89 research outputs found
Minimizing Variability of Cascade Impaction Measurements in Inhalers and Nebulizers
- Author
- A. Kamiya
- A. Kamiya
- B. Olsson
- B. Wiktorsson
- B. Wyka
- Bernd Walther
- Brent Donovan
- Bruce Wyka
- C. K. Bayne
- C. M. Shelton
- C. M. Shelton
- C. Merrin
- C. Peng
- Chris Quale
- D. Christopher
- D. J. Rader
- D. J. Rader
- D. L. Roberts
- D. L. Roberts
- David Christopher
- David Cipolla
- David Goodwin
- Dilraj Singh
- E. Berg
- E. Berg
- E. Morgan
- E. Stewart
- G. E. Box
- G. E. P. Box
- G. W. Hallworth
- Gunilla Pettersson
- H. Bagger-Jörgensen
- H. Lundbäck
- J. C. Keil
- J. Jozwiakowski
- J. Mitchell
- J. Mitchell
- J. P. Mitchell
- J. P. Mitchell
- J. P. Mitchell
- J. P. Mitchell
- J. P. Mitchell
- J. P. Mitchell
- J. P. Mitchell
- J. Peart
- J. Peart
- Jolyon Mitchell
- K. D. Horton
- K. Fransson
- K. Leung
- K. Milhomme
- K. Milhomme
- L. Eriksson
- M. Copley
- M. Crampton
- M. Dolovich
- M. M. Nasr
- M. M. Nasr
- M. Murtomaa
- M. Murtomaa
- M. Oort Van
- M. Oort Van
- M. Oort Van
- M. Oort Van
- M. P. Smith
- M. R. Feddah
- M. Smith
- M. Svensson
- M. Svensson
- M. Taki
- Matthew Bonam
- Mike Van Oort
- N. C. Miller
- N. Kadrichu
- Nagaraja Rao
- P. A. Carter
- P. A. Carter
- P. C. L. Kwok
- P. Kwok
- P. M. Holzner
- P. R. Byron
- P. R. Byron
- P. R. Byron
- R. Mead
- S. W. Stein
- S. W. Stein
- Steve Nichols
- Susan Holmes
- Svetlana Lyapustina
- T. S. Purewal
- Terrence Tougas
- V. A. Marple
- V. A. Marple
- V. A. Marple
- W. C. Hinds
- W. Glover
- W. Glover
- W. Glover
- W. H. Finlay
- Publication venue
- Springer US
- Publication date
- Field of study
The purpose of this article is to catalogue in a systematic way the available information about factors that may influence the outcome and variability of cascade impactor (CI) measurements of pharmaceutical aerosols for inhalation, such as those obtained from metered dose inhalers (MDIs), dry powder inhalers (DPIs) or products for nebulization; and to suggest ways to minimize the influence of such factors. To accomplish this task, the authors constructed a cause-and-effect Ishikawa diagram for a CI measurement and considered the influence of each root cause based on industry experience and thorough literature review. The results illustrate the intricate network of underlying causes of CI variability, with the potential for several multi-way statistical interactions. It was also found that significantly more quantitative information exists about impactor-related causes than about operator-derived influences, the contribution of drug assay methodology and product-related causes, suggesting a need for further research in those areas. The understanding and awareness of all these factors should aid in the development of optimized CI methods and appropriate quality control measures for aerodynamic particle size distribution (APSD) of pharmaceutical aerosols, in line with the current regulatory initiatives involving quality-by-design (QbD)
Comparison of metal-dependent catalysis by HIV-1 and ASV integrase proteins using a new and rapid, moderate throughput assay for joining activity in solution
- Author
- A Engelman
- A Landgraf
- A Narezkina
- AG Holman
- AM Skalka
- Anna Marie Skalka
- B Müller
- DJ Hazuda
- DJ Hazuda
- DP Grandgenett
- E Asante-Appiah
- E Guiot
- EM Poeschla
- G Merkel
- George Merkel
- H Leh
- HQ He
- J Kulkosky
- J Ramcharan
- J-H Zhang
- JA Grobler
- JM Coffin
- Joseph Ramcharan
- M Katzman
- M Smolov
- Mark D Andrake
- N Neamati
- N Neamati
- R Craigie
- R Craigie
- RA Katz
- RA Katz
- RS Mitchell
- S John
- SA Chow
- SJ Flint
- Terrence R Burke
- X Wu
- Xue Zhi Zhao
- XZ Zhao
- Y Hwang
- Publication venue
- BioMed Central
- Publication date
- 01/01/2009
- Field of study
<p>Abstract</p> <p>Background</p> <p>HIV-1 integrase (IN) is an attractive target for the development of drugs to treat AIDS, and inhibitors of this viral enzyme are already in the clinic. Nevertheless, there is a continuing need to devise new approaches to block the activity of this viral protein because of the emergence of resistant strains. To facilitate the biochemical analysis of wild-type IN and its derivatives, and to measure the potency of prospective inhibitory compounds, a rapid, moderate throughput solution assay was developed for IN-catalyzed joining of viral and target DNAs, based on the detection of a fluorescent tag.</p> <p>Results</p> <p>A detailed, step-by-step description of the new joining assay is provided. The reactions are run in solution, the products captured on streptavidin beads, and activity is measured by release of a fluorescent tag. The procedure can be scaled up for the analysis of numerous samples, and is substantially more rapid and sensitive than the standard radioactive gel methods. The new assay is validated and its utility demonstrated via a detailed comparison of the Mg<sup>++</sup>- and Mn<sup>++</sup>-dependent activities of the IN proteins from human immunodeficiency virus type 1 (HIV-1) and the avian sarcoma virus (ASV). The results confirm that ASV IN is considerably more active than HIV-1 IN, but with both enzymes the initial rates of joining, and the product yields, are higher in the presence of Mn<sup>++ </sup>than Mg<sup>++</sup>. Although the pH optima for these two enzymes are similar with Mn<sup>++</sup>, they differ significantly in the presence of Mg<sup>++</sup>, which is likely due to differences in the molecular environment of the binding region of this physiologically relevant divalent cation. This interpretation is strengthened by the observation that a compound that can inhibit HIV-1 IN in the presence of either metal cofactors is only effective against ASV in the presence of Mn<sup>++</sup>.</p> <p>Conclusion</p> <p>A simplified, assay for measuring the joining activity of retroviral IN in solution is described, which offers several advantages over previous methods and the standard radioactive gel analyses. Based on comparisons of signal to background ratios, the assay is 10–30 times more sensitive than gel analysis, allows more rapid and accurate biochemical analyses of IN catalytic activity, and moderate throughput screening of inhibitory compounds. The assay is validated, and its utility demonstrated in a comparison of the metal-dependent activities of HIV-1 and ASV IN proteins.</p
Shunting Inhibition Controls the Gain Modulation Mediated by Asynchronous Neurotransmitter Release in Early Development
- Author
- A Destexhe
- A Kuhn
- C Morris
- CF Stevens
- CY Chang
- DJ Hagler
- E Salinas
- E Salinas
- FS Chance
- G Chen
- G Fuhrmann
- GO Hjelmstad
- GR Holt
- Herbert Levine
- J de la Rocha
- J Jones
- JC Magee
- JM Fellous
- JS Rothman
- KJ Iremonger
- LE Dobrunz
- LF Abbott
- Lyle J. Graham
- M Megias
- M Migliore
- M Rudolph
- M Tsodyks
- P Lau
- P Poirazi
- R Ravin
- S Hefft
- SA Prescott
- SA Prescott
- SJ Mitchell
- SM Sherman
- T Branco
- T Lu
- T Opitz
- T Schikorski
- Terrence J. Sejnowski
- V Volman
- Vladislav Volman
- VY Bolshakov
- Y Ben Ari
- Y Goda
- Y Otsu
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
The sensitivity of a neuron to its input can be modulated in several ways. Changes in the slope of the neuronal input-output curve depend on factors such as shunting inhibition, background noise, frequency-dependent synaptic excitation, and balanced excitation and inhibition. However, in early development GABAergic interneurons are excitatory and other mechanisms such as asynchronous transmitter release might contribute to regulating neuronal sensitivity. We modeled both phasic and asynchronous synaptic transmission in early development to study the impact of activity-dependent noise and short-term plasticity on the synaptic gain. Asynchronous release decreased or increased the gain depending on the membrane conductance. In the high shunt regime, excitatory input due to asynchronous release was divisive, whereas in the low shunt regime it had a nearly multiplicative effect on the firing rate. In addition, sensitivity to correlated inputs was influenced by shunting and asynchronous release in opposite ways. Thus, asynchronous release can regulate the information flow at synapses and its impact can be flexibly modulated by the membrane conductance
Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy
- Author
- Abdulrahim M.M. (Maha M.)
- Al-Owain M. (Mohammed)
- Aldhalaan H.M. (Hesham M.)
- Algain S.M. (Sulwan M.)
- Alkuraya F.S. (Fowzan S)
- AlSayed M.D. (Moeenaldeen D.)
- Andrews M.V. (Marisa V.)
- Asmari A.A. (Ali Al)
- Awaji A. (Ali)
- Barakat T.S. (Tahsin Stefan)
- Barresi S. (Sabina)
- Barycki J.J. (Joseph J.)
- Bauer P. (Peter)
- Begtrup A. (Amber)
- Bonnard C. (Carine)
- Bosso-Lefèvre C. (Célia)
- Ciruna B. (Brian)
- Claridge-Chang A. (Adam)
- Deigendesch W. (Werner)
- Eio M.Y. (Michelle Y.)
- Faqeih E.A. (Eissa A.)
- Gavrilova R.H. (Ralitza H.)
- Gilboa T. (Tal)
- Grady G. (George)
- Gulsuner S. (Suleyman)
- Gunay-Aygun M. (Meral)
- Handal N. (Nader)
- Hashem M.O. (Mais O.)
- Haye D. (Damien)
- Helbig I. (Ingo)
- Hengel H. (Holger)
- Jad L.A. (Lamyaa A.)
- Jamuar S.S. (Saumya S.)
- Keimer R. (Reinhard)
- Keren B. (Boris)
- Klee E.W. (Eric W.)
- Koolen D.A. (David)
- Kraegeloh-Mann I. (Ingeborg)
- Lebigot É. (Élise)
- Lefeber D.J. (Dirk J.)
- Li H. (Hankun)
- Lim J.Y. (Jiin Ying)
- Maddirevula S. (Sateesh)
- Mahida S. (Sonal)
- Mahmoud A.A.H. (Adel A. H.)
- Martinelli D. (Diego)
- Marzouqa H.M. (Hiyam M.)
- Mathuru A.S. (Ajay S.)
- Mitchell W.G. (Wendy G.)
- Mor-Shaked H. (Hagar)
- Muriello M.J. (Michael J.)
- Naidu S. (Sakkubai)
- Narayanan G. (Gunaseelan)
- Ng A.Y.J. (Alvin Yu Jin)
- Oegema R. (Renske)
- Pfundt R. (Rolph)
- Pierce S. (Sarah)
- Pierson T.M. (Tyler Mark)
- Pouladi M.A. (Mahmoud A.)
- Reversade B. (Bruno)
- Rieß A. (Angelika)
- Rodan L.H. (Lance H.)
- Schultz-Rogers L.E. (Laura E.)
- Schöls L. (Ludger)
- Schüle R. (Rebecca)
- Simpson M.A. (Melanie A.)
- Slegtenhorst M.A. (Marjon) van
- Stamberger H. (Hannah)
- Stewart J.C. (James C.)
- Szenker-Ravi E. (Emmanuelle)
- Tamim A.M. (Abdullah M.)
- Tan E.S. (Ee Shien)
- Tan T.-T. (Thong-Teck)
- Tang S. (Sha)
- Tartaglia M. (Marco)
- Telegrafi A. (Aida)
- Thomas T.G. (Terrence G.)
- Tohari S. (Sumanty)
- Utami K.H. (Kagistia Hana)
- Venkatesh B. (Byrappa)
- Verhelst H. (H.)
- Weckhuysen S. (Sarah)
- Willemsen M.A. (Michél)
- Willing M.C. (Marcia C.)
- Yau M. (Monica)
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/12/2020
- Field of study
Developmental epileptic encephalopathies are devastating disorders characterized by intractable epileptic seizures and developmental delay. Here, we report an allelic series of germline recessive mutations in UGDH in 36 cases from 25 families presenting with epileptic encephalopathy with developmental delay and hypotonia. UGDH encodes an oxidoreductase that converts UDP-glucose to UDP-glucuronic acid, a key component of specific proteoglycans and glycolipids. Consistent with being loss-of-function alleles, we show using patients’ primary fibroblasts and biochemical assays, that these mutations either impair UGDH stability, oligomerization, or enzymatic activity. In vitro, patient-derived cerebral organoids are smaller with a reduced number of proliferating neuronal progenitors while mutant ugdh zebrafish do not phenocopy the human disease. Our study defines UGDH as a key player for the production of extracellular matrix components that are essential for human brain development. Based on the incidence of variants observed, UGDH mutations are likely to be a frequent cause of recessive epileptic encephalopathy
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
- Author
- Abecasis GR
- Abecasis Gonçalo R.
- Absher D
- Adair Linda S.
- Adeyemo Adebowale
- Aherrahrou Z
- Ahmadi KR
- Ala-Korpela Mika
- Alexander Myriam
- Altshuler D
- Altshuler David
- Amin Najaf
- Andersen K
- Aragam J
- Arfan Ikram M.
- Arking DE
- Arking Dan E.
- Arnett D
- Arora Pankaj
- Artigas Maria Soler
- Aspelund T
- Aspelund Thor
- Assimes TL
- Atkinson EJ
- Aulchenko YS
- Aulchenko YS
- Aulchenko YS
- Aulchenko Yurii
- Badola S
- Bakker SJ
- Bakker Stephan J. L.
- Ball SG
- Balmforth AJ
- Bandinelli Stefania
- Barbalic M
- Barroso Inês
- Beckmann J
- Beckmann Jacques S.
- Beilby John P.
- Benjamin E
- Benjamin EJ
- Bergman Richard N.
- Bergmann Sven
- Bickel C
- Bilo HJ
- Bis J
- Bis JC
- Bis JC
- Bis Joshua C.
- Blankenberg S
- Blankenberg S
- Blankenberg S
- Blettner M
- Boban M
- Bochud M
- Bochud Murielle
- Boehnke Michael
- Boerwinkle E
- Boerwinkle E
- Boerwinkle E
- Boerwinkle Eric
- Bolton Judith A Hoffman
- Bonnycastle Lori L.
