cross section. The presence of the
standard model Higgs boson with a mass in the 270-440 GeV range is excluded at
95% confidence level.Comment: Submitted to JHE
Search for New Physics with Jets and Missing Transverse Momentum in pp collisions at sqrt(s) = 7 TeV
A search for new physics is presented based on an event signature of at least
three jets accompanied by large missing transverse momentum, using a data
sample corresponding to an integrated luminosity of 36 inverse picobarns
collected in proton--proton collisions at sqrt(s)=7 TeV with the CMS detector
at the LHC. No excess of events is observed above the expected standard model
backgrounds, which are all estimated from the data. Exclusion limits are
presented for the constrained minimal supersymmetric extension of the standard
model. Cross section limits are also presented using simplified models with new
particles decaying to an undetected particle and one or two jets
Combined search for the quarks of a sequential fourth generation
Results are presented from a search for a fourth generation of quarks
produced singly or in pairs in a data set corresponding to an integrated
luminosity of 5 inverse femtobarns recorded by the CMS experiment at the LHC in
2011. A novel strategy has been developed for a combined search for quarks of
the up and down type in decay channels with at least one isolated muon or
electron. Limits on the mass of the fourth-generation quarks and the relevant
Cabibbo-Kobayashi-Maskawa matrix elements are derived in the context of a
simple extension of the standard model with a sequential fourth generation of
fermions. The existence of mass-degenerate fourth-generation quarks with masses
below 685 GeV is excluded at 95% confidence level for minimal off-diagonal
mixing between the third- and the fourth-generation quarks. With a mass
difference of 25 GeV between the quark masses, the obtained limit on the masses
of the fourth-generation quarks shifts by about +/- 20 GeV. These results
significantly reduce the allowed parameter space for a fourth generation of
fermions.Comment: Replaced with published version. Added journal reference and DO
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