419 research outputs found
Activity-Independent Prespecification of Synaptic Partners in the Visual Map of Drosophila
- Author
- Publication venue
- Elsevier Ltd.
- Publication date
- 19/09/2006
- Field of study
SummarySpecifying synaptic partners and regulating synaptic numbers are at least partly activity-dependent processes during visual map formation in all systems investigated to date [1â5]. In Drosophila, six photoreceptors that view the same point in visual space have to be sorted into synaptic modules called cartridges in order to form a visuotopically correct map [6, 7]. Synapse numbers per photoreceptor terminal and cartridge are both precisely regulated [8â10]. However, it is unknown whether an activity-dependent mechanism or a genetically encoded developmental program regulates synapse numbers. We performed a large-scale quantitative ultrastructural analysis of photoreceptor synapses in mutants affecting the generation of electrical potentials (norpA, trp;trpl), neurotransmitter release (hdc, syt), vesicle endocytosis (synj), the trafficking of specific guidance molecules during photoreceptor targeting (sec15), a specific guidance receptor required for visual map formation (Dlar), and 57 other novel synaptic mutants affecting 43 genes. Remarkably, in all these mutants, individual photoreceptors form the correct number of synapses per presynaptic terminal independently of cartridge composition. Hence, our data show that each photoreceptor forms a precise and constant number of afferent synapses independently of neuronal activity and partner accuracy. Our data suggest cell-autonomous control of synapse numbers as part of a developmental program of activity-independent steps that lead to a âhard-wiredâ visual map in the fly brain
Drosophila NMNAT Maintains Neural Integrity Independent of Its NAD Synthesis Activity
- Author
- Adalbert
- Araki
- Balducci
- Barry Dickson
- Bellen
- Bentrop
- Benzer
- Bloomquist
- Bonini
- Chung
- Coleman
- Conforti
- Conforti
- Cummings
- Emanuelli
- Fang
- Finn
- Georgiev
- Gillingwater
- Hay
- Hiesinger
- Hiesinger
- Hoopfer
- Hotta
- Hugo J Bellen
- Imai
- Jacobson
- Jellinger
- Karen L Schulze
- Laser
- Lee
- Lee
- Ludwin
- Lunn
- MacDonald
- Mack
- Masai
- Matsumoto
- McKay
- Mehta
- Meinertzhagen
- Montell
- Newsome
- Noell
- P. Robin Hiesinger
- Patrik Verstreken
- Perry
- R. Grace Zhai
- Raffaelli
- Raghu
- Ranganathan
- Ribchester
- Rongvaux
- Sagot
- Saigoh
- Schweiger
- Shieh
- Sunil Q Mehta
- Tsuda
- Verstreken
- Waller
- Wang
- Warrick
- Whitmore
- Wolff
- Yi Zhou
- Yoon
- Yu Cao
- Zhai
- Zhai
- Zhai
- Zhang
- Publication venue
- Public Library of Science
- Publication date
- 01/11/2006
- Field of study
Wallerian degeneration refers to a loss of the distal part of an axon after nerve injury. Wallerian degeneration slow (Wld(s)) mice overexpress a chimeric protein containing the NAD synthase NMNAT (nicotinamide mononucleotide adenylyltransferase 1) and exhibit a delay in axonal degeneration. Currently, conflicting evidence raises questions as to whether NMNAT is the protecting factor and whether its enzymatic activity is required for such a possible function. Importantly, the link between nmnat and axon degeneration is at present solely based on overexpression studies of enzymatically active protein. Here we use the visual system of Drosophila as a model system to address these issues. We have isolated the first nmnat mutations in a multicellular organism in a forward genetic screen for synapse malfunction in Drosophila. Loss of nmnat causes a rapid and severe neurodegeneration that can be attenuated by blocking neuronal activity. Furthermore, in vivo neuronal expression of mutated nmnat shows that enzymatically inactive NMNAT protein retains strong neuroprotective effects and rescues the degeneration phenotype caused by loss of nmnat. Our data indicate an NAD-independent requirement of NMNAT for maintaining neuronal integrity that can be exploited to protect neurons from neuronal activity-induced degeneration by overexpression of the protein
First measurement of the Hubble Constant from a Dark Standard Siren using the Dark Energy Survey Galaxies and the LIGO/Virgo BinaryâBlack-hole Merger GW170814
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2019
- Field of study