- Borecki I
- Bornstein Stefan R.
- Bots Michiel L.
- Bragg-Gresham Jennifer L.
- Brand Eva
- Brand Stefan-Martin
- Brandstätter A
- Braund PS
- Braund Peter S.
- Brown MJ
- Brown Morris J.
- Bruse P
- Burnett MS
- Burton Paul R.
- Burtt N
- Böger CA
- Böhm BO
- Cambien F
- Campbell H
- Campbell S
- Campbell Harry
- Casas Juan P.
- Caulfield MJ
- Caulfield Mark J.
- Cavalieri M
- Chakravarti Aravinda
- Chambers JC
- Chambers John C.
- Chandak Giriraj R.
- Chang PP
- Chang Yen-Pei C.
- Charchar Fadi J.
- Charlotte Onland-Moret N.
- Chasman DI
- Chasman Daniel I.
- Chaturvedi Nish
- Chen IY
- Chen L
- Chen Ming-Huei
- Cho Yoon Shin
- Clarke Robert
- Collins Francis S.
- Connell JM
- Connell John M.
- Cook HT
- Cook HT
- Cooper Jackie A.
- Cooper Matthew N.
- Cooper Richard S.
- Coresh J
- Coresh Josef
- Cornelis MC
- Corsi Anna Maria
- Cotlarciuc I
- Cotlarciuc I
- Couper D
- Cupples LA
- Cupples LA
- Curhan GC
- Dahgam Santosh
- Dandona S
- Danesh John
- Davey Smith G
- Davey Smith G
- Day Ian N. M.
- de Andrade M
- de Boer J
- de Jong PE
- de Silva R
- de Silva R
- Deckers JW
- Dehghan A
- Dehghan A
- Dehghan A
- Dehghan A
- Dehghan Abbas
- Deloukas Panos
- Demirkan Ayse
- Demissie S
- Demissie-Banjaw S
- Deng G
- Deng G
- Denniff Matthew
- Devaney J
- Devuyst O
- Devuyst O
- Dikkeschei LD
- Dikkeschei LD
- Dimkovic T
- Dobnig H
- Dockrell M
- Doering A
- Dominiczak A
- Dominiczak Anna F.
- Dong Yanbin
- Doumatey Ayo
- Dreisbach Albert W.
- Dörr M
- Dörr Marcus
- Ebrahim S
- Eggermann T
- Ehret Georg B.
- Eiriksdottir G
- Ellinghaus D
- Elliot P
- Elliott Paul
- Elosua R
- Elosua Roberto
- Emilsson Valur
- Endlich K
- Epstein S
- Erdmann J
- Erdmann J
- Erdmann Jeanette
- Eyheramendy Susana
- Farrall M
- Farrall Martin
- Fava Cristiano
- Feitosa M
- Felix JF
- Felix JF
- Felix JF
- Felix SB
- Ferrucci L
- Ferrucci L
- Ferrucci Luigi
- Fisher M
- Floege J
- Folsom A
- Folsom AR
- Forouhi NG
- Forrester Terrence
- Fortmann S
- Fowkes F. Gerald R.
- Fox CS
- Fox ER
- Fox Ervin R.
- Franke A
- Frayling Timothy M.
- Freyer J
- Friedrich N
- Fuchsberger C
- Gabriel SB
- Galan Pilar
- Gale DP
- Ganesh Santhi K.
- Gansevoort RT
- Gao X
- Garcia Melissa
- Gaunt Tom R.
- Giallauria Francesco
- Gieger Christian
- Glazer N
- Glazer NL
- Glazer NL
- Glazer NL
- Glazer Nicole L.
- Go A
- Go Min Jin
- Goel Anuj
- Gottdiener JS
- Gottdiener JS
- Grammer TB
- Greiser KH
- Gretarsdottir S
- Grobbee Diederick E.
- Groop Leif
- Grosshennig A
- Grosshennig A
- Grässler Jürgen
- Guarrera Simonetta
- Gudnason V
- Gudnason V
- Gudnason Vilmundur
- Guiducci C
- Gulcher JR
- Gulde S
- Guo Xiuqing
- Gyllensten U
- Gyllensten Ulf B.
- Hadley David
- Haerting J
- Hakonarson HH
- Hall AS
- Halperin E
- Hamsten Anders
- Han X
- Han Bok-Ghee
- Hardy Rebecca
- Haritunians T
- Haritunians T
- Haritunians T
- Harris T
- Harris TB
- Harris Tamara B.
- Hartikainen Anna-Liisa
- Hastie N
- Hayward C
- Hayward Caroline
- Heath Simon
- Heckbert S
- Heckbert SR
- Heckbert SR
- Heckbert Susan R.
- Hedblad B
- Hedblad Bo
- Heid IM
- Hengstenberg C
- Hepkema BG
- Hercberg Serge
- Hernandez Dena
- Hernandez-Fuentes M
- Hicks Andrew A.
- Hilton Gina
- Hingorani Aroon D.
- Hlatky M
- Hoang Nguyen Khanh-Dung
- Hoffmann M
- Hofman A
- Hofman A
- Hofman A
- Hofman A
- Hofman Albert
- Holm H
- Homan van der Heide JJ
- Homuth G
- Hopewell Jemma C.
- Howard Philip
- Hu FB
- Humphries Steve E.
- Hunt Steven C.
- Hunter Young J.
- Hveem Kristian
- Hwang SJ
- Hwang Shih-Jen
- Hypponen E
- Igl W
- Igl Wilmar
- Illig T
- Illig T
- Imboden M
- Ingelsson E
- Iribarren C
- Isaacs A
- Isaacs Aaron
- Islam Muhammad
- Iwai Naoharu
- Jackson Anne U.
- Jafar Tazeen H.
- Janipalli Charles S.
- Jarinova O
- Jarvelin MR
- Johansson A
- Johnson A
- Johnson T
- Johnson Andrew D.
- Johnson Toby
- Järvelin Marjo-Riitta
- Kangas Antti J.
- Kao WH
- Kao Wen Hong Linda
- Kardia SL
- Kardia Sharon L.
- Kathiresan S
- Kathiresan S
- Kathiresan Sekar
- Kedenko L
- Kent KM
- Ketkar S
- Kettunen Johannes
- Khaw Kay-Tee
- Kim Hyung-Lae
- Kinra Sanjay
- Kita Yoshikuni
- Kivimaki Mika
- Kleber M
- Kleefstra N
- Klopp N
- Klopp N
- Knouf CW
- Knowles J
- Koenig W
- Kolcic I
- Kollerits B
- Kong A
- Kooner JS.
- Kooner Jaspal S.
- Kovacs P
- Kranthi Kumar M. V.
- Kroemer HK
- Kroemer HK
- Kroemer Heyo K.
- Kronenberg F
- Krämer BK
- Kuh Diana
- Kulkarni Smita R.
- Kullo I
- Kumari Meena
- Kuusisto Johanna
- Kuznetsova Tatiana
- Kähönen Mika
- König IR
- König IR
- Köttgen A
- Köttgen Anna
- Laakso Markku
- Laaksonen R
- Laan Maris
- Lackner K
- Lackner KJ
- Lagou V
- Laitinen Jaana
- Lakatta Edward G.
- Langefeld Carl D.
- Lapsley M
- Larson MG
- Larson Martin G.
- Lathrop Mark
- Launer LJ
- Launer Lenore
- Lawlor DA
- Lawlor Debbie A.
- Lawrence Robert W.
- Leak TS
- Lee Jong-Young
- Lee Nanette R.
- Lehtimäki Terho
- Levy D
- Levy D
- Levy D
- Levy Daniel
- Li M
- Li M
- Li Y
- Li Yali
- Lieb W
- Lieb W
- Lieb W
- Lightstone L
- Lind L
- Lindsay JM
- Linsel-Nitschke P
- Liu Y
- Liu Yongmei
- Loehr LR
- Lohman K
- Lohman Kurt K.
- Loley C
- Longstreth Jr. W. T.
- Loos RJ
- Loos Ruth J. F.
- Lord GM
- Luan J
- Luan Jian'an
- Lucas Gavin
- Ludwig Barbara
- Lumley T
- Lumley T
- Lumley T
- Lumley T
- Luttropp K
- Lyytikäinen Leo-Pekka
- Mangino Massimo
- Marciante K
- Marmot Michael G.
- Maréchal C
- Mattace-Raso Francesco U. S.
- Mattha W
- Matullo Giuseppe
- Maxwell PH
- McArdle Wendy L.
- McCarthy MI
- McKenzie Colin A.
- McPherson R
- Medack A
- Meinitzer A
- Meisinger C
- Meisinger C
- Meitinger T
- Meitinger T
- Meitinger Thomas
- Melander O
- Melander O
- Melander Olle
- Meneton Pierre
- Meschia James F.
- Metter J
- Meyers R
- Miki Tetsuro
- Milaneschi Yuri
- Minelli C
- Mitchell BD
- Mitchell GF
- Mohlke Karen L.
- Mooser V
- Mooser V
- Mooser Vincent
- Morken Mario A.
- Morris Richard W.
- Morrison A
- Morrison AC
- Morrison Alanna C.
- Mosley Thomas H.
- Munroe PB
- Munroe Patricia B.
- Munzel TF
- Munzel TF
- Murabito J
- Musunuru K
- Mägi R
- März W
- Münzel T
- Nahrstedt J
- Najjar Samer
- Nalls Michael A.
- Narisu Narisu
- Nauck M
- Navis G
- Navis Gerjan
- Nelson C
- Newton-Cheh Christopher
- Nicaud V
- Nilsson Peter
- Nitsch D
- Nordfors L
- Nyberg Fredrik
- O'Connell JR
- O'Connell Jeffrey R.
- O'Donnell CJ
- O'Donnell CJ
- O'Donnell CJ
- O'Donnell Christopher J.
- O'Reilly Paul F.
- Ogihara Toshio
- Ohkubo Takayoshi
- Okamura Tomonori
- Olden M
- Olden Matthias
- Ongen Halit
- Oostra BA
- Oostra Ben A.
- Org Elin
- Orru Marco
- Palmas Walter
- Palmen Jutta
- Palmer Lyle J.
- Palmer Nicholette D.
- Parker AN
- Parker Alex N.
- Parsa A
- Parsa A
- Parsa Afshin
- Paré G
- Pattaro C
- Pattaro Cristian
- Paulweber B
- Peden John F.
- Peltonen L
- Peltonen L
- Peltonen Leena
- Penninx BW
- Perola Markus
- Perret C
- Perucha E
- Peters A
- Pichard AD
- Pihur Vasyl
- Pilz S
- Platou Carl G. P.
- Plump Andrew
- Polasek O
- Polasek Ozren
- Pouta A
- Prabhakaran Dorairaj
- Pramstaller PP
- Pramstaller Peter P.
- Preuss M
- Probst-Hensch NM
- Prokopenko I
- Prokopenko I
- Prokopenko Inga
- Proust C
- Province M
- Psaty BM
- Psaty BM
- Psaty BM
- Psaty BM
- Psaty Bruce M.
- Qu L
- Quertermous T
- Rader DJ
- Radha Mani K.
- Raffel Leslie J.
- Raitakari Olli
- Ramachandran V
- Rampersaud E
- Rao Dabeeru C.
- Rasheed Asif
- Redfield MM
- Reffelmann T
- Reilly MP
- Renner W
- Rettig R
- Rettig Rainer
- Ricceri Fulvio
- Rice K
- Rice K
- Rice KM
- Rice Kenneth M.
- Ridker PM
- Ridker Paul M.
- Risch N
- Rivadeneira F
- Rivadeneira F
- Rivadeneira F
- Rivadeneira Fernando
- Roberts R
- Rochat T
- Rodeheffer RJ
- Roderick PJ
- Rosamond WD
- Rosengren Annika
- Rotimi Charles
- Rotter JI
- Rotter JI
- Rotter JI
- Rotter Jerome I.
- Rudan I
- Rudan Igor
- Rudock Megan E.
- Ruokonen A
- Rupprecht HJ
- Salako Tunde
- Saleheen Danish
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- Samani NJ
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- Sanna S
- Satler L
- Schalling M
- Scharnagl H
- Schillert A
- Schillert A
- Schillert A
- Schlessinger D
- Schlieper G
- Schmidt H
- Schmidt H
- Schmidt R
- Schmidt R
- Schnabel R
- Schnabel RB
- Schnabel RB
- Schreiber S
- Schreiber S
- Schunkert H
- Schunkert H
- Schwartz SM
- Schwartz Stephen M.
- Schwarz Peter E. H.
- Scott J
- Scott James
- Scott Laura J.
- Scuteri Angelo
- Seelen MA
- Sehmi JS
- Sehmi Joban S.
- Seielstad Mark
- Seshadri Sudha
- Sharma Pankaj
- Shaw-Hawkins Sue
- Shi Gang
- Shlipak MG
- Shrine Nick R. G.
- Shriner Daniel
- Shuldiner AR
- Shuldiner AR
- Shuldiner Alan R.
- Shyong Tai E.
- Sidney S
- Sijbrands Eric J. G.
- Sim Xueling
- Singleton A
- Singleton Andrew
- Sinning C
- Siscovick D
- Siscovick DS
- Sjögren M
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- Smit JH
- Smith A
- Smith AV
- Smith N
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- Smith Albert V.
- Smith George Davey
- Smith Nicholas L.
- Snieder H
- Snieder Harold
- Sober Siim
- Soininen Pasi
- Soranzo N
- Soranzo Nicole
- Spector TD
- Spector Tim D.
- Staessen Jan A.
- Stančáková Alena
- Stark K
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- Steinle Nanette I.
- Stenvinkel P
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- Stewart AF
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- Strachan David P.
- Stricker B
- Stricker BH
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- Stritzke J
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- Sun Yan V.
- Swaminathan R
- Swift Amy J.
- Tabara Yasuharu
- Talmud Philippa J.
- Tanaka T
- Tanaka T
- Tanaka Toshiko
- Tang H
- Taylor KD
- Taylor Andrew
- Tayo Bamidele
- Terzic Janos
- Teumer A
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- Teumer Alexander
- Thelle Dag S.
- Thompson JR
- Thorgeirsson G
- Thorleifsson G
- Thorsteinsdottir U
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- Tobin Martin D.
