Testing water-soluble carbohydrate QTL effects in perennial ryegrass (Lolium perenne L.) by marker selection

Water-soluble carbohydrates (WSC) are an important factor determining the nutritional value of grass forage and development of genetic markers for selection of WSC traits in perennial ryegrass would benefit future breeding programmes. Quantitative trait loci (QTLs) for WSC have been published for an F-2 ryegrass mapping family. Markers showing significant associations with these QTLs were used to design narrow-based populations with homozygosity for target QTLs. Founders were selected from within the mapping family. The divergent populations produced were analysed for WSC content in the glasshouse and the field. There was evidence of complex interactions between WSC content and other factors and traits, including the scale of assessment, time/degree of sward establishment and other forage quality parameters. Differences between the divergent pairs of the various populations were small. However, differences observed between the founder selection groups were maintained and the roles of the QTL regions in regulating forage WSC content were confirmed. In general, the individual divergent populations exploited only a limited extent of the large phenotypic variation available within the mapping family. However, this study sets the scene for exploring the opportunities for marker-assisted breeding strategies for complex traits in obligate out-breeding species, and the challenges of doing this are discussed

From cosmic deceleration to acceleration: new constraints from SN Ia and BAO/CMB

We use type Ia supernovae (SN Ia) data in combination with recent baryonic acoustic oscillations (BAO) and cosmic microwave background (CMB) observations to constrain a kink-like parametrization of the deceleration parameter ($q$). This $q$-parametrization can be written in terms of the initial ($q_i$) and present ($q_0$) values of the deceleration parameter, the redshift of the cosmic transition from deceleration to acceleration ($z_t$) and the redshift width of such transition ($\tau$). By assuming a flat space geometry, $q_i=1/2$ and adopting a likelihood approach to deal with the SN Ia data we obtain, at the 68% confidence level (C.L.), that: $z_t=0.56^{+0.13}_{-0.10}$, $\tau=0.47^{+0.16}_{-0.20}$ and $q_0=-0.31^{+0.11}_{-0.11}$ when we combine BAO/CMB observations with SN Ia data processed with the MLCS2k2 light-curve fitter. When in this combination we use the SALT2 fitter we get instead, at the same C.L.: $z_t=0.64^{+0.13}_{-0.07}$, $\tau=0.36^{+0.11}_{-0.17}$ and $q_0=-0.53^{+0.17}_{-0.13}$. Our results indicate, with a quite general and model independent approach, that MLCS2k2 favors Dvali-Gabadadze-Porrati-like cosmological models, while SALT2 favors $\Lambda$CDM-like ones. Progress in determining the transition redshift and/or the present value of the deceleration parameter depends crucially on solving the issue of the difference obtained when using these two light-curve fitters.Comment: 25 pages, 9 figure

Scaling anomaly in cosmic string background

We show that the classical scale symmetry of a particle moving in cosmic string background is broken upon inequivalent quantization of the classical system, leading to anomaly. The consequence of this anomaly is the formation of single bound state in the coupling interval \gamma\in(-1,1). The inequivalent quantization is characterized by a 1-parameter family of self-adjoint extension parameter \omega. It has been conjectured that the formation of loosely bound state in cosmic string background may lead to the so called anomalous scattering cross section for the particles, which is usually seen in molecular physics.Comment: 4 pages,1 figur

PGFinder, a novel analysis pipeline for the consistent, reproducible, and high-resolution structural analysis of bacterial peptidoglycans

Many software solutions are available for proteomics and glycomics studies, but none are ideal for the structural analysis of peptidoglycan (PG), the essential and major component of bacterial cell envelopes. It icomprises glycan chains and peptide stems, both containing unusual amino acids and sugars. This has forced the field to rely on manual analysis approaches, which are time-consuming, labour-intensive, and prone to error. The lack of automated tools has hampered the ability to perform high-throughput analyses and prevented the adoption of a standard methodology. Here, we describe a novel tool called PGFinder for the analysis of PG structure and demonstrate that it represents a powerful tool to quantify PG fragments and discover novel structural features. Our analysis workflow, which relies on open-access tools, is a breakthrough towards a consistent and reproducible analysis of bacterial PGs. It represents a significant advance towards peptidoglycomics as a full-fledged discipline

During pregnancy, recreational drug-using women stop taking ecstasy (3,4-methylenedioxy-N-methylamphetamine) and reduce alcohol consumption but continue to smoke tobacco and cannabis

While recreational drug use in UK women is prevalent, to date there is little prospective data on patterns of drug use in recreational drug-using women immediately before and during pregnancy. A total of 121 participants from a wide range of backgrounds were recruited to take part in the longitudinal Development and Infancy Study (DAISY) study of prenatal drug use and outcomes. Eighty-six of the women were interviewed prospectively while pregnant and/or soon after their infant was born. Participants reported on use immediately before and during pregnancy and on use over their lifetime. Levels of lifetime drug use of the women recruited were high, with women reporting having used at least four different illegal drugs over their lifetime. Most users of cocaine, 3,4-methylenedioxy-N-methylamphetamine (MDMA) and other stimulants stopped using these by the second trimester and levels of use were low. However, in pregnancy, 64% of the sample continued to use alcohol, 46% tobacco and 48% cannabis. While the level of alcohol use reduced substantially, average tobacco and cannabis levels tended to be sustained at pre-pregnancy levels even into the third trimester (50 cigarettes and/or 11 joints per week). In sum, while the use of ‘party drugs’ and alcohol seems to reduce, levels of tobacco and cannabis use are likely to be sustained throughout pregnancy. The data provide polydrug profiles that can form the basis for the development of more realistic animal models

Relativistic quantum dynamics of a charged particle in cosmic string spacetime in the presence of magnetic field and scalar potential

In this paper we analyze the relativistic quantum motion of charged spin-0 and spin-1/2 particles in the presence of a uniform magnetic field and scalar potentials in the cosmic string spacetime. In order to develop this analysis, we assume that the magnetic field is parallel to the string and the scalar potentials present a cylindrical symmetry with their center on the string. Two distinct configurations for the scalar potential, $S(r)$, are considered: $(i)$ the potential proportional to the inverse of the polar distance, i.e., $S\propto1/r$, and $(ii)$ the potential proportional to this distance, i.e., $S\propto r$. The energy spectra are explicitly computed for different physical situations and presented their dependences on the magnetic field strength and scalar coupling constants.Comment: New version with 20 pages and no figure. Some minor revisions and six references added. Accepted for publication in EJP

The Semidwarfs - A New Era in Rice Production.

52 p

Measurements of differential production cross sections for a Z boson in association with jets in pp collisions at root s=8 TeV

Peer reviewe

Search for the associated production of the Higgs boson with a top-quark pair

A search for the standard model Higgs boson produced in association with a top-quark pair t t ¯ H (tt¯H) is presented, using data samples corresponding to integrated luminosities of up to 5.1 fb −1 and 19.7 fb −1 collected in pp collisions at center-of-mass energies of 7 TeV and 8 TeV respectively. The search is based on the following signatures of the Higgs boson decay: H → hadrons, H → photons, and H → leptons. The results are characterized by an observed t t ¯ H tt¯H signal strength relative to the standard model cross section, μ = σ/σ SM ,under the assumption that the Higgs boson decays as expected in the standard model. The best fit value is μ = 2.8 ± 1.0 for a Higgs boson mass of 125.6 GeV