International audienceWe present a multi-messenger measurement of the Hubble constant H 0 using the binaryâblack-hole merger GW170814 as a standard siren, combined with a photometric redshift catalog from the Dark Energy Survey (DES). The luminosity distance is obtained from the gravitational wave signal detected by the Laser Interferometer Gravitational-Wave Observatory (LIGO)/Virgo Collaboration (LVC) on 2017 August 14, and the redshift information is provided by the DES Year 3 data. Black hole mergers such as GW170814 are expected to lack bright electromagnetic emission to uniquely identify their host galaxies and build an object-by-object Hubble diagram. However, they are suitable for a statistical measurement, provided that a galaxy catalog of adequate depth and redshift completion is available. Here we present the first Hubble parameter measurement using a black hole merger. Our analysis results in , which is consistent with both SN Ia and cosmic microwave background measurements of the Hubble constant. The quoted 68% credible region comprises 60% of the uniform prior range [20, 140] km sâ1 Mpcâ1, and it depends on the assumed prior range. If we take a broader prior of [10, 220] km sâ1 Mpcâ1, we find (57% of the prior range). Although a weak constraint on the Hubble constant from a single event is expected using the dark siren method, a multifold increase in the LVC event rate is anticipated in the coming years and combinations of many sirens will lead to improved constraints on H 0
Constraints on the cosmic expansion history from GWTC-3
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- Publication venue
- Publication date
- 19/11/2021
- Field of study
We use 47 gravitational-wave sources from the Third LIGO-Virgo-KAGRA Gravitational-Wave Transient Catalog (GWTC-3) to estimate the Hubble parameter H(z), including its current value, the Hubble constant H0â. Each gravitational-wave (GW) signal provides the luminosity distance to the source and we estimate the corresponding redshift using two methods: the redshifted masses and a galaxy catalog. Using the binary black hole (BBH) redshifted masses, we simultaneously infer the source mass distribution and H(z). The source mass distribution displays a peak around 34Mââ, followed by a drop-off. Assuming this mass scale does not evolve with redshift results in a H(z) measurement, yielding H0â=68â7+12âkmsâ1Mpcâ1 (68% credible interval) when combined with the H0â measurement from GW170817 and its electromagnetic counterpart. This represents an improvement of 17% with respect to the H0â estimate from GWTC-1. The second method associates each GW event with its probable host galaxy in the catalog GLADE+, statistically marginalizing over the redshifts of each event's potential hosts. Assuming a fixed BBH population, we estimate a value of H0â=68â6+8âkmsâ1Mpcâ1 with the galaxy catalog method, an improvement of 42% with respect to our GWTC-1 result and 20% with respect to recent H0â studies using GWTC-2 events. However, we show that this result is strongly impacted by assumptions about the BBH source mass distribution; the only event which is not strongly impacted by such assumptions (and is thus informative about H0â) is the well-localized event GW190814
Search for gravitational waves from Scorpius X-1 in the second Advanced LIGO observing run with an improved hidden Markov model
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- Publication venue
- College Park, MD : American Physical Society
- Publication date
- 01/01/2019
- Field of study
We present results from a semicoherent search for continuous gravitational waves from the low-mass x-ray binary Scorpius X-1, using a hidden Markov model (HMM) to track spin wandering. This search improves on previous HMM-based searches of LIGO data by using an improved frequency domain matched filter, the J-statistic, and by analyzing data from Advanced LIGO's second observing run. In the frequency range searched, from 60 to 650 Hz, we find no evidence of gravitational radiation. At 194.6 Hz, the most sensitive search frequency, we report an upper limit on gravitational wave strain (at 95% confidence) of h095%=3.47Ă10-25 when marginalizing over source inclination angle. This is the most sensitive search for Scorpius X-1, to date, that is specifically designed to be robust in the presence of spin wandering. © 2019 American Physical Society
Search for continuous gravitational waves from 20 accreting millisecond x-ray pulsars in O3 LIGO data
- Author
- Abbott R
- Abbott T
- Acernese F
- Ackley K
- Adams C
- Adhikari N
- Adhikari R
- Adya V
- Affeldt C
- Agarwal D
- Agathos M
- Agatsuma K
- Aggarwal N
- Aguiar O
- Aiello L
- Ain A
- Akutsu T
- Albanesi S
- Albayati A
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- Publication venue
- Publication date
- 01/01/2022
- Field of study
Search for gravitational waves from Scorpius X-1 with a hidden Markov model in O3 LIGO data
- Author
- Abbott R
- Abe H
- Acernese F
- Ackley K
- Adhikari N
- Adhikari R
- Adkins V
- Adya V
- Affeldt C
- Agarwal D
- Agathos M
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- Publication venue
- Publication date
- 01/01/2022
- Field of study
Search for continuous gravitational wave emission from the Milky Way center in O3 LIGO--Virgo data
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- D. E.