- Tomaschitz A
- Tomaszewski Maciej
- Tripathy Vikal
- Tukiainen Taru
- Tuomilehto Jaakko
- Turne ST
- Twee-HeeOng Rick
- Tzoulaki Ioanna
- Tönjes A
- Ubink-Veltmaat LJ
- Uda M
- Uda Manuela
- Ueshima Hirotsugu
- Uiterwaal Cuno S. P. M.
- Uitterlinden A
- Uitterlinden AG
- Uitterlinden AG
- Uitterlinden AG
- Uitterlinden Andre G.
- Umemura Satoshi
- van der Harst P
- van der Harst Pim
- van der Schouw Yvonne T.
- van Duijn C
- van Duijn CM
- van Duijn CM
- van Duijn CM
- van Duijn Cornelia M.
- van Gilst Wiek H.
- Vartiainen Erkki
- Vasan R
- Vasan RS
- Vasan Ramachandran S.
- Veldre Gudrun
- Verwoert Germaine C.
- Viigimaa Margus
- Viikari Jorma
- Vinay D. G.
- Vineis Paolo
- Vitart V
- Vitart Veronique
- Voight BF
- Voight Benjamin F.
- Volcik K
- Vollenweider P
- Vollenweider Peter
- Völker U
- Völker U
- Völker Uwe
- Völzke H
- Völzke H
- Völzke Henry
- Waeber G
- Wagenknecht Lynne E.
- Wain Louise V.
- Waksman R
- Walker M
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- Wang TJ
- Wang TJ
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- Wang YA
- Wang Thomas J.
- Wang Xiaoling
- Wareham NJ
- Wareham Nicholas J.
- Wass MN
- Waterworth D
- Waterworth DM
- Watkins Hugh
- Watzinger N
- Weder Alan B.
- Wells GA
- Werdan K
- Whincup Peter H.
- Whitteman J
- Wichmann HE
- Wichmann HE
- Wichmann HE
- Wichmann H. -Erich
- Wiggins Kerri L.
- Wild P
- Wild PS
- Wild PS
- Wild SH
- Wild Sarah H.
- Wilde S
- Wilensky R
- Willenborg C
- Willerson JT
- Wilson JF
- Wilson James F.
- Winkelmann BR
- Winkler K
- Witteman JC
- Witteman JC
- Witteman JC
- Witteman Jacqueline C. M.
- Wong Andrew
- Wong Tien Y.
- Wright AF
- Wright BJ
- Wright Alan F.
- Wu Ying
- Würtz Peter
- Yajnik Chittaranjan S.
- Yang Q
- Yao Jie
- Zaboli G
- Zelenika Diana
- Zeller T
- Zeller T
- Zeller T
- Zemunik T
- Zerres K
- Zgaga L
- Zhai Guangju
- Zhang W
- Zhang Feng
- Zhang Weihua
- Zhao Jing Hua
- Zhu Haidong
- Zhu Xiaofeng
- Ziegler A
- Ziegler A
- Ziegler A
- Zillikens MC
- Zitting Paavo
- Zukowska-Szczechowska Ewa
- Zweiker R
- Publication venue
- Nature
- Publication date
- 01/01/2011
- Field of study
Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or ≥90 mm Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention
Causal effect of plasminogen activator inhibitor type 1 on coronary heart disease
- Author
- Abecasis Gonçalo R.
- Adair Linda S.
- Adeyemo Adebowale
- Adrienne Cupples L.
- Ala-Korpela Mika
- Alexander Myriam
- Altshuler David
- Amin Najaf
- Andrade Mariza de
- Arfan Ikram M.
- Arking Dan E.
- Arora Pankaj
- Artigas Maria Soler
- Aspelund Thor
- Asselbergs Folkert W.
- Aulchenko Yurii
- Bakker Stephan J. L.
- Ballantyne Christie
- Bandinelli Stefania
- Barroso Inês
- Basu Saonli
- Baumert Jens
- Becker Diane M.
- Becker Lewis C.
- Beckmann Jacques S.
- Beilby John P.
- Bergman Richard N.
- Bergmann Sven
- Bevan Steve
- Bielak Lawrence F.
- Bis Joshua C.
- Blankenberg Stefan
- Bochud Murielle
- Boehm Bernhard O.
- Boehnke Michael
- Boerwinkle Eric
- Bonnycastle Lori L.
- Borecki Ingrid B.
- Bornstein Stefan R.
- Bots Michiel L.
- Bragg-Gresham Jennifer L.
- Brand Eva
- Brand Stefan-Martin
- Braund Peter S.
- Brown Morris J.
- Burgess Stephen
- Burton Paul R.
- Cambien Francois
- Campbell Harry
- Carter Angela M.
- Casas Juan P.
- Caulfield Mark J.
- Chakravarti Aravinda
- Chambers John C.
- Chandak Giriraj R.
- Chang Yen-Pei C.
- Charchar Fadi J.
- Chasman Daniel I.
- Chaturvedi Nish
- Chen Ming-Huei
- Cheng Yu-Ching
- Chilukoti Ravi Kumar
- Cho Yoon Shin
- Clarke Robert
- Collins Francis S.
- Collins Rory
- Connell John M.
- Cooper Jackie A.
- Cooper Matthew N.
- Cooper Richard S.
- Coresh Josef
- Corsi Anna Maria
- Couper David J.
- Cunningham Julie
- Cushman Mary
- D'Agostino Ralph B.
- Dahgam Santosh
- Danesh John
- Day Ian N. M.
- Dehghan Abbas
- Deloukas Panos
- Demirkan Ayse
- Demissie Serkalem
- Denniff Matthew
- Ding Jingzhong
- Dominiczak Anna F.
- Dong Yanbin
- Doumatey Ayo
- Dreisbach Albert W.
- Duijn Cornelia van
- Dörr Marcus
- Ehret Georg B.
- Eicher John D.
- Eiriksdottir Gudny
- Elias-Smale Suzette E.
- Elliott Paul
- Elosua Roberto
- Emilsson Valur
- Erdmann Jeanette
- Erich Wichmann H.
- Eriksson Per
- Ernst Florian
- Eyheramendy Susana
- Farrall Martin
- Fava Cristiano
- Feitosa Mary F.
- Ferrucci Luigi
- Folkersen Lasse
- Folsom Aaron R.
- Forrester Terrence
- Fowkes F. Gerald R.
- Fox Caroline S.
- Fox Ervin R.
- Franceschini Nora
- Franco-Cereceda Anders
- Franzosi Maria Grazia
- Frayling Timothy M.
- Galan Pilar
- Ganesh Santhi K.
- Garcia Melissa
- Gaunt Tom R.
- Gieger Christian
- Glazer Nicole L.
- Go Min Jin
- Goel Anuj
- Goodall Alison H.
- Grant Peter J.
- Grobbee Diederick E.
- Groop Leif
- Grässler Jürgen
- Guarrera Simonetta
- Gudnason Vilmundur
- Guo Xiuqing
- Gyllensten Ulf B.
- Hadley David
- Halperin Eran
- Hamsten Anders
- Han Bok-Ghee
- Hardy Rebecca
- Harris Tamara B.
- Hartikainen Anna-Liisa
- Hayward Caroline
- Heath Simon
- Heckbert Susan R.
- Hedblad Bo
- Heiss Gerardo
- Hercberg Serge
- Hernandez Dena
- Herrington David M.
- Hicks Andrew A.
- Hillege Hans L.
- Hilton Gina
- Hingorani Aroon D.
- Hoffman Bolton Judith A.
- Hoffmann Udo
- Hofman Albert
- Homuth Georg
- Hopewell Jemma C.
- Howard Philip
- Howard Timothy D.
- Huang Jie
- Huffman Jennifer E.
- Humphries Steve E.
- Hunt Steven C.
- Hveem Kristian
- Hwang Shih-Jen
- Igl Wilmar
- Ikram Mohammad A.
- Illig Thomas
- Isaacs Aaron
- Islam Muhammad
- Iwai Naoharu
- Jackson Anne U.
- Jafar Tazeen H.
- Janipalli Charles S.
- Johnson Andrew D.
- Johnson Toby
- Järvelin Marjo-Riitta
- Kangas Antti J.
- Karakas Mahir
- Kardia Sharon L.
- Kathiresan Sekar
- Kavousi Maryam
- Kettunen Johannes
- Khaw Kay-Tee
- Kim Hyung-Lae
- Kinra Sanjay
- Kita Yoshikuni
- Kivimaki Mika
- Kleber Marcus E.
- Klopp Norman
- Koenig Wolfgang
- Kooner Jaspal S.
- Kraja Aldi T.
- Krestin Gabriel P.
- Kroemer Heyo K.
- Kuh Diana
- Kulkarni Smita R.
- Kumar M. V. Kranthi
- Kumari Meena
- Kuusisto Johanna
- Kuznetsova Tatiana
- Kähönen Mika
- Köttgen Anna
- Laakso Markku
- Laan Maris
- Laitinen Jaana
- Lakatta Edward G.
- Langefeld Carl D.
- Larson Martin G.
- Lathrop Mark
- Launer Lenore
- Launer Lenore J.
- Lawlor Debbie A.
- Lawrence Robert W.
- Lee Jong-Young
- Lee Nanette R.
- Lehtimäki Terho
- Levy Daniel
- Li Xia
- Li Yali
- Linda Kao Wen Hong
- Liu Yongmei
- Lohman Kurt
- Lohman Kurt K.
- Longstreth W. T.
- Loos Ruth J. F.
- Luan Jian'an
- Lucas Gavin
- Ludwig Barbara
- Lundmark Per
- Lyytikäinen Leo-Pekka
- Lüdemann Jan
- Mangino Massimo
- Mani K. Radha
- Markus Hugh S.
- Marmot Michael G.
- Massaro Joseph M.
- Matijevic Nena
- Mattace-Raso Francesco U. S.
- Matullo Giuseppe
- McArdle Wendy L.
- McKenzie Colin A.
- McKnight Barbara
- Meigs James B.
- Meisinger Christa
- Meitinger Thomas
- Melander Olle
- Meneton Pierre
- Meschia James F.
- Miki Tetsuro
- Milaneschi Yuri
- Mitchell Braxton D.
- Mohlke Karen L.
- Moore Jason H.
- Mooser Vincent
- Morange Pierre-Emmanuel
- Morken Mario A.
- Morris Richard W.
- Morrison Alanna C.
- Mosley Thomas H.
- Munroe Patricia B.
- Murabito Joanne M.
- Mychaleckyj Josyf C.
- März Winfried
- Müller-Nurasyid Martina
- Münzel Thomas
- Najjar Samer
- Nalls Michael
- Nalls Michael A.
- Nambi Vijay
- Narisu Narisu
- Navis Gerjan
- Navis Gerjan J.
- Newman Anne B.
- Newton-Cheh Christopher
- Nguyen Khanh-Dung Hoang
- Nilsson Peter
- North Kari
- Nyberg Fredrik
- O'Connell Jeffrey R.
- O'Donnell Christopher J.
- O'Leary Daniel H.
- O'Reilly Paul F.
- Ogihara Toshio
- Ohkubo Takayoshi
- Okamura Tomonori
- Olden Matthias
- Ong Rick Twee-Hee
- Ongen Halit
- Onland-Moret N. Charlotte
- Oostra Ben
- Oostra Ben A.
- Org Elin
- Orru Marco
- Oudkerk Matthijs
- Oudot-Mellakh Tiphaine
- Palmas Walter
- Palmen Jutta
- Palmer Lyle J.
- Palmer Nicholette D.
- Parker Alex N.
- Parsa Afshin
- Pattaro Cristian
- Peden John F.
- Peltonen Leena
- Perola Markus
- Peters Annette
- Petrovic Katja E.
- Peyser Patricia A.
- Pihur Vasyl
- Platou Carl G. P.
- Plump Andrew
- Polak Joseph F.
- Polasek Ozren
- Post Wendy S.
- Prabhakaran Dorairaj
- Pramstaller Peter P.
- Prokopenko Inga
- Province Michael A.
- Psaty Bruce M.
- Raffel Leslie J.
- Raitakari Olli
- Rao Dabeeru C.
- Rasheed Asif
- Rathmann Wolfgang
- Reilly Muredach P.
- Rettig Rainer
- Ricceri Fulvio
- Rice Kenneth
- Rice Kenneth M.
- Ridker Paul M.
- Rivadeneira Fernando
- Rosengren Annika
- Rotimi Charles
- Rotter Jerome I.
- Rudan Igor
- Rudock Megan E.
- Sabater-Lleal Maria
- Salako Tunde
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J.
- Sanna Serena
- Schillert Arne
- Schmidt Helena
- Schmidt Reinhold
- Schminke Ulf
- Schnabel Renate B.
- Schrijvers Elisabeth M. C.
- Schwartz Stephen M.
- Schwarz Peter E. H.
- Scott James
- Scott Laura J.
- Scuteri Angelo
- Seedorf Udo
- Sehmi Joban S.
- Seielstad Mark
- Seissler Jochen
- Sennblad Bengt
- Seshadri Sudha
- Sharma Pankaj
- Shaw-Hawkins Sue
- Shen Haiqing
- Shi Gang
- Shin So-Youn
- Shrine Nick R. G.
- Shriner Daniel
- Shuldiner Alan R.
- Shyong Tai E.
- Sigurdsson Sigurdur
- Sijbrands Eric J. G.
- Silbernagel Günther
- Silveira Angela
- Sim Xueling
- Singleton Andrew
- Siscovick David S.
- Sitzer Matthias
- Sjögren Marketa
- Smith Albert V.
- Smith George Davey
- Smith Nicholas L.
- Smith Shelly
- Snieder Harold
- Soininen Pasi
- Song Ci
- Soranzo Nicole
- Spector Timothy D.
- Staessen Jan A.
- Stančáková Alena
- Steinle Nanette I.
- Stoegerer Eva-Maria
- Strachan David P.
- Strawbridge Rona J.
- Stringham Heather M.
- Sun Yan V.
- Swift Amy J.
- Syvänen Ann-Christine
- Sõber Siim
- Tabara Yasuharu
- Talmud Philippa J.
- Tanaka Toshiko
- Tang Weihong
- Taylor Andrew
- Taylor Kent
- Tayo Bamidele
- Terzic Janos
- Teumer Alexander
- Thelle Dag S.
- Thiery Joachim
- Thorsson Bolli
- Tobin Martin D.
- Tofler Geoffrey H.
