Preferential solvation of 4-(4-nitrophenylazo) aniline in alcohol-dioxane binary solvent mixture

Electronic spectroscopy is a suitable method for studying solvation. It has been observed that maximum energy of electronic transition of various solutes depends to a great extent on the local environment around the solute. In binary solvent, the composition of liquid mixture around the solute (solvation shell) is different from that of the bulk. The inhomogenecity created by the solute molecule in the solvation shell is known as preferential solvation. Owing to the applicability of various azo dyes and the importance to study solute-solvent interaction, herein we have made an attempt to study the preferential solvation of 4-(4-nitrophenylazo) aniline (NPA) in binary solvent mixtures of alcohol with dioxane. With increase in solvent polarity, the maximum spectroscopic absorption of NPA experience a red shift (bathochromic shift) indicating a positive solvatochromism. These facts can be explained in terms of the greater stabilization of the excited state compared to the ground state by greater solvating power of polar solvents through specific (hydrogen bonding) and nonspecific (dipole-dipole) interaction, which reduces the energy difference between ground and excited state intern reducing the maximum energy of absorption. In all the case, the molecule of solute is preferentially solvated by alcohols over dioxane due to (i) hydrogen bonding (ii) dipole- dipole interaction and (iii) apolar/hydrophobic interaction In some cases, synergism is observed due to higher solvent-solvent interaction than solute-solvent interaction. The balancing of both polar and apolar characetrisitcs in the solvent cage show significant solvatochromism

Transition metal complexes produced from dipicolinic acid: synthesis, structural characterization, and anti-microbial investigations

  ABSTRACT. A novel series of mononuclear complexes of the type, [M(L)(H2O)2] [M = Co(II) (1), Ni(II) (2), Zn(II) (3), Cd(II) (4), L = dipicolinate), has been investigated using various techniques, including elemental analyses, FT-IR, 1H- and 13C NMR spectroscopy, powder XRD and thermogravimetric analysis. The results indicate that the coordination of the dipicolinic acid to the metal ions involves two carboxylate O atoms, the pyridine N atom, and two water molecules. The pyridine-2,6-dicarboxylic acid and its studied compounds have been screened against microbial species. The findings show that the complexes have higher activity in comparison to the free pyridine-dicarboxylic acid.   KEY WORDS: Dipicolinic acid, Metal complexes, Antimicrobial activity   Bull. Chem. Soc. Ethiop. 2022, 36(3), 607-615.                                                               DOI: https://dx.doi.org/10.4314/bcse.v36i3.10                                                       &nbsp

ANTIMICROBIAL AND ANTIOXIDANT ACTIVITIES OF SOME NEWLY SYNTHESIZED BENZENE-1, 3-DIOL CONGENERS AND THEIR CHARACTERIZATION

Objective: Synthesis of novel Benzene-1, 3-diol analogues by incorporation of various aryl and hetero arylazo moieties. The newly synthesized Benzene-1, 3-diol congeners were evaluated to study their in vitro antimicrobial and antioxidant activities.Methods: This part of research work was included with the synthesis of a series of Benzene-1, 3-diol analogues by coupling of Benzene-1, 3-diol with different diazotized aryl and heteroaryl amines and their structures and physical characteristics were confirmed by different modern analytical techniques viz. FT/IR, 1H NMR, UV spectroscopy, LC-MS, DSC and elemental analysis. The in vitro antimicrobial activity of the synthesized compounds were conducted by cup and plate method against different gram positive and gram negative bacterial pathogens and fungal strains. The radical scavenging activity of the Benzene-1, 3-diol analogues were measured by DPPH method. The results of antimicrobial and antioxidant activity were statistically interpreted.Results: The newly synthesized compounds of Benzene-1, 3-diol substituted with 4-carboxy phenyl, antipyrinyl and isoxazolyl nucleus showed significant antibacterial activity. Whereas, the antipyrinyl and isoxazolyl substitued benzene-1, 3-diol analogues showed significant antifungal activities when compared with standard drugs. The Benzene-1, 3-diol analogues also exhibited effective antioxidant activity.Conclusion: This research work concluded that the newly synthesized benzene-1, 3-diol analogues posses significant antimicrobial and potential antioxidant activity

