179 research outputs found

    Unique Shortest Vector Problem for max norm is NP-hard

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    The unique Shortest vector problem (uSVP) in lattice theory plays a crucial role in many public-key cryptosystems. The security of those cryptosystems bases on the hardness of uSVP. However, so far there is no proof for the proper hardness of uSVP even in its exact version. In this paper, we show that the exact version of uSVP for ℓ∞\ell_\infty norm is NP-hard. Furthermore, many other lattice problems including unique Subspace avoiding problem, unique Closest vector problem and unique Generalized closest vector problem, for any ℓp\ell_p norm, are also shown to be NP-hard

    Dynamic Analysis of Mindlin Plates Resting on a Viscoelastic Foundation Subjected to Moving Loads During Abrupt Braking using Moving Element Method

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    The paper proposes a new computational approach using the moving element method (MEM) for simulating the dynamic responses of Mindlin plate resting on a viscoelastic foundation subjected to moving loads during abrupt braking. In this approach, the governing equations as well as the plate element mass, damping and stiffness matrices are formulated in a convected coordinate in which the origin is attached to the applied point of the moving load. Thus, the proposed method simply treats the moving loads as ‘stationary’ at the nodes of the plate to avoid updating the locations of moving loads due to the change of the contact points on the plate. The interaction between the moving load and the plate during abrupt braking is accounted for through the vertical force and tangential wheel-pavement friction force. The effects of wheel sliding, load deceleration magnitude, friction coefficient, and plate thickness on the dynamic responses of plate are investigated

    Multi-layer moving plate method for dynamic analysis of pavement structures subjected to moving loads

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    This paper presents a new approach, namely multi-layer moving plate method (MMPM), for the dynamic analysis of pavement structures subjected to moving load. The pavement resting on multi-layer foundation is modeled as a two-layer plate connected by a spring-damper system resting on a viscoelastic foundation. This model gives a accurately pavement structure model so that the dynamic responses of the surface slab and the base can be obtained. The governing equations as well as the plate element mass, damping and stiffness matrices are formulated in a convected coordinate with the idea of attaching its origin to the applied point of the moving load. The proposed method simply treats the moving load as ‘stationary’ at the node of the plate to avoid the updating of the location of moving load due to change of contact points on the plate. Numerical examples related to the dynamic analysis of the pavement structure subjected to a moving load are conducted to investigate the effects of various parameters such as concrete slab thickness, base thickness, foundation stiffness and the load’s velocity on dynamic responses of the pavement structure

    Prevalence of Human Papillomavirus in Women with Abnormal Cervical Smears from Sarawak, Malaysia

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    Introduction Cervical cancer is common cancer and ranked in fourth place in both incidence and mortality worldwide. It is 3rd most common female cancer in Malaysia with a lifetime risk of 1 in 116. Infection with high-risk oncogenic human papillomavirus (HPV) is recognized as one of the substantial risk factors for the development of cervical cancers. Methods It was a cross-sectional study conducted to determine the prevalence of HPV infection and its subtypes among women with various degrees of abnormal smears, who were seen in the colposcopy clinic of Sarawak General Hospital within six months’ period from January to June 2018. We recruited 56 participants. There were 23 each for an atypical squamous cell of undetermined significance (ASC-US) and low-grade squamous intraepithelial lesion (LSIL) and 10 high- grade squamous intraepithelial lesion (HSIL). DNA was extracted, and HPV genotypes were determined via polymerase chain reaction (PCR) using two primer pairs MY09/MY11 and GP5+/GP6+. Results The age ranged from 23 to 56 years, with a mean age of 42.96 years. HPV was detected in 20 out of 56 (35.7%). There were 6 high-risk oncogenic HPVs (18, 51, 52, 56, 58, 68) detected in participants and the most prevalent subtypes were 18, 52, and 58 (20% each). Four low-risk HPVs detected were 6, 53, 70, and 84. There was a significant association between the severity of cervical lesions and HPV positivity (P < 0.004). HSIL had the highest positive predictive value to have HPV infection as 70% compared to 43.4% of LSIL and 9.3% of ASC-US. Conclusion Distribution of HPV subtypes from women with abnormal smears from Sarawak indicated a high prevalence of HPV 18, 52, and 58. We also identified HPV 70, which has never been reported in West Malaysia. These findings could contribute valuable information for HPV vaccination strategies, particularly for Sarawakian women

    Hybrid phishing detection using joint visual and textual identity

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    In recent years, phishing attacks have evolved considerably, causing existing adversarial features that were widely utilised for detecting phishing websites to become less discriminative. These developments have fuelled growing interests among security researchers towards an anti-phishing strategy known as the identity-based detection technique. Identity-based detection techniques have consistently achieved high true positive rates in a rapidly changing phishing landscape, owing to its capitalisation on fundamental brand identity relations that are inherent in most legitimate webpages. However, existing identity-based techniques often suffer higher false positive rates due to complexities and challenges in establishing the webpage’s brand identity. To close the existing performance gap, this paper proposes a new hybrid identity-based phishing detection technique that leverages webpage visual and textual identity. Extending earlier anti-phishing work based on the website logo as visual identity, our method incorporates novel image features that mimic human vision to enhance the logo detection accuracy. The proposed hybrid technique integrates the visual identity with a textual identity, namely, brand-specific keywords derived from the webpage content using textual analysis methods. We empirically demonstrated on multiple benchmark datasets that this joint visual-textual identity detection approach significantly improves phishing detection performance with an overall accuracy of 98.6%. Benchmarking results against an existing technique showed comparable true positive rates and a reduction of up to 3.4% in false positive rates, thus affirming our objective of reducing the misclassification of legitimate webpages without sacrificing the phishing detection performance. The proposed hybrid identitybased technique is proven to be a significant and practical contribution that will enrich the anti-phishing community with improved defence strategies against rapidly evolving phishing schemes