- Tomaszewski Maciej
- Tracy Russell P.
- Tregouet David
- Tripathy Vikal
- Truong Vinh
- Tukiainen Taru
- Tuomilehto Jaakko
- Tzoulaki Ioanna
- Uda Manuela
- Ueshima Hirotsugu
- Uiterwaal Cuno S. P. M.
- Uitterlinden Andre
- Uitterlinden Andre G.
- Umemura Satoshi
- Usala Gianluca
- van der Harst Pim
- van der Lugt Aad
- van der Schouw Yvonne T.
- van Duijn Cornelia M.
- van Gilst Wiek H.
- Vartiainen Erkki
- Vasan Ramachandran S.
- Veldre Gudrun
- Verwoert Germaine C.
- Viigimaa Margus
- Viikari Jorma
- Vinay D. G.
- Vineis Paolo
- Vitart Veronique
- Voight Benjamin F.
- Vollenweider Peter
- Völker Uwe
- Völzke Henry
- Wagenknecht Lynne E.
- Wain Louise V.
- Wang Thomas J.
- Wang Xiaoling
- Wareham Nicholas J.
- Watkins Hugh
- Weder Alan B.
- Whincup Peter H.
- White Charles C.
- Wichmann H. -Erich
- Wiggins Kerri L.
- Wild Philipp S.
- Wild Sarah H.
- Williams Frances M. K.
- Williams Scott M.
- Wilson James F.
- Winkelmann Bernhard R.
- Witteman Jacqueline
- Witteman Jacqueline C. M.
- Wolf Philip A.
- Wong Andrew
- Wong Tien Y.
- Wright Alan F.
- Wu Ying
- Würtz Peter
- Yajnik Chittaranjan S.
- Yanek Lisa R.
- Yang Qiong
- Yao Jie
- Young J. Hunter
- Zelenika Diana
- Zeller Tanja
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhu Haidong
- Zhu Xiaofeng
- Ziegler Andreas
- Zitting Paavo
- Zukowska-Szczechowska Ewa
- Öhrvik John
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2017
- Field of study
Background--Plasminogen activator inhibitor type 1 (PAI-1) plays an essential role in the fibrinolysis system and thrombosis. Population studies have reported that blood PAI-1 levels are associated with increased risk of coronary heart disease (CHD). However, it is unclear whether the association reflects a causal influence of PAI-1 on CHD risk. Methods and Results--To evaluate the association between PAI-1 and CHD, we applied a 3-step strategy. First, we investigated the observational association between PAI-1 and CHD incidence using a systematic review based on a literature search for PAI-1 and CHD studies. Second, we explored the causal association between PAI-1 and CHD using a Mendelian randomization approach using summary statistics from large genome-wide association studies. Finally, we explored the causal effect of PAI-1 on cardiovascular risk factors including metabolic and subclinical atherosclerosis measures. In the systematic meta-analysis, the highest quantile of blood PAI-1 level was associated with higher CHD risk comparing with the lowest quantile (odds ratio=2.17; 95% CI: 1.53, 3.07) in an age- and sex-adjusted model. The effect size was reduced in studies using a multivariable-adjusted model (odds ratio=1.46; 95% CI: 1.13, 1.88). The Mendelian randomization analyses suggested a causal effect of increased PAI-1 level on CHD risk (odds ratio=1.22 per unit increase of log-transformed PAI-1; 95% CI: 1.01, 1.47). In addition, we also detected a causal effect of PAI-1 on elevating blood glucose and high-density lipoprotein cholesterol. Conclusions--Our study indicates a causal effect of elevated PAI-1 level on CHD risk, which may be mediated by glucose dysfunction
New genetic loci link adipose and insulin biology to body fat distribution.
- Author
- Aalto Ville
- Aasarød Knut
- Abecasis Goncalo R
- Abecasis Gonçalo
- Absher Devin
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Ahlqvist Emma
- Ahmadi Kourosh R
- Ahola Aila
- Ainali Chrysanthi
- Akylbekova Ermeg
- Ala-Korpela Mika
- Alavere Helen
- Albagha Omar M E
- Albrecht Eva
- Alen Markku
- Alexander Myriam
- Alhenc-Gelas François
- Alizadeh Behrooz Z
- Allison Matthew A
- Alonso Nerea
- Altshuler David
- Ambite Jose Luis
- Amin Najaf
- Amouyel Philippe
- An Ping
- Anderson Carl A
- Anderson Denise
- Anderson Garnet
- Andrews Jeanette S
- Antonella Mulas
- Antti Jula
- Aragaki Aaron K
- Arking Dan E
- Arnold Alice
- Arnold Alice M
- Arora Pankaj
- Arscott Gillian M
- Artigas Maria Soler
- Arveiler Dominique
- Asiki Gershim
- Aspelund Thor
- Assimes Themistocles L
- Atalay Mustafa
- Atkinson Elizabeth J
- Aulchenko Yurii
- Avery Christy
- Bain Stephen C
- Bakker Stephan J L
- Balcells Susana
- Balkau Beverley
- Ballantyne Christie M
- Balmforth Anthony J
- Bandinelli Stefania
- Barbalic Maja
- Barrett Amy
- Barroso Ines
- Barroso Inês
- Basart Hanneke
- Basart Hanneke V
- Bataille Veronique
- Baumert Jens
- Beckmann Jacques S
- Beekman Marian
- Been Latonya F
- Beilby John
- Beilby John P
- Bell Jordana T
- Bellis Claire
- Bennett Amanda J
- Bennett Franklyn
- Berenson Gerald S
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Berne Christian
- Bidulescu Aurelian
- Bielak Lawrence F
- Bierut Laura J
- Biffar Reiner
- Bis Joshua C
- Blackburn Hannah
- Blangero John
- Blankenberg Stefan S
- Blüher Matthias
- Boban Mladen
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Boezen H Marike
- Bolton Jennifer L
- Bolton Judith A Hoffman
- Bonnet Fabrice
- Bonnycastle Lori L
- Boomsma Dorret I
- Borecki Ingrid
- Boright Andrew P
- Borja Judith B
- Bornstein Stefan R
- Boston Jonathan
- Bots Michiel L
- Bouatia-Naji Nabila
- Bouchard Claude
- Bovet Pascal
- Boyd Heather A
- Bragg-Gresham Jennifer L
- Brambilla Paolo
- Brand Eva
- Brand Stefan-Martin
- Brandi Maria Luisa
- Braund Peter S
- Brennan Eoin P
- Brismar Kerstin
- Brody Jennifer
- Broekmans Frank J
- Broer Linda
- Brown Matthew A
- Brown Morris J
- Brown-Gentry Kristin
- Bruinenberg Marcel
- Buchkovich Martin L
- Buckley Brendan M
- Buil Alfonso
- Bull Shelley B
- Burgdorf Christof
- Buring Julie E
- Burnett Mary S
- Burnier Michel
- Burri Andrea
- Burton Paul R
- Bush William S
- Busonero Fabio
- Buxbaum Sarah G
- Buyske Steve
- Buzkova Petra
- Byrne Enda M
- Böger Carsten A
- Böhringer Stefan
- Böttcher Yvonne
- Cambien Francois
- Campbell Harry
- Campbell Susan
- Carba Delia B
- Carlson Chris
- Carlson Olga D
- Carty Cara
- Casas Juan P
- Caspersen Ida H
- Castano-Betancourt Martha
- Cauchi Stéphane
- Cauley Jane A
- Caulfield Mark
- Cavalieri Margherita
- Cazier Jean-Baptiste
- Center Jacqueline R
- Cesana Giancarlo
- Chakravarti Aravinda
- Chambers John
- Chandak Giriraj R
- Chang Hsing-Yi
- Chang Yen-Pei C
- Chanock Stephen J
- Charchar Fadi J
- Chasman Dan
- Chaturvedi Nish
- Chen Constance
- Chen Han
- Chen Ida
- Chen Jin
- Chen Ming-Huei
- Chen Wei
- Chen Yii-Der Ida
- Cheng Iona
- Cheng Sulin
- Chines Peter S
- Cho Yoon Shin
- Choi Murim
- Chouraki Vincent
- Christiansen Claus
- Chu Audrey Y
- Cimponeriu Dan
- Ciullo Marina
- Clark Graeme R
- Clarke Robert
- Claudi-Boehm Simone
- Coassin Stefan
- Cochran Barbara
- Cole Shelley
- Colhoun Helen
- Colhoun Helen M
- Collins Francis S
- Collins Rory
- Connell John M
- Cooper Cyrus
- Cooper Jackie A
- Cooper Matthew N
- Cooper Richard S
- Coresh Josef
- Cornelis Marilyn C
- Corre Tanguy
- Corsi Anna Maria
- Couper David
- Cousminer Diana L
- Coviello Andrea D
- Cox David
- Crawford Dana
- Crisponi Laura
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- Thorleifsson Gudmar
- Thorn Lena M
- Thornton-Wells Tricia
- Thorsteinsdottir Unnur
- Thun Gian-Andri
- Tiirikainen Maarit
- Tikkanen Emmi
- Tikkanen Heikki
- Timpson Nicholas
- Timpson Nicholas J
- Tin Adrienne
- Tiret Laurence
- Tobin Martin
- Tobin Martin D
- Toenjes Anke
- Tolonen Nina
- Tomaschitz Andreas
- Tomaszewski Maciej
- Toniolo Daniela
- Townsend Raymond R
- Tracy Russell P
- Travers Mary E
- Tregouet David-Alexandre
- Treloar Susan A
- Tremblay Angelo
- Tremoli Elena
- Tripathy Vikal
- Troffa Chiara
- Trompet Stella
- Trummer Olivia
- Tryggvadottir Laufey
- Tryggvason Karl
- Trégouët David-Alexandre
- Tsaprouni Loukia
- Tsoka Sophia
- Tsui Kim
- Tukiainen Taru
- Tuomilehto Jaakko
- Turner Stephen T
- Tylavsky Frances A
- Tyrer Jonathon
- Tzoulaki Ioanna
- Tönjes Anke
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- Uitterlinden Andre G
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- Ulivi Sheila
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- Urreizti Roser
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- van der Schoot C Ellen
- van der Schouw Yvonne T
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- Van Duijn Cornelia
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- van Gilst Wiek H
- van Heemst Diana
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- van Wingerden Sophie
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- Van Zuydam Natalie
- Vandenput Liesbeth
- Varga Tibor V
- Vartiainen Erkki
- Vasan Ramachandran S
- Vedantam Sailaja
- Veldre Gudrun
- Verlaan Dominique
- Vernon Smith Albert
- Veronesi Giovanni
- Verweij Niek
- Verwoert Germaine
- Verwoert Germaine C
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- Viikari Jorma
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- Vitart Veronique
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- Völzke Henry
- Wadén Johan
- Waeber Gerard
- Waeber Gérard
- Wagenknecht Lynne E
- Waggott Daryl
- Wagner Peter J
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- Waite Lindsay L
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- Wang Jie Jin
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- Wang Xiaoling
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- Wareham Nick J
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- Waterworth Dawn
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- Wells George A
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- Wheeler Eleanor
- Wheeler Heather E
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- Whitfield John B
- Wichmann H Erich
- Wichmann H-Erich
- Widen Elisabeth
- Wiggins Kerri L
- Wijmenga Cisca
- Wijnands-van Gent Colette J M
- Wild Philipp S
- Wild Sarah H
- Wilk Alicja
- Wilkens Lynne
- Willems Sara M
- Willemsen Gonneke
- Willemsvan-vanDijk Ko
- Willenborg Christina
- Willer Cristen J
- Williams Frances M K
- Williams Rasheeda
- Williams Winfred W
- Willner Dana
- Wilsgaard Tom
- Wilson James F
- Wilson James G
- Wilson Sarah
- Wilson Scott G
- Winkler Thomas
- Witteman Jacqueline C
- Witteman Jacqueline C M
- Wojczynski Mary K
- Wolffenbuttel Bruce H R
- Wong Andrew
- Wong Tien Y
- Woo Jean
- Wood Andrew R
- Wood Andy
- Workalemahu Tsegaselassie
- Wright Alan F
- Wu Chunyuan
- Wu Joseph M W
- Wu Ying
- Würtz Peter
- Xiao Su-Mei
- Yajnik Chittaranjan S
- Yang Jian
- Yang Qiong
- Yang Tsun-Po
- Yao Jie
- Yengo Loïc
- Yerges-Armstrong Laura M
- Young Alicia
- Young Elizabeth H
- Young J H
- Young Lauren
- Yuan Xin
- Zaboli Ghazal
- Zalloua Pierre A
- Zarrabeitia María T
- Zelenika Diana
- Zemunik Tatijana
- Zerbini Gianpaolo
- Zgaga Lina
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Hou-Feng
- Zheng Wei
- Zhou Yanhua
- Zhu Haidong
- Zhu Kun
- Zhu Xiaofeng
- Zhuang Wei V
- Zhuang Wei Vivian
- Ziegler Andreas
- Zillikens M Carola
- Zimmermann Martina E
- Zitting Paavo
- Zondervan Krina T
- Zukowska-Szczechowska Ewa
- Zygmunt Marek
- Ärnlöv Johan
- Österholm Anne-May
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
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- Banerjee Ruby
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- Bituin Aleksandr
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- Chen Xinyi
- Chen Yanjiong
- Chen Yiyu
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- Chillingworth Neil
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- Coates Julia
- Cobley Victoria
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- Colayco Rick
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- Comstock Robin
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- Dawoe Tenzin
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- Hart Elizabeth
- Hasegawa Tomoko
- Hashimoto Etsuko
- Hashimoto Wakako
- Hassan Daniel
- Hatcher Beath
- Hattori Masahira
- Haugen Eric
- Haussler David
- Havlak Paul
- Hawes Alicia C.
- Hawkins Ebere Sylvia Onyirioha
- Hawkins Natalie
- Hawkins Trevor
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- Haydu Lauren
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- Hepa Victor
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- Hernandez Judith
- Hernandez Omar
- Herseim Allyson
- Hewitt Stephen
- Heyen Joshua
- Higgs Douglas
- Hildebrand Carl E.
- Hillier LaDeana
- Hillyard Guy
- Hines Sandra
- Hinkins Russell
- Hinrichs Angela S.
- Hitchens Matthew Edward
- Ho Issac
- Ho Sara-Jane
- Hodgson Anne V.
- Hodgson David
- Hoffman Susan M.G.
