63 research outputs found
Fuse Selection for the Two-Stage Explosive Type Switches
In the two-level explosive switch destruction of a delay happens in the form of electric explosion. Criteria of similarity of electric explosion in transformer oil are defined. The challenge of protecting the power electrical equipment from short circuit currents is still urgent, especially with the growth of unit capacity. Is required to reduce the tripping time as much as possible, and limit the amplitude of the fault current, that is very important for saving of working capacity of life-support systems. This is particularly important when operating in remote stand-alone power supply systems with a high share of renewable energy, working through the inverter transducers, as well as inverter-type diesel generators. The explosive breakers copes well with these requirements. High-speed flow of transformer oil and high pressure provides formation rate of a contact gap of 20 - 100 m/s. In these conditions there is as a rapid increase in voltage on the discontinuity, and recovery of electric strength (Ures) after current interruption
Transformer Oil Dielectric Strength in the Contact Gap of the Explosive Arc-Extinguishing Device
The article describes the experimental results on the breakdown of the high-speed flow of transformer oil. In real conditions, the flow moves in the contact gap of a high-voltage explosive switch with speeds from 67 to 152 m /s. The geometry of the contact gap is sharply inhomogeneous and forms turbulence in the flow zone. In the arc chute medium the air inclusions pass from the dissolved state to the gaseous and the emerging bubbles enter to the electric field. Breakdown occurs, mainly through gas inclusions. In the moment, the gradient of the breakdown voltage is reduced by 91.6% compared to the static state of the oil. The experiments were carried out on the model of a high-voltage explosive switch, connected to the power circuit of the surge generator. The probing of the gap was made by a standard pulse of 1.5 / 50 [mu]s. As a result, the dependences of the gradient of the breakdown voltage on the flow rate of the transformer oil for the usual geometry of the high-voltage explosive switch contact system are constructed
Radiative Decay Width of Neutral non-Strange Baryons from PWA
An overview of the GW SAID and ITEP groups effort to analyze pion
photoproduction on the neutron-target will be given. The disentanglement the
isoscalar and isovector EM couplings of N* and Delta* resonances does require
compatible data on both proton and neutron targets. The final-state interaction
plays a critical role in the state-of-the-art analysis in extraction of the
gamma n --> pi N data from the deuteron target experiments. It is important
component of the current JLab, MAMI-C, SPring-8, ELSA, and ELPH programsComment: 7 pages, 7 figures, 1 table; Proceedings of International Conference
Dark Matter, Hadron Physics and Fusion Physics, Messina, Italy, Sept. 2014;
will be published in EPJ Web of Conference
Manin matrices and Talalaev's formula
We study special class of matrices with noncommutative entries and
demonstrate their various applications in integrable systems theory. They
appeared in Yu. Manin's works in 87-92 as linear homomorphisms between
polynomial rings; more explicitly they read: 1) elements in the same column
commute; 2) commutators of the cross terms are equal: (e.g. ). We claim
that such matrices behave almost as well as matrices with commutative elements.
Namely theorems of linear algebra (e.g., a natural definition of the
determinant, the Cayley-Hamilton theorem, the Newton identities and so on and
so forth) holds true for them.
On the other hand, we remark that such matrices are somewhat ubiquitous in
the theory of quantum integrability. For instance, Manin matrices (and their
q-analogs) include matrices satisfying the Yang-Baxter relation "RTT=TTR" and
the so--called Cartier-Foata matrices. Also, they enter Talalaev's
hep-th/0404153 remarkable formulas: ,
det(1-e^{-\p}T_{Yangian}(z)) for the "quantum spectral curve", etc. We show
that theorems of linear algebra, after being established for such matrices,
have various applications to quantum integrable systems and Lie algebras, e.g
in the construction of new generators in (and, in general,
in the construction of quantum conservation laws), in the
Knizhnik-Zamolodchikov equation, and in the problem of Wick ordering. We also
discuss applications to the separation of variables problem, new Capelli
identities and the Langlands correspondence.Comment: 40 pages, V2: exposition reorganized, some proofs added, misprints
e.g. in Newton id-s fixed, normal ordering convention turned to standard one,
refs. adde
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD
52 Genetic Loci Influencing Myocardial Mass.
BACKGROUND: Myocardial mass is a key determinant of cardiac muscle function and hypertrophy. Myocardial depolarization leading to cardiac muscle contraction is reflected by the amplitude and duration of the QRS complex on the electrocardiogram (ECG). Abnormal QRS amplitude or duration reflect changes in myocardial mass and conduction, and are associated with increased risk of heart failure and death. OBJECTIVES: This meta-analysis sought to gain insights into the genetic determinants of myocardial mass. METHODS: We carried out a genome-wide association meta-analysis of 4 QRS traits in up to 73,518 individuals of European ancestry, followed by extensive biological and functional assessment. RESULTS: We identified 52 genomic loci, of which 32 are novel, that are reliably associated with 1 or more QRS phenotypes at p < 1 × 10(-8). These loci are enriched in regions of open chromatin, histone modifications, and transcription factor binding, suggesting that they represent regions of the genome that are actively transcribed in the human heart. Pathway analyses provided evidence that these loci play a role in cardiac hypertrophy. We further highlighted 67 candidate genes at the identified loci that are preferentially expressed in cardiac tissue and associated with cardiac abnormalities in Drosophila melanogaster and Mus musculus. We validated the regulatory function of a novel variant in the SCN5A/SCN10A locus in vitro and in vivo. CONCLUSIONS: Taken together, our findings provide new insights into genes and biological pathways controlling myocardial mass and may help identify novel therapeutic targets
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N=293,051) genome-wide association meta-analysis for the PR interval, discovering 202 loci of which 141 have not previously been reported. Variants at identified loci increase the percentage of heritability explained, from 33.5% to 62.6%. We observe enrichment for cardiac muscle developmental/contractile and cytoskeletal genes, highlighting key regulation processes for atrioventricular conduction. Additionally, 8 loci not previously reported harbor genes underlying inherited arrhythmic syndromes and/or cardiomyopathies suggesting a role for these genes in cardiovascular pathology in the general population. We show that polygenic predisposition to PR interval duration is an endophenotype for cardiovascular disease, including distal conduction disease, AF, and atrioventricular pre-excitation. These findings advance our understanding of the polygenic basis of cardiac conduction, and the genetic relationship between PR interval duration and cardiovascular disease. On the electrocardiogram, the PR interval reflects conduction from the atria to ventricles and also serves as risk indicator of cardiovascular morbidity and mortality. Here, the authors perform genome-wide meta-analyses for PR interval in multiple ancestries and identify 141 previously unreported genetic loci.Peer reviewe
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