SYNTHESIS & IN-VITRO PROTEIN DENATURATION SCREENING OF 2-[(1, 5-DISUBSTITUTEDPHENYL-4,5-DIHYDRO-1H-PYRAZOL-3-YL)OXY]BENZOIC ACID DERIVATIVES

Abstract Novel 2-[(1,5-diphenyl-4,5-dihydro-1H-pyrazol-3-yl)oxy]benzoic acid (2a) & 2-[5-(2-hydroxyphenyl)-1-Phenyl-4,5-dihydro-1H-pyrazol-3-yl]benzoic acid (2b) were produced and examined for their in-vitro protein denaturation activities. It was discovered that compound 2b showed promise and had more potency than acetylsalicylic acid (NSAID) in inhibiting denaturation of bovine serum albumin. Docking research also supports this. The compound 2b has the highest docking scores with COX1(PDB ID 3N8Z), COX2 (PDB ID 4PH9), and TNF (PDB ID 2AZ5), respectively, of Etotal -233.75, -256.48, and -255.83. TLC and elemental tests were used to determine the compounds' purity. All of the generated molecules' analytical and spectral data (1H NMR, FTIR, and MS) were entirely consistent with the proposed structures

Evaluation of medicinal potential and antibacterial activity of selected plants against Streptococcus mutans

Article Details: Received: 2020-06-15 | Accepted: 2020-09-28 | Available online: 2021-03-31 https://doi.org/10.15414/afz.2021.24.01.9-15The aim of the study is to screen the bioactive compounds (saponin, tannin, phenolic compounds, terpenoid & steroid) present in selected ethnomedicinal plants, Terminalia bellirica (fruits), Smilax zeylanica (leaves) and Dioscorea oppositifolia (fruits) from Odisha state, India. The single formulation was prepared using the selected plants parts in the ratio 1 : 6 : 3 respectively for quantitative analysis of tannin & total phenol, antioxidant activity and analysis of MIC (Minimum Inhibitory Concentration) against Streptococcus mutans causing bacteria of tooth decay. Results revealed that selected plant parts are rich source of bioactive compounds like tannin, phenolic compounds and saponin. The quantitative analysis of secondary metabolites showed highest concentration of tannin. It was noted that antioxidant activity is highest in methanol extract as compared to aqueous and acetone. MIC analysis also revealed that formulated powder had excellent antibacterial activity against S. mutans and it was observed the lowest values (450 µg ml-1) showed aqueous & methanol followed by acetone. The herbal formulation might be used to formulate new herbal products against tooth decay in near future.Keywords: antibacterial activity, antioxidant activity, ethnomedicinal plants, secondary metabolites, tooth decay ReferencesANDERSON, T. (2004). Dental treatment in medieval England. British Dental Journal, 197(7), 419–425.DESHMUKH, M.A. and THENG, M.A. (2018). Phytochemical screening, quantitative analysis of primary secondary metabolites of Acacia aeabica bark. International Journal of Current Pharmaceutical Research, 10(2), 35–37.DHANYA, S.V.S., et al. (2018). Preliminary phytochemical activity of Smilax zeylanica L. (Smilaceaceae). 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Chapman and Hall Ltd, 49–188.HAZRA, K. (2019). Phytochemical investigation of Terminalia bellirica fruit inside. Asian Journal of Pharmaceutical and Clinical Research, 12(8), 191–194.JYOTHI, T., et al. (2012). Phytochemical evaluation of Smilax zeylanica Linn. Soushrutam, 1(1), 1–14.KANDUTI, D. (2016). Fluoride: a review of use and effects on health. Mater Sociomed, 28, 133–137.MAST, P. et al. (2013). Understanding MIH: definition, epidemiology, differential diagnosis and new treatment guidelines. European Journal of Paediatrics Dent, 14(3), 204–8.MEJÁRE, I. and MJÖR, I.A. (2003). Dental caries: The Disease and its Clinical Management. Wiley-Blackwell.MOORE, W.J. (1983). The role of sugar in the aetiology of dental caries. 1. Sugar and the antiquity of dental caries. Journal of Dentist,11(3), 189–190.NATIONS, M.K. and NUTO, S.D.A.S. (2002). Tooth worms: poverty tattoos and dental care conflicts in Northeast Brazil. Social Sciences & Medicines, 54(2), 229–244.NEVILLE, B.W. and Day, T.A. (2002). Oral cancer and precancerous lesions. CA: A Cancer Journal for Clinicians, 52(4), 195–215.RAAMAN, N. (2006). Qualitative phytochemical screening and Phytochemical Techniques. New Delhi Publishing.RAI, A. et al. (2010). Antibiotic mediated synthesis of gold nanoparticles with potent antimicrobial activity and their application in antimicrobial coatings.  Journal of Materials Chemistry, 20(32), 6789–6798.SAXENA, H.O. and BRAHMAM, M. (1994). The flora of Orissa. Regional Research Laboratory; Orissa Forest Development Corporation, pp. 437–439.SHARMA, D. et al. (2018). Role of plant extract in the inhibition of dental caries. International Journal of Life Science & Pharma Research, 8(2), 9–23.SHEKARCHIZADEH, H. et al. (2013). Oral health of drugs abusers: a review of health effects and care. 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Forward-central two-particle correlations in p-Pb collisions at root s(NN)=5.02 TeV