- Hoffs Michael
- Hogues Marilyn E.
- Holden Jane
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- Holmes Sarah
- Holroyd Simon
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- Holtzer Caleb
- Homsi Deana K.
- Homsi Farah J.
- Honan Tracy
- Hood Leroy
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- Hyde David
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- Idlebird Devincent G.
- Iliev Ilian
- Imbro Paula
- Imo Kelvin C.
- Inacio Nicole
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- Ince Michael
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- Ishibashi Akiko
- Ishikawa Sabine K.
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- Jackson Terri
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- Jaffe David B.
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- Jaklevic Michael
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- Jia Jia
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- Jones Myrna D.
- Jones Steven
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- Keenan Stephen
- Kegelmeyer Laura
- Kegg Lisa
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- Kershaw Joanna
- Kettleborough Ross
- Keys David
- Khan Arsi
- Khan Umer F.
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- Khine Susu
- Khurama Divya
- Kidd Cathy
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- Kong Yi
- Korf Ian
- Kosiura Anna
- Kou Zhaohui
- Kovar Christie L.
- Krawczyk Marie-Claude
- Kremitzki Colin
- Kremmidiotis Gabriel
- Krogh Anders
- Kronmiller Brent
- Kruchowski Scott S.
- Kube Michael
- Kubischta Duane
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- Kuehl Jennifer
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- Lam Edward
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- Lambart Christine
- Lamble Ralph
- Lamerdin Jane E.
- Lander Eric S.
- Landers Tom
- Langford Cordelia
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- Lapidus Alla
- Larke Ben
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- Leversha Margaret
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- Lewis Doreen
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- Lewis Keith
- Lewis Lakeshia C.
- Lewis Lora R.
- Lewis Tammy
- Leyba Tina
- Li Changfeng
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- Lim Meng K.
- Lindblad-Toh Kerstin
- Lindo Ken
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- Longmire Johnathan L.
- Lopez Frederick
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- Lorensuhewa Lorna M.
- Lou Yunian
- Loulseged Hermela
- Loveland Jane
- Lovell Jamie
- Lovett Demetria A.
- Lowenstein Michael G.
- Lowry Stephen
- Lozado Ryan J.
- Lu Lingfeng
- Lu Tao
- Lu Xiuhua
- Lu Yongxiang
- Lu Yontao T.
- Lu Yue
- Lucas Robert
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- Lucier Alice
- Lucier Raymond L.
- Ludeman Thom
- Lui Annie
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- Macken Catherine A.
- MacLean Christine
- Madabhushi Ramki
- Madu Renita C.
- Maeda Hideto
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- Maheshwari Manjula
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- Mahnke Ryan
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- Mangum Brian
- Manning Jonathan
- Manohar Chitra
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- Mardis Elaine R.
- Mareth David
- Mariano Marisa
- Marinelli Lisa
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- Marquis-Homeyer Catherine
- Marr Thomas G.
- Marra Marco
- Marriott Neil
- Marrone Anne
- Marroquin Christian
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- Matthews Charles D.
- Matthews Lucy
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- Matthews Sterling D.
- Mauceli Evan
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- McLeod Michael P.
- McMurdo John
- McMurray Amanda
- McMurray Des
- McMurray Kimberly
- McMurray Kimberly L.
- McNinch Jenny
- McPherson John
- McPherson John D.
- McVicker Graham
- McWilliams Natalie
- Mead Kelly
- Meador Michael G.
- Medina Catherine
- Mehta Nalini
- Meidi Patrick
- Meier Elke
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- Menuge Noel
- Mercado Christian
- Mercado George
- Mercado Iracema C.
- Mercer Simon
- Merritt Christina E.
- Mesirov Jill P.
- Metzker Michael Lee
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- Miller Christie
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- Miner George R.
- Miner Sheri
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- Minja Emmanuel
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- Morgan Margaret B.
- Morita Hiroko
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- Morton Jerry
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- Mott Richard
- Moyzis Robert K.
- Mu Feng
- Mukherjee Shibani
- Mullenger Ian
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- Mulrain Leon
- Munday Brian
- Munday Elaine
- Mundt Mark O.
- Mungall Andy
- Munidasa Mala
- Munk A. Christine
- Munk Christie A.
- Munson Glen
- Murakami Katsuhiko
- Murayama Yuji
- Murnane Clare
- Murphy Matthew B.
- Murphy Michael
- Murray Christine
- Murray Debra Dianne
- Murray Jennifer
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- Muzny Donna Marie
- Myers Alison
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- Müller Ines
- Nagamine Kentaro
- Nagao Syunsuke
- Nagaraja R.
- Nair Latha
- Nair Seema R.
- Naka Maho
- Nakagawa Masayo
- Nakagawa Saori
- Nakamura Etsuko
- Nakato Eriko
- Nanavati Amit N.
- Nandkeshwar Richard
- Nankervis Colin E.
- Naranjo Cleo M.
- Nash William
- Naylor Jerome
- Nazareth Lynne V.
- Neal Dearl D.
- Negus David
- Nelson Catherine
- Nelson David O.
- Nelson Deborah A.
- Nelson Joanne
- Nelson Kathryn
- Nelson Ward
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- Neunkirch Jennifer
- Newes Christian
- Newman April
- Ng Bee
- Ng Terrance
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- Nguyen Natalie M.
- Nguyen Ngoc Bich
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- Ni Lin
- Niblett David
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- Ning Zemin
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- Niu Yuxin
- Nivens Amber
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- Norbu Chou Dolma
- Norbu Nyima
- Nordsiek Gabriele
- Norris Sarah Louise
- Novik Karen
- Nowlin Larry
- Nusbaum Chad
- Nwaokelemeh Ogechi O.
- Nwokenkwo Stanley
- O\u27Donnell Paula
- O\u27Donovan Daniel
- O\u27Leary Sinead
- O\u27Loughlin Jennifer
- O\u27Neill Keith
- Obayashi Izumi
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- Ohno Saho
- Ohta Nao
- Ohtsubo Masafumi
- Oinn Tom
- Okoawo Ose
- Okui Michiyo
- Okumura Reina
- Okwuonu Geoffrey O.
- Okwuonu Kenneth C.
- Olarnpunsagoon Alisa
- Olivas Jason
- Oliver Hayley
- Oliver Karen
- Olsen Anne S.
- Olson Maynard V.
- Omotosho Bamidele
- Onoda Junko
- Oomori Nobuhiro
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- Oragunye Njideka
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- Ovcharenko Ivan
- Overton-Larty Emma
- Oviedo Rodolfo J.
- Ow David
- Ozawa Ritsuko
- Ozersky Philip
- Pace Araceli C.
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- Padki Anuradha
- Pahlavan Shane
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- Palazzolo Michael
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- Pan Jiaofeng
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- Parker David Neil
- Parker Stephen
- Parkin Christopher
- Parkin Kim
- Parks Kenya L.
- Parry-Brown Ginny
- Parson-Quintana Beverly
- Pasternak Shiran
- Patel Bella Mayurkumar
- Patel Dina
- Patel Jalpa N.
- Patel Ritesh
- Patel Shripa
- Patel Vishal V.
- Patrick James
- Paul Heidie A.
- Paul Shelia
- Paulson Edward
- Payton Brett A.
- Pearce Alexandra
- Pearman Charlene
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- Pecherer Robert M.
- Peck Anna
- Peck Richard
- Pedan John
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- Pelletier Eric
- Peng Vivian
- Peng Vivian
- Peng Yi
- Peng Yi
- Peng Ze
- Peng Ze
- Pennacchio Len A.
- Pennacchio Len A.
- Percy Chantel
- Perez Agapito
- Perez Lesette M.
- Perito Andrew
- Perrault Isabelle
- Perrier Rene
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- Perrin William
- Pesavento Brad
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- Polman Jos
- Ponting Chris P.
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- Porter Keith
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- Poundstone Pat
- Pourrajabi Nima M.
- Powell Don
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- Prathalingham Radhika
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- Prigmore Elena
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- Qiang Boqin
- Qiao Zhenyong
- Qin Xiang
- Quail Michael
- Quan Glenda
- Quarrie Hannah
- Quiles Miyo M.
- Quince Chris
- Quiroz Juana B.
- Qureshi Matloob
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- Rachlin Eric K.
- Rachupka Anthony
- Radionenko Maxim
- Rajagopal Mohan
- Ramasami Umadevi
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- Reily Amy D.
- Reinhardt Astrid
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- Ren Shuangxi
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- Richardson Paul
- Richardson Paul
- Richardson Susan
- Ricke Darryl O.
- Ridler Kerry
- Riethman Harold
- Riethoven Lyn
- Rigby Rachel
- Riley B.E
- Rise Cecil
- Rivera Angel
- Rives Catharine M.
- Road JungShing
- Robert Catherine
- Roberts Simon
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- Robinson Dezere
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- Robinson Donna L.
- Robinson Melanie
- Rochford Rebecca
- Rock Susan M.
- Rodkey Travis L.
- Rodriguez Alex
- Rodriguez Joseph
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- Rohlfing Theresa
- Rojas Alberto
- Rokhsar Daniel
- Rong Li
- Rong Li
- Rosenbloom Kate R.
- Roskin Krishna M.
- Ross Hugh
- Ross Mark
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- Rowen Lee
- Rubenfield Marc
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- Ruef Barbara
- Ruiz Erica M.
- Ruiz San Juana
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- Sanuki Naoko
- Sarmiento R.
- Sasaki Takashi
- Satpathy Suraj
- Saunders David
- Saunders Elizabeth H.
- Saurin William
- Savery Glenford G.
- Sawada Nori
- Sawhill William W.
- Saxman Eric
- Scarpelli Claude
- Scharfe Maren
- Schatzkamer Kyriena L.
- Scherer Steven Edward
- Schilhabel Markus
- Schlessinger David
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- Shownkeen Ratna
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- Siddiqui Roman
- Siepel Adam C.
- Silk Richard
- Silk Richard
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- Sinha Prashant
- Sisson Ida
- Sivadasan Shanthi
- Sivadasan Shanthi
- Skowronski Evan
- Skuce Carl
- Skuce Carl
- Slater Nathaniel
- Slezak Tom
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- Smink Luc
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- Smith Andrew
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- Smith Douglas R.
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- Song Liping
- Song Liping
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- Song Xing-Zhi
- Sonnhammer Erik
- Sonnhammer Erik
- Sorelle Richard P.
- Sotheran Elizabeth
- Sougnez Carrie
- Spainhower Corey
- Sparks Anastasia L.
- Spencer Brian
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- Spooner William
- Spraggon Lee
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- Squares Janet
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- Stalker James
- Stalker John
- Stallings Raymond I.
- Stalvey Malinda
- Stamford Steve
- Stammers Melanie
- Standring Lisa
- Stange-Thomann Nicole
- Stavropoulos Sharon
- Steffen David
- Stege Justin T.
- Steingruber Helen
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- Stephens-Bolds Shaela
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- Stubbs Matthew
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- Su Xiaohu
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- Sudbrak Ralf
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- Sulston John
- Summers Leslie J.
- Sun Hui
- Sun Jiajia
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- Sun Yongqiao
- Sun Yu
- Sun Yue
- Sutherland Grant R.
- Sutherland Robert D.
- Sutton Angelica E.
- Svatek Amanda F.
- Svetz Jessica
- Svetz Leah Anne
- Swainson Chris
- Swann Mark
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- Sycamore Neil
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- Tabor Paul E.
- Tacey Kristina
- Tagett Beckie
- Tagney Matthew
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- Takenaka Tracy
- Talamas Jessica
- Tam Serena
- Tamerisa Kavitha S.
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- Tan Olivia
- Tan Steven
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- Tansey Jennifer
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- Tatum Owatha I.
- Taudien Stefan
- Taylor Amy
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- Taylor Gillian
- Taylor Kate
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- Tchuinga Pierre
- Tee Louise
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- Tesmer Judith G.
- Tester Julieanne
- Thayer Nina
- Theaker Andrew
- Theil James
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- Thexton David
- Thies Stephanie
- Thomas Craig
- Thomas Daniel
- Thomas Daryl J.
- Thomas Karen
- Thomas Nicole
- Thomas Paulette
- Thomas Ruth
- Thomas Shereen
- Thommai Roselin
- Thompson Linda S.
- Thorne Rachel Diane
- Thorpe Andrea
- Thorpe Karen
- Thoulutsang Yama
- Threadgold Glen
- Thurston Scott
- Tian Chaoguang
- Tian Chaoguang
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- Tian Yan
- Tian Yong
- Tian Yuqing
- Tice Hope
- Tighe Damon
- Tin-Wollam Aye M.
- Tinsley Emma
- Tochigi Miwako
- Togashi Naoko
- Tomizawa Iori
- Tomlinson Chad
- Tong Jingli
- Topham Kerri
- Torcaso Bill
- Torney David C.
- Totoki Yasushi
- Towey Sarah
- Toyoda Atsushi
- Tracey Alan
- Tran Ly Thanh
- Tran-Gyamfi Mary
- Trani Lee
- Trankiem Margie
- Trask Barbara J.
- Travers Johnathan
- Trejos Zulma Y.
- Treuhaft Marianne
- Trevino Brenda Kaye
- Tromans Anthony
- Trong Stephan
- Trumbower Heather
- Tsai Ming
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- Tsujimoto Susan
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- Tu Yuefeng
- Tubby Ben
- Tufarelli Cristina
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- Tynan Katherine
- Ueland Stephanie
- Ueng Samantha
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- Ulanovsky Levy E.
- Un Chun
- Ung Quyen
- Upson Darren
- Urban Jeremy B.
- Ureta-Vidal Abel
- Ureta-Vidal Abel
- Usmani Kamran
- Ustaszewska Anna
- Uyama Nozomi
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- Valdez Michelle
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- Vasquez Lydia I.
- Vassiliev Helen
- Vastrik Imre
- Vaudin Mark
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- Vera Virginia A.
- Verduzco Daniel
- Vergez Lisa
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- Villasana Donna M.
- Vine Wendy
- Viswanathan Vijay
- Vo Andy
- Vo Nu
- Voak Paul
- Vollenhoven David
- Wada Hiromi
- Wagner Mark
- Wagner-McPherson Caryn
- Waldron Lenee
- Waligorski Jason E.
- Walker Davian L.
- Walker Keya
- Walker Sarah
- Wall Melanie
- Wall Randy E.