- J. F. J.
- N. A.
- a N.
- a P. K.
- Abbott R.
- Abe H.
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- Publication venue
- Publication date
- 01/01/2022
- Field of study
We present a directed search for continuous gravitational wave (CW) signals
emitted by spinning neutron stars located in the inner parsecs of the Galactic
Center (GC). Compelling evidence for the presence of a numerous population of
neutron stars has been reported in the literature, turning this region into a
very interesting place to look for CWs. In this search, data from the full O3
LIGO--Virgo run in the detector frequency band [10,2000]Â Hz have been
used. No significant detection was found and 95% confidence level upper
limits on the signal strain amplitude were computed, over the full search band,
with the deepest limit of about 7.6Ă10â26 at â142Â Hz.
These results are significantly more constraining than those reported in
previous searches. We use these limits to put constraints on the fiducial
neutron star ellipticity and r-mode amplitude. These limits can be also
translated into constraints in the black hole mass -- boson mass plane for a
hypothetical population of boson clouds around spinning black holes located in
the GC.Comment: 25 pages, 5 figure
Search for gravitational waves from Scorpius X-1 in the second Advanced LIGO observing run with an improved hidden Markov model
- Author
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- Wysocki Dm
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- Xu R
- Yamamoto H
- Yancey Cc
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- Zhao G
- Zhou M
- Zhou Z
- Zhu Xj
- Zimmerman Ab
- Zucker Me
- Zweizig J
- Publication venue
- College Park, MD : American Physical Society
- Publication date
- 01/01/2019
- Field of study
We present results from a semicoherent search for continuous gravitational waves from the low-mass x-ray binary Scorpius X-1, using a hidden Markov model (HMM) to track spin wandering. This search improves on previous HMM-based searches of LIGO data by using an improved frequency domain matched filter, the J-statistic, and by analyzing data from Advanced LIGO's second observing run. In the frequency range searched, from 60 to 650 Hz, we find no evidence of gravitational radiation. At 194.6 Hz, the most sensitive search frequency, we report an upper limit on gravitational wave strain (at 95% confidence) of h095%=3.47Ă10-25 when marginalizing over source inclination angle. This is the most sensitive search for Scorpius X-1, to date, that is specifically designed to be robust in the presence of spin wandering. © 2019 American Physical Society
Search for gravitational waves from Scorpius X-1 in the second Advanced LIGO observing run with an improved hidden Markov model
- Author
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- Sennett N
- Sentenac D
- Sequino V
- Sergeev A
- Setyawati Y
- Shaddock Da
- Shaffer T
- Shahriar Ms
- Shaner Mb
- Sharma A
- Sharma P
- Shawhan P
- Shen H
- Shink R
- Shoemaker Dh
- Shoemaker Dm
- Shukla K
- ShyamSundar S
- Siellez K
- Sieniawska M
- Sigg D
- Singer Lp
- Singh D
- Singh N
- Singhal A
- Sintes Am
- Sitmukhambetov S
- Skliris V
- Slagmolen Bjj
- Slaven-Blair Tj
- Smith Jr
- Smith Rje
- Somala S
- Son Ej
- Soni S
- Sorazu B
- Sorrentino F
- Souradeep T
- Sowell E
- Spencer Ap
- Spera M
- Srivastava Ak
- Srivastava V
- Staats K
- Stachie C
- Standke M
- Steer Da
- Steinke M
- Steinlechner J