Two-particle angular correlations between trigger particles in the forward pseudorapidity range (2.5 2GeV/c. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B. V.Peer reviewe

Azimuthal anisotropy of charged jet production in root s(NN)=2.76 TeV Pb-Pb collisions

We present measurements of the azimuthal dependence of charged jet production in central and semi-central root s(NN) = 2.76 TeV Pb-Pb collisions with respect to the second harmonic event plane, quantified as nu(ch)(2) (jet). Jet finding is performed employing the anti-k(T) algorithm with a resolution parameter R = 0.2 using charged tracks from the ALICE tracking system. The contribution of the azimuthal anisotropy of the underlying event is taken into account event-by-event. The remaining (statistical) region-to-region fluctuations are removed on an ensemble basis by unfolding the jet spectra for different event plane orientations independently. Significant non-zero nu(ch)(2) (jet) is observed in semi-central collisions (30-50% centrality) for 20 <p(T)(ch) (jet) <90 GeV/c. The azimuthal dependence of the charged jet production is similar to the dependence observed for jets comprising both charged and neutral fragments, and compatible with measurements of the nu(2) of single charged particles at high p(T). Good agreement between the data and predictions from JEWEL, an event generator simulating parton shower evolution in the presence of a dense QCD medium, is found in semi-central collisions. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Peer reviewe

Event-shape engineering for inclusive spectra and elliptic flow in Pb-Pb collisions at root(NN)-N-S=2.76 TeV

Peer reviewe

Pseudorapidity and transverse-momentum distributions of charged particles in proton-proton collisions at root s=13 TeV

The pseudorapidity (eta) and transverse-momentum (p(T)) distributions of charged particles produced in proton-proton collisions are measured at the centre-of-mass energy root s = 13 TeV. The pseudorapidity distribution in vertical bar eta vertical bar <1.8 is reported for inelastic events and for events with at least one charged particle in vertical bar eta vertical bar <1. The pseudorapidity density of charged particles produced in the pseudorapidity region vertical bar eta vertical bar <0.5 is 5.31 +/- 0.18 and 6.46 +/- 0.19 for the two event classes, respectively. The transverse-momentum distribution of charged particles is measured in the range 0.15 <p(T) <20 GeV/c and vertical bar eta vertical bar <0.8 for events with at least one charged particle in vertical bar eta vertical bar <1. The evolution of the transverse momentum spectra of charged particles is also investigated as a function of event multiplicity. The results are compared with calculations from PYTHIA and EPOS Monte Carlo generators. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Peer reviewe