- Wallace John
- Wallis Justine
- Wallis Michelle
- Walsh Jennifer
- Walsham Natalie
- Wan Ma
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- Wang Dong
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- Wang Guangxin
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- Wang Huifeng
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- Wang Xuegang
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- Wang Yimin
- Wang Ying
- Wang Ying
- Wang Yuanyuan
- Wangchuck Tsering
- Wangdi Tsering
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- Warren Graham
- Warren James T.
- Warry Georgina
- Watanabe Hidemi
- Watanabe Saki
- Waterston Robert H.
- Watson Andy
- Watt Nicola
- Webb Anthony
- Webb Jeannette
- Webber Caleb
- Weber Ryan J.
- Wehri Edward
- Wei Shulin
- Wei Xuehong
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- Weinstock George
- Weinstock Keith
- Weir John
- Weissenbach Jean
- Wells Alan
- Wells Sarah
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- Wen Gaiping
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- Wesley Mary Melissa
- West Paul
- West Tony
- Wetterstrand Kris
- Wheatley Angela
- Wheatley Carl
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- Wheeler Gideon
- Wheeler Jeremy
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- White Amelia
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- White Scott P.
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- Whitmore Scott
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- Whittaker Charles
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- Wickremasinghe Manosha I.
- Widaa Sara
- Wiegel Sarah
- Wild Anna
- Wilkinson Jane
- Wilkinson Jane
- Wilkinson Paul
- Willey David
- Williams Albert L.
- Williams Andy
- Williams Bill
- Williams Gabrielle A.
- Williams Leanne
- Williamson Angela L.
- Williamson Helen
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- Wills Richard
- Wilmer Tamsin
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- Wilson Gareth
- Wilson Margaret
- Wilson Nyree
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- Wilson Richard K.
- Wilson Siobhan
- Wilson Steve
- Wilson Wendy
- Wincker Patrick
- Window Philip
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- Witt James
- Wleczyk Regina
- Wobus Fred
- Woessner Jeffrey
- Wohldmann Patty
- Wollard Jessica
- Womack Andrew W.
- Wong Benjamin
- Wong Gane K-S
- Wood Diane
- Wood Emma
- Wood Joe
- Wooden Hailey S.
- Wooden Steven H.
- Woodeson Sharon
- Woodfine Kathryn
- Woodmansey Rebecca
- Woods Eric
- Woodwark Cara
- Wooster Richard
- Worley Kim Carlyle
- Woyke Tanja
- Wray Matthew
- Wray Paul
- Wright Charmain
- Wright Debbie
- Wright Kathrine
- Wright Kristin
- Wright Rita A.
- Wu Chungen
- Wu Dongying
- Wu Jiaqian
- Wu Jung-Rung
- Wu Kevin
- Wu Qingfa
- Wu Qingfa
- Wu Ruiming
- Wu Xiao
- Wu Xiaojing
- Wu Zaining
- Wyatt Julia
- Wycoff-Montenegro Melissa
- Wylie Kris
- Wyman Dudley
- Wyman Stacia
- Xi Yan
- Xi Yingying
- Xie Fei
- Xie Gary
- Xie Jane
- Xiong Hui
- Xiong Yuqing
- Xu Alex
- Xu Jing
- Xu Jing
- Xu Ruqin
- Xu Shuhua
- Xu Wei
- Xu Xinlai
- Xu Yan
- Xu Yuning
- Xu Zhihong
- Xu Zuyuan
- Xuan Yali
- Xuan Zhenyu
- Xue Rui
- Yada Tetsushi
- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
- Yamamoto Noriko
- Yamamoto Yuko
- Yamashita Yasue
- Yamazaki Satoru
- Yang Hao
- Yang Huanming
- Yang Huanming
- Yang Joan
- Yang Shiaw-Pyng
- Yang Shudong
- Yang Xiaonan
- Yang Xiaonan
- Yang Xiaoping
- Yang Yongkui
- Yano Candance
- Yao Zhijian
- Yao Zhijian
- Yaspo Marie-Laure
- Ye Chen
- Yeager Shane
- Yeh Mimi
- Yen Jennifer
- Yeshitela Rahel Retta
- Yoakum Martin
- Yokobata Kathy
- Yokoyama Jennifer
- Yonezawa Miho
- Yoon Lillienne
- Yoon Vivienne
- Yoshida Satoru
- You Bo
- Young Geneva
- Young Louise
- Young Shelia
- Younger Ruth
- Yu Bing
- Yu Charles
- Yu Fuli
- Yu Jun
- Yu Jun
- Yu Jun
- Yuan Kaiwen
- Yuan Ye
- Yuan Yida
- Yue Shujie
- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2
- Author
- Abban Dzifa
- Abdul Nasser
- Abelson Mark
- Ackermann Alan
- Adams Fran
- Adams Luthando
- Adrag\ue3o Pedro
- Ageno Walter
- Aggarwal Rajesh
- Agosti Sergio
- Aguilar Linares Julio Alberto
- Aguilar Francisco
- Aguinaga Luis
- Ahmad Zia
- Ainsworth Paul
- Al Dallow Raed
- Al Ghalayini Kamal
- Al Ismail Saad
- Al Joundi Tammam
- Al Mahameed Soufian
- Al Obaidi Mohamed
- Al Zoebi Ayham
- Alasfar Abdelfatah
- Alawwa Abdul
- Alderson Lisa
- Alexopoulos Dimitrios
- Ali Abdullah
- Ali Malik
- Aliyar Pareed
- Almassi Hossein
- Almuti Khalid
- Alshehri Mohamed
- Altmann Ute
- Alves Alvaro Rabelo
- Amara Walid
- Amelot Mathieu
- Amjadi Nima
- Ammirati Fabrizio
- Andrawis Nabil
- Angela Koh Su Mei
- Angoulvant Denis
- Annoni Giorgio
- Ansalone Gerardo
- Antonescu Sorin Alexandru
- Ariani Mehrdad
- Arias Juan Carlos
- Armero S\ue9bastien
- Arora Chander
- Arora Rohit
- Ashcraft William
- Aslam M. Shakil
- Astesiano Alfredo
- Audouin Philippe
- Augenbraun Charles
- Aydin S.
- Azar Rabih
- Azim Abul
- Aziz Shahid
- B\uf8hmer Ellen
- Backes Luciano Marcelo
- Baig Mirza
- Bains Suchdeep
- Bakbak Asaad
- Baker Seth
- Bakhtiar Karim
- Bala Richard
- Banayan Jonathan
- Bandh Stellan
- Bando Shigenobu
- Banerjee Subhash
- Bank Alan
- Bar\uf3n Gonzalo
- Barbarash Olga
- Barr Craig
- Barrera Carlos
- Bartels Dorothee B.
- Barton John
- Baula Giovanni
- Bayeh Hamid
- Bazargani Nooshin
- Behrens Steffen
- Bell Alan
- Benezet Mazuecos Juan
- Benhalima Bouziane
- Berdagu\ue9 Philippe
- Berg van den B. J.
- Bergen van P. F. M. M.
- Berngard Edvard
- Bernstein Richard
- Berrospi Percy
- Berti Sergio
- Bertomeu Vicente
- Berz Andrea
- Bettencourt Paulo
- Betzu Robert
- Beyer Westendorf Jan
- Bhagwat Ravi
- Black Toby
- Blanco Ibaceta Jorge Hugo
- Bloom Stephen
- Blumberg Edwin
- Bo Mario
- Bockisch Valerie
- Bongiorni Maria Grazia
- Boriani Giuseppe
- Borret Mariano Ruiz
- Bosch Ralph
- Boswijk D. J.
- Bott Jochen
- Bottacchi Edo
- Brandes Axel
- Bratland Bj\uf8rn
- Brautigam Donald
- Breton Nicolas
- Briones Ignacio Rodriguez
- Brkljacic Diana Delic
- Brouwers P. J. A. M.
- Browne Kevin
- Bruguera Jordi
- Brunehaut Myriam
- Brunschwig Claude
- Bryan Yan Ping Yen
- Buathier Herv\ue9
- Buenostro Gabriel Contreras
- Buhl Aur\ue9lie
- Bullinga John
- Butcher Kenneth
- Cabrera Honorio Jose Walter
- Caccavo Alberto
- Cadinot Didier
- Cai Shanglang
- Caiedo Carolina Guevara
- Calin Podoleanu Cristian Gheorghe
- Calvi Valeria
- Camm John
- Candeias Rui
- Cao Phai G\ue9rald Phan
- Capo James
- Capucci Alessandro
- Cardoso Juliano Novaes
- Carlson Brian
- Carvalho Paula
- Cary Susanna
- Casanova Rene
- Casu Gavino
- Cattan Simon
- Cavallini Claudio
- Cayla Guillaume
- Cha Kwang Soo
- Cha Tae Joon
- Chaaban Said
- Chae Jei Keon
- Challappa Krishnan
- Chand Sunil
- Chandrashekar Harinath
- Chang Mark
- Charbel Paul
- Chartier Ludovic
- Chatterjee Kausik
- Cheema Aamir
- Chen Shih Ann
- Chevallereau Pierre
- Chiang Fu Tien
- Chiarella Francesco
- Chih Chan Lin
- Cho Yong Keun
- Choi Dong Ju
- Chouinard Guy
- Chow Hoi Fan
- Chreih Rami Mihail
- Chrysos Dimitrios
- Chumakova Galina
- Cieza Lara Tomas
- Ciobotaru Vlad
- Cislowski David
- Citerne Olivier
- Claus Matthias
- Clay Anthony
- Clifford Piers
- Cocina Emilio Gonzalez
- Cohen Andrew
- Cohen Serge
- Colivicchi Furio
- Collins R\uf3n\ue1n
- Compton Steve
- Connors Sean
- Conti Alberto
- Coodley Gregg
- Cooper Martin
- Corbett Lynn
- Corey Oran
- Coronel Juli\ue1n
- Corrigan John
- Cotrina Pereyra Rosa Ysabel
- Cottin Yves
- Coutu Benoit
- Cracan Aurel
- Crean Peter
- Crenshaw James
- Crijns H. J. G. M.
- Crump Charles
- Cucher Fred
- Cudmore David
- Cui Lianqun
- Culp John
- D'Souza Anthony
- Daniel Oh Chia Theng
- Danny Null
- Darius Harald
- Dary Patrick
- Dascotte Olivier
- Dauber Ira
- Davee Thomas
- Davies Ruth
- Davis Gershan
- Davy Jean Marc
- Dayer Mark
- De La Briolle Axel
- de Los Rios Ibarra Manuel Odin
- de Mora Manuel
- de Souza Olga Ferreira
- De Teresa Eduardo
- De Wolf Luc
- Decoulx Eric
- Deepak Sasalu
- Defaye Pascal
- Del Carpio Munoz Freddy
- Deluche Laurent
- Destrac Sylvain
- Deumite N. Joseph
- Di Legge Silvia
- Dibon Olivier
- Diemberger Igor
- Diener Hans Christoph
- Dillinger Jean
- Dion\uedsio Pedro
- Dotani Imran
- Dotcheva Elena
- Duarte Vera Yan Carlos
- Dubner Sergio J.
- Dubrey Simon
- Ducrocq Xavier
- Dupljakov Dmitry
- Duthinh Vuong
- Dutra Oscar Pereira
- Dutta Dipankar
- Duvilla Nathalie
- Dy Johnny
- Dziewas Rainer
- Eaton Charles
- Eaves William
- Ebinger Matthew
- Eck van J. W. M.
- Edwards Tim
- Egocheaga Isabel
- Ehrlich Clifford
- Eisenberg Steven
- El Hallak Abdel
- El Hamdani Mehiar
- El Jabali Adnan
- El Mahmoud Rami
- El Sayed Hassan
- El Shahawy Mahfouz
- Eldadah Zayd
- Elghelbazouri Fouad
- Elhag Omar
- Elias Darlene
- Ellery Adam
- Elsaesser Amelie
- Elvan A.
- Erickson Bernard
- Espaliat Eric
- Essandoh Louis
- Everington Tamara
- Evonich Rudolph
- Ezhov Andrey
- F\ue1cila Lorenzo
- Farsad Ramin
- Fayard Maxime
- Fedele Francesco
- Ferreira Daniel
- Ferrier Anna
- Finsen Alexandra
- First Brian
- Fisher Raymond
- Floyd John
- Folk Thomas
- Fonseca Catarina
- Fonseca Luisa
- Fonteles Ritt Luiz Eduardo
- Forman Steven
- Forsgren Magnus
- Foster Malcolm
- Foster Nathan
- Frais Michael
- Frandsen Brad
- Frapp\ue9 Thierry
- Freixa Ramon
- French William
- Freydlin Marina
- Frickel Siegfried
- Fruntelata Ana Gabriela
- Fujii Shigeru
- Fujino Yusuke
- Fukunaga Hiroshi
- Furukawa Yutaka
- G\uf6tte Andreas
- Gabelmann Matthias
- Gabris Michael
- Gadsb\uf8ll Niels
- Galin Pavel
- Galinier Michel
- Ganim Ricky
- Garcia Ronnie
- Gartenlaub Olivier
- Genz Conrad
- Georger Fr\ue9d\ue9ric
- Georges Jean Louis
- Georgeson Steven
- Ghanbasha Ali
- Giedrimas Evaldas
- Gierba Mariusz
- Gillespie Eve
- Giniger Alberto
- Gkotsis Alexandros
- Gmehling Joachim
- Gniot Jacek
- Goethals Peter
- Goldberg Ronald
- Goldmann Britta
- Goldscher David
- Golitsyn Sergey
- Gomes Ferreira Luis Gustavo
- Gomez Lopez Efrain Alonso
- Gomez Mesa Juan Esteban
- Gonzalez Efrain
- Gorbunov Vladimir
- Gordon Brian
- Gorka Herv\ue9
- Gornick Charles
- Gorog Diana
- Goss Franz
- Goube Pascal
- Goudevenos Ioannis
- Goulden Dudley
- Gr\uf6nefeld Gerian
- Graham Brett
- Grande Angel
- Greco Cesare
- Green Martin
- Greer Gerald
- Gremmler Uwe
- Grena Paul
- Grinshstein Yuriy
- Grond Martin
- Gronda Edoardo
- Grondin Francois
- Groot de J. R.
- Guardigli Gabriele
- Guarnieri Thomas
- Guignier Alexandre
- Gulizia Michele
- Gumbley Michael
- Gupta Dhiraj
- Hack Terrence
- Haerer Winfried
- Hakas Joseph
- Hall Christian
- Halperin Jonathan L.