    20th International Medical, Pharmaceutical, Cosmeceutical and Health Science Symposium

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    The 20th International Medical, Pharmaceutical, Cosmeceutical & Health Science Symposium (iMPaCHS) is an annual symposium co-organized by Faculty of Life and Health Sciences, International Medical School, School of Pharmacy, Management & Science of the Management & Science University, Malaysia. With the theme 'Advancing Health Science Innovations through Interdisciplinary Collaboration', the 20th iMPaCHS aims to promote holistic research skills for future betterment. Advancing health science innovations requires a multidisciplinary approach, which involves the collaboration of experts from various fields. Interdisciplinary collaboration enables the integration of knowledge, perspectives, and methodologies from different disciplines, leading to the development of novel and effective solutions to complex health challenges. By fostering interdisciplinary collaboration, health science can leverage the strengths of each field and accelerate the translation of research findings into clinical practice, ultimately improving and advancing the overall state of health science. This is in line with the sustainable development goal and collaborative research activity in the university. The 20th International Medical, Pharmaceutical, Cosmeceutical & Health Science Symposium (iMPaCHS) is an annual symposium co-organized by Faculty of Life and Health Sciences, International Medical School, School of Pharmacy, Management & Science of the Management & Science University, Malaysia. With the theme 'Advancing Health Science Innovations through Interdisciplinary Collaboration', the 20th iMPaCHS aims to promote holistic research skills for future betterment. Advancing health science innovations requires a multidisciplinary approach, which involves the collaboration of experts from various fields. Interdisciplinary collaboration enables the integration of knowledge, perspectives, and methodologies from different disciplines, leading to the development of novel and effective solutions to complex health challenges. By fostering interdisciplinary collaboration, health science can leverage the strengths of each field and accelerate the translation of research findings into clinical practice, ultimately improving and advancing the overall state of health science. This is in line with the sustainable development goal and collaborative research activity in the university

    Prevalence of Human Papilloma virus in women with Abnormal Cervical Smears from Sarawak, Malaysia

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    Introduction: Cervical cancer is common cancer and ranked in fourth place in both incidence and mortality worldwide. It is 3rd most common female cancer in Malaysia with a lifetime risk of 1 in 116. Infection with high-risk oncogenic human papillomavirus (HPV) is recognized as one of the substantial risk factors for the development of cervical cancers. Methods: It was a cross-sectional study conducted to determine the prevalence of HPV infection and its subtypes among women with various degrees of abnormal smears, who were seen in the colposcopy clinic of Sarawak General Hospital within six months’ period from January to June 2018. We recruited 56 participants. There were 23 each for an atypical squamous cell of undetermined significance (ASC-US) and low-grade squamous intraepithelial lesion (LSIL) and 10 high- grade squamous intraepithelial lesion (HSIL). DNA was extracted, and HPV genotypes were determined via polymerase chain reaction (PCR) using two primer pairs MY09/MY11 and GP5+/GP6+. Results: The age ranged from 23 to 56 years, with a mean age of 42.96 years. HPV was detected in 20 out of 56 (35.7%). There were 6 high-risk oncogenic HPVs (18, 51, 52, 56, 58, 68) detected in participants and the most prevalent subtypes were 18, 52, and 58 (20% each). Four low-risk HPVs detected were 6, 53, 70, and 84. There was a significant association between the severity of cervical lesions and HPV positivity (P < 0.004). HSIL had the highest positive predictive value to have HPV infection as 70% compared to 43.4% of LSIL and 9.3% of ASC-US. Conclusion: Distribution of HPV subtypes from women with abnormal smears from Sarawak indicated a high prevalence of HPV 18, 52, and 58. We also identified HPV 70, which has never been reported in West Malaysia. These findings could contribute valuable information for HPV vaccination strategies, particularly for Sarawakian women

    Building Burma: Constructing Rangoon's Urban Influence on Citizenship and Nationhood

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    This is the author accepted manuscript. The final version is available from Wiley via https://doi.org/10.1111/hic3.12340While Burma has often been discussed at the margins of South and Southeast Asian historiography, contemporary scholarship has begun to construct Burma as central to wider regional and inter-Asian histories. This essay considers how notions of nationhood and citizenship relating to Rangoon’s urban environment can begin to be understood in light of recent historical work on other Asian port cities. Looking at published work on Asian cities like Bombay, Hong Kong and Singapore, this article constructs a contextual framework from which Rangoon’s role in building a Burmese identity can be analysed. Nikhil Rao’s House, But No Garden\small \textit{House, But No Garden} on Bombay offers a productive means through which a middle-class and commercial Burmese identity could be constructed in Rangoon’s pre-war ‘suburbs’, while Alan Smart’s The Shek Kip Mei Myth\small \textit{The Shek Kip Mei Myth} on Hong Kong and Loh Kah Seng’s Squatters into Citizens\small \textit{Squatters into Citizens} on Singapore provide a way of understanding the role that disaster and crisis play on forming identities of belonging and citizenship among the poorest sections of Rangoon’s war torn post-war society. These cities, along with others across the Indian Ocean world – each with a long, continuous and often separate tradition of historical inquiry – can then help begin to build an understanding of citizenship and nationhood in Burma as it relates to the construction of Rangoon’s urban environment.Cambridge Trusts via a Cambridge International Scholarship and the Smuts Memorial Fun

    Extracellular vesicles generated by placental tissues ex vivo: A transport system for immune mediators and growth factors

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    Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/144634/1/aji12860_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/144634/2/aji12860.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/144634/3/aji12860-sup-0001-Supinfo.pd
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