- Steinlechner S
- Steinmeyer D
- Stevenson Sp
- Stocks D
- Stone R
- Stops Dj
- Strain Ka
- Stratta G
- Strigin Se
- Strunk A
- Sturani R
- Stuver Al
- Sudhir V
- Summerscales Tz
- Sun L
- Sunil S
- Sur A
- Suresh J
- Sutton Pj
- Swinkels Bl
- Szczepanczyk Mj
- Tacca M
- Tait Sc
- Talbot C
- Tanner Db
- Tao D
- Tapai M
- Tapia A
- Tasson Jd
- Taylor R
- Tenorio R
- Terkowski L
- Thomas M
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- Thondapu Sr
- Thorne Ka
- Thrane E
- Tiwari S
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- Tiwari V
- Toland K
- Tonelli M
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- Torres-Forne A
- Torrie Ci
- Toyra D
- Travasso F
- Traylor G
- Tringali Mc
- Tripathee A
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- Tsang Kw
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- Tsukada L
- Tsuna D
- Tsutsui T
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- Ueno K
- Ugolini D
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- Urban Al
- Usman Sa
- Vahlbruch H
- Vajente G
- Valdes G
- Valentini M
- van Bakel N
- van Beuzekom M
- van den Brand Jfj
- Van Den Broeck C
- van der Schaaf L
- van Veggel Aa
- Vander-Hyde Dc
- VanHeijningen Jv
- Vardaro M
- Varma V
- Vass S
- Vasuth M
- Vecchio A
- Vedovato G
- Veitch J
- Veitch Pj
- Venkateswara K
- Venugopalan G
- Verkindt D
- Vetrano F
- Vicere A
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- Villa Em
- Vinciguerra S
- Vine Dj
- Vinet Jy
- Vitale S
- Vivanco Fh
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- Vorvick C
- Vyatchanin Sp
- Wade Ar
- Wade Le
- Wade M
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- Wallace L
- Walsh S
- Wang H
- Wang Jz
- Wang S
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- Watchi J
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- Weinert M
- Weinstein Aj
- Weiss R
- Wellmann F
- Wen L
- Wessel K
- Wessels P
- Westhouse Jw
- Wette K
- Whelan Jt
- Whiting Bf
- Whittle C
- Wilken Dm
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- Williamson Ar
- Willis Jl
- Willke B
- Winkler W
- Wipf Cc
- Wittel H
- Woan G
- Woehler J
- Wofford Jk
- Wright Jl
- Wu Ds
- Wysocki Dm
- Xiao S
- Xu R
- Yamamoto H
- Yancey Cc
- Yang L
- Yang Y
- Yang Z
- Yap Mj
- Yazback M
- Yeeles Dw
- Yu H
- Yu Hc
- Yuen Shr
- Zadrozny A
- Zadrozny Ak
- Zanolin M
- Zelenova T
- Zendri Jp
- Zevin M
- Zhang J
- Zhang L
- Zhang T
- Zhao C
- Zhao G
- Zhou M
- Zhou Z
- Zhu Xj
- Zimmerman Ab
- Zucker Me
- Zweizig J
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2019
- Field of study
We present results from a semicoherent search for continuous gravitational waves from the low-mass x-ray binary Scorpius X-1, using a hidden Markov model (HMM) to track spin wandering. This search improves on previous HMM-based searches of LIGO data by using an improved frequency domain matched filter, the J-statistic, and by analyzing data from Advanced LIGOâs second observing run. In the frequency range searched, from 60 to 650 Hz, we find no evidence of gravitational radiation. At 194.6 Hz, the most sensitive search frequency, we report an upper limit on gravitational wave strain (at 95% confidence) of h95%0=3.47Ă10â25 when marginalizing over source inclination angle. This is the most sensitive search for Scorpius X-1, to date, that is specifically designed to be robust in the presence of spin wandering
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