- Hampsey James
- Hananis Georgios
- Hanbali Basel
- Handel Franklin
- Hargrove Joe
- Hargroves David
- Harris Kenneth
- Hartley David
- Haruna Tetsuya
- Hata Yoshiki
- Hayek Emil
- Healey Jeff
- Hearne Steven
- Heggelund Geir
- Hemels M. E. W.
- Hemery Yann
- Henein Sam
- Henz Benhur
- Her Sung Ho
- Hermany Paul
- Hern\ue1ndez Norberto Matadamas
- Hernandes Mauro Esteves
- Higashino Yorihiko
- Hill Michael
- Hisadome Tetsuo
- Hishida Eiji
- Hitchcock James
- Hoffer Etienne
- Hoghton Matthew
- Holmes Clare
- Hong Suk Keun
- Houppe Nousse Marie Paule
- Howard Victor
- Hsu Li Fern
- Huang Chi Hung
- Huckins David
- Huehnergarth Kier
- Huisman Menno V
- Huizenga A.
- Huntley Richard
- Hussein Gamal
- Hwang Gyo Seung
- Igbokidi Oyidie
- Iglesias Ignacio
- Ikpoh Margaret
- Imberti Davide
- Ince H\ufcseyin
- Indolfi Ciro
- Ionova Tatiana
- Ip John
- Irles Didier
- Iseki Harukazu
- Ismail Younus
- Israel Noah
- Isserman Steven
- Iteld Bruce
- Ivanchura Galina
- Iyer Ramakrishnan
- Iyer Venkat
- Iza Villanueva Ruben Omar
- J\ue4ger Frank
- Jackson Voyzey Ewart
- Jaffrani Naseem
- Jain Manish
- James Martin
- Jamon Yann
- Jang Sung Won
- Jarmukli Nabil
- Jeanfreau Robert
- Jenkins Ronald
- Jiang Heng
- Jiang Nan
- Jiang Tiemin
- Jiang Xianyan
- Jimenez Javier
- Jobe Robert
- Joffe Ian
- Johansson Bengt
- Jones Nick
- Jos\ue9 Roberto Chuquiure Valenzuela Eduardo Juli\ue1n
- Jouve Bernard
- Juanatey Carlos Gonzalez
- Jundi Mayar
- Jung Byung Chun
- Jung Kyung Tae
- Jung Werner
- K\uf6hrmann Martin
- K\ufcmler Thomas
- K\ufcppers Achim
- Kabbani Samer
- Kabour Ameer
- Kafkala Chrystalenia
- Kajiwara Koji
- Kalan Marica Bracic
- Kalinina Larisa
- Kampus Priit
- Kanda Junji
- Kapadia Shaival
- Karim Amin
- Karolyi Laszlo
- Kashou Hisham
- Kastrup Andreas
- Katsivas Apostolos
- Kaufman Elizabeth
- Kawai Kazuya
- Kawajiri Kenji
- Kazmierski John
- Keeling Phil
- Kerfes Galal Ali
- Kerr Saraiva Jos\ue9 Francisco
- Kes Vanja Basic
- Ketova Galina
- Khaira Ajit
- Khalid Muhammad
- Khludeeva Elena
- Khripun Aleksey
- Kim Dae Kyeong
- Kim Doo Il
- Kim Jeong Su
- Kim Jin bae
- Kim June Soo
- Kim Ki Seok
- Kim Nam Ho
- Kim Young Hoon
- Kinova Elena
- Klein Alexander
- Kleinschnitz Christoph
- Kmetzo James
- Kneller G. Larsen
- Knezevic Aleksandar
- Koch Stanley
- Koenig Kai
- Koons Jay
- Korabathina Ravikiran
- Korennova Olga
- Koschutnik Martin
- Kosinski Edward
- Kovacic Dragan
- Kowalczyk Jacek
- Koziolova Natalya
- Kragten J. A.
- Krause Lars Udo
- Kreidieh Imad
- Krenning B. J.
- Krishnaswamy Kannappan
- Krysiak Waldemar
- Kuck Karl Heinz
- Kumar Somnath
- Kuniss Malte
- Kuo Jen Yuan
- Kurrelmeyer Karla
- Kwan Tak
- Kyo Eisho
- L\uf3pez Send\uf3n Jos\ue9
- Labovitz Arthur
- Lacroix Alain
- Lam Andy
- Lanas Zanetti Fernando Tomas
- Landau Charles
- Landini Giancarlo
- Lang Wilfried
- Larsen Torben Bjerregaard
- Laske Volker
- Lavandier Karine
- Law Nicki
- Lawrence Wong Ka Sing
- Lee Daniel
- Lee Moon Hyoung
- Leit\ue3o Ana
- Lejay Dominique
- Lelonek Malgorzata
- Lenarczyk Radoslaw
- Leprince Patrick
- Lequeux Benoit
- Leschke Matthias
- Ley Nicolas
- Li Weihua
- Li Xiaodong
- Li Yansheng
- Li Zhanquan
- Li Zicheng
- Liang Jianqiu
- Lieber Ira
- Lillestol Michael
- Limon Rodriguez Ramon Horacio
- Lin Hailong
- Lip Gregory
- Lip Gregory Y. H.
- Litchfield Jennifer
- Liu Feng
- Liu Wenhui
- Liu Xuebo
- Liu Yalin
- Liu Zhitao
- Llamas Esperon Guillermo Antonio
- Llisterri Jose Luis
- Lo Eric
- Lo Ted
- Lobos Jose Maria
- Lodde Bernhard Paul
- Loiselet Philippe
- Lorga Filho Adalberto Menezes
- Lori Ido
- Luo Ming
- Lupovitch Steven
- Lyrer Philippe
- M\ufcgge Andreas
- Ma Chang Sheng
- Ma Changsheng
- Ma Genshan
- Ma Hong
- Madariaga Irene
- Maeno Koji
- Magnin Dominique
- Mahmood Shahid
- Mahood Karen
- Maid Gustavo
- Mainigi Sumeet
- Makaritsis Konstantinos
- Maldonado Villalon Jos\ue9 Arturo
- Malhotra Rohit
- Malik Amir
- Mallecourt Catherine
- Mallik Rajiv
- Manning Rickey
- Manolis Athanasios
- Mantas Ioannis
- Manzur Jattin Fernando Gabriel
- Mar\uedn Francisco
- Marcionni Niccolo'
- Marin Javier Aguila
- Martinez Jorge
- Martinez Luis
- Maskova Petra
- Matskeplishvili Simon
- Matsuda Katsuhiro
- Mavri Alenka
- May Erik
- Mayer Nolan
- Mazon Pilar
- Mcclure John
- Mccormack Terry
- Mcgarity William
- Mcguire Michael
- Mcintyre Hugh
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- Mclaurin Brent
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- Mehta Paresh
- Mehzad Reza
- Meinel Andreas
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- Michel Patrik
- Mikdadi Ghiath
- Mikhail Magdy
- Mikus Milan
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- Militaru Constantin
- Miller Gary
- Milonas Christos
- Minescu Bogdan
- Mintale Iveta
- Miralles Aur\ue9lien
- Mirault Tristan
- Mistry Dinesh
- Mitchell George
- Miu Nicoleta Violeta
- Miyamoto Naomasa
- Moccetti Tiziano
- Mohammed Akber
- Molina de Salazar Dora Ines
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- Moodley Rajendra
- Moore Roger
- Morales Oscar Saenz
- Mori Kiyoo
- Moriarty Andrew
- Morka Jacek
- Moschos Nikitas
- Mota Gomes Marco Ant\uf4nio
- Moura Jorge Jose Carlos
- Mousallem Nicolas
- Moya Angel
- Mulhearn Thomas
- Muller Jean Joseph
- Muresan Carmen Manuela
- Muse Derek
- Musial Wlodzimierz
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- Nadar Venkatesh
- Nageh Thuraia
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- Nakagawa Hidemitsu
- Nakamura Yuichiro
- Nakayama Toru
- Nam Ki Byeong
- Napalkov Dmitry
- Natarajan Indira
- Nayak Hemal
- Naydenov Stefan
- Nechvatal Libor
- Neiman James
- Nerheim Pamela
- Neuenschwander Fernando Carvalho
- Nica Violeta Cindea
- Nishida Kunihiro
- Nizov Alexey
- Nor Azlisham Mohd
- Novikova Tatiana
- Novo Salvatore
- Nowalany Kozielska Ewa
- Nsah Emmanuel
- Nunez Fragoso Juan Carlos
- Nyvad Ole
- O'Donnell Martin
- O'Donnell Philip
- O'Hara Gilles
- Oh Dong Jin
- Oh Yong Seog
- Oikonomou Kostas
- Olalla Juan Jose
- Olivari Zoran
- Oliver Richard
- Olympios Christoforos
- Osborne John
- Osca Joaquin
- Osman Raed
- Osunkoya Abayomi
- Padanilam Benzy
- Panchenko Elizaveta
- Pandey A. Shekhar
- Paquette Miney
- Paraschos Alexander
- Pardell Herbert
- Park Hyung Wook
- Park Jong Sung
- Parkash Ratika
- Parker Ian
- Parrens Eric
- Parris Robert
- Pascual Carlos Rodr\uedguez
- Passamonti Enrico
- Patel Jaydutt
- Patel Rajesh
- Pentz William H.
- Pereira Jardim Cesar Augusto
- Persic Viktor
- Perticone Francesco
- Peters Patrick
- Petkar Sanjiv
- Pezo Luis Felipe
- Pham David
- Phlaum Stephen
- Pineau Julien
- Pineda Velez Armando
- Pini Riccardo
- Pinter Arnold
- Pinto Fausto
- Pirelli Salvatore
- Pivac Nediljko
- Pizzini Attilia Maria
- Pocanic Darko
- Polanczyk Carisi Anne
- Polasek Petr
- Poljakovic Zdravka
- Pollock Stewart
- Polo Jose
- Poock James
- Poppert Holger
- Porro Yamile
- Pose Antonio
- Poulain Fran\ue7ois
- Poulard Jean Ernst
- Pouzar Joe
- Povolny Petr
- Pozzer Domingo
- Pras Athanasios
- Prasad Neeraj
- Prevot S\ue9bastien
- Protasov Konstantin
- Prunier Laurent
- Puleo John
- Pye Maurice
- Qaddoura Fatma
- Quedillac Jean Michel
- Quintana Antonio Garcia
- Raev Dimitar
- Rahimi Sidiqullah
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- Rama Bhola
- Ranadive Nandkishore
- Randall Katie
- Ranjith Naresh
- Raposo Nuno
- Rashid Haroon
- Raters Christa
- Rauch Kroehnert Ursula
- Rebane Thomas
- Regner Stefan
- Renzi Michael
- Reyes Rocha Miguel Agustin
- Reyes Humberto Rodriguez
- Reza Shabbir
- Ria Luigi
- Ribeiro Moreira Dalmo Antonio
- Richter Dimitrios
- Rickli Hans
- Rickner Kyle
- Rieker Werner
- Rigo Fausto
- Ripoll Tomas
- Roberts Douglas
- Roelke Marc
- Roman Mark
- Romeo Francesco
- Ronner E.
- Ronziere Thomas
- Rooyer F. A.
- Rosenbaum David
- Roth Sherryn
- Rothman Kenneth J.
- Rozkova Nadezda
- Rubacek Miroslav
- Rubalcava Frank
- Rubanenko Olesya
- Rubin Andrew
- Rybak Karin
- Sabbour Hani
- Sakai Tetsuo
- Salacata Abraham
- Salecker Ilsbe
- Salem Adrien
- Salfity Marwan
- Salguero Rafael
- Salvioni Alessandro
- Samson Mercedes
- Sanchez Gregorio
- Sandesara Chirag
- Santana Antonio Mart\uedn
- Santos Jos\ue9 Ferreira
- Saporito Wladmir Faustino
- Sasaoka Taishi
- Sattar Payman
- Savard Daniel
- Scala Pierre Jean
- Scemama Jacques
- Sch\uf6n Norbert
- Schaupp Thierry
- Schellinger Peter
- Scherr Carlos
- Schmitz Bettina
- Schmitz Karl Heinz
- Schmitz Lisa
- Schnitzler Robert
- Schnupp Steffen
- Schoeniger Peter
- Schuster Stefan
- Schwimmbeck Peter
- Seamark Clare
- Seebass Ruediger
- Seidl Karl Heinz
- Seidman Barry
- Sek Jaroslaw
- Sekaran Lakshmanan
- Seko Yoshinori
- Sepulveda Varela Pablo Andres
- Sevilla Bego\uf1a
- Shah Aman
- Shah Anil
- Shah Neerav
- Shah Vinay
- Shanes Jeffrey
- Sharareh Ali
- Sharma Vijay Kumar
- Shaw Louise
- Shimizu Yutaka
- Shimomura Hideki
- Shin Dong Gu
- Shin Eun Seok
- Shite Junya
- Shoukfeh Mohammad
- Shoultz Charles
- Silver Frank
- Sime Iveta
- Simmers T. A.
- Singal Dinesh
- Singh Narendra
- Siostrzonek Peter
- Sirajuddin Mohiburrahman
- Skeppholm Mika
- Smadja Didier
- Smith David
- Smith Richard
- Soda Hassan
- Sofley C. Wilson
- Sokal Adam
- Sotolongo Rodolfo
- Sparby Jon Arne
- Spinar Jindrich
- Sprigings David
- Spyropoulos Alex
- Stakos Dimitrios
- Steinberg Alon
- Steinwender Clemens
- Stergiou Georgios
- Stites H. William
- Stoikov Anastas
- Strasser Ruth
- Streb Witold
- Styliadis Ioannis
- Su Guohai
- Su Xi
- Suarez Rafael Martin
- Sudnik Wanda
- Sueyoshi Atsushi
- Sukles Kai
- Sun Li
- Suneja Randeep
- Svensson Peter
- Szavits Nossan Janko
- Taggeselle Jens
- Takagi Yuichiro
- Takhar Amrit
- Tallet Julio
- Tamm Angelika
- Tanaka Katsumi
- Tanaka Shozo
- Tang Aylmer
- Tang Sherman
- Tassinari Tiziana
- Tayama Shinji
- Tayebjee Muzahir
- Tebbe Ulrich
- Teixeira Jose
- Tesloianu Dan Nicolae
- Tessier Pascal
- Teutsch Christine
- The S. H. K.
- Thevenin J\ue9rome
- Thomas Harold
- Timsit Serge
- Topkis Robert
- Torosoff Mikhail
- Touze Emmanuel
- Traissac Thalie
- Trendafilova Elina
- Troyan Barry
- Tsai Wenchi Kevin
- Tse Hung Fat
- Tsutsui Hiroshi
- Tsutsui Takashi
- Tuininga Y. S.
- Turakhia Minang
- Turk Samir
- Turner Wayne
- Tveit Arnljot
- Twiddy Shannon
- Tytus Richard
- Ukrainski Gerald
- Valdovinos Chavez Salvador Bruno
- Van De Graaff Eric
- Vanacker Peter
- Vardas Panagiotis
- Vargas Michael
- Vassilikos Vassilios
- Vazquez Juan
- Venkataraman Asok
- Verdecchia Paolo
- Vester Ernst G\ufcnter
- Vial Hubert
- Vicenzo de Paola Angelo Amato
- Vinereanu Dragos
- Vlastaris Anthony
- Vogel Craig
- vom Dahl J\ufcrgen
- von Mering Matthias
- Vora Kishor
- Wakefield Paul
- Walia Jasjit
- Walter Thomas
- Wang Feng
- Wang Kuo Yang
- Wang Mingsheng
- Wang Ningfu
- Wang Xinhua
- Wang Zulu
- Watanabe Kouki
- Wei Jeanne
- Weimar Christian
- Weinrich Renate
- Wen Ming Shien
- Wheelan Kevin
- Wicke Jens
- Wiemer Marcus
- Wild Beate
- Wilke Andreas
- Willems Stephan
- Williams David
- Williams Marcus
- Winkler Andreas
- Wirtz Jost Henner
- Witzenbichler Bernhard
- Wong Brian
- Wong Danny H. K.
- Wozakowska Kaplon Beata
- Wu Shulin
- Wu Zhaohui
- Wyatt Nell
- Xu Xiangdong
- Xu Yong
- Yamada Akira
- Yamamoto Kazuya
- Yamanoue Hiroki
- Yamashita Takeshi
- Yang Tianlun
- Yang Yanmin
- Yao Jing
- Yarlagadda Chakri
- Yeh Kuo Ho
- Yotov Yoto
- Yvorra Serge
- Zahn Ralf
- Zamorano Jos\ue9
- Zanini Roberto
- Zarich Stuart
- Zebrack James
- Zenin Sergei
- Zeuthen Elisabeth Louise
- Zhang Dadong
- Zhang Donghui
- Zhang Huanyi
- Zhang Quansan
- Zhang Xingwei
- Zhao Shuiping
- Zhao Xinwen
- Zheng Qiangsun
- Zheng Yang
- Zhou Jian
- Zhou Jing
- Ziekenhuis Antonius
- Zimmermann Rainer
- Zimmermann Sergio Luiz
- Zint Kristina
- Zuhairy Hamed M.
- Zukerman L. Steven
- Zwaan van der C.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age 6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score 652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701
Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries
- Author
- Aamir Faiqa Binte
- Aamir Syed Roohan
- Ababneh Adnan
- Abbal Muhammad Anas
- Abbas Ahmed M
- Abbas Mostafa
- Abd-Albain Montasir A
- Abdalei Abdulwahab
- Abdalla Ahmed
- Abdalla Ahmed Yassir
- Abdalla Mohamed Galal Ali
- Abdalla Zainab
- Abdallah Mohamed M
- Abdalmahmoud Noon Ezzeldien
- Abdalsadeg Rowa
- Abdelaal Ahmed M
- Abdelbagi Alnazeer Y
- Abdelbaky Mostafa
- Abdelbaset Doaa
- AbdElbaset Esraa
- Abdelbast Menhag
- Abdelfatah Mohammed Abdelnasser
- Abdelgawad Samia
- Abdelhamid Mohamed M
- Abdeljaber Mahmoud
- Abdelkhalig Mubarak
- Abdelmaksoud Mohamed
- Abdelmeguid Rana
- Abdelmelek Dhia Errahmane
- Abdelnaeam Samah
- Abdelnasser Mohammad K
- Abdelrahim Najwa
- Abdelrahman Amira
- Abdelrahman Ayman
- Abdelsalam Hebatalla
- Abdelsamed Enas Abdelbaset
- Abdelwahab Khaled
- Abdoun Meriem
- Abdulali Fatima
- Abdulaziz Mohamed
- Abdulla Dheba Almukhtar
- Abdullah Bahiyah
- Abdullah Bahiyah
- Abdullah Walaa
- Abdullahi Habiba Ibrahim
- Abdulrahman Ahmed
- Abdulrasheed Lubabatu
- Abdulwahed Eman
- Abdulwahed Eman
- Abeysirigunawardana Dewmi
- Abidin Muhammad Fihmi Zainal
- Abiola Olukayode
- Abiyere Henry
- Abodina Ahmed Mohammed
- Aboelela Reham
- AboElfarh Hadeer Elsaeed
- Aboudlal Husein
- AbouHiekal Osama
- Aboulfotouh Ahmed
- Abozid Anwaar
- Abubaker Noora
- Abubaker Noora
- Abufanas Asma
- Abughanima Mahmoud
- Abuhashem Shehab
- Abulafia Daniel
- Abushaala Fatima
- Abushanab Khaled
- AbuShawareb Issa
- Abuuqteish Hamza
- Abuzaho Amany
- Achem Arome
- Adam Eithar
- Adam Mohammed
- Adam Mohammed A
- Addalla Mohamed
- Addley Jordan
- Adeleye Gbadebo
- Adeniyi Adebayo
- Adewole Nathaniel
- Adeyemo Olabisi
- Adeyeye Ademola
- Adeyeye Ademola
- Adly Michael
- Adnan Siti Nasyirah Nisya
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adze Joel Amwe
- Afeikhena Ehis
- Agida Teddy
- Agilla Hamza
- Agnew Emilie
- Agu Joy Onyekachi
- Ahmad Zatul Akmar
- Ahmed Abdalla
- Ahmed Ahmed
- Ahmed Ahmed
- Ahmed Alaaaldeen
- Ahmed Entisar
- Ahmed Habeeba
- Ahmed Hatem
- Ahmed Reem
- Ahmed Rehab
- Ahmed Rihab
- Ahmed Rogia Ahmed Abdalla
- Ahmed Ruaa
- Ahmed Sharwany
- Ahmed Uzair
- Ahmed Wahiba
- Ahmeed Sultan
- Airede Lydia Regina
- Aitchison Lori
- Ajredini Mirac
- Ajulo Adeshina A
- Akaba Godwin
- Akasha Mazin
- Akbar Maha Ghulam
- Akbuz Seyma Orcan
- Akdere Hakan
- Akın Bilge
- Akkaya Ege Nur
- Akpamgbo Chukwunonso Nnamdi
- Akwaisah Ayoub
- Al Hammoud Amr
- Al Rawashdeh Toka
- Al-Baw Mahmoud
- Al-Dahdouh Mosheer
- Al-Haek Safa’
- Al-Hazaimeh Mo'ath
- Al-issawi Dima
- Al-Issawi Subhi
- Al-jammal Maryam
- Al-Juaifari Maytham A
- Al-Mwajeh Tesneem
- Al-Omary Sohaib
- Al-Quossi Mohammed
- Al-Shambaty Yasir Babkir Ali
- Al-Shami Qotadah
- Al-Smirat Heba
- Al-Tahayneh Sief-Addeen
- Al-Touny Aiman
- Al-Touny Shimaa
- Al-zawaydeh Alia
- Alaa Ali
- Alabed Ebtihal
- Alagelli Fatma
- Alagoz Ahmet Can
- Alameen Hind
- Alameen Maram
- Alamlih Laith
- Alaqoubi Retaj
- Alarabi Rehab
- Alariby Fatima
- Alatefi Dawood
- Alathameen Nassar
- Albakosh Bashir Abobaker
- Albanopoulos Konstantinos
- Albarhomy Osama
- Albarki Aisha
- Albashaireh Alaa
- Albatni Safa Sasi
- Albayadi Eslam
- Alboon Mosab
- Alboridy Muneera
- Alboueishi Asraa Ali
- Aldeges Marwan
- Aldreawi Mohammed
- Alflite Asil Omar Saleh
- Alfrijat Tamam
- Alfrjani Tariq
- Algabbasi Salima
- Algatanesh Nassib
- Alhadad Qamrah
- Alhaddad Hoda Salem
- Alhaleem Ayah
- Alhaleeq Saif
- Alharam Abtisam
- Alhashimi Abdulhadi Mohammed Alhadi
- Alhassan Monzer
- Alhudhairy Sara
- Ali Ahmed
- Ali Aml
- Ali Doua
- Ali Eithar M
- Ali Iqra Fatima Munawar
- Ali Maab
- Ali Manal
- Ali Muhammad
- Ali Radwa
- Ali Rawan Alsheikh
- Ali Rzan Ali Hamedelneel
- Ali Shehroz
- Aliosin Oleg
- Aljamal Mohammad
- Aljamal Sarah
- Alkaraja Layth
- Alkaseek Akram
- Alkazali Mustafa
- Alkchr Hayat Ben Hasan Mohamed A A
- Alkhatib Abed Alazeez
- Allam Shereen
- Almahroush Marin
- Almakki Doha Mohammed Ahmed
- Alnajjar Lara
- Alnajjar Majjd
- Alnatsheh Wesam
- Alnour Ammar
- Alomar Rabiaa
- Alomari Yazan
- Alqaarh Aya
- Alragig Zahra
- Alrifae Ghaliya Mohamed H
- Alrosan Risan
- Alsagoff Sharifah Nor Amirah Syed Abdul Latiff
- Alsaid Hamza
- Alsaify Esmat
- Alsaih Sawsan
- Alsari Najah
- Alshareea Entisar
- Alshawadfy Abdelrhman
- Alshawesh Aisha
- Alsheik Ahmad
- Alsori Mohamed
- Alsoudani Ali
- Altabbaa Hashem
- Altahir Mohamed
- Altair Mawadda
- Altaweel Ahmad
- Altughar Bushra
- Alvarez Matias
- Alvarez-Lozada Luis Adrian
- Alvarez-Lozada Luis Adrian
- Alwahaib Anas
- Alwash Mohammed
- Alzarga Ali
- Alzarouq Ebtisam
- Alzarroug Amal
- Alzghoul Bader
- Alzyoud Osama
- Amarasekara Mishka
- Amary Marwa
- Ametov Amet
- Amin Mostafa K
- Aminu Bashiru
- Aminu Muhammad Baffah
- Ammar Ahmed Siddique
- Amro Dana
- Ananthapadmanabhan Shravankrishna
- Anderson Paul
- Andrew Paul Chimezie
- Andriani Adelaide
- Anestiadou Elissavet
- Angelis Fragkiskos
- Angeslis Fragkiskos
- Aqeel Syed Talha Bin
- Aral Canan
- Arebi Jaber
- Arnaoutoglou Eleni
- Arslangilay Mert
- Arvanitaki Alexandra
- Asadyari-Lupo Shadie
- Ashar Nur Ayuni Khirul
- Ashour Amira
- Ashraf Hamza
- Ashur Abir Ben
- Asjad Imran
- Askar Aamal
- Askin Abdullah Emre
- Aslam Muhammad Nadeem
- Aslan Merve
- Aslangilay Mert
- Astal Mohammed
- Asudo Felicia
- Atadag Yildiz Buyukdereli
- Atef Dina
- Athamneh Tayseer
- Athanasiadis Apostolos
- Ather M Hammad
- Atherton Kristy
- Atia Ahmed
- Atici Semra Demirli
- Atilhan Ridvan
- Atim Terkaa
- Atiq Tabish
- Atta Raneem
- Attia Mohamed
- Attiya Omar
- Awad Hasan
- Awadallah Safaa
- Awoyinka Babatunde
- Ayasrah Salem
- Aydin Cemil
- Aydoğdu Erhan Onur
- Ayogu Emeka
- Ayoub Kerillos
- Ayyad Alaa
- Azboy Ibrahim
- Azer Armia
- Azhari Malaz
- Aziz Aliya Begum
- Babalola Olakunle
- Babar Daniyal
- Babekir Enas Mohammedtom Abdulhameed
- Babiker Afra
- Bacariza Loreto
- Baccar Marwen
- Badawy Asmaa
- Badi Hussameddin
- Badr Karim
- Badri Danniel
- Bagazi Doaa
- Bailey Ashley
- Bakare Adewumi
- Bakari Maisaratu A
- Bakeer Hibah Bileid
- Bakeer Mohammed
- Balciscueta Zutoia
- Ballah Shirahn
- Balogh Zsolt
- Baltacı Zeynep Hazal
- Banaga Essam Eldien Abuobaida
- Banerjee Arnab
- Banihani Farah
- Barbara Silvia Jasmine
- Barbaro Antonio
- Bareka Metaxia
- Bariun Yara
- Barka Sharf
- Barker John
- Barker Sally
- Barsoum Fady
- Basam Aya
- Basam Aya
- Bassam Ahmad
- Bassey Asi-oqua
- Bataineh Saad
- Bature Stephen Bodam
- Bayram Cigdem
- Baysallar Duygu
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- Yusuf Stephen
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- Zaed Moahmed
- Zafar Fatima
- Zaghloul Ahmed
- Zaheer Adil
- Zaidi Faseeh
- Zain Ahmad
- Zakaria Ahmed
- Zakaria Andee Dzulkarnaen
- Zakaria Mohd Zaim
- Zalloum Jihad
- Zamanbandhon Bushra
- Zambon Mattia
- Zapsalis Konstantinos
- Zargar Kamran
- Zarzour Mohamed A
- Zeng Raymond
- Zeng Raymond
- Zengin Kagan
- Zertuche Juventino Tadeo Guerrero
- Zhang Caitlin
- Zhang Edward
- Zhang Shane
- Zhang Yichi
- Zhao Hailin
- Zheng Helen
- Zhou Karen
- Zhou Yida
- Ziergiebel Felix
- Zou Peishan
- Zuylekom Kate Van
- Zuylekom Katie Van
- Zwain Yasir Adnan
- Zyul'korneeva Sof'ya
- Aladna Abdallah
- Aljoumaa Abdullah
- Nawfal Hamdi
- Niazi Ammar